Linshang Chemical
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2-Chloro-4-Iodo-1-Methylbenzene
Linshang Chemical
|
HS Code |
312683 |
| Chemical Formula | C7H6ClI |
| Molar Mass | 254.48 g/mol |
| Appearance | Colorless to light yellow liquid or solid |
| Boiling Point | Approximately 243 - 245 °C |
| Melting Point | Around 23 - 25 °C |
| Density | 1.86 g/cm³ (estimated) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, etc. |
| Odor | Characteristic aromatic odor |
| Flash Point | Approximately 100 °C |
As an accredited 2-Chloro-4-Iodo-1-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 4 - iodo - 1 - methylbenzene packaged in a sealed glass bottle. |
| Storage | 2 - Chloro - 4 - iodo - 1 - methylbenzene should be stored in a cool, well - ventilated area away from heat and ignition sources. It should be stored in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Keep it separate from oxidizing agents, strong acids, and bases to prevent potential reactions. |
| Shipping | 2 - chloro - 4 - iodo - 1 - methylbenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported via approved carriers following strict hazardous material regulations to ensure safe transit. |
Competitive 2-Chloro-4-Iodo-1-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 2-chloro-4-iodo-1-methylbenzene?
2-Chloro-4-iodine-1-methylbenzene is an organic compound. Its molecular structure is unique, and its structure can be inferred according to the naming convention.
Benzene is a six-membered ring structure, which is connected by six carbon atoms with special covalent bonds to form a flat regular hexagon. In this hexagon, each carbon atom has a remaining one-valent electron, which together forms a large π bond, giving benzene special stability.
In 2-chloro-4-iodine-1-methylbenzene, "1-methyl" means that the No. 1 carbon atom of the benzene ring is connected with a methyl group (-CH 🥰). The methyl group is a group formed by covalent bonding of one carbon atom and three hydrogen atoms, which is connected to the benzene ring and affects the electron cloud distribution and chemical properties of the benzene ring.
"2-chlorine" means that the No. 2 carbon atom of the benzene ring is connected with a chlorine atom (-Cl). Chlorine atoms have high electronegativity and can absorb electrons, which reduces the electron cloud density of the benzene ring and affects the electrophilic substitution reaction on the benzene ring.
"4-iodine", that is, the No. 4 carbon atom of the benzene ring is connected with an iodine atom (-I). Although the electronegativity of the iodine atom is slightly lower than that of the chlorine atom, its atomic radius is large, and it also plays a role in the electron cloud and spatial structure of the benzene ring.
These three are connected at a specific position in the benzene ring to form a unique chemical structure of 2-chloro-4-iodine-1-methylbenzene. Its structure determines its physical and chemical properties, such as solubility, boiling point, chemical reaction activity, etc., and may have specific uses and research values in organic synthesis, medicinal chemistry and other fields.
Benzene is a six-membered ring structure, which is connected by six carbon atoms with special covalent bonds to form a flat regular hexagon. In this hexagon, each carbon atom has a remaining one-valent electron, which together forms a large π bond, giving benzene special stability.
In 2-chloro-4-iodine-1-methylbenzene, "1-methyl" means that the No. 1 carbon atom of the benzene ring is connected with a methyl group (-CH 🥰). The methyl group is a group formed by covalent bonding of one carbon atom and three hydrogen atoms, which is connected to the benzene ring and affects the electron cloud distribution and chemical properties of the benzene ring.
"2-chlorine" means that the No. 2 carbon atom of the benzene ring is connected with a chlorine atom (-Cl). Chlorine atoms have high electronegativity and can absorb electrons, which reduces the electron cloud density of the benzene ring and affects the electrophilic substitution reaction on the benzene ring.
"4-iodine", that is, the No. 4 carbon atom of the benzene ring is connected with an iodine atom (-I). Although the electronegativity of the iodine atom is slightly lower than that of the chlorine atom, its atomic radius is large, and it also plays a role in the electron cloud and spatial structure of the benzene ring.
These three are connected at a specific position in the benzene ring to form a unique chemical structure of 2-chloro-4-iodine-1-methylbenzene. Its structure determines its physical and chemical properties, such as solubility, boiling point, chemical reaction activity, etc., and may have specific uses and research values in organic synthesis, medicinal chemistry and other fields.
What are the physical properties of 2-chloro-4-iodo-1-methylbenzene?
2-Chloro-4-iodine-1-methylbenzene is an organic compound. It has specific physical properties, so let me tell you in detail.
First appearance, at room temperature and pressure, it is mostly colorless to light yellow liquid, but it also varies slightly depending on the purity and environmental conditions. Its smell often has a special aromatic smell. Although this smell is not pungent, it can also be noticed at high concentrations.
When it comes to the melting point, the melting point is about [X] ° C, and the boiling point is about [X] ° C. This melting point characteristic is actually related to the intermolecular force. Its molecules contain halogen atoms such as chlorine and iodine, and the halogen atoms have high electronegativity, so there is a strong van der Waals force between the molecules, so the melting boiling point is slightly higher than that of some simple aromatic hydrocarbons.
In terms of solubility, 2-chloro-4-iodine-1-methylbenzene is insoluble in water. This is because water is a polar molecule, and the polarity of the organic molecule is relatively weak. According to the principle of "similar miscibility", its interaction with water is weak, so it is insoluble. However, it has good solubility in organic solvents, such as ethanol, ether, benzene, etc. Because these organic solvents have similar forces to the organic molecules, they are mutually soluble.
In terms of density, it is slightly larger than water, about [X] g/cm ³. When mixed with water, it can be seen that it sinks to the bottom of the water, which is of great practical value in separation and identification.
In addition, the compound exhibits unique activity in chemical reactions because it contains halogen atoms and methyl groups. Halogen atoms can undergo nucleophilic substitution reactions, while methyl groups can participate in various reactions, affecting the reactivity and selectivity of molecules.
The physical properties of 2-chloro-4-iodine-1-methylbenzene are of great significance in organic synthesis, chemical production and other fields, providing a basic basis for related research and applications.
First appearance, at room temperature and pressure, it is mostly colorless to light yellow liquid, but it also varies slightly depending on the purity and environmental conditions. Its smell often has a special aromatic smell. Although this smell is not pungent, it can also be noticed at high concentrations.
When it comes to the melting point, the melting point is about [X] ° C, and the boiling point is about [X] ° C. This melting point characteristic is actually related to the intermolecular force. Its molecules contain halogen atoms such as chlorine and iodine, and the halogen atoms have high electronegativity, so there is a strong van der Waals force between the molecules, so the melting boiling point is slightly higher than that of some simple aromatic hydrocarbons.
In terms of solubility, 2-chloro-4-iodine-1-methylbenzene is insoluble in water. This is because water is a polar molecule, and the polarity of the organic molecule is relatively weak. According to the principle of "similar miscibility", its interaction with water is weak, so it is insoluble. However, it has good solubility in organic solvents, such as ethanol, ether, benzene, etc. Because these organic solvents have similar forces to the organic molecules, they are mutually soluble.
In terms of density, it is slightly larger than water, about [X] g/cm ³. When mixed with water, it can be seen that it sinks to the bottom of the water, which is of great practical value in separation and identification.
In addition, the compound exhibits unique activity in chemical reactions because it contains halogen atoms and methyl groups. Halogen atoms can undergo nucleophilic substitution reactions, while methyl groups can participate in various reactions, affecting the reactivity and selectivity of molecules.
The physical properties of 2-chloro-4-iodine-1-methylbenzene are of great significance in organic synthesis, chemical production and other fields, providing a basic basis for related research and applications.
What are the main uses of 2-chloro-4-iodo-1-methylbenzene?
2-Chloro-4-iodine-1-methylbenzene is also an organic compound. It has a wide range of uses and has important applications in many fields.
In the field of organic synthesis, this compound often acts as a key intermediary. Because its structure contains functional groups such as chlorine, iodine and methyl, it can be prepared by various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to prepare a series of organic compounds with special structures and properties. Chemists can modify and transform its functional groups to synthesize drug molecules with specific biological activities, or organic materials that play unique roles in the field of materials science.
In the field of medicinal chemistry, 2-chloro-4-iodine-1-methylbenzene can be used as a starting material for lead compounds. After chemical modification and optimization, it is possible to develop new drugs. The halogen atoms and methyl groups in its structure may affect the interaction between the drug and the biological target, which in turn affects the activity, selectivity and pharmacokinetic properties of the drug. By carefully designing and synthesizing derivatives based on this compound, scientists are expected to find effective drugs for treating specific diseases.
In the field of materials science, this compound also has potential application value. Through appropriate chemical reactions, it can be introduced into the structure of polymer materials to impart unique electrical, optical or mechanical properties. For example, it can be used to prepare organic semiconductor materials with specific photoelectric properties, which can be used in organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices.
Furthermore, 2-chloro-4-iodine-1-methylbenzene also plays an important role in studying the mechanism of organic reactions. Due to its unique structure, it can be used as a model compound to help chemists deeply explore the specific processes and influencing factors of various organic reactions, thus providing experimental basis and theoretical support for the development of organic chemistry theory.
In the field of organic synthesis, this compound often acts as a key intermediary. Because its structure contains functional groups such as chlorine, iodine and methyl, it can be prepared by various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to prepare a series of organic compounds with special structures and properties. Chemists can modify and transform its functional groups to synthesize drug molecules with specific biological activities, or organic materials that play unique roles in the field of materials science.
In the field of medicinal chemistry, 2-chloro-4-iodine-1-methylbenzene can be used as a starting material for lead compounds. After chemical modification and optimization, it is possible to develop new drugs. The halogen atoms and methyl groups in its structure may affect the interaction between the drug and the biological target, which in turn affects the activity, selectivity and pharmacokinetic properties of the drug. By carefully designing and synthesizing derivatives based on this compound, scientists are expected to find effective drugs for treating specific diseases.
In the field of materials science, this compound also has potential application value. Through appropriate chemical reactions, it can be introduced into the structure of polymer materials to impart unique electrical, optical or mechanical properties. For example, it can be used to prepare organic semiconductor materials with specific photoelectric properties, which can be used in organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices.
Furthermore, 2-chloro-4-iodine-1-methylbenzene also plays an important role in studying the mechanism of organic reactions. Due to its unique structure, it can be used as a model compound to help chemists deeply explore the specific processes and influencing factors of various organic reactions, thus providing experimental basis and theoretical support for the development of organic chemistry theory.
What are the preparation methods of 2-chloro-4-iodo-1-methylbenzene?
To prepare 2-chloro-4-iodine-1-methylbenzene, one can do it by numerical methods. First, toluene is used as the beginning, and the halogenation method is carried out first. Under the condition of light or heating, toluene and chlorine can easily replace the hydrogen on the methyl group to obtain benzyl chloride. After benzyl chloride and sodium iodide are added to acetone solution, according to the nucleophilic substitution reaction, the chlorine is replaced by iodine to obtain benzyl iodine. Then benzyl iodine is used as the substrate, and in the presence of suitable catalysts such as iron or ferric chloride, it reacts with chlorine. At this time, chlorine will selectively enter the benzene ring, and because methyl is an ortho-para-locator group, 2-chloro-4-iodine-1-methylbenzene can be obtained.
Second, toluene can also be used as the starting material, and toluene is nitrified first. Methyl is an ortho-para-locator, so the nitrification products are mainly o-nitrotoluene and p-nitrotoluene. After separating the two, if p-nitrotoluene is used as an example, the nitro group is first reduced to an amino group to obtain p-methylaniline. In the reaction of p-methylaniline with iodine, iodine will preferentially enter the ortho-position of the amino group to obtain 4-amino-2-iodine-1-methylbenzene. After that, the diazotization reaction is used to convert the amino group into a diazonium salt, and then reacts with cuprous chloride, and the diazonium group is replaced by chlorine to obtain 2-chloro-4-iodine-1-methylbenzene.
Alternatively, toluene can be sulfonated first to obtain p-methylbenzenesulfonic acid. The sulfonic acid group is an intersite group, and then the iodization reaction is carried out. Iodine enters the intersite of the sulfonic acid group to obtain 4-methyl After that, the sulfonic acid group is hydrolyzed under certain conditions, and then chlorination is carried out. Using the positioning effect of methyl groups, the target product 2-chloro-4-iodine-1-methylbenzene can be obtained. The above methods have their own advantages and disadvantages, and need to be carefully selected according to the actual situation, such as the availability of raw materials, the conditions of the reaction, and the purity requirements of the product.
Second, toluene can also be used as the starting material, and toluene is nitrified first. Methyl is an ortho-para-locator, so the nitrification products are mainly o-nitrotoluene and p-nitrotoluene. After separating the two, if p-nitrotoluene is used as an example, the nitro group is first reduced to an amino group to obtain p-methylaniline. In the reaction of p-methylaniline with iodine, iodine will preferentially enter the ortho-position of the amino group to obtain 4-amino-2-iodine-1-methylbenzene. After that, the diazotization reaction is used to convert the amino group into a diazonium salt, and then reacts with cuprous chloride, and the diazonium group is replaced by chlorine to obtain 2-chloro-4-iodine-1-methylbenzene.
Alternatively, toluene can be sulfonated first to obtain p-methylbenzenesulfonic acid. The sulfonic acid group is an intersite group, and then the iodization reaction is carried out. Iodine enters the intersite of the sulfonic acid group to obtain 4-methyl After that, the sulfonic acid group is hydrolyzed under certain conditions, and then chlorination is carried out. Using the positioning effect of methyl groups, the target product 2-chloro-4-iodine-1-methylbenzene can be obtained. The above methods have their own advantages and disadvantages, and need to be carefully selected according to the actual situation, such as the availability of raw materials, the conditions of the reaction, and the purity requirements of the product.
What do 2-chloro-4-iodo-1-methylbenzene need to pay attention to when storing and transporting?
2-Chloro-4-iodine-1-methylbenzene is also an organic compound. During its storage and transportation, many matters need to be paid attention to.
First words storage, this compound should be stored in a cool and ventilated warehouse. Cover because it may have a certain chemical activity, high temperature is prone to reaction, endangering safety. The warehouse temperature should not be too high to maintain its chemical stability. And it should be kept away from fire and heat sources. Open flames and hot topics can cause accidental reactions, which cannot be ignored.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and should not be stored together. Due to their chemical properties, contact with their substances can easily trigger chemical reactions, or cause serious consequences such as combustion and explosion. At the same time, the storage area should be equipped with suitable materials to contain leaks, so as to prevent accidental leakage, and can be properly handled in time to avoid greater harm.
As for transportation, make sure that the container is well sealed before transportation, and there is no risk of leakage. If the container is damaged and the compound leaks, it will not only pollute the environment, but also cause safety accidents. During transportation, it is also necessary to prevent exposure to sun and rain, and avoid high temperature and humid environment. Vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment to prevent accidents.
When transporting, follow the specified route and do not stop in densely populated areas and residential areas. Once an accident occurs, the densely populated area will be severely damaged. And transport personnel should also be familiar with the characteristics of the compound and emergency treatment methods, so that they can store and transport 2-chloro-4-iodine-1-methylbenzene safely.
First words storage, this compound should be stored in a cool and ventilated warehouse. Cover because it may have a certain chemical activity, high temperature is prone to reaction, endangering safety. The warehouse temperature should not be too high to maintain its chemical stability. And it should be kept away from fire and heat sources. Open flames and hot topics can cause accidental reactions, which cannot be ignored.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and should not be stored together. Due to their chemical properties, contact with their substances can easily trigger chemical reactions, or cause serious consequences such as combustion and explosion. At the same time, the storage area should be equipped with suitable materials to contain leaks, so as to prevent accidental leakage, and can be properly handled in time to avoid greater harm.
As for transportation, make sure that the container is well sealed before transportation, and there is no risk of leakage. If the container is damaged and the compound leaks, it will not only pollute the environment, but also cause safety accidents. During transportation, it is also necessary to prevent exposure to sun and rain, and avoid high temperature and humid environment. Vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment to prevent accidents.
When transporting, follow the specified route and do not stop in densely populated areas and residential areas. Once an accident occurs, the densely populated area will be severely damaged. And transport personnel should also be familiar with the characteristics of the compound and emergency treatment methods, so that they can store and transport 2-chloro-4-iodine-1-methylbenzene safely.
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