Linshang Chemical
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2-Chloro-4-Methyl-1-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
402030 |
| Chemical Formula | C8H6ClF3 |
| Molar Mass | 194.58 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 162 - 164 °C |
| Melting Point | N/A |
| Density | 1.286 g/cm³ |
| Flash Point | 50 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
| Vapor Pressure | N/A |
| Odor | Characteristic aromatic odor |
| Stability | Stable under normal conditions |
As an accredited 2-Chloro-4-Methyl-1-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250 - gram bottle of 2 - chloro - 4 - methyl - 1 - (trifluoromethyl)benzene, well - sealed. |
| Storage | 2 - chloro - 4 - methyl - 1 - (trifluoromethyl)benzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. It should be stored in a tightly - sealed container, preferably made of materials resistant to chemical corrosion, like stainless steel or certain plastics. Keep it separate from oxidizing agents and incompatible substances to prevent potential reactions. |
| Shipping | 2 - chloro - 4 - methyl - 1 - (trifluoromethyl)benzene is shipped in specialized, well - sealed containers compliant with chemical transportation regulations. Care is taken to prevent spills, with proper labeling indicating its hazardous nature. |
Competitive 2-Chloro-4-Methyl-1-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 2-chloro-4-methyl-1- (trifluoromethyl) benzene
2-Chloro-4-methyl-1- (trifluoromethyl) benzene is one of the organic compounds. Its chemical properties are unique and closely related to many chemical reactions.
In this compound, the presence of chlorine atoms, methyl and trifluoromethyl significantly affects its properties. Chlorine atoms have certain electronegativity, which can change the electron cloud density of the benzene ring. In electrophilic substitution reactions, it can cause changes in reactivity and check point preference. Methyl as the power supply group will increase the electron cloud density of the benzene ring, making the benzene ring more susceptible to electrophilic attack, which is common in halogenation, nitrification, sulfonation and other electrophilic substitution reactions.
Trifluoromethyl exhibits a strong electron-absorbing effect due to the strong electronegativity of fluorine atoms, which greatly reduces the electron cloud density of benzene ring, which not only affects the reactivity, but also changes the reaction selectivity in some reactions. For example, when electrophilic substitution, it tends to guide the substituent into the meta-site.
2-chloro-4-methyl-1 - (trifluoromethyl) benzene is relatively stable, and it is liquid or solid at room temperature and pressure, with certain volatility. However, under specific conditions, such as high temperature, light or the presence of catalysts, various reactions can occur. In addition to electrophilic substitution, chlorine atoms or trifluoromethyl can also participate in the reaction under the action of strong bases or strong reducing agents, and the transformation occurs such as substitution and reduction. In the field of organic synthesis, its structure can be modified and transformed to prepare a variety of organic materials with special properties, pharmaceutical intermediates, etc.
In this compound, the presence of chlorine atoms, methyl and trifluoromethyl significantly affects its properties. Chlorine atoms have certain electronegativity, which can change the electron cloud density of the benzene ring. In electrophilic substitution reactions, it can cause changes in reactivity and check point preference. Methyl as the power supply group will increase the electron cloud density of the benzene ring, making the benzene ring more susceptible to electrophilic attack, which is common in halogenation, nitrification, sulfonation and other electrophilic substitution reactions.
Trifluoromethyl exhibits a strong electron-absorbing effect due to the strong electronegativity of fluorine atoms, which greatly reduces the electron cloud density of benzene ring, which not only affects the reactivity, but also changes the reaction selectivity in some reactions. For example, when electrophilic substitution, it tends to guide the substituent into the meta-site.
2-chloro-4-methyl-1 - (trifluoromethyl) benzene is relatively stable, and it is liquid or solid at room temperature and pressure, with certain volatility. However, under specific conditions, such as high temperature, light or the presence of catalysts, various reactions can occur. In addition to electrophilic substitution, chlorine atoms or trifluoromethyl can also participate in the reaction under the action of strong bases or strong reducing agents, and the transformation occurs such as substitution and reduction. In the field of organic synthesis, its structure can be modified and transformed to prepare a variety of organic materials with special properties, pharmaceutical intermediates, etc.
What are the physical properties of 2-chloro-4-methyl-1- (trifluoromethyl) benzene
2-Chloro-4-methyl-1- (trifluoromethyl) benzene is an organic compound. It has the following physical properties:
In terms of appearance, it is mostly colorless to light yellow liquid under normal conditions. This color characteristic is quite common in many organohalogenated aromatic hydrocarbons, reflecting the absorption and reflection characteristics of the molecular structure to light. Its properties are liquid, which is related to its intermolecular forces. Due to the interaction between halogen atoms and methyl groups, trifluoromethyl groups and other groups in the molecule, the molecules cannot form a close and orderly arrangement, so it appears liquid.
In smell, it often emits a special aromatic smell. This is due to the presence of the benzene ring structure, which imparts unique aromaticity to the compound. However, due to the substitution of chlorine atoms with trifluoromethyl, the smell is different from ordinary benzene series, with the unique irritating smell of halogenated aromatics.
Melting point and boiling point, the melting point is low, generally between -20 ° C and -10 ° C. Due to the influence of different groups in the molecule, the regular arrangement of molecules is destroyed, resulting in a decrease in lattice energy and a decrease in melting point. The boiling point is usually between 160 ° C and 170 ° C. Although the benzene ring can cause the accumulation of π-π between molecules, the introduction of chlorine atoms and trifluoromethyl increases the polarity of the molecule, and the van der Waals force changes, and the boiling point is higher than that of benzene The density of
is larger than that of water, about 1.3 to 1.4 g/cm ³. This is due to the large relative atomic weight of chlorine atoms and trifluoromethyl in the molecule, resulting in an increase in the mass of the substance per unit volume, and the density is higher than that of water. In organic synthesis and separation operations, there will be stratification phenomenon, which is in the lower layer.
In terms of solubility, it is difficult to dissolve in water. Because it is a non-polar or weakly polar molecule, and water is a strong polar solvent, according to the principle of "similar miscibility", the forces between the two molecules are different and the mutual solubility is poor. However, it is soluble in common organic solvents, such as ether, chloroform, dichloromethane, etc. Because these organic solvents are similar to the polarity of the compound, the intermolecules can interact through van der Waals forces to achieve
In terms of appearance, it is mostly colorless to light yellow liquid under normal conditions. This color characteristic is quite common in many organohalogenated aromatic hydrocarbons, reflecting the absorption and reflection characteristics of the molecular structure to light. Its properties are liquid, which is related to its intermolecular forces. Due to the interaction between halogen atoms and methyl groups, trifluoromethyl groups and other groups in the molecule, the molecules cannot form a close and orderly arrangement, so it appears liquid.
In smell, it often emits a special aromatic smell. This is due to the presence of the benzene ring structure, which imparts unique aromaticity to the compound. However, due to the substitution of chlorine atoms with trifluoromethyl, the smell is different from ordinary benzene series, with the unique irritating smell of halogenated aromatics.
Melting point and boiling point, the melting point is low, generally between -20 ° C and -10 ° C. Due to the influence of different groups in the molecule, the regular arrangement of molecules is destroyed, resulting in a decrease in lattice energy and a decrease in melting point. The boiling point is usually between 160 ° C and 170 ° C. Although the benzene ring can cause the accumulation of π-π between molecules, the introduction of chlorine atoms and trifluoromethyl increases the polarity of the molecule, and the van der Waals force changes, and the boiling point is higher than that of benzene The density of
is larger than that of water, about 1.3 to 1.4 g/cm ³. This is due to the large relative atomic weight of chlorine atoms and trifluoromethyl in the molecule, resulting in an increase in the mass of the substance per unit volume, and the density is higher than that of water. In organic synthesis and separation operations, there will be stratification phenomenon, which is in the lower layer.
In terms of solubility, it is difficult to dissolve in water. Because it is a non-polar or weakly polar molecule, and water is a strong polar solvent, according to the principle of "similar miscibility", the forces between the two molecules are different and the mutual solubility is poor. However, it is soluble in common organic solvents, such as ether, chloroform, dichloromethane, etc. Because these organic solvents are similar to the polarity of the compound, the intermolecules can interact through van der Waals forces to achieve
What are the main uses of 2-chloro-4-methyl-1- (trifluoromethyl) benzene?
2-Chloro-4-methyl-1 - (trifluoromethyl) benzene, this substance has a wide range of uses and is often a key raw material in the field of chemical synthesis. It can be involved in organic synthesis reactions and assist in the preparation of many organic compounds.
In the field of pharmaceutical chemistry, it can be integrated into the molecular structure of the drug through a series of reactions, which affects the activity and characteristics of the drug. Or due to the halogen atom and trifluoromethyl groups contained in its own structure, it endows the drug with specific physical and chemical properties, such as improving fat solubility, which is conducive to the drug's passage through the biofilm and enhancing the efficacy.
In the field of materials science, it is also useful. Using it as a raw material, materials with special properties can be prepared For example, introducing it into polymer, or changing the electrical and optical properties of the polymer, can be used to make plastics, fibers and other materials with special functions to meet the needs of electronic and optical device manufacturing.
In pesticide chemistry, using this as the starting material, synthetic derivatives may have insecticidal and bactericidal activities. Due to the strong electronegativity and special spatial structure of trifluoromethyl, it can interfere with the physiological process of pests and pathogens, achieve the purpose of preventing and controlling pests, and provide effective protection for agricultural production.
In conclusion, 2-chloro-4-methyl-1 - (trifluoromethyl) benzene plays an important role in many fields such as chemical industry, medicine, materials, pesticides, etc., with its unique structure and reactivity, and is of great significance to the development of various fields.
In the field of pharmaceutical chemistry, it can be integrated into the molecular structure of the drug through a series of reactions, which affects the activity and characteristics of the drug. Or due to the halogen atom and trifluoromethyl groups contained in its own structure, it endows the drug with specific physical and chemical properties, such as improving fat solubility, which is conducive to the drug's passage through the biofilm and enhancing the efficacy.
In the field of materials science, it is also useful. Using it as a raw material, materials with special properties can be prepared For example, introducing it into polymer, or changing the electrical and optical properties of the polymer, can be used to make plastics, fibers and other materials with special functions to meet the needs of electronic and optical device manufacturing.
In pesticide chemistry, using this as the starting material, synthetic derivatives may have insecticidal and bactericidal activities. Due to the strong electronegativity and special spatial structure of trifluoromethyl, it can interfere with the physiological process of pests and pathogens, achieve the purpose of preventing and controlling pests, and provide effective protection for agricultural production.
In conclusion, 2-chloro-4-methyl-1 - (trifluoromethyl) benzene plays an important role in many fields such as chemical industry, medicine, materials, pesticides, etc., with its unique structure and reactivity, and is of great significance to the development of various fields.
What are the synthesis methods of 2-chloro-4-methyl-1- (trifluoromethyl) benzene
There are several methods for synthesizing 2-chloro-4-methyl-1 - (trifluoromethyl) benzene.
One is to use suitable halogenated aromatics as starting materials. Halogenated benzene containing methyl can be selected first, such as p-methyl chlorobenzene. P-methyl chlorobenzene reacts with trifluoromethylation reagents. Commonly used trifluoromethylation reagents include Grignard reagents such as trifluoromethylhalide magnesium. Under suitable reaction conditions, such as in anhydrous ether or tetrahydrofuran and other organic solvents, at low temperature to room temperature, the trifluoromethyl negative ion of the trifluoromethylation reagent attacks a specific position on the benzene ring of p-methyl chlorobenzene. After nucleophilic substitution, trifluoromethyl can be introduced to obtain the target product 2-chloro-4-methyl-1 - (trifluoromethyl) benzene. However, this process requires attention to the precise control of the reaction conditions. Due to the high activity of Grignard reagents, the reaction may lead to side reactions if it is too violent.
The second can be started from another angle, with aromatic hydrocarbons containing trifluoromethyl as the starting material. For example, 1-trifluoromethyl-4-chlorobenzene is selected and methylated. At this time, suitable methylation reagents, such as iodomethane and magnesium metal, can be used to make methylmagnesium iodide Grignard reagent. In the presence of suitable catalysts, such as some transition metal catalysts, at a suitable temperature and reaction time, the methyl group of the methylmagnesium iodide Grignard reagent attacks a specific position on the 1-trifluoromethyl-4-chlorobenzene ring, and the nucleophilic substitution realizes the introduction of methyl groups, and then synthesizes 2-chloro-4-methyl-1 - (trifluoromethyl) benzene. This method also requires attention to the selection of catalysts and the regulation of reaction conditions to ensure reaction selectivity and yield.
In addition, it can also be achieved by stepwise functionalization of the benzene ring. First, chlorine atoms and methyl groups are introduced into the benzene ring, and methyl groups can be introduced by Fu-gram alkylation reaction, and then chlorine atoms are introduced by halogenation reaction to form a specific substituted chloromethylbenzene. After that, trifluoromethyl groups are introduced by suitable trifluoromethylation methods, such as using conditions similar to the Ullman reaction, under the action of catalysts such as bases and copper salts, and trifluoromethylation reagents, thereby achieving the synthesis of 2-chloro-4-methyl-1 - (trifluoromethyl) benzene. This path involves many steps, and each step requires fine control to ensure the purity and yield of the final product.
One is to use suitable halogenated aromatics as starting materials. Halogenated benzene containing methyl can be selected first, such as p-methyl chlorobenzene. P-methyl chlorobenzene reacts with trifluoromethylation reagents. Commonly used trifluoromethylation reagents include Grignard reagents such as trifluoromethylhalide magnesium. Under suitable reaction conditions, such as in anhydrous ether or tetrahydrofuran and other organic solvents, at low temperature to room temperature, the trifluoromethyl negative ion of the trifluoromethylation reagent attacks a specific position on the benzene ring of p-methyl chlorobenzene. After nucleophilic substitution, trifluoromethyl can be introduced to obtain the target product 2-chloro-4-methyl-1 - (trifluoromethyl) benzene. However, this process requires attention to the precise control of the reaction conditions. Due to the high activity of Grignard reagents, the reaction may lead to side reactions if it is too violent.
The second can be started from another angle, with aromatic hydrocarbons containing trifluoromethyl as the starting material. For example, 1-trifluoromethyl-4-chlorobenzene is selected and methylated. At this time, suitable methylation reagents, such as iodomethane and magnesium metal, can be used to make methylmagnesium iodide Grignard reagent. In the presence of suitable catalysts, such as some transition metal catalysts, at a suitable temperature and reaction time, the methyl group of the methylmagnesium iodide Grignard reagent attacks a specific position on the 1-trifluoromethyl-4-chlorobenzene ring, and the nucleophilic substitution realizes the introduction of methyl groups, and then synthesizes 2-chloro-4-methyl-1 - (trifluoromethyl) benzene. This method also requires attention to the selection of catalysts and the regulation of reaction conditions to ensure reaction selectivity and yield.
In addition, it can also be achieved by stepwise functionalization of the benzene ring. First, chlorine atoms and methyl groups are introduced into the benzene ring, and methyl groups can be introduced by Fu-gram alkylation reaction, and then chlorine atoms are introduced by halogenation reaction to form a specific substituted chloromethylbenzene. After that, trifluoromethyl groups are introduced by suitable trifluoromethylation methods, such as using conditions similar to the Ullman reaction, under the action of catalysts such as bases and copper salts, and trifluoromethylation reagents, thereby achieving the synthesis of 2-chloro-4-methyl-1 - (trifluoromethyl) benzene. This path involves many steps, and each step requires fine control to ensure the purity and yield of the final product.
2-chloro-4-methyl-1- (trifluoromethyl) benzene in storage and transportation
2-Chloro-4-methyl-1- (trifluoromethyl) benzene, when storing and transporting, must pay attention to many matters. This substance has certain chemical activity, and when storing, the first choice is the environment. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, to avoid chemical reactions caused by excessive temperature and danger.
Furthermore, the packaging must be tight. Packaging materials that meet relevant standards must be used to prevent leakage. Because if it leaks, it will not only damage the environment, but also may endanger personal safety. During transportation, do not slack off. Vehicles need to be equipped with corresponding fire equipment and leakage emergency treatment equipment. Drivers and escorts must be professionally trained to be familiar with the characteristics of this substance and emergency response methods.
When transporting, you should follow the specified route and do not stop in densely populated areas and busy cities for a long time. The loading and unloading process also needs to be handled with caution, light loading and unloading, to avoid collisions and dragging, so as to avoid packaging damage. It is not suitable for mixed storage and transportation with oxidants, alkalis and other substances. Due to the difference in chemical properties, mixed transportation is prone to chemical reactions and disasters. In short, when storing and transporting 2-chloro-4-methyl-1- (trifluoromethyl) benzene, all details are related to safety and must not be neglected.
Furthermore, the packaging must be tight. Packaging materials that meet relevant standards must be used to prevent leakage. Because if it leaks, it will not only damage the environment, but also may endanger personal safety. During transportation, do not slack off. Vehicles need to be equipped with corresponding fire equipment and leakage emergency treatment equipment. Drivers and escorts must be professionally trained to be familiar with the characteristics of this substance and emergency response methods.
When transporting, you should follow the specified route and do not stop in densely populated areas and busy cities for a long time. The loading and unloading process also needs to be handled with caution, light loading and unloading, to avoid collisions and dragging, so as to avoid packaging damage. It is not suitable for mixed storage and transportation with oxidants, alkalis and other substances. Due to the difference in chemical properties, mixed transportation is prone to chemical reactions and disasters. In short, when storing and transporting 2-chloro-4-methyl-1- (trifluoromethyl) benzene, all details are related to safety and must not be neglected.
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