Linshang Chemical
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2-Chloro-4-Methoxy-1-Nitrobenzene
Linshang Chemical
|
HS Code |
680149 |
| Chemical Formula | C7H6ClNO3 |
| Molar Mass | 187.58 g/mol |
| Appearance | Solid (usually a yellowish solid) |
| Melting Point | Data needed |
| Boiling Point | Data needed |
| Density | Data needed |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone |
| Flash Point | Data needed |
| Hazard Class | May be harmful if swallowed, inhaled or in contact with skin; Irritant |
As an accredited 2-Chloro-4-Methoxy-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2 - chloro - 4 - methoxy - 1 - nitrobenzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 2 - Chloro - 4 - methoxy - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture absorption and vapor leakage. Label the storage container clearly to avoid confusion and ensure proper handling. |
| Shipping | 2 - Chloro - 4 - methoxy - 1 - nitrobenzene should be shipped in tightly sealed, corrosion - resistant containers. Label it clearly as a hazardous chemical. Ensure transportation follows safety regulations to prevent spills and exposure during transit. |
Competitive 2-Chloro-4-Methoxy-1-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-4-Methoxy-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-4-methoxy-1-nitrobenzene?
2-Chloro-4-methoxy-1-nitrobenzene is also an organic compound. It has a wide range of uses and is particularly important as a raw material and intermediate in the field of organic synthesis.
First, it can be used to create medicine. In the field of pharmaceutical chemistry, it is often a key starting material for the synthesis of specific drug molecules. Through a series of chemical reactions, such as nucleophilic substitution, reduction, etc., compounds with specific biological activities can be derived, or can be used to develop antibacterial, anti-inflammatory and other drugs.
Second, it also has significant functions in the manufacture of pesticides. Based on it, a variety of pesticide ingredients can be prepared through carefully designed reaction paths. Such pesticides may have the characteristics of insecticides and weeds, which can help agricultural pest control and ensure the yield and quality of crops.
Third, in the field of dye industry, 2-chloro-4-methoxy-1-nitrobenzene also plays an important role. Its structure can be modified and transformed to become an important intermediate for the synthesis of various dyes. The synthesized dyes are widely used in textile, printing and dyeing industries, giving fabrics a rich and colorful color.
Fourth, in scientific research and exploration, this compound is often used as a model substrate. By studying its reaction properties, chemists can gain in-depth insights into the mechanism of organic reactions, provide theoretical basis for the development and optimization of new reactions, and promote the development of organic chemistry.
In short, 2-chloro-4-methoxy-1-nitrobenzene has important uses in many fields such as chemical industry, medicine, and agriculture, and has made great contributions to the progress of modern industry and scientific research.
First, it can be used to create medicine. In the field of pharmaceutical chemistry, it is often a key starting material for the synthesis of specific drug molecules. Through a series of chemical reactions, such as nucleophilic substitution, reduction, etc., compounds with specific biological activities can be derived, or can be used to develop antibacterial, anti-inflammatory and other drugs.
Second, it also has significant functions in the manufacture of pesticides. Based on it, a variety of pesticide ingredients can be prepared through carefully designed reaction paths. Such pesticides may have the characteristics of insecticides and weeds, which can help agricultural pest control and ensure the yield and quality of crops.
Third, in the field of dye industry, 2-chloro-4-methoxy-1-nitrobenzene also plays an important role. Its structure can be modified and transformed to become an important intermediate for the synthesis of various dyes. The synthesized dyes are widely used in textile, printing and dyeing industries, giving fabrics a rich and colorful color.
Fourth, in scientific research and exploration, this compound is often used as a model substrate. By studying its reaction properties, chemists can gain in-depth insights into the mechanism of organic reactions, provide theoretical basis for the development and optimization of new reactions, and promote the development of organic chemistry.
In short, 2-chloro-4-methoxy-1-nitrobenzene has important uses in many fields such as chemical industry, medicine, and agriculture, and has made great contributions to the progress of modern industry and scientific research.
What are the physical properties of 2-chloro-4-methoxy-1-nitrobenzene?
2-Chloro-4-methoxy-1-nitrobenzene is one of the organic compounds. Its physical properties are unique, let me tell them one by one.
Looking at its shape, it is mostly solid under normal conditions, and its quality is relatively stable. Its melting point and boiling point are also important physical properties. The melting point is the specific temperature at which a substance changes from solid to liquid. The melting point of 2-chloro-4-methoxy-1-nitrobenzene is of great significance in the fields of chemical industry and scientific research. Its purity can be determined based on this, and it also provides important parameters for related process operations. As for the boiling point, that is, the temperature at which a substance changes from a liquid state to a gaseous state, this property is related to the behavior of the compound in processes such as heating and distillation.
Solubility is also its key physical property. This compound has different solubility in different solvents. In common organic solvents, such as ethanol, ether, etc., it may have a certain solubility. In water, because its molecular structure contains hydrophobic groups such as chlorine atoms and nitro groups, as well as a weak hydrophilic group such as methoxy, its solubility in water is generally low. This difference in solubility plays an important guiding role in separation, purification and choice of reaction medium.
Again, its density is higher than that of water. This property is crucial when it involves liquid-liquid separation and other operations, and can be effectively separated from other liquids according to its density difference.
In addition, the color state of its appearance is often a white or light yellow solid, and this color characteristic may be affected by its purity and impurities. The change of color can also be used as a reference for judging the quality of its quality.
In summary, the physical properties of 2-chloro-4-methoxy-1-nitrobenzene play an indispensable role in many fields such as chemical production and scientific research, and it is essential to explore it in depth.
Looking at its shape, it is mostly solid under normal conditions, and its quality is relatively stable. Its melting point and boiling point are also important physical properties. The melting point is the specific temperature at which a substance changes from solid to liquid. The melting point of 2-chloro-4-methoxy-1-nitrobenzene is of great significance in the fields of chemical industry and scientific research. Its purity can be determined based on this, and it also provides important parameters for related process operations. As for the boiling point, that is, the temperature at which a substance changes from a liquid state to a gaseous state, this property is related to the behavior of the compound in processes such as heating and distillation.
Solubility is also its key physical property. This compound has different solubility in different solvents. In common organic solvents, such as ethanol, ether, etc., it may have a certain solubility. In water, because its molecular structure contains hydrophobic groups such as chlorine atoms and nitro groups, as well as a weak hydrophilic group such as methoxy, its solubility in water is generally low. This difference in solubility plays an important guiding role in separation, purification and choice of reaction medium.
Again, its density is higher than that of water. This property is crucial when it involves liquid-liquid separation and other operations, and can be effectively separated from other liquids according to its density difference.
In addition, the color state of its appearance is often a white or light yellow solid, and this color characteristic may be affected by its purity and impurities. The change of color can also be used as a reference for judging the quality of its quality.
In summary, the physical properties of 2-chloro-4-methoxy-1-nitrobenzene play an indispensable role in many fields such as chemical production and scientific research, and it is essential to explore it in depth.
What are the chemical properties of 2-chloro-4-methoxy-1-nitrobenzene?
2-Chloro-4-methoxy-1-nitrobenzene is one of the organic compounds. Its chemical properties are unique and can be investigated.
When it comes to reactivity, because there are chlorine atoms, methoxy groups and nitro groups attached to the benzene ring, these numbers have different effects on the electron cloud density of the benzene ring, so the reactivity of the compound is unique. Nitro is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring, cause the activity of the electrophilic substitution of the benzene ring to decrease, and especially reduce the density of the electron cloud of the ortho and para-position. Methoxy group is a power supply group, which can increase the electron cloud density of the benzene ring and improve the activity of the electrophilic substitution of the benzene ring, which mainly affects the ortho and para Although chlorine atoms have electron-absorbing induction effects, they also have electron-donating conjugation effects, which have a complex effect on the electron cloud density of the benzene ring. Overall, the activity of the electrophilic substitution reaction of the benzene ring is slightly reduced, and it also mainly acts on the adjacent and para-sites.
In the electrophilic substitution reaction, due to the electron-absorbing effect of nitro and chlorine atoms, and the electron-donating effect of methoxy groups, the reaction check point is mostly at the ortho-site of the methoxy group (because the ortho-site of the chlorine atom is affected by the steric resistance, the reaction activity is slightly lower). For example, during the nitrification reaction, the nitro group is most likely to introduce the methoxy ortho-site.
In the hydrolysis reaction, the chlorine atom of 2-chloro-4-methoxy-1-nitrobenzene can be replaced by a hydroxyl group under appropriate conditions. Due to the uneven distribution of electron cloud density on the benzene ring, the electron cloud density of the carbon check point connected to the chlorine atom is relatively low, which is vulnerable to attack by nucleophiles.
Reduction reaction is also one of its important chemical properties. Nitro groups can be converted into amino groups by reduction means, such as iron powder, hydrochloric acid, etc., to generate 2-chloro-4-methoxy-1-aniline. In addition, this compound can also participate in many organic synthesis reactions, and is an important intermediate for the preparation of other complex organic compounds, which is widely used in the field of organic chemistry.
When it comes to reactivity, because there are chlorine atoms, methoxy groups and nitro groups attached to the benzene ring, these numbers have different effects on the electron cloud density of the benzene ring, so the reactivity of the compound is unique. Nitro is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring, cause the activity of the electrophilic substitution of the benzene ring to decrease, and especially reduce the density of the electron cloud of the ortho and para-position. Methoxy group is a power supply group, which can increase the electron cloud density of the benzene ring and improve the activity of the electrophilic substitution of the benzene ring, which mainly affects the ortho and para Although chlorine atoms have electron-absorbing induction effects, they also have electron-donating conjugation effects, which have a complex effect on the electron cloud density of the benzene ring. Overall, the activity of the electrophilic substitution reaction of the benzene ring is slightly reduced, and it also mainly acts on the adjacent and para-sites.
In the electrophilic substitution reaction, due to the electron-absorbing effect of nitro and chlorine atoms, and the electron-donating effect of methoxy groups, the reaction check point is mostly at the ortho-site of the methoxy group (because the ortho-site of the chlorine atom is affected by the steric resistance, the reaction activity is slightly lower). For example, during the nitrification reaction, the nitro group is most likely to introduce the methoxy ortho-site.
In the hydrolysis reaction, the chlorine atom of 2-chloro-4-methoxy-1-nitrobenzene can be replaced by a hydroxyl group under appropriate conditions. Due to the uneven distribution of electron cloud density on the benzene ring, the electron cloud density of the carbon check point connected to the chlorine atom is relatively low, which is vulnerable to attack by nucleophiles.
Reduction reaction is also one of its important chemical properties. Nitro groups can be converted into amino groups by reduction means, such as iron powder, hydrochloric acid, etc., to generate 2-chloro-4-methoxy-1-aniline. In addition, this compound can also participate in many organic synthesis reactions, and is an important intermediate for the preparation of other complex organic compounds, which is widely used in the field of organic chemistry.
What are 2-chloro-4-methoxy-1-nitrobenzene synthesis methods?
There are many methods for synthesizing 2-chloro-4-methoxy-1-nitrobenzene. One of the common ones is to use p-methoxy chlorobenzene as the starting material.
First, p-methoxy chlorobenzene is heated with mixed acid (a mixture of nitric acid and sulfuric acid) and nitrified. In this reaction, nitric acid is catalyzed by sulfuric acid to produce nitroyl cation (NO 2O 🥰), which attacks the benzene ring as an electrophilic reagent. Since methoxy is an ortho-and para-locator group, and chlorine atoms also have a certain influence on the benzene ring, a mixture of 2-chloro-4-methoxy-1-nitrobenzene and 4-chloro-2-methoxy-1-nitrobenzene is mainly formed. Subsequently, the target product 2-chloro-4-methoxy-1-nitrobenzene can be separated and purified from the mixture by means of separation methods such as column chromatography and recrystallization.
Others use p-methoxyphenol as the starting material. First, p-methoxyphenol is reacted with chlorinated reagents (such as thionyl chloride, phosphorus oxychloride, etc.) to convert phenolic hydroxyl groups into chlorine atoms to obtain p-methoxychlorobenzene. Subsequent to the above nitration and separation steps of p-methoxychlorobenzene, 2-chloro-4-methoxy-1-nitrobenzene is prepared.
Or starting from 2-chloro-4-methoxyaniline, it is reacted with diazotization, treated with sodium nitrite and hydrochloric acid to generate diazonium salts. The target product 2-chloro-4-methoxy-1-nitrobenzene was obtained by the Sandmeyer reaction of diazonium salt with sodium nitrite and copper powder. Different synthetic methods have their own advantages and disadvantages, and the actual operation needs to be carefully selected according to many factors such as the availability of raw materials, reaction conditions, yield and purity requirements.
First, p-methoxy chlorobenzene is heated with mixed acid (a mixture of nitric acid and sulfuric acid) and nitrified. In this reaction, nitric acid is catalyzed by sulfuric acid to produce nitroyl cation (NO 2O 🥰), which attacks the benzene ring as an electrophilic reagent. Since methoxy is an ortho-and para-locator group, and chlorine atoms also have a certain influence on the benzene ring, a mixture of 2-chloro-4-methoxy-1-nitrobenzene and 4-chloro-2-methoxy-1-nitrobenzene is mainly formed. Subsequently, the target product 2-chloro-4-methoxy-1-nitrobenzene can be separated and purified from the mixture by means of separation methods such as column chromatography and recrystallization.
Others use p-methoxyphenol as the starting material. First, p-methoxyphenol is reacted with chlorinated reagents (such as thionyl chloride, phosphorus oxychloride, etc.) to convert phenolic hydroxyl groups into chlorine atoms to obtain p-methoxychlorobenzene. Subsequent to the above nitration and separation steps of p-methoxychlorobenzene, 2-chloro-4-methoxy-1-nitrobenzene is prepared.
Or starting from 2-chloro-4-methoxyaniline, it is reacted with diazotization, treated with sodium nitrite and hydrochloric acid to generate diazonium salts. The target product 2-chloro-4-methoxy-1-nitrobenzene was obtained by the Sandmeyer reaction of diazonium salt with sodium nitrite and copper powder. Different synthetic methods have their own advantages and disadvantages, and the actual operation needs to be carefully selected according to many factors such as the availability of raw materials, reaction conditions, yield and purity requirements.
2-chloro-4-methoxy-1-nitrobenzene need to pay attention to when storing and transporting
2-Chloro-4-methoxy-1-nitrobenzene is also an organic compound. During its storage and transportation, many matters must not be ignored.
Bear the brunt of it. When storing, you must find a cool, dry and well-ventilated place. This is because the compound is heated and damp, prone to changes, resulting in unstable properties. If placed in a high temperature, humid place, or cause the risk of decomposition and deterioration, damage its quality, and even lead to safety.
Furthermore, keep away from fires and heat sources. Because of its flammability, in case of open flames, hot topics, or combustion, if the fire breaks out, it is difficult to control and endanger the surrounding. And can not be mixed with oxidizing agents, reducing agents and other co-storage. 2-chloro-4-methoxy-1-nitrobenzene meets with oxidizing agents, or promotes violent oxidation reactions, and the risk of explosion; mixed with reducing agents, there is also the possibility of accidental reactions.
During transportation, the packaging must be tight and stable. Make sure that during transportation, the packaging is not damaged due to bumps and collisions, and the material leaks. Once leaked, it will not only pollute the environment, but also threaten the safety of transporters and surrounding people. The means of transportation used should also be clean and free of residual impurities to avoid adverse reactions with the compound.
When handling, the operation should be light and do not handle brutally. Because it is a fine chemical, it is overstressed or causes the package to break, and at the same time avoids static electricity caused by friction and impact, and then ignites the compound. Transportation and storage personnel should be professionally trained to be familiar with the characteristics and safety precautions of the compound. In case of emergencies, they can properly deal with and reduce the harm.
All of these are the precautions for the storage and transportation of 2-chloro-4-methoxy-1-nitrobenzene, and should not be slack to ensure safety.
Bear the brunt of it. When storing, you must find a cool, dry and well-ventilated place. This is because the compound is heated and damp, prone to changes, resulting in unstable properties. If placed in a high temperature, humid place, or cause the risk of decomposition and deterioration, damage its quality, and even lead to safety.
Furthermore, keep away from fires and heat sources. Because of its flammability, in case of open flames, hot topics, or combustion, if the fire breaks out, it is difficult to control and endanger the surrounding. And can not be mixed with oxidizing agents, reducing agents and other co-storage. 2-chloro-4-methoxy-1-nitrobenzene meets with oxidizing agents, or promotes violent oxidation reactions, and the risk of explosion; mixed with reducing agents, there is also the possibility of accidental reactions.
During transportation, the packaging must be tight and stable. Make sure that during transportation, the packaging is not damaged due to bumps and collisions, and the material leaks. Once leaked, it will not only pollute the environment, but also threaten the safety of transporters and surrounding people. The means of transportation used should also be clean and free of residual impurities to avoid adverse reactions with the compound.
When handling, the operation should be light and do not handle brutally. Because it is a fine chemical, it is overstressed or causes the package to break, and at the same time avoids static electricity caused by friction and impact, and then ignites the compound. Transportation and storage personnel should be professionally trained to be familiar with the characteristics and safety precautions of the compound. In case of emergencies, they can properly deal with and reduce the harm.
All of these are the precautions for the storage and transportation of 2-chloro-4-methoxy-1-nitrobenzene, and should not be slack to ensure safety.
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