Linshang Chemical
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2-Chloro-4-Methoxy-1-Methylbenzene
Linshang Chemical
|
HS Code |
461646 |
| Chemical Formula | C8H9ClO |
| Molar Mass | 156.609 g/mol |
| Appearance | Liquid (likely) |
| Boiling Point | Estimated value based on similar compounds |
| Density | Estimated based on related aromatic compounds |
| Solubility In Water | Low (hydrophobic due to aromatic and alkyl groups) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Vapor Pressure | Low at room temperature |
| Odor | Aromatic odor (characteristic of benzene derivatives) |
As an accredited 2-Chloro-4-Methoxy-1-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 4 - methoxy - 1 - methylbenzene packaged in a sealed plastic bottle. |
| Storage | 2 - Chloro - 4 - methoxy - 1 - methylbenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames as it is flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals. Ensure the storage area is dry to avoid potential hydrolysis reactions. |
| Shipping | 2 - chloro - 4 - methoxy - 1 - methylbenzene should be shipped in tightly sealed, corrosion - resistant containers. It must be transported in accordance with hazardous chemical regulations, with proper labeling and safety measures to prevent spills and ensure safe transit. |
Competitive 2-Chloro-4-Methoxy-1-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Chloro-4-Methoxy-1-Methylbenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-4-Methoxy-1-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-4-methoxy-1-methylbenzene?
2-Chloro-4-methoxy-1-methylbenzene has a wide range of uses. In the chemical industry, it is often used as a raw material for organic synthesis. Due to its unique chemical structure, it can undergo a series of chemical reactions to derive many high-value organic compounds.
For example, in pharmaceutical synthesis, it can be used as a key intermediate. In the process of many drug development, it is necessary to use its specific structure to build a skeleton of pharmaceutical active ingredients, and then to prepare drugs with specific pharmacological activities, or to treat certain diseases, or to prevent specific symptoms, providing an important material basis for the development of the pharmaceutical industry.
In the field of materials science, 2-chloro-4-methoxy-1-methylbenzene also has outstanding performance. It can participate in the synthesis of functional polymer materials and endow the materials with special properties, such as improving the thermal stability, mechanical properties or optical properties of the materials. After appropriate chemical modification and polymerization, it is integrated into the structure of polymer materials, injecting new vitality into the development of materials science and meeting the needs of material properties in different application scenarios.
In addition, in the fragrance industry, it can be used as one of the raw materials for synthesizing fragrances. Due to its chemical properties, after participating in the fragrance synthesis reaction, it endows the fragrance with a unique aroma, adds fragrance types, and meets the market demand for diverse aromas. It is widely used in perfume, cosmetics, and food additives industries to improve the sensory quality of products and enhance market competitiveness.
In summary, although 2-chloro-4-methoxy-1-methylbenzene is an organic compound, it plays a key role in many important fields and promotes the continuous progress and development of related industries.
For example, in pharmaceutical synthesis, it can be used as a key intermediate. In the process of many drug development, it is necessary to use its specific structure to build a skeleton of pharmaceutical active ingredients, and then to prepare drugs with specific pharmacological activities, or to treat certain diseases, or to prevent specific symptoms, providing an important material basis for the development of the pharmaceutical industry.
In the field of materials science, 2-chloro-4-methoxy-1-methylbenzene also has outstanding performance. It can participate in the synthesis of functional polymer materials and endow the materials with special properties, such as improving the thermal stability, mechanical properties or optical properties of the materials. After appropriate chemical modification and polymerization, it is integrated into the structure of polymer materials, injecting new vitality into the development of materials science and meeting the needs of material properties in different application scenarios.
In addition, in the fragrance industry, it can be used as one of the raw materials for synthesizing fragrances. Due to its chemical properties, after participating in the fragrance synthesis reaction, it endows the fragrance with a unique aroma, adds fragrance types, and meets the market demand for diverse aromas. It is widely used in perfume, cosmetics, and food additives industries to improve the sensory quality of products and enhance market competitiveness.
In summary, although 2-chloro-4-methoxy-1-methylbenzene is an organic compound, it plays a key role in many important fields and promotes the continuous progress and development of related industries.
What are the physical properties of 2-chloro-4-methoxy-1-methylbenzene?
2-Chloro-4-methoxy-1-methylbenzene, this is an organic compound with unique physical properties. Its properties are mostly liquid at room temperature, and the appearance is clear and transparent, or slightly colored, but the color is very light, almost colorless.
Smell, has a special aromatic smell, the smell is rich and volatile, and can spread rapidly in the air, which is perceived by people.
Its boiling point varies depending on the intermolecular forces, usually within a certain temperature range. Due to the molecular structure containing chlorine atoms, methoxy groups and methyl groups, the boiling point has a specific value due to the interaction with each other, generally between several degrees Celsius and more than 100 degrees Celsius. This property makes it change from liquid to gaseous at a specific temperature.
The melting point is also an important physical property. At this temperature, the substance melts from solid to liquid. The melting point of 2-chloro-4-methoxy-1-methylbenzene is determined by the molecular arrangement and interaction. It is in a specific low temperature range and is solid below this temperature.
In terms of solubility, because it is an organic compound, it is easily soluble in organic solvents such as ethanol, ethyl ether, benzene, etc. according to the principle of similar miscibility. It can be well dispersed and mixed in it to form a uniform solution. However, the solubility in water is not good. Due to the large difference between molecular polarity and water, the two are difficult to interact and mix.
Density may be different from that of water, and the specific value depends on accurate determination. Due to its molecular composition and structure, its unit volume mass may be greater or smaller than that of water. This characteristic is of great significance in the process of material separation and mixing.
In summary, the physical properties of 2-chloro-4-methoxy-1-methylbenzene, such as its properties, odor, boiling point, melting point, solubility and density, are determined by molecular structure, and have a key impact on its application and treatment in the fields of organic synthesis and chemical production.
Smell, has a special aromatic smell, the smell is rich and volatile, and can spread rapidly in the air, which is perceived by people.
Its boiling point varies depending on the intermolecular forces, usually within a certain temperature range. Due to the molecular structure containing chlorine atoms, methoxy groups and methyl groups, the boiling point has a specific value due to the interaction with each other, generally between several degrees Celsius and more than 100 degrees Celsius. This property makes it change from liquid to gaseous at a specific temperature.
The melting point is also an important physical property. At this temperature, the substance melts from solid to liquid. The melting point of 2-chloro-4-methoxy-1-methylbenzene is determined by the molecular arrangement and interaction. It is in a specific low temperature range and is solid below this temperature.
In terms of solubility, because it is an organic compound, it is easily soluble in organic solvents such as ethanol, ethyl ether, benzene, etc. according to the principle of similar miscibility. It can be well dispersed and mixed in it to form a uniform solution. However, the solubility in water is not good. Due to the large difference between molecular polarity and water, the two are difficult to interact and mix.
Density may be different from that of water, and the specific value depends on accurate determination. Due to its molecular composition and structure, its unit volume mass may be greater or smaller than that of water. This characteristic is of great significance in the process of material separation and mixing.
In summary, the physical properties of 2-chloro-4-methoxy-1-methylbenzene, such as its properties, odor, boiling point, melting point, solubility and density, are determined by molecular structure, and have a key impact on its application and treatment in the fields of organic synthesis and chemical production.
What are the chemical properties of 2-chloro-4-methoxy-1-methylbenzene?
2-Chloro-4-methoxy-1-methylbenzene is one of the organic compounds. Its chemical properties are rich and unique, and it shows a different style in many chemical reactions.
The substitution reaction is first discussed. Because of the different electron cloud density distribution on the benzene ring, the chlorine atom interacts with methoxy group and methyl group, resulting in the specific position activity of the benzene ring being different from others. The chlorine atom is an ortho-para-site group, and the methoxy group is also an ortho-para-site group, and the methoxy group has stronger electron-giving ability than the chlorine atom. Therefore, during the electrophilic substitution reaction, the new substituent is mostly into the methoxy ortho-site or para-site. Taking the bromination reaction as an example, under the action of an appropriate catalyst, the bromine molecule is polarized, and the positively charged part attacks the region with high electron cloud density of the benzene ring to form bromo derivatives.
Let's talk about its oxidation reaction again. For the methyl-linked benzene ring, under the action of a strong oxidant such as acidic potassium permanganate, methyl can be oxidized to a carboxyl group to obtain 2-chloro-4-methoxybenzoic acid. During this process, the valence state of manganese element in potassium permanganate decreases, and the valence state of methyl-carbon element increases, resulting in a redox reaction.
For hydrolysis, the activity of chlorine atoms is changed due to the connection with the benzene ring and the influence of the electron effect of the benzene ring In strong alkali aqueous solution and under heating conditions, chlorine atoms can be replaced by hydroxyl groups to form 2-hydroxy-4-methoxy-1-methylbenzene, which is a kind of nucleophilic substitution reaction. Hydroxy negative ions attack the carbon atoms connected to chlorine as nucleophiles.
In addition, in 2-chloro-4-methoxy-1-methylbenzene, the oxygen atom of the methoxy group has a lone pair of electrons, which can bind to protons and exhibit a certain alkalinity. At the same time, the conjugated system of the benzene ring makes it stable, which affects its activity and selectivity in the reaction. The chemical properties of this compound are diverse, and it has great potential for application in organic synthesis, medicinal chemistry and other fields. It can be used as an intermediate to synthesize more complex organic compounds.
The substitution reaction is first discussed. Because of the different electron cloud density distribution on the benzene ring, the chlorine atom interacts with methoxy group and methyl group, resulting in the specific position activity of the benzene ring being different from others. The chlorine atom is an ortho-para-site group, and the methoxy group is also an ortho-para-site group, and the methoxy group has stronger electron-giving ability than the chlorine atom. Therefore, during the electrophilic substitution reaction, the new substituent is mostly into the methoxy ortho-site or para-site. Taking the bromination reaction as an example, under the action of an appropriate catalyst, the bromine molecule is polarized, and the positively charged part attacks the region with high electron cloud density of the benzene ring to form bromo derivatives.
Let's talk about its oxidation reaction again. For the methyl-linked benzene ring, under the action of a strong oxidant such as acidic potassium permanganate, methyl can be oxidized to a carboxyl group to obtain 2-chloro-4-methoxybenzoic acid. During this process, the valence state of manganese element in potassium permanganate decreases, and the valence state of methyl-carbon element increases, resulting in a redox reaction.
For hydrolysis, the activity of chlorine atoms is changed due to the connection with the benzene ring and the influence of the electron effect of the benzene ring In strong alkali aqueous solution and under heating conditions, chlorine atoms can be replaced by hydroxyl groups to form 2-hydroxy-4-methoxy-1-methylbenzene, which is a kind of nucleophilic substitution reaction. Hydroxy negative ions attack the carbon atoms connected to chlorine as nucleophiles.
In addition, in 2-chloro-4-methoxy-1-methylbenzene, the oxygen atom of the methoxy group has a lone pair of electrons, which can bind to protons and exhibit a certain alkalinity. At the same time, the conjugated system of the benzene ring makes it stable, which affects its activity and selectivity in the reaction. The chemical properties of this compound are diverse, and it has great potential for application in organic synthesis, medicinal chemistry and other fields. It can be used as an intermediate to synthesize more complex organic compounds.
What are 2-chloro-4-methoxy-1-methylbenzene synthesis methods?
To prepare 2-chloro-4-methoxy-1-methylbenzene, the following methods can be followed.
First, p-cresol is used as the starting material. First, p-cresol and dimethyl sulfate are reacted in an alkaline environment. Sodium hydroxide can be used as the base. This step aims to methylate the phenol hydroxyl group to obtain p-methoxytoluene. During the reaction, p-cresol is dissolved in an appropriate solvent such as acetone, an aqueous solution of sodium hydroxide is added, and dimethyl sulfate is slowly added dropwise under stirring to control the reaction temperature and time. The product can be obtained by separation and purification.
Then, p-methoxytoluene and chlorine gas undergo free radical substitution reaction in the presence of light or initiator. Using benzoyl peroxide as the initiator, p-methoxytoluene is mixed with an appropriate amount of initiator, and chlorine gas is introduced. Under light conditions, chlorine atoms replace hydrogen atoms on methyl groups to form p-methoxybenzyl chloride. The product is separated by distillation, extraction and other operations.
Finally, p-methoxybenzyl chloride reacts with magnesium powder in anhydrous ethyl ether to make Grignard reagent, and then reacts with formaldehyde. After hydrolysis, 2-chloro-4-methoxy-1-methylbenzene can be obtained. After the reaction is completed, the pure product is obtained through acidification, extraction, and distillation.
Second, p-chlorotoluene is used as the starting material. First, p-chlorotoluene is reacted with an aqueous solution of sodium hydroxide under high temperature and pressure to realize the hydroxylation of chlorine atoms to form p-methylphenol. This reaction requires specific reaction equipment to maintain high temperature and high pressure conditions. After the reaction, it is acidified and separated to obtain the product.
Next, p-methylphenol is reacted with dimethyl sulfate under basic conditions. As described above, the phenol is hydroxylated to form p-methoxytoluene.
The following steps are the same as the first method, that is, p-methoxytoluene is substituted by free radicals, made into Grignard reagent and reacted with formaldehyde and hydrolyzed to finally obtain 2-chloro-4-methoxy-1-methylbenzene. After each step of reaction, proper separation and purification operations are required to ensure the purity of the product.
First, p-cresol is used as the starting material. First, p-cresol and dimethyl sulfate are reacted in an alkaline environment. Sodium hydroxide can be used as the base. This step aims to methylate the phenol hydroxyl group to obtain p-methoxytoluene. During the reaction, p-cresol is dissolved in an appropriate solvent such as acetone, an aqueous solution of sodium hydroxide is added, and dimethyl sulfate is slowly added dropwise under stirring to control the reaction temperature and time. The product can be obtained by separation and purification.
Then, p-methoxytoluene and chlorine gas undergo free radical substitution reaction in the presence of light or initiator. Using benzoyl peroxide as the initiator, p-methoxytoluene is mixed with an appropriate amount of initiator, and chlorine gas is introduced. Under light conditions, chlorine atoms replace hydrogen atoms on methyl groups to form p-methoxybenzyl chloride. The product is separated by distillation, extraction and other operations.
Finally, p-methoxybenzyl chloride reacts with magnesium powder in anhydrous ethyl ether to make Grignard reagent, and then reacts with formaldehyde. After hydrolysis, 2-chloro-4-methoxy-1-methylbenzene can be obtained. After the reaction is completed, the pure product is obtained through acidification, extraction, and distillation.
Second, p-chlorotoluene is used as the starting material. First, p-chlorotoluene is reacted with an aqueous solution of sodium hydroxide under high temperature and pressure to realize the hydroxylation of chlorine atoms to form p-methylphenol. This reaction requires specific reaction equipment to maintain high temperature and high pressure conditions. After the reaction, it is acidified and separated to obtain the product.
Next, p-methylphenol is reacted with dimethyl sulfate under basic conditions. As described above, the phenol is hydroxylated to form p-methoxytoluene.
The following steps are the same as the first method, that is, p-methoxytoluene is substituted by free radicals, made into Grignard reagent and reacted with formaldehyde and hydrolyzed to finally obtain 2-chloro-4-methoxy-1-methylbenzene. After each step of reaction, proper separation and purification operations are required to ensure the purity of the product.
2-chloro-4-methoxy-1-methylbenzene What are the precautions during storage and transportation?
For 2-chloro-4-methoxy-1-methylbenzene, many matters should be paid attention to during storage and transportation.
This substance has certain chemical activity. When stored, the first environment is dry. If it is in a humid place, moisture may react with the substance, causing it to deteriorate and affecting the quality and use. Therefore, it is very important to choose a dry warehouse with moisture-proof facilities.
Temperature is also a key factor. It should be stored in a cool place to avoid hot topics. Because it is heated, it may cause chemical changes, or even cause safety risks. Generally speaking, normal temperature or slightly lower temperature is appropriate, and it must not be exposed to the hot sun or near a heat source.
Furthermore, the substance may be toxic and volatile to a certain extent. The storage place must be well ventilated to prevent the accumulation of harmful gases and endanger the health of personnel. And it must be sealed and stored to prevent its volatilization and escape, and to prevent external impurities from mixing in to maintain its purity.
When transporting, the packaging must be solid and reliable. Choose suitable packaging materials, which are shock-resistant and pressure-resistant, and prevent package damage and material leakage caused by collision during the journey. And in the prominent part of the packaging, post a warning mark according to regulations, indicating its characteristics and hazards, so that the transporter can know.
The means of transportation should also be clean and free of other chemical residues, so as not to react with 2-chloro-4-methoxy-1-methylbenzene. During transportation, regular inspections should also be carried out to check whether the packaging is abnormal and ensure that the transportation is safe and secure. In this way, the quality of 2-chloro-4-methoxy-1-methylbenzene can be guaranteed during storage and transportation to avoid safety hazards.
This substance has certain chemical activity. When stored, the first environment is dry. If it is in a humid place, moisture may react with the substance, causing it to deteriorate and affecting the quality and use. Therefore, it is very important to choose a dry warehouse with moisture-proof facilities.
Temperature is also a key factor. It should be stored in a cool place to avoid hot topics. Because it is heated, it may cause chemical changes, or even cause safety risks. Generally speaking, normal temperature or slightly lower temperature is appropriate, and it must not be exposed to the hot sun or near a heat source.
Furthermore, the substance may be toxic and volatile to a certain extent. The storage place must be well ventilated to prevent the accumulation of harmful gases and endanger the health of personnel. And it must be sealed and stored to prevent its volatilization and escape, and to prevent external impurities from mixing in to maintain its purity.
When transporting, the packaging must be solid and reliable. Choose suitable packaging materials, which are shock-resistant and pressure-resistant, and prevent package damage and material leakage caused by collision during the journey. And in the prominent part of the packaging, post a warning mark according to regulations, indicating its characteristics and hazards, so that the transporter can know.
The means of transportation should also be clean and free of other chemical residues, so as not to react with 2-chloro-4-methoxy-1-methylbenzene. During transportation, regular inspections should also be carried out to check whether the packaging is abnormal and ensure that the transportation is safe and secure. In this way, the quality of 2-chloro-4-methoxy-1-methylbenzene can be guaranteed during storage and transportation to avoid safety hazards.
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