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2-Chloro-4-Methoxybenzeneboronic Acid
Linshang Chemical
|
HS Code |
449398 |
| Name | 2-Chloro-4-Methoxybenzeneboronic Acid |
| Chemical Formula | C7H8BClO3 |
| Molar Mass | 186.40 g/mol |
| Appearance | White to off - white solid |
| Melting Point | 145 - 150 °C |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, ethyl acetate |
| Pka | Approximately 8 - 9 (boronic acid group) |
| Stability | Stable under normal conditions, but moisture - sensitive, may react with strong oxidizing agents |
As an accredited 2-Chloro-4-Methoxybenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 4 - methoxybenzeneboronic acid packaged in a sealed plastic bottle. |
| Storage | 2 - Chloro - 4 - methoxybenzeneboronic acid should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly sealed container to prevent moisture absorption, as boronic acids can react with water. Store separately from oxidizing agents and incompatible substances to avoid potential chemical reactions that could compromise its integrity. |
| Shipping | 2 - chloro - 4 - methoxybenzeneboronic acid is shipped in sealed, corrosion - resistant containers. Shipment adheres to strict chemical transport regulations, ensuring proper handling to prevent spills and maintain product integrity during transit. |
Competitive 2-Chloro-4-Methoxybenzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Chloro-4-Methoxybenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-4-methoxybenzeneboronic Acid?
2-Chloro-4-methoxyphenylboronic acid has a wide range of uses. It is often used as a key intermediate in the field of organic synthesis. Organic synthesis aims to create various organic compounds. This process is complex and delicate, and requires the coordination of various reagents and steps. 2-chloro-4-methoxyphenylboronic acid plays a significant role in this process, or involves the construction of carbon-carbon bonds. Carbon-carbon bonds are the foundation of organic molecular frameworks, and their successful construction is crucial for the synthesis of complex organic structures. With the help of specific reactions, such as the Suzuki-Miyaura coupling reaction, this boric acid can be precisely linked with halogenated aromatics or olefins under the action of metal catalysts to form products with specific structures and functions, which is of great significance in drug development, materials science and many other aspects.
In the field of drug development, in order to find effective drugs to treat diseases, it is often necessary to synthesize compounds with diverse structures for screening. 2-Chloro-4-methoxyphenylboronic acid can participate in the synthesis of molecules with unique biological activities, or can become potential drug lead compounds. By adjusting its structure and reaction conditions, the pharmacological properties of the products can be changed, providing rich options for pharmaceutical chemists.
The field of materials science is also indispensable. When synthesizing new organic functional materials, it can be used to construct polymers or small molecule materials with special optoelectronic properties. For example, the preparation of organic Light Emitting Diode (OLED) materials, or the improvement of material charge transport ability, luminous efficiency and other properties, promote the development of display technology and other related fields.
In the field of drug development, in order to find effective drugs to treat diseases, it is often necessary to synthesize compounds with diverse structures for screening. 2-Chloro-4-methoxyphenylboronic acid can participate in the synthesis of molecules with unique biological activities, or can become potential drug lead compounds. By adjusting its structure and reaction conditions, the pharmacological properties of the products can be changed, providing rich options for pharmaceutical chemists.
The field of materials science is also indispensable. When synthesizing new organic functional materials, it can be used to construct polymers or small molecule materials with special optoelectronic properties. For example, the preparation of organic Light Emitting Diode (OLED) materials, or the improvement of material charge transport ability, luminous efficiency and other properties, promote the development of display technology and other related fields.
What are the synthetic methods of 2-chloro-4-methoxybenzeneboronic Acid?
The synthesis of 2-chloro-4-methoxyphenylboronic acid has many different paths. First, it can be through the metallization reaction of halogenated aromatics. First, take 2-chloro-4-methoxybromobenzene as the starting material, and add a strong base such as n-butyl lithium in a low temperature and suitable solvent environment, such as in anhydrous tetrahydrofuran. This strong base will interact with halogenated aromatics, so that the hydrogen in the adjacent position of the halogen atom is replaced by the lithium atom to form an organolithium intermediate. Subsequently, this intermediate is reacted with borate esters, such as trimethyl borate. After the reaction is completed, 2-chloro-4-methoxyphenylboronic acid can be obtained by hydrolysis step and treatment with dilute acid.
Second, the coupling reaction strategy catalyzed by palladium can be used. With 2-chloro-4-methoxyhalobenzene and diphenoxanal borate as the reactant, under the catalysis of palladium catalyst, such as tetra (triphenylphosphine) palladium (0), a suitable base, such as potassium carbonate, etc., is added to heat the reaction in a suitable solvent such as 1,4-dioxane. In this process, the palladium catalyst promotes the coupling of halobenzene and borate esters to form the target product 2-chloro-4-methoxyphenylboronic acid. After the reaction, the product can be purified by conventional separation methods such as extraction and column chromatography.
Furthermore, 2-chloro-4-methoxyaniline can be used. It is first subjected to a diazotization reaction, and the diazonium salt is prepared at low temperature with sodium nitrite and inorganic acids such as hydrochloric acid. Next, the diazonium salt is reacted with sodium borohydride and an appropriate amount of additives. After a series of conversions, 2-chloro-4-methoxyphenylboronic acid can also be obtained. Each method has its own advantages and disadvantages, and it is necessary to choose the appropriate synthesis method according to the actual situation, such as the availability of raw materials, the controllability of reaction conditions and the requirements of product purity.
Second, the coupling reaction strategy catalyzed by palladium can be used. With 2-chloro-4-methoxyhalobenzene and diphenoxanal borate as the reactant, under the catalysis of palladium catalyst, such as tetra (triphenylphosphine) palladium (0), a suitable base, such as potassium carbonate, etc., is added to heat the reaction in a suitable solvent such as 1,4-dioxane. In this process, the palladium catalyst promotes the coupling of halobenzene and borate esters to form the target product 2-chloro-4-methoxyphenylboronic acid. After the reaction, the product can be purified by conventional separation methods such as extraction and column chromatography.
Furthermore, 2-chloro-4-methoxyaniline can be used. It is first subjected to a diazotization reaction, and the diazonium salt is prepared at low temperature with sodium nitrite and inorganic acids such as hydrochloric acid. Next, the diazonium salt is reacted with sodium borohydride and an appropriate amount of additives. After a series of conversions, 2-chloro-4-methoxyphenylboronic acid can also be obtained. Each method has its own advantages and disadvantages, and it is necessary to choose the appropriate synthesis method according to the actual situation, such as the availability of raw materials, the controllability of reaction conditions and the requirements of product purity.
What are the physical properties of 2-chloro-4-methoxybenzeneboronic Acid?
2-Chloro-4-methoxyphenylboronic acid, its physical properties are as follows:
This compound is usually white to light yellow solid. Looking at its appearance, it is fine and uniform in texture, without obvious impurities or uneven color.
When it comes to the melting point, it is between 150-155 ° C. In this temperature range, the substance gradually converts from a solid state to a liquid state. This melting point characteristic makes it possible to change its phase state under a specific temperature environment, which is an important guide for its operation in chemical synthesis and other operations.
In terms of solubility, it is slightly soluble in water. As a common solvent, this compound has limited interaction with it and is difficult to disperse in large quantities. However, it has good solubility in some organic solvents such as dichloromethane and tetrahydrofuran. It can be uniformly dispersed in these organic solvents to form a uniform and stable system. This provides a suitable medium environment for the reaction in the organic synthesis reaction, which is conducive to the smooth progress of the reaction. It can fully contact the reactants and improve the reaction efficiency and yield.
Its density is slightly larger than that of water. During storage and operation, if it comes into contact with liquids with low density such as water, it will sink to the bottom. This density property can be used as an important physical basis in chemical operations such as separation and purification. It can be used as an important physical basis to achieve preliminary separation from other substances through reasonable stratification and liquid separation.
In terms of stability, under normal temperature and pressure, if there is no special external disturbance, such as high temperature, strong acid-base environment, strong oxidizing or reducing agent, etc., it can maintain a relatively stable chemical structure and is not prone to spontaneous decomposition or other violent chemical reactions. However, it should be noted that although the normal state is stable, it should still be avoided to mix with some highly active substances and stored in a dry, cool and well-ventilated place to ensure the stability of its physical and chemical properties, so as to ensure that it can play the expected effect when used.
This compound is usually white to light yellow solid. Looking at its appearance, it is fine and uniform in texture, without obvious impurities or uneven color.
When it comes to the melting point, it is between 150-155 ° C. In this temperature range, the substance gradually converts from a solid state to a liquid state. This melting point characteristic makes it possible to change its phase state under a specific temperature environment, which is an important guide for its operation in chemical synthesis and other operations.
In terms of solubility, it is slightly soluble in water. As a common solvent, this compound has limited interaction with it and is difficult to disperse in large quantities. However, it has good solubility in some organic solvents such as dichloromethane and tetrahydrofuran. It can be uniformly dispersed in these organic solvents to form a uniform and stable system. This provides a suitable medium environment for the reaction in the organic synthesis reaction, which is conducive to the smooth progress of the reaction. It can fully contact the reactants and improve the reaction efficiency and yield.
Its density is slightly larger than that of water. During storage and operation, if it comes into contact with liquids with low density such as water, it will sink to the bottom. This density property can be used as an important physical basis in chemical operations such as separation and purification. It can be used as an important physical basis to achieve preliminary separation from other substances through reasonable stratification and liquid separation.
In terms of stability, under normal temperature and pressure, if there is no special external disturbance, such as high temperature, strong acid-base environment, strong oxidizing or reducing agent, etc., it can maintain a relatively stable chemical structure and is not prone to spontaneous decomposition or other violent chemical reactions. However, it should be noted that although the normal state is stable, it should still be avoided to mix with some highly active substances and stored in a dry, cool and well-ventilated place to ensure the stability of its physical and chemical properties, so as to ensure that it can play the expected effect when used.
What are the chemical properties of 2-chloro-4-methoxybenzeneboronic Acid?
2-Chloro-4-methoxyphenylboronic acid, which is like a fine powder and has a nearly pure white color, is often used as a key raw material for organic synthesis. This substance has stable properties at room temperature and pressure, and when it encounters hot topics, it may be threatened to decompose, releasing harmful gases such as chlorine and boron.
In terms of its solubility, it can be slightly soluble in water, and it has good solubility in common organic solvents such as ethanol, ether, and dichloromethane. Because of its boron-oxygen bond and benzene ring structure, its chemical activity is unique. The presence of chlorine atoms and methoxy groups on the benzene ring changes the electron cloud density of the benzene ring, causing its electrophilic substitution reaction activity to be different from that of the ordinary benzene ring.
In the process of organic synthesis, this substance is often involved in the coupling reaction of Suzuki. By forming carbon-carbon bonds with halogenated aromatics or olefins under the action of palladium catalysts and bases, complex organic molecular structures are formed. It is widely used in the fields of medicinal chemistry and materials science.
In addition, its boric acid group is weakly acidic and can specifically bind with diol compounds to form stable cyclic borate esters. This property is also used in the identification and separation of carbohydrates, nucleosides and other compounds with o-diol structures.
In terms of its solubility, it can be slightly soluble in water, and it has good solubility in common organic solvents such as ethanol, ether, and dichloromethane. Because of its boron-oxygen bond and benzene ring structure, its chemical activity is unique. The presence of chlorine atoms and methoxy groups on the benzene ring changes the electron cloud density of the benzene ring, causing its electrophilic substitution reaction activity to be different from that of the ordinary benzene ring.
In the process of organic synthesis, this substance is often involved in the coupling reaction of Suzuki. By forming carbon-carbon bonds with halogenated aromatics or olefins under the action of palladium catalysts and bases, complex organic molecular structures are formed. It is widely used in the fields of medicinal chemistry and materials science.
In addition, its boric acid group is weakly acidic and can specifically bind with diol compounds to form stable cyclic borate esters. This property is also used in the identification and separation of carbohydrates, nucleosides and other compounds with o-diol structures.
What are the precautions for 2-chloro-4-methoxybenzeneboronic Acid in storage and transportation?
For 2-chloro-4-methoxyphenylboronic acid, there are several important items to be paid attention to during storage and transportation.
This compound is delicate and easy to change in response to water. Therefore, when storing, it must be placed in a dry place, away from water vapor, and a sealed container can be selected to prevent moisture from invading and causing it to deteriorate. If the place of storage is heavy with moisture or the packaging is not tight, it may be hydrolyzed and its purity and quality will be damaged.
Temperature is also critical. It should be stored in a cool place to avoid high temperature hot topics. If it is placed in a high temperature environment, it may cause its chemical reaction or cause decomposition, causing its chemical structure to be changed and its activity to be reduced, which will affect the effectiveness of future use.
When transporting, the packaging must be solid and stable. Because it is a chemical substance, it may be bumped and vibrated on the way. If the packaging is not good, it is easy to leak, which not only endangers the safety of transportation, but also damages the surrounding environment. When using suitable packaging materials, ensure that it is properly protected during transportation.
And this product may have certain chemical hazards, the transporter must clarify its characteristics and comply with relevant laws and regulations. During transportation, if there is an accident such as leakage, it should be handled according to the established emergency measures to ensure the safety of personnel and reduce environmental pollution.
In conclusion, the storage and transportation of 2-chloro-4-methoxyphenylboronic acid requires careful attention to moisture resistance, temperature control, solid packaging, and compliance with regulations in order to ensure its quality and safety.
This compound is delicate and easy to change in response to water. Therefore, when storing, it must be placed in a dry place, away from water vapor, and a sealed container can be selected to prevent moisture from invading and causing it to deteriorate. If the place of storage is heavy with moisture or the packaging is not tight, it may be hydrolyzed and its purity and quality will be damaged.
Temperature is also critical. It should be stored in a cool place to avoid high temperature hot topics. If it is placed in a high temperature environment, it may cause its chemical reaction or cause decomposition, causing its chemical structure to be changed and its activity to be reduced, which will affect the effectiveness of future use.
When transporting, the packaging must be solid and stable. Because it is a chemical substance, it may be bumped and vibrated on the way. If the packaging is not good, it is easy to leak, which not only endangers the safety of transportation, but also damages the surrounding environment. When using suitable packaging materials, ensure that it is properly protected during transportation.
And this product may have certain chemical hazards, the transporter must clarify its characteristics and comply with relevant laws and regulations. During transportation, if there is an accident such as leakage, it should be handled according to the established emergency measures to ensure the safety of personnel and reduce environmental pollution.
In conclusion, the storage and transportation of 2-chloro-4-methoxyphenylboronic acid requires careful attention to moisture resistance, temperature control, solid packaging, and compliance with regulations in order to ensure its quality and safety.
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