Linshang Chemical
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2-Chloro-4-Fluorobromobenzene
Linshang Chemical
|
HS Code |
433026 |
| Chemical Formula | C6H3BrClF |
| Molecular Weight | 225.44 |
| Appearance | Liquid (usually) |
| Boiling Point | Around 190 - 200 °C |
| Density | Data may vary, but typically in the range of halogenated benzenes |
| Solubility In Water | Low (immiscible, as it is non - polar) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ether, benzene |
| Odor | Characteristic halogenated aromatic odor |
| Stability | Stable under normal conditions, but can react with strong bases or reducing agents |
As an accredited 2-Chloro-4-Fluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 4 - fluorobromobenzene packaged in a sealed glass bottle. |
| Storage | 2 - chloro - 4 - fluorobromobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store it in a tightly sealed container to prevent evaporation and leakage. Since it is a potentially hazardous chemical, ensure storage areas are restricted to authorized personnel only. |
| Shipping | 2 - Chloro - 4 - fluorobromobenzene should be shipped in well - sealed, corrosion - resistant containers. Label it clearly as a chemical. Ensure compliance with regulations for transporting hazardous substances, with proper handling to prevent spills during transit. |
Competitive 2-Chloro-4-Fluorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Chloro-4-Fluorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 2-chloro-4-fluorobromobenzene?
2-Chloro-4-fluorobromobenzene is one of the organic compounds. In its molecular structure, the benzene ring is the core structure, and there are three substituents on it, namely the chlorine atom at the 2nd position, the fluorine atom at the 4th position, and the bromine atom at another position connected to the benzene ring.
Looking at its benzene ring, it is a six-membered ring structure composed of six carbon atoms connected by conjugated double bonds, which has unique stability and electron cloud distribution characteristics. The chlorine atom at the 2nd position, that is, on the carbon atom numbered 2 in the benzene ring, is connected to the carbon atom by a single bond. The electronegativity of chlorine atoms is quite large, which will affect the density distribution of electron clouds in the benzene ring, reduce the density of electron clouds in the adjacent and para-site of the benzene ring, and then affect the chemical activity and reaction check point of this compound.
The fluorine atom at position 4 is also connected by a single bond on the carbon atom of benzene ring number 4. The electronegativity of fluorine atoms is more significant, and it is the largest among all elements. Its effect on the electron cloud density of the benzene ring is more prominent, strengthening the electron cloud migration of the benzene ring, and further changing the physical and chemical properties of the compound.
As for the bromine atom, it is also connected to the benzene ring by a single bond. The bromine atom is relatively large, and its steric hindrance and electronic effect interact with chlorine and fluorine atoms to jointly determine the overall structure, stability and chemical reactivity of 2-chloro-4-fluorobromobenzene.
The structural characteristics of this compound enable it to build more complex organic molecules through nucleophilic substitution, electrophilic substitution and other reactions in the field of organic synthesis, which has potential application value in pharmaceutical chemistry, materials science and other fields.
Looking at its benzene ring, it is a six-membered ring structure composed of six carbon atoms connected by conjugated double bonds, which has unique stability and electron cloud distribution characteristics. The chlorine atom at the 2nd position, that is, on the carbon atom numbered 2 in the benzene ring, is connected to the carbon atom by a single bond. The electronegativity of chlorine atoms is quite large, which will affect the density distribution of electron clouds in the benzene ring, reduce the density of electron clouds in the adjacent and para-site of the benzene ring, and then affect the chemical activity and reaction check point of this compound.
The fluorine atom at position 4 is also connected by a single bond on the carbon atom of benzene ring number 4. The electronegativity of fluorine atoms is more significant, and it is the largest among all elements. Its effect on the electron cloud density of the benzene ring is more prominent, strengthening the electron cloud migration of the benzene ring, and further changing the physical and chemical properties of the compound.
As for the bromine atom, it is also connected to the benzene ring by a single bond. The bromine atom is relatively large, and its steric hindrance and electronic effect interact with chlorine and fluorine atoms to jointly determine the overall structure, stability and chemical reactivity of 2-chloro-4-fluorobromobenzene.
The structural characteristics of this compound enable it to build more complex organic molecules through nucleophilic substitution, electrophilic substitution and other reactions in the field of organic synthesis, which has potential application value in pharmaceutical chemistry, materials science and other fields.
What are the physical properties of 2-chloro-4-fluorobromobenzene?
2-Chloro-4-fluorobromobenzene is one of the organic halogenated aromatic hydrocarbons. Its physical properties are unique and valuable for investigation.
When it comes to its properties, it is usually a colorless to light yellow transparent liquid, which is clear in appearance. This state is conducive to being used as a raw material or solvent in many chemical reactions, because it has good fluidity and is easy to mix and react.
Smell it, it has a special aromatic smell, but this smell is not pleasant and irritating to a certain extent. During operation, caution is required, because its smell may irritate the respiratory tract and skin, causing discomfort to the human body.
Its boiling point is in a specific range, about 190-200 ° C. The boiling point property is of great significance when separating and purifying the substance. By distillation, it can be precisely separated from the mixture according to its boiling point to ensure purity.
In terms of melting point, it is roughly around - 20 ° C. The low melting point means that it is easy to maintain a liquid state at room temperature, which enhances its adaptability in various reaction systems.
2-chloro-4-fluorobromobenzene has a density greater than that of water, about 1.8 g/cm ³. This property is crucial in experimental or industrial processes involving liquid-liquid separation. When mixed with liquids of different densities such as water, it will be stratified according to the density difference to facilitate the separation operation.
In addition, the substance has good solubility in organic solvents, such as common ethanol, ether, acetone, etc., which can be miscible with it. This solubility provides convenience for organic synthesis reactions and can be used as a reaction medium to promote full contact of the reactants, speed up the reaction process, and improve the reaction efficiency.
When it comes to its properties, it is usually a colorless to light yellow transparent liquid, which is clear in appearance. This state is conducive to being used as a raw material or solvent in many chemical reactions, because it has good fluidity and is easy to mix and react.
Smell it, it has a special aromatic smell, but this smell is not pleasant and irritating to a certain extent. During operation, caution is required, because its smell may irritate the respiratory tract and skin, causing discomfort to the human body.
Its boiling point is in a specific range, about 190-200 ° C. The boiling point property is of great significance when separating and purifying the substance. By distillation, it can be precisely separated from the mixture according to its boiling point to ensure purity.
In terms of melting point, it is roughly around - 20 ° C. The low melting point means that it is easy to maintain a liquid state at room temperature, which enhances its adaptability in various reaction systems.
2-chloro-4-fluorobromobenzene has a density greater than that of water, about 1.8 g/cm ³. This property is crucial in experimental or industrial processes involving liquid-liquid separation. When mixed with liquids of different densities such as water, it will be stratified according to the density difference to facilitate the separation operation.
In addition, the substance has good solubility in organic solvents, such as common ethanol, ether, acetone, etc., which can be miscible with it. This solubility provides convenience for organic synthesis reactions and can be used as a reaction medium to promote full contact of the reactants, speed up the reaction process, and improve the reaction efficiency.
What are the main uses of 2-chloro-4-fluorobromobenzene?
2-Chloro-4-fluorobromobenzene is one of the organic compounds. Its main uses are quite extensive and have applications in various fields of chemical industry.
First of all, in the field of organic synthesis, it is often used as a key intermediate. As far as the preparation of special drugs is concerned, among the synthesis paths of many drugs, 2-chloro-4-fluorobromobenzene can be combined with other organic molecules through specific chemical reactions, and through ingenious steps, complex drug molecular structures can be constructed. Due to the unique activities and spatial structures of chlorine, fluorine, bromine and other atoms in the benzene ring, it can endow the synthesized drugs with specific pharmacological activities and physicochemical properties.
Furthermore, in the field of materials science, it also has important functions. For example, in the preparation of special polymer materials, 2-chloro-4-fluorobromobenzene can participate in the polymerization reaction and become part of the polymer chain, which in turn imparts materials such as excellent thermal stability, chemical stability or special optical properties. These properties are quite valuable in the material requirements of high-end fields such as aerospace and electronics.
In addition, in the preparation of fine chemicals, 2-chloro-4-fluorobromobenzene is also indispensable. The production of fine chemicals such as certain high-performance coatings and pigments requires their unique chemical structures to meet specific product requirements such as color, durability, and adhesion. Through subsequent chemical modifications and reactions, fine chemicals can be developed to meet different application scenarios.
In short, 2-chloro-4-fluorobromobenzene, with its special molecular structure and chemical activity, plays a crucial role in many important fields such as organic synthesis, materials science, and fine chemical preparation, and plays a crucial role in promoting the development of related industries.
First of all, in the field of organic synthesis, it is often used as a key intermediate. As far as the preparation of special drugs is concerned, among the synthesis paths of many drugs, 2-chloro-4-fluorobromobenzene can be combined with other organic molecules through specific chemical reactions, and through ingenious steps, complex drug molecular structures can be constructed. Due to the unique activities and spatial structures of chlorine, fluorine, bromine and other atoms in the benzene ring, it can endow the synthesized drugs with specific pharmacological activities and physicochemical properties.
Furthermore, in the field of materials science, it also has important functions. For example, in the preparation of special polymer materials, 2-chloro-4-fluorobromobenzene can participate in the polymerization reaction and become part of the polymer chain, which in turn imparts materials such as excellent thermal stability, chemical stability or special optical properties. These properties are quite valuable in the material requirements of high-end fields such as aerospace and electronics.
In addition, in the preparation of fine chemicals, 2-chloro-4-fluorobromobenzene is also indispensable. The production of fine chemicals such as certain high-performance coatings and pigments requires their unique chemical structures to meet specific product requirements such as color, durability, and adhesion. Through subsequent chemical modifications and reactions, fine chemicals can be developed to meet different application scenarios.
In short, 2-chloro-4-fluorobromobenzene, with its special molecular structure and chemical activity, plays a crucial role in many important fields such as organic synthesis, materials science, and fine chemical preparation, and plays a crucial role in promoting the development of related industries.
What are the preparation methods of 2-chloro-4-fluorobromobenzene?
To prepare 2-chloro-4-fluorobromobenzene, the following methods are often followed.
First, benzene is used as the beginning, and halogenation is performed first. Iron bromide is used as the catalyst to react benzene with bromine to obtain bromobenzene. This step is electrophilic substitution, and the bromine atom enters the benzene ring. Next, under specific conditions, chlorine gas and ferric chloride are used to catalyze the chlorination of bromobenzene to obtain 4-bromochlorobenzene. After fluoridation, the chlorine atom of 4-bromochlorobenzene is replaced by the fluorine atom under suitable solvents and catalysts, and finally 2-chloro-4-fluorobromobenzene is obtained.
Second, take fluorobenzene as the starting material. First brominate fluorobenzene, use bromine and an appropriate catalyst, and select bromine atoms into the benzene ring to obtain o-bromofluorobenzene or p-bromofluorobenzene, and separate p-bromofluorobenzene. Then chlorinate p-bromofluorobenzene and react with chlorine gas in the presence of a catalyst to obtain 2-chloro-4-fluorobenzene.
Third, start with chlorobenzene. First fluoride p-chlorobenzene to obtain the isomer of fluorochlorobenzene and separate p-fluorobenzene. Then, brominate p-chlorobenzene and react with bromine under the action of a catalyst to obtain 2-chloro-4-fluorob
Each of these methods has its own advantages and disadvantages. The availability of raw materials, the difficulty of reaction conditions, the purity and yield of the product, etc., all need to be weighed. In actual preparation, according to the specific situation, carefully choose the appropriate method.
First, benzene is used as the beginning, and halogenation is performed first. Iron bromide is used as the catalyst to react benzene with bromine to obtain bromobenzene. This step is electrophilic substitution, and the bromine atom enters the benzene ring. Next, under specific conditions, chlorine gas and ferric chloride are used to catalyze the chlorination of bromobenzene to obtain 4-bromochlorobenzene. After fluoridation, the chlorine atom of 4-bromochlorobenzene is replaced by the fluorine atom under suitable solvents and catalysts, and finally 2-chloro-4-fluorobromobenzene is obtained.
Second, take fluorobenzene as the starting material. First brominate fluorobenzene, use bromine and an appropriate catalyst, and select bromine atoms into the benzene ring to obtain o-bromofluorobenzene or p-bromofluorobenzene, and separate p-bromofluorobenzene. Then chlorinate p-bromofluorobenzene and react with chlorine gas in the presence of a catalyst to obtain 2-chloro-4-fluorobenzene.
Third, start with chlorobenzene. First fluoride p-chlorobenzene to obtain the isomer of fluorochlorobenzene and separate p-fluorobenzene. Then, brominate p-chlorobenzene and react with bromine under the action of a catalyst to obtain 2-chloro-4-fluorob
Each of these methods has its own advantages and disadvantages. The availability of raw materials, the difficulty of reaction conditions, the purity and yield of the product, etc., all need to be weighed. In actual preparation, according to the specific situation, carefully choose the appropriate method.
2-chloro-4-fluorobromobenzene what are the precautions during storage and transportation?
2-Chloro-4-fluorobromobenzene is an organic compound. When storing and transporting, many matters need to be paid attention to.
First words storage. Because of its certain chemical activity, it must be stored in a cool, dry and well-ventilated place. Keep away from high temperatures, fire sources and strong oxidants to prevent unexpected chemical reactions, which may cause fire and explosion. This compound may be sensitive to air and moisture, so it should be sealed and stored to prevent contact with air and water vapor and deterioration. And the storage place should be clearly marked, detailing its name, nature and precautions, so that relevant personnel can see it at a glance and be cautious when operating.
Second discussion on transportation. Before transportation, make sure that the packaging is sturdy. Use suitable packaging materials, such as special glass bottles, metal drums, etc., to resist vibration and collision during transportation. Outside the packaging, clear hazard labels should also be posted to indicate its chemical properties and hazard level, so that both transporters and regulators can be alert. During transportation, strictly control the temperature to prevent excessive temperature fluctuations. If it is a long-distance transportation, it is necessary to regularly check whether the packaging is in good condition and whether there is any leakage. Transportation personnel should also be professionally trained to be familiar with the characteristics of this compound and emergency response methods. In case of leakage, they can respond quickly and properly to reduce the damage.
In conclusion, the storage and transportation of 2-chloro-4-fluorobromobenzene requires great care and strict regulations and procedures to ensure safety.
First words storage. Because of its certain chemical activity, it must be stored in a cool, dry and well-ventilated place. Keep away from high temperatures, fire sources and strong oxidants to prevent unexpected chemical reactions, which may cause fire and explosion. This compound may be sensitive to air and moisture, so it should be sealed and stored to prevent contact with air and water vapor and deterioration. And the storage place should be clearly marked, detailing its name, nature and precautions, so that relevant personnel can see it at a glance and be cautious when operating.
Second discussion on transportation. Before transportation, make sure that the packaging is sturdy. Use suitable packaging materials, such as special glass bottles, metal drums, etc., to resist vibration and collision during transportation. Outside the packaging, clear hazard labels should also be posted to indicate its chemical properties and hazard level, so that both transporters and regulators can be alert. During transportation, strictly control the temperature to prevent excessive temperature fluctuations. If it is a long-distance transportation, it is necessary to regularly check whether the packaging is in good condition and whether there is any leakage. Transportation personnel should also be professionally trained to be familiar with the characteristics of this compound and emergency response methods. In case of leakage, they can respond quickly and properly to reduce the damage.
In conclusion, the storage and transportation of 2-chloro-4-fluorobromobenzene requires great care and strict regulations and procedures to ensure safety.
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