Linshang Chemical
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2-Chloro-4-Isocyanato-1-Methylbenzene
Linshang Chemical
|
HS Code |
888415 |
| Chemical Formula | C8H6ClNO |
| Molar Mass | 167.59 g/mol |
| Appearance | Liquid |
| Color | Colorless to pale yellow |
| Odor | Pungent |
| Density | 1.22 g/cm³ |
| Boiling Point | 232 - 234 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Flash Point | 97 °C |
| Hazard Class | Corrosive, Toxic |
| Cas Number | 19313-93-4 |
As an accredited 2-Chloro-4-Isocyanato-1-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2 - chloro - 4 - isocyanato - 1 - methylbenzene in a tightly - sealed glass bottle. |
| Storage | 2 - Chloro - 4 - isocyanato - 1 - methylbenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and direct sunlight. It must be stored in a tightly sealed container, preferably made of corrosion - resistant materials. Keep it separate from incompatible substances like amines, alcohols, and water to prevent dangerous reactions. Regularly check storage conditions and containers for integrity. |
| Shipping | 2 - Chloro - 4 - isocyanato - 1 - methylbenzene is a hazardous chemical. It must be shipped in accordance with strict regulations. Use appropriate packaging to prevent leakage, and clearly label it as hazardous for safe transportation. |
Competitive 2-Chloro-4-Isocyanato-1-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What is the chemistry of 2-chloro-4-isocyanato-1-methylbenzene?
2-Chloro-4-isocyanate-1-methylbenzene, this physical property is special, and it is related to the chemical industry. I will explain it in detail.
Looking at its structure, the chlorine atom, isocyanate group and methyl group are connected to the benzene ring, and this unique structure gives it different properties. First of all, its physical rationality, at room temperature, or in a liquid state, has a certain volatility, and has a special smell, pungent and unpleasant, because of its isocyanate group. Its density is also different from that of water, insoluble in water, but soluble in most organic solvents, such as ethanol, ether, etc. This is due to the principle of similar compatibility.
When it comes to chemistry, isocyanate groups are very active and easily react with compounds containing active hydrogen. In contact with water, they hydrolyze to form corresponding amines and carbon dioxide, which hydrolyze quickly and release energy. When they meet alcohols, they form carbamate compounds, which are commonly used in the preparation of polyurethane materials. Furthermore, chlorine atoms on the benzene ring can be replaced by nucleophiles, but suitable conditions are required, because the electron cloud distribution of the benzene ring affects the reactivity. Although methyl is relatively stable, it can also be oxidized under strong oxidation conditions.
For industrial use, 2-chloro-4-isocyanate-1-methylbenzene is an important intermediate in organic synthesis, and is required for the preparation of polyurethane, pesticides, and medicine. However, its toxicity cannot be underestimated. Isocyanate groups are highly irritating and corrosive to human respiratory tract, skin, and eyes. When operating, protection must be comprehensive.
In summary, 2-chloro-4-isocyanate-1-methylbenzene has unique physical and chemical properties due to its special structure and wide industrial use. However, due to its toxicity, it must be used with caution, follow procedures, and ensure safety.
Looking at its structure, the chlorine atom, isocyanate group and methyl group are connected to the benzene ring, and this unique structure gives it different properties. First of all, its physical rationality, at room temperature, or in a liquid state, has a certain volatility, and has a special smell, pungent and unpleasant, because of its isocyanate group. Its density is also different from that of water, insoluble in water, but soluble in most organic solvents, such as ethanol, ether, etc. This is due to the principle of similar compatibility.
When it comes to chemistry, isocyanate groups are very active and easily react with compounds containing active hydrogen. In contact with water, they hydrolyze to form corresponding amines and carbon dioxide, which hydrolyze quickly and release energy. When they meet alcohols, they form carbamate compounds, which are commonly used in the preparation of polyurethane materials. Furthermore, chlorine atoms on the benzene ring can be replaced by nucleophiles, but suitable conditions are required, because the electron cloud distribution of the benzene ring affects the reactivity. Although methyl is relatively stable, it can also be oxidized under strong oxidation conditions.
For industrial use, 2-chloro-4-isocyanate-1-methylbenzene is an important intermediate in organic synthesis, and is required for the preparation of polyurethane, pesticides, and medicine. However, its toxicity cannot be underestimated. Isocyanate groups are highly irritating and corrosive to human respiratory tract, skin, and eyes. When operating, protection must be comprehensive.
In summary, 2-chloro-4-isocyanate-1-methylbenzene has unique physical and chemical properties due to its special structure and wide industrial use. However, due to its toxicity, it must be used with caution, follow procedures, and ensure safety.
What are the main uses of 2-chloro-4-isocyanato-1-methylbenzene?
2-Chloro-4-isocyanate-1-methylbenzene is an organic compound with a wide range of uses.
In the field of pharmaceutical synthesis, it is often used as a key intermediate. It can be combined with other compounds through specific chemical reactions to build molecular structures with specific pharmacological activities. For example, in the development of some new anti-cancer drugs, it may be able to participate in the construction of drug molecules. With its unique chemical structure, it gives the final product the ability to bind to cancer cell targets, thus demonstrating anti-cancer effects.
also plays an important role in the creation of pesticides. It can be used to synthesize new pesticides. The chlorine atom, isocyanate group and methyl group in its structure endow the compound with certain biological activities. These activities can enable the synthesized pesticides to inhibit or kill specific pests and bacteria, providing strong support for pest control in agricultural production.
In the field of materials science, 2-chloro-4-isocyanate-1-methylbenzene can be used to prepare polymer materials with special properties. For example, it can polymerize with compounds containing active hydrogen to generate polymers with special structures and properties. These polymers may have good thermal stability, mechanical properties, etc., and can be used in aerospace, automotive, and other fields that require demanding material properties to meet their demand for high-performance materials.
In the field of pharmaceutical synthesis, it is often used as a key intermediate. It can be combined with other compounds through specific chemical reactions to build molecular structures with specific pharmacological activities. For example, in the development of some new anti-cancer drugs, it may be able to participate in the construction of drug molecules. With its unique chemical structure, it gives the final product the ability to bind to cancer cell targets, thus demonstrating anti-cancer effects.
also plays an important role in the creation of pesticides. It can be used to synthesize new pesticides. The chlorine atom, isocyanate group and methyl group in its structure endow the compound with certain biological activities. These activities can enable the synthesized pesticides to inhibit or kill specific pests and bacteria, providing strong support for pest control in agricultural production.
In the field of materials science, 2-chloro-4-isocyanate-1-methylbenzene can be used to prepare polymer materials with special properties. For example, it can polymerize with compounds containing active hydrogen to generate polymers with special structures and properties. These polymers may have good thermal stability, mechanical properties, etc., and can be used in aerospace, automotive, and other fields that require demanding material properties to meet their demand for high-performance materials.
What is the preparation method of 2-chloro-4-isocyanato-1-methylbenzene?
2-Chloro-4-isocyanate-1-methylbenzene, the preparation method is very complicated, and it is detailed today.
One method is to use 2-chloro-4-amino-1-methylbenzene as the starting material. Shilling it to interact with phosgene in a suitable reaction environment. Phosgene is a highly toxic and highly reactive gas. This reaction must be carried out at low temperature and in the presence of suitable solvents, such as toluene, dichloromethane and other organic solvents, so that the reaction system is more uniform to facilitate the reaction. At the beginning of the reaction, the amino group of 2-chloro-4-amino-1-methylbenzene undergoes a nucleophilic substitution reaction with phosgene to form an intermediate product. This intermediate product is further reacted to remove hydrogen chloride, and then 2-chloro-4-isocyanate-1-methylbenzene is obtained. However, the use of phosgene requires extreme caution. Due to its extreme toxicity, a little carelessness will endanger personal safety. Therefore, the reaction device must be well sealed and have a complete exhaust gas treatment system.
There is another way, using 2-chloro-1-methylbenzene as the starting material, first through nitration reaction, nitro is introduced. The introduction of nitro groups can change the electron cloud density of the benzene ring and lay the foundation for subsequent reactions. This nitrification reaction is often carried out with mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid) as nitrifying reagents within a certain temperature range. After the reaction is completed, the reaction is separated and purified to obtain 2-chloro-4-nitro-1-methylbenzene. Then the nitro is reduced to amino groups by suitable reducing agents, such as the combination of iron filings and hydrochloric acid, or by catalytic hydrogenation to obtain 2-chloro-4-amino-1-methylbenzene. After that, the target product 2-chloro-4-isocyanate-1-methylbenzene was prepared by the reaction with phosgene as described above. Although this route has a little more steps, the raw materials are relatively easy to obtain, and the operation process is slightly safer than those who directly react with phosgene.
Preparation of 2-chloro-4-isocyanate-1-methylbenzene requires fine operation and strict control of the reaction conditions to ensure the purity and yield of the product, and safety factors need to be fully considered, and no slack should be allowed.
One method is to use 2-chloro-4-amino-1-methylbenzene as the starting material. Shilling it to interact with phosgene in a suitable reaction environment. Phosgene is a highly toxic and highly reactive gas. This reaction must be carried out at low temperature and in the presence of suitable solvents, such as toluene, dichloromethane and other organic solvents, so that the reaction system is more uniform to facilitate the reaction. At the beginning of the reaction, the amino group of 2-chloro-4-amino-1-methylbenzene undergoes a nucleophilic substitution reaction with phosgene to form an intermediate product. This intermediate product is further reacted to remove hydrogen chloride, and then 2-chloro-4-isocyanate-1-methylbenzene is obtained. However, the use of phosgene requires extreme caution. Due to its extreme toxicity, a little carelessness will endanger personal safety. Therefore, the reaction device must be well sealed and have a complete exhaust gas treatment system.
There is another way, using 2-chloro-1-methylbenzene as the starting material, first through nitration reaction, nitro is introduced. The introduction of nitro groups can change the electron cloud density of the benzene ring and lay the foundation for subsequent reactions. This nitrification reaction is often carried out with mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid) as nitrifying reagents within a certain temperature range. After the reaction is completed, the reaction is separated and purified to obtain 2-chloro-4-nitro-1-methylbenzene. Then the nitro is reduced to amino groups by suitable reducing agents, such as the combination of iron filings and hydrochloric acid, or by catalytic hydrogenation to obtain 2-chloro-4-amino-1-methylbenzene. After that, the target product 2-chloro-4-isocyanate-1-methylbenzene was prepared by the reaction with phosgene as described above. Although this route has a little more steps, the raw materials are relatively easy to obtain, and the operation process is slightly safer than those who directly react with phosgene.
Preparation of 2-chloro-4-isocyanate-1-methylbenzene requires fine operation and strict control of the reaction conditions to ensure the purity and yield of the product, and safety factors need to be fully considered, and no slack should be allowed.
What 2-chloro-4-isocyanato-1-methylbenzene need to pay attention to when storing and transporting
2-Chloro-4-isocyanate-1-methylbenzene, this is an organic compound. When storing and transporting, special attention should be paid to the following numbers:
First, it is related to storage. This compound should be stored in a cool, dry and well-ventilated place. Because it is more sensitive to heat and high temperature can easily cause reactions such as decomposition, it should be kept away from fire and heat sources. If the storage environment temperature is too high, it may cause danger. Furthermore, it is necessary to ensure that the storage place has good ventilation conditions to prevent the concentration of gas accumulation from being too high and causing safety accidents. At the same time, it should be strictly stored separately from oxidants, acids, alkalis and edible chemicals, and should not be mixed. Due to its active chemical properties, contact with these substances is very likely to cause violent chemical reactions, which can cause serious consequences such as fire and explosion. Moreover, the storage area should be equipped with suitable containment materials, so that in the event of leakage and other unexpected situations, it can be contained in time to avoid greater harm caused by its spread.
Second, about transportation. Before transportation, ensure that the packaging is complete and well sealed. Packaging materials need to have certain strength and corrosion resistance to prevent the packaging from being damaged due to collision, friction, etc. during transportation, which may lead to material leakage. During transportation, vehicles should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. In the event of leakage, measures can be taken to deal with it in a timely manner to reduce hazards. When transporting, follow the prescribed route and do not stop in sensitive areas such as densely populated areas and residential areas. Due to the toxicity and danger of this substance, if an accident occurs in a densely populated area, it will pose a serious threat to the safety of many people. At the same time, transporters need to undergo special training to be familiar with its dangerous characteristics and emergency treatment methods, so as to be able to deal with various emergencies during transportation and ensure the safety of transportation.
First, it is related to storage. This compound should be stored in a cool, dry and well-ventilated place. Because it is more sensitive to heat and high temperature can easily cause reactions such as decomposition, it should be kept away from fire and heat sources. If the storage environment temperature is too high, it may cause danger. Furthermore, it is necessary to ensure that the storage place has good ventilation conditions to prevent the concentration of gas accumulation from being too high and causing safety accidents. At the same time, it should be strictly stored separately from oxidants, acids, alkalis and edible chemicals, and should not be mixed. Due to its active chemical properties, contact with these substances is very likely to cause violent chemical reactions, which can cause serious consequences such as fire and explosion. Moreover, the storage area should be equipped with suitable containment materials, so that in the event of leakage and other unexpected situations, it can be contained in time to avoid greater harm caused by its spread.
Second, about transportation. Before transportation, ensure that the packaging is complete and well sealed. Packaging materials need to have certain strength and corrosion resistance to prevent the packaging from being damaged due to collision, friction, etc. during transportation, which may lead to material leakage. During transportation, vehicles should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. In the event of leakage, measures can be taken to deal with it in a timely manner to reduce hazards. When transporting, follow the prescribed route and do not stop in sensitive areas such as densely populated areas and residential areas. Due to the toxicity and danger of this substance, if an accident occurs in a densely populated area, it will pose a serious threat to the safety of many people. At the same time, transporters need to undergo special training to be familiar with its dangerous characteristics and emergency treatment methods, so as to be able to deal with various emergencies during transportation and ensure the safety of transportation.
2-chloro-4-isocyanato-1-methylbenzene impact on the environment and human health
2-Chloro-4-isocyanate-1-methylbenzene, an organic compound, has an impact on both the environment and human health and should not be underestimated.
First of all, its impact on the environment. If this compound is released into the environment, it may interfere with the balance of the ecosystem due to its certain chemical activity. In water bodies, it may be toxic to aquatic organisms. Microorganisms in water may be destroyed by their metabolism and growth processes, resulting in a decrease in the self-purification ability of water bodies. If it enters the soil or is adsorbed by the soil, it affects the structure and function of soil microbial communities, which in turn is detrimental to plant growth. Plant root absorption is affected, which may cause slow growth, stunted development, and even death, ultimately affecting the stability of the entire terrestrial ecosystem.
Let's talk about the impact on human health. 2-Chloro-4-isocyanate-1-methylbenzene is irritating. If the human skin comes into contact, or causes contact dermatitis, the skin is red, swollen, itchy, and painful. If inhaled inadvertently, it will irritate the respiratory tract, causing cough, asthma, breathing difficulties in mild cases, and severe respiratory diseases such as pulmonary edema in severe cases. Long-term exposure to this compound has a potential carcinogenic risk. It can accumulate in the human body, interfere with normal cell metabolism and gene expression, and increase the risk of cancer. Therefore, in the production and use of products containing this compound, strict protective measures and environmental protection measures are taken to reduce its harm to the environment and human health, and to maintain ecological harmony and human well-being.
First of all, its impact on the environment. If this compound is released into the environment, it may interfere with the balance of the ecosystem due to its certain chemical activity. In water bodies, it may be toxic to aquatic organisms. Microorganisms in water may be destroyed by their metabolism and growth processes, resulting in a decrease in the self-purification ability of water bodies. If it enters the soil or is adsorbed by the soil, it affects the structure and function of soil microbial communities, which in turn is detrimental to plant growth. Plant root absorption is affected, which may cause slow growth, stunted development, and even death, ultimately affecting the stability of the entire terrestrial ecosystem.
Let's talk about the impact on human health. 2-Chloro-4-isocyanate-1-methylbenzene is irritating. If the human skin comes into contact, or causes contact dermatitis, the skin is red, swollen, itchy, and painful. If inhaled inadvertently, it will irritate the respiratory tract, causing cough, asthma, breathing difficulties in mild cases, and severe respiratory diseases such as pulmonary edema in severe cases. Long-term exposure to this compound has a potential carcinogenic risk. It can accumulate in the human body, interfere with normal cell metabolism and gene expression, and increase the risk of cancer. Therefore, in the production and use of products containing this compound, strict protective measures and environmental protection measures are taken to reduce its harm to the environment and human health, and to maintain ecological harmony and human well-being.
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