Linshang Chemical
PRODUCTS
2-Chloro-4-Fluoroiodobenzene
Linshang Chemical
|
HS Code |
621941 |
| Chemical Formula | C6H3ClFI |
| Molecular Weight | 272.44 |
| Appearance | Liquid (usually) |
| Boiling Point | Approximately 215 - 220 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Cas Number | 100367-46-6 |
| Purity Typical | Often available in 95%+ purity |
As an accredited 2-Chloro-4-Fluoroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 4 - fluoroiodobenzene packaged in a sealed glass bottle. |
| Storage | 2 - chloro - 4 - fluoroiodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions. Regularly check storage conditions to ensure product integrity. |
| Shipping | 2 - chloro - 4 - fluoroiodobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous material shipping regulations, ensuring safe transportation to prevent any chemical leakage or risk. |
Competitive 2-Chloro-4-Fluoroiodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Chloro-4-Fluoroiodobenzene in China?
As a trusted 2-Chloro-4-Fluoroiodobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-4-Fluoroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2-chloro-4-fluoroiodobenzene?
2-Chloro-4-fluoroiodobenzene is an organohalogenated aromatic hydrocarbon. Its chemical properties are unique and are closely related to many reactions.
Let's talk about the nucleophilic substitution reaction first, because there are chlorine, fluorine and iodine atoms attached to the benzene ring, which can be used as a check point for nucleophilic substitution. The iodine atom is quite active and often reacts with nucleophilic reagents such as alkoxides and amines first, and then leaves to form new organic compounds. For example, if it reacts with sodium ethanol, the iodine atom leaves, and the ethoxy group replaces it to obtain an ethoxy-containing benzene derivative.
Let's talk about the electrophilic substitution reaction. Although there are electron-absorbing halogen atoms on the ben In view of the fact that the halogen atom is an ortho-para-localization group, electrophilic reagents often attack the ortho or para-position of chlorine and fluorine atoms. For example, under appropriate conditions, when reacting with mixed acid of nitric acid and sulfuric acid, nitro groups can be introduced at specific positions in the benzene ring.
In addition, 2-chloro-4-fluoroiodobenzene can also participate in metal-catalyzed reactions. Like palladium-catalyzed coupling reactions, iodine atoms can be coupled with other organic halides or olefins under the action of palladium catalysts to form carbon-carbon bonds, thereby synthesizing more complex organic molecules.
As for its stability, due to the high electronegativity of the halogen atom, the bond formed with the benzene ring has a certain polarity, making the compound relatively active under specific conditions and less stable than benzene itself. When storing and using, be careful to avoid contact with active reagents or extreme conditions to prevent unnecessary reactions.
Let's talk about the nucleophilic substitution reaction first, because there are chlorine, fluorine and iodine atoms attached to the benzene ring, which can be used as a check point for nucleophilic substitution. The iodine atom is quite active and often reacts with nucleophilic reagents such as alkoxides and amines first, and then leaves to form new organic compounds. For example, if it reacts with sodium ethanol, the iodine atom leaves, and the ethoxy group replaces it to obtain an ethoxy-containing benzene derivative.
Let's talk about the electrophilic substitution reaction. Although there are electron-absorbing halogen atoms on the ben In view of the fact that the halogen atom is an ortho-para-localization group, electrophilic reagents often attack the ortho or para-position of chlorine and fluorine atoms. For example, under appropriate conditions, when reacting with mixed acid of nitric acid and sulfuric acid, nitro groups can be introduced at specific positions in the benzene ring.
In addition, 2-chloro-4-fluoroiodobenzene can also participate in metal-catalyzed reactions. Like palladium-catalyzed coupling reactions, iodine atoms can be coupled with other organic halides or olefins under the action of palladium catalysts to form carbon-carbon bonds, thereby synthesizing more complex organic molecules.
As for its stability, due to the high electronegativity of the halogen atom, the bond formed with the benzene ring has a certain polarity, making the compound relatively active under specific conditions and less stable than benzene itself. When storing and using, be careful to avoid contact with active reagents or extreme conditions to prevent unnecessary reactions.
What are the common uses of 2-chloro-4-fluoroiodobenzene?
2-Chloro-4-fluoroiodobenzene is a common compound in organic synthesis. Its preparation method follows the method of organic chemistry. The common preparation route is the first halogenation reaction.
First, the corresponding benzene derivative is used as the starting material, and chlorine, fluorine and iodine atoms are introduced through the action of halogenation reagents. For example, the benzene ring can be chlorinated and fluorinated first to obtain the benzene intermediate containing chlorine and fluorine, and then the iodine substitution reaction is carried out. During the iodine substitution, iodide is often used as the iodine source, supplemented by suitable catalysts and reaction conditions, to achieve the purpose of introducing iodine atoms.
Furthermore, palladium-catalyzed cross-coupling reactions can also be used. The structure of 2-chloro-4-fluoroiodobenzene was formed by coupling the appropriate halogenated aromatic hydrocarbons with iodine in the presence of palladium catalyst, ligand and base. This method has mild conditions and high selectivity, and is widely used in the field of organic synthesis.
Or it can be started from other benzene compounds containing specific substituents and gradually converted into functional groups to form the target product. First, the substituents of the starting compound are modified to have suitable reactivity, and then chlorine, fluorine and iodine atoms are introduced in sequence to obtain 2-chloro-4-fluoroiodobenzene through multi-step reaction.
When preparing this compound, attention should be paid to the control of reaction conditions, such as temperature, reaction time, proportion of reactants, etc., which have a great influence on the yield and purity of the product. After each step of reaction, separation and purification operations are often required to remove impurities and obtain pure 2-chloro-4-fluoroiodobenzene.
First, the corresponding benzene derivative is used as the starting material, and chlorine, fluorine and iodine atoms are introduced through the action of halogenation reagents. For example, the benzene ring can be chlorinated and fluorinated first to obtain the benzene intermediate containing chlorine and fluorine, and then the iodine substitution reaction is carried out. During the iodine substitution, iodide is often used as the iodine source, supplemented by suitable catalysts and reaction conditions, to achieve the purpose of introducing iodine atoms.
Furthermore, palladium-catalyzed cross-coupling reactions can also be used. The structure of 2-chloro-4-fluoroiodobenzene was formed by coupling the appropriate halogenated aromatic hydrocarbons with iodine in the presence of palladium catalyst, ligand and base. This method has mild conditions and high selectivity, and is widely used in the field of organic synthesis.
Or it can be started from other benzene compounds containing specific substituents and gradually converted into functional groups to form the target product. First, the substituents of the starting compound are modified to have suitable reactivity, and then chlorine, fluorine and iodine atoms are introduced in sequence to obtain 2-chloro-4-fluoroiodobenzene through multi-step reaction.
When preparing this compound, attention should be paid to the control of reaction conditions, such as temperature, reaction time, proportion of reactants, etc., which have a great influence on the yield and purity of the product. After each step of reaction, separation and purification operations are often required to remove impurities and obtain pure 2-chloro-4-fluoroiodobenzene.
What are 2-chloro-4-fluoroiodobenzene synthesis methods?
The synthesis method of 2-chloro-4-fluoroiodobenzene has been explored by many scholars in the past, and the methods are various, and the number is slightly listed today.
First, halogenated aromatics are used as starting materials and can be obtained by nucleophilic substitution reaction. First, take a benzene ring compound containing an appropriate substituent, and its halogen atom can be replaced with a nucleophilic reagent under specific conditions. For example, 2-chloro-4-fluorobenzene is used as the substrate, and an iodizing agent, such as potassium iodide, is added to a suitable solvent, such as dimethylformamide (DMF), and a catalyst, such as a copper salt, is heated and stirred. The halogen atoms can be exchanged to obtain 2-chloro-4-fluoroiodobenzene. In this process, the polarity of the solvent, the type and amount of the catalyst, and the reaction temperature and time all have a significant impact on the reaction yield and selectivity.
Second, it is synthesized by the reaction of aryl boric acid or boric acid ester. First, 2-chloro-4-fluorophenylboronic acid or its borate ester is prepared, which can be obtained by reacting the corresponding halogenated benzene with a metal reagent, such as butyl lithium, and then reacting with a borate ester reagent. Then, the boric acid or borate ester is coupled with an iodine reagent under the catalysis of a transition metal catalyst, such as a palladium catalyst, and the target product can also be obtained. In this method, factors such as the activity of the catalyst, the selection of ligands, and the pH of the reaction system need to be carefully regulated to obtain good results.
Third, the reaction of diazonium salts is used. First, aniline compounds containing 2-chloro-4-fluorine are prepared into diazonium salts, which can be obtained by treating with sodium nitrite and inorganic acid at low temperature. Subsequently, the diazonium salt reacts with iodine sources such as potassium iodide, and the diazonium group is replaced by iodine atoms to generate 2-chloro-4-fluoroiodobenzene. This process requires strict control of temperature to prevent the decomposition of diazonium salts, and the properties of the reaction medium also have a significant effect on the reaction process.
The above methods have their own advantages and disadvantages. In practical application, it is necessary to weigh and choose according to the availability of raw materials, cost, and difficulty in controlling reaction conditions.
First, halogenated aromatics are used as starting materials and can be obtained by nucleophilic substitution reaction. First, take a benzene ring compound containing an appropriate substituent, and its halogen atom can be replaced with a nucleophilic reagent under specific conditions. For example, 2-chloro-4-fluorobenzene is used as the substrate, and an iodizing agent, such as potassium iodide, is added to a suitable solvent, such as dimethylformamide (DMF), and a catalyst, such as a copper salt, is heated and stirred. The halogen atoms can be exchanged to obtain 2-chloro-4-fluoroiodobenzene. In this process, the polarity of the solvent, the type and amount of the catalyst, and the reaction temperature and time all have a significant impact on the reaction yield and selectivity.
Second, it is synthesized by the reaction of aryl boric acid or boric acid ester. First, 2-chloro-4-fluorophenylboronic acid or its borate ester is prepared, which can be obtained by reacting the corresponding halogenated benzene with a metal reagent, such as butyl lithium, and then reacting with a borate ester reagent. Then, the boric acid or borate ester is coupled with an iodine reagent under the catalysis of a transition metal catalyst, such as a palladium catalyst, and the target product can also be obtained. In this method, factors such as the activity of the catalyst, the selection of ligands, and the pH of the reaction system need to be carefully regulated to obtain good results.
Third, the reaction of diazonium salts is used. First, aniline compounds containing 2-chloro-4-fluorine are prepared into diazonium salts, which can be obtained by treating with sodium nitrite and inorganic acid at low temperature. Subsequently, the diazonium salt reacts with iodine sources such as potassium iodide, and the diazonium group is replaced by iodine atoms to generate 2-chloro-4-fluoroiodobenzene. This process requires strict control of temperature to prevent the decomposition of diazonium salts, and the properties of the reaction medium also have a significant effect on the reaction process.
The above methods have their own advantages and disadvantages. In practical application, it is necessary to weigh and choose according to the availability of raw materials, cost, and difficulty in controlling reaction conditions.
2-chloro-4-fluoroiodobenzene what are the precautions during storage and transportation?
2-Chloro-4-fluoroiodobenzene is an organic compound. When storing and transporting, it is necessary to pay attention to many matters to prevent the generation of hazards and ensure safety.
First words storage. This compound should be placed in a cool and well-ventilated place. Because the temperature is too high, or its chemical properties are unstable, causing decomposition and other reactions. And good ventilation can prevent the accumulation of its volatile gases and avoid risks such as explosion and poisoning. Storage must be kept away from fire and heat sources, both of which can cause the temperature of the compound to rise and trigger dangerous reactions, such as combustion and explosion.
Furthermore, it should be stored separately from oxidizing agents, acids, bases, etc. Due to its chemical activity, in case of oxidants, or severe oxidation reaction; in case of acids, alkalis, or uncontrollable chemical changes occur, endangering safety. Storage containers must be tightly sealed to prevent leakage. If there is a leak, it will not only pollute the environment, but also may cause poisoning and other accidents.
Times and transportation. Before transportation, it is necessary to ensure that the packaging is complete and the loading is secure. Improper packaging, easy to damage and leak during transportation. When loading and unloading, the operation must be light, and it is strictly forbidden to drop and heavy pressure. Because of its certain sensitivity, rough operation or danger. Vehicles used for transportation should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. Once there is a leak or fire on the way, it can be dealt with in time. During transportation, follow the specified route and do not stop in densely populated areas, residential areas, etc. If it is unfortunate to leak, emergency responders should quickly wear gas masks and protective clothing, handle it at a safe distance, and do not let unrelated personnel approach.
In short, 2-chloro-4-fluoroiodobenzene needs to be carefully treated during storage and transportation, from environmental conditions, item compatibility, to packaging, handling, and emergency preparation, in order to ensure the safety of the process and avoid accidents.
First words storage. This compound should be placed in a cool and well-ventilated place. Because the temperature is too high, or its chemical properties are unstable, causing decomposition and other reactions. And good ventilation can prevent the accumulation of its volatile gases and avoid risks such as explosion and poisoning. Storage must be kept away from fire and heat sources, both of which can cause the temperature of the compound to rise and trigger dangerous reactions, such as combustion and explosion.
Furthermore, it should be stored separately from oxidizing agents, acids, bases, etc. Due to its chemical activity, in case of oxidants, or severe oxidation reaction; in case of acids, alkalis, or uncontrollable chemical changes occur, endangering safety. Storage containers must be tightly sealed to prevent leakage. If there is a leak, it will not only pollute the environment, but also may cause poisoning and other accidents.
Times and transportation. Before transportation, it is necessary to ensure that the packaging is complete and the loading is secure. Improper packaging, easy to damage and leak during transportation. When loading and unloading, the operation must be light, and it is strictly forbidden to drop and heavy pressure. Because of its certain sensitivity, rough operation or danger. Vehicles used for transportation should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. Once there is a leak or fire on the way, it can be dealt with in time. During transportation, follow the specified route and do not stop in densely populated areas, residential areas, etc. If it is unfortunate to leak, emergency responders should quickly wear gas masks and protective clothing, handle it at a safe distance, and do not let unrelated personnel approach.
In short, 2-chloro-4-fluoroiodobenzene needs to be carefully treated during storage and transportation, from environmental conditions, item compatibility, to packaging, handling, and emergency preparation, in order to ensure the safety of the process and avoid accidents.
What are the effects of 2-chloro-4-fluoroiodobenzene on the environment and human health?
2-Chloro-4-fluoroiodobenzene is one of the organic compounds. The impact on the environment and human health is really insignificant.
In terms of the environment, such halogenated aromatics have certain chemical stability. If released in nature, it is difficult to be easily degraded by microorganisms, and it is easy to cause them to accumulate in the environment. For example, in soil, it will change the chemical properties of soil, affecting the absorption and growth of nutrients by plants. In water bodies, it may interfere with aquatic ecosystems and have adverse effects on the survival and reproduction of aquatic organisms, such as fish and plankton. It may be transmitted and enriched through the food chain, gradually from lower organisms to higher organisms, resulting in higher concentrations in higher trophic organisms, endangering the balance of the entire ecosystem.
As for human health, 2-chloro-4-fluoroiodobenzene may be potentially harmful. It can enter the human body through respiratory inhalation, skin contact or accidental ingestion. After entering the body, it may interfere with the normal physiological and biochemical processes of the human body. Because it contains halogen atoms, or reacts with biological macromolecules in the body, such as proteins, nucleic acids, etc., it affects its normal function. Long-term exposure may damage human organs, such as the liver, kidneys, etc., affecting their metabolism and detoxification functions. What's more, it may have the risk of mutation and carcinogenesis, disrupting normal cell division and genetic information transmission, triggering abnormal cell proliferation, and eventually leading to tumors and other diseases.
Therefore, the use, production and discharge of 2-chloro-4-fluoroiodobenzene should be done with caution to prevent serious harm to the environment and human health.
In terms of the environment, such halogenated aromatics have certain chemical stability. If released in nature, it is difficult to be easily degraded by microorganisms, and it is easy to cause them to accumulate in the environment. For example, in soil, it will change the chemical properties of soil, affecting the absorption and growth of nutrients by plants. In water bodies, it may interfere with aquatic ecosystems and have adverse effects on the survival and reproduction of aquatic organisms, such as fish and plankton. It may be transmitted and enriched through the food chain, gradually from lower organisms to higher organisms, resulting in higher concentrations in higher trophic organisms, endangering the balance of the entire ecosystem.
As for human health, 2-chloro-4-fluoroiodobenzene may be potentially harmful. It can enter the human body through respiratory inhalation, skin contact or accidental ingestion. After entering the body, it may interfere with the normal physiological and biochemical processes of the human body. Because it contains halogen atoms, or reacts with biological macromolecules in the body, such as proteins, nucleic acids, etc., it affects its normal function. Long-term exposure may damage human organs, such as the liver, kidneys, etc., affecting their metabolism and detoxification functions. What's more, it may have the risk of mutation and carcinogenesis, disrupting normal cell division and genetic information transmission, triggering abnormal cell proliferation, and eventually leading to tumors and other diseases.
Therefore, the use, production and discharge of 2-chloro-4-fluoroiodobenzene should be done with caution to prevent serious harm to the environment and human health.
Scan to WhatsApp
