Linshang Chemical
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2-Chloro-4-Methyl-1-Trifluoromethyl-Benzene
Linshang Chemical
|
HS Code |
593981 |
| Chemical Formula | C8H6ClF3 |
| Molecular Weight | 194.58 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 170 - 175 °C |
| Density | Approx. 1.28 - 1.32 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Vapor Pressure | Low at room temperature |
| Flash Point | Around 50 - 60 °C |
| Odor | Characteristic aromatic odor |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 2-Chloro-4-Methyl-1-Trifluoromethyl-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottles packaged for 2 - chloro - 4 - methyl - 1 - trifluoromethyl - benzene. |
| Storage | 2 - chloro - 4 - methyl - 1 - trifluoromethyl - benzene should be stored in a cool, well - ventilated area, away from heat sources and ignition points. It should be placed in a tightly sealed container, preferably made of corrosion - resistant materials. Keep it separate from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions. Store in accordance with local safety regulations. |
| Shipping | 2 - chloro - 4 - methyl - 1 - trifluoromethyl - benzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling, secure packaging to prevent leakage during transit. |
Competitive 2-Chloro-4-Methyl-1-Trifluoromethyl-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 2-chloro-4-methyl-1-trifluoromethyl-benzene?
2-Chloro-4-methyl-1-trifluoromethylbenzene, an organic compound containing chlorine atoms, methyl and trifluoromethyl based on the benzene ring. Its chemical properties are particularly important and are related to many fields of chemistry.
As far as electrophilic substitution is concerned, the benzene ring is rich in electrons, nucleophilic, and vulnerable to attack by electrophilic reagents. As a power supply radical, methyl can increase the electron cloud density of the benzene ring, especially in the ortho and para-positions, resulting in an increase in its electrophilic substitution activity. Although the chlorine atom has an electron-absorbing effect, its lone pair electrons can be conjugated with the benzene ring, which also affects the check point of the electrophil In combination, the electrophilic substitution reaction of the compound may occur more easily in the ortho or para-position of the methyl group.
In the oxidation reaction, the methyl group can be oxidized. In case of strong oxidizing agent, the methyl group may be gradually oxidized to the carboxyl group to form products such as 2-chloro-4-carboxyl-1-trifluoromethylbenzene.
In the halogenation reaction, due to the presence of substituents on the benzene ring, the reactivity and check point will be affected. Under light or heating conditions, the hydrogen atom on the side chain methyl group can be replaced by halogen to form halogenated methyl products.
From the perspective of substituent interactions, trifluoromethyl is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and affect the reactions involving other substituents. There are electronic effects and spatial effects between it and methyl and chlorine atoms, which jointly determine the chemical properties and reactivity of the compound.
2-chloro-4-methyl-1-trifluoromethylbenzene Each substituent has unique chemical properties and is of great significance in the fields of organic synthesis, pharmaceutical chemistry, etc. It can be used as a key intermediate to participate in many chemical reactions and prepare more complex organic compounds.
As far as electrophilic substitution is concerned, the benzene ring is rich in electrons, nucleophilic, and vulnerable to attack by electrophilic reagents. As a power supply radical, methyl can increase the electron cloud density of the benzene ring, especially in the ortho and para-positions, resulting in an increase in its electrophilic substitution activity. Although the chlorine atom has an electron-absorbing effect, its lone pair electrons can be conjugated with the benzene ring, which also affects the check point of the electrophil In combination, the electrophilic substitution reaction of the compound may occur more easily in the ortho or para-position of the methyl group.
In the oxidation reaction, the methyl group can be oxidized. In case of strong oxidizing agent, the methyl group may be gradually oxidized to the carboxyl group to form products such as 2-chloro-4-carboxyl-1-trifluoromethylbenzene.
In the halogenation reaction, due to the presence of substituents on the benzene ring, the reactivity and check point will be affected. Under light or heating conditions, the hydrogen atom on the side chain methyl group can be replaced by halogen to form halogenated methyl products.
From the perspective of substituent interactions, trifluoromethyl is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and affect the reactions involving other substituents. There are electronic effects and spatial effects between it and methyl and chlorine atoms, which jointly determine the chemical properties and reactivity of the compound.
2-chloro-4-methyl-1-trifluoromethylbenzene Each substituent has unique chemical properties and is of great significance in the fields of organic synthesis, pharmaceutical chemistry, etc. It can be used as a key intermediate to participate in many chemical reactions and prepare more complex organic compounds.
What are the physical properties of 2-chloro-4-methyl-1-trifluoromethyl-benzene?
2-Chloro-4-methyl-1-trifluoromethylbenzene, this is an organic compound, its physical properties are quite unique, and it is widely used in organic synthesis and other fields.
Looking at its properties, under room temperature and pressure, it is mostly colorless to light yellow liquid, its color is elegant, if the morning sun shines, it is clear and shimmering. Its smell often has a special fragrance, but this fragrance is unusually rich, but it has a unique smell of some chemicals, just like the hidden fragrance in the depths of the forest, which is fascinating to explore.
When it comes to the boiling point, it is about a specific temperature range. This temperature is like the node of material sublimation, just like water boiling at 100 degrees Celsius, changing its form and showing its inherent characteristics. The boiling point of this compound makes it exist as a liquid at room temperature, and when heated, it can be turned into a gaseous state and participate in various reactions, just like a dancer on a stage, changing his posture according to the command of temperature.
The melting point also has its fixed value, just like the freezing point of the earth in winter. Below this temperature, the compound is like a hibernating beast, changing from a flowing state to a solid state, and the molecules are arranged neatly and orderly, just like an army waiting for it.
In terms of density, compared to water, it has its specific value, either lighter than water, like a boat floating on a blue wave; or heavier than water, like a rock sinking at the bottom of the abyss. This density characteristic, in separation, mixing and other operations, is like a compass that guides the direction, helping chemists control the reaction process.
In terms of solubility, among organic solvents, such as alcohols and ethers, the degree of solubility varies. In some solvents, it can be fused infinitely, like water emulsion, while in others, it is difficult to dissolve like oil and water. This difference in solubility, just like how people get along with each other, or hit it off at once, or it is out of place, determines its behavior and application in different chemical systems.
In terms of volatility, it has a certain degree of volatility, such as the dew in the morning, which quietly disappears over time. Its volatilization rate is affected by factors such as temperature and pressure, just like a leaf in the wind, dancing according to the force of the environment. This volatility should be treated with caution during storage and use to prevent its dissipation and affect subsequent applications.
The physical properties of 2-chloro-4-methyl-1-trifluoromethylbenzene are useful for each. They are used in the stage of organic synthesis, such as delicate musical instruments. Under the command of chemists, they play beautiful chemical movements.
Looking at its properties, under room temperature and pressure, it is mostly colorless to light yellow liquid, its color is elegant, if the morning sun shines, it is clear and shimmering. Its smell often has a special fragrance, but this fragrance is unusually rich, but it has a unique smell of some chemicals, just like the hidden fragrance in the depths of the forest, which is fascinating to explore.
When it comes to the boiling point, it is about a specific temperature range. This temperature is like the node of material sublimation, just like water boiling at 100 degrees Celsius, changing its form and showing its inherent characteristics. The boiling point of this compound makes it exist as a liquid at room temperature, and when heated, it can be turned into a gaseous state and participate in various reactions, just like a dancer on a stage, changing his posture according to the command of temperature.
The melting point also has its fixed value, just like the freezing point of the earth in winter. Below this temperature, the compound is like a hibernating beast, changing from a flowing state to a solid state, and the molecules are arranged neatly and orderly, just like an army waiting for it.
In terms of density, compared to water, it has its specific value, either lighter than water, like a boat floating on a blue wave; or heavier than water, like a rock sinking at the bottom of the abyss. This density characteristic, in separation, mixing and other operations, is like a compass that guides the direction, helping chemists control the reaction process.
In terms of solubility, among organic solvents, such as alcohols and ethers, the degree of solubility varies. In some solvents, it can be fused infinitely, like water emulsion, while in others, it is difficult to dissolve like oil and water. This difference in solubility, just like how people get along with each other, or hit it off at once, or it is out of place, determines its behavior and application in different chemical systems.
In terms of volatility, it has a certain degree of volatility, such as the dew in the morning, which quietly disappears over time. Its volatilization rate is affected by factors such as temperature and pressure, just like a leaf in the wind, dancing according to the force of the environment. This volatility should be treated with caution during storage and use to prevent its dissipation and affect subsequent applications.
The physical properties of 2-chloro-4-methyl-1-trifluoromethylbenzene are useful for each. They are used in the stage of organic synthesis, such as delicate musical instruments. Under the command of chemists, they play beautiful chemical movements.
What are the main uses of 2-chloro-4-methyl-1-trifluoromethyl-benzene?
2-Chloro-4-methyl-1-trifluoromethylbenzene has a wide range of uses. In the field of organic synthesis, it is often an important raw material. Due to its unique chemical structure, it plays a key role in the preparation of various functional organic compounds.
First, in pharmaceutical chemistry, it can be used as a starting material for the synthesis of specific drug molecules. With its functional groups such as chlorine atoms, methyl and trifluoromethyl, it can construct a molecular skeleton with specific biological activities through a series of organic reactions. For example, in the process of developing some antiviral and anti-tumor drugs, its structure can be cleverly modified to meet the needs of drug interaction with specific targets and facilitate the creation of new drugs.
Second, it also has outstanding performance in the field of materials science. Due to the introduction of trifluoromethyl, it can significantly change the physical and chemical properties of materials, such as improving the stability, corrosion resistance and hydrophobicity of materials. Therefore, it can be used to prepare high-performance coatings, plastics and other materials. Taking coatings as an example, adding special ingredients synthesized from this material can make the coating have better protective properties and prolong the service life of the coated object.
Furthermore, in the field of pesticide chemistry, it can be used as an important intermediate for the synthesis of new pesticides. Its structural characteristics help to give pesticides better biological activity and environmental adaptability, and can effectively improve the control effect of pesticides on pests and pathogens, while reducing the adverse impact on the environment, promoting the development of green pesticides.
In conclusion, 2-chloro-4-methyl-1-trifluoromethylbenzene is indispensable in many fields related to organic synthesis, such as medicine, materials, and pesticides, and plays an important supporting role in the development of various industries.
First, in pharmaceutical chemistry, it can be used as a starting material for the synthesis of specific drug molecules. With its functional groups such as chlorine atoms, methyl and trifluoromethyl, it can construct a molecular skeleton with specific biological activities through a series of organic reactions. For example, in the process of developing some antiviral and anti-tumor drugs, its structure can be cleverly modified to meet the needs of drug interaction with specific targets and facilitate the creation of new drugs.
Second, it also has outstanding performance in the field of materials science. Due to the introduction of trifluoromethyl, it can significantly change the physical and chemical properties of materials, such as improving the stability, corrosion resistance and hydrophobicity of materials. Therefore, it can be used to prepare high-performance coatings, plastics and other materials. Taking coatings as an example, adding special ingredients synthesized from this material can make the coating have better protective properties and prolong the service life of the coated object.
Furthermore, in the field of pesticide chemistry, it can be used as an important intermediate for the synthesis of new pesticides. Its structural characteristics help to give pesticides better biological activity and environmental adaptability, and can effectively improve the control effect of pesticides on pests and pathogens, while reducing the adverse impact on the environment, promoting the development of green pesticides.
In conclusion, 2-chloro-4-methyl-1-trifluoromethylbenzene is indispensable in many fields related to organic synthesis, such as medicine, materials, and pesticides, and plays an important supporting role in the development of various industries.
What are 2-chloro-4-methyl-1-trifluoromethyl-benzene synthesis methods?
There are many ways to synthesize 2-chloro-4-methyl-1-trifluoromethylbenzene. First, chlorine atoms can be introduced through a halogenation reaction starting from a suitable aromatic compound. Choose an aromatic hydrocarbon containing methyl and treat it with chlorine reagents such as chlorine gas and thionyl chloride under specific reaction conditions. Control the reaction temperature, time and proportion of the reactants to precisely locate the chlorine atoms to the target position, that is, the 2-position, to obtain chlorine-containing intermediates with methyl groups.
Then, trifluoromethyl is introduced through the trifluoromethylation step. Commonly used trifluoromethylation reagents, such as sodium trifluoromethanesulfonate, trifluoromethyl copper reagent, etc. In the presence of an appropriate solvent and catalyst, the intermediate is reacted with the trifluoromethylation reagent. In this process, the polarity of the solvent and the activity of the catalyst have a significant impact on the reaction process and product selectivity. The reaction parameters are precisely regulated so that the trifluoromethyl is successfully connected to the 1-position, and then 2-chloro-4-methyl-1-trifluoromethylbenzene is obtained.
Alternatively, different reaction routes can be designed. Trifluoromethyl is introduced first based on the aromatic ring, and then halogenation and methylation steps are performed. Using aromatic compounds containing trifluoromethyl as raw materials, through methylation reaction, suitable methylation reagents such as iodomethane, dimethyl sulfate, etc. are selected. Under alkali catalysis, the methyl groups are connected to specific positions in the aromatic ring. Then, halogenation is carried out to introduce chlorine atoms. The key to this route lies in the optimization of the reaction conditions at each step to ensure high yield and selectivity in each step, and finally 2-chloro-4-methyl-1-trifluoromethylbenzene can be obtained.
In addition, there is a strategy that is achieved by constructing aromatic rings. With appropriate non-aromatic raw materials, a benzene ring containing the target substituent is formed by cyclization reaction. For example, chain compounds containing chlorine, methyl and trifluoromethyl related functional groups are selected, and under specific catalysts and reaction conditions, they are cyclized within the molecule to form a benzene ring structure. This method requires in-depth understanding of the reaction mechanism and fine regulation of the reaction conditions to achieve efficient and selective synthesis. Successful preparation of 2-chloro-4-methyl-1-trifluoromethylbenzene.
Then, trifluoromethyl is introduced through the trifluoromethylation step. Commonly used trifluoromethylation reagents, such as sodium trifluoromethanesulfonate, trifluoromethyl copper reagent, etc. In the presence of an appropriate solvent and catalyst, the intermediate is reacted with the trifluoromethylation reagent. In this process, the polarity of the solvent and the activity of the catalyst have a significant impact on the reaction process and product selectivity. The reaction parameters are precisely regulated so that the trifluoromethyl is successfully connected to the 1-position, and then 2-chloro-4-methyl-1-trifluoromethylbenzene is obtained.
Alternatively, different reaction routes can be designed. Trifluoromethyl is introduced first based on the aromatic ring, and then halogenation and methylation steps are performed. Using aromatic compounds containing trifluoromethyl as raw materials, through methylation reaction, suitable methylation reagents such as iodomethane, dimethyl sulfate, etc. are selected. Under alkali catalysis, the methyl groups are connected to specific positions in the aromatic ring. Then, halogenation is carried out to introduce chlorine atoms. The key to this route lies in the optimization of the reaction conditions at each step to ensure high yield and selectivity in each step, and finally 2-chloro-4-methyl-1-trifluoromethylbenzene can be obtained.
In addition, there is a strategy that is achieved by constructing aromatic rings. With appropriate non-aromatic raw materials, a benzene ring containing the target substituent is formed by cyclization reaction. For example, chain compounds containing chlorine, methyl and trifluoromethyl related functional groups are selected, and under specific catalysts and reaction conditions, they are cyclized within the molecule to form a benzene ring structure. This method requires in-depth understanding of the reaction mechanism and fine regulation of the reaction conditions to achieve efficient and selective synthesis. Successful preparation of 2-chloro-4-methyl-1-trifluoromethylbenzene.
2-chloro-4-methyl-1-trifluoromethyl-benzene what are the precautions during storage and transportation?
2-Chloro-4-methyl-1-trifluoromethylbenzene, this is an organic compound. When storing and transporting, care should be taken to ensure safety.
When storing, the first choice of environment. When placed in a cool, dry and well-ventilated place, do not approach fire and heat sources. Because of its flammability, in case of open flame or hot topic, it may cause fire risk. The temperature of the warehouse should be controlled within a suitable range to prevent its volatilization from being intensified due to excessive temperature, or its stability from being affected by sudden temperature changes.
Furthermore, pay attention to the integrity of the package. Packaging should be firmly sealed to avoid material leakage. Once it leaks, it will not only pollute the environment, but also evaporate steam, or cause poisoning risk, which is harmful to human health. Storage areas should be kept away from oxidants, acids, alkalis and other substances, because of their active chemical properties, contact with the above substances, or cause severe chemical reactions, which will bring serious consequences.
When transporting, there are also many key points. Vehicles must meet safety standards and have reliable fire and explosion-proof devices. The loading and unloading process must be handled with care, and it is strictly forbidden to drop and heavy pressure to prevent package damage. During transportation, drivers should be vigilant, drive cautiously, and avoid intense operations such as sudden braking and sharp turns. At the same time, they should drive according to the specified route to avoid sensitive areas such as water source reserves and densely populated areas.
Transportation and storage personnel need to be professionally trained and familiar with the characteristics of 2-chloro-4-methyl-1-trifluoromethylbenzene and emergency treatment methods. In the event of a leak or other accident, they can respond quickly and correctly to reduce losses and hazards. In this way, the safety of 2-chloro-4-methyl-1-trifluoromethylbenzene during storage and transportation is guaranteed.
When storing, the first choice of environment. When placed in a cool, dry and well-ventilated place, do not approach fire and heat sources. Because of its flammability, in case of open flame or hot topic, it may cause fire risk. The temperature of the warehouse should be controlled within a suitable range to prevent its volatilization from being intensified due to excessive temperature, or its stability from being affected by sudden temperature changes.
Furthermore, pay attention to the integrity of the package. Packaging should be firmly sealed to avoid material leakage. Once it leaks, it will not only pollute the environment, but also evaporate steam, or cause poisoning risk, which is harmful to human health. Storage areas should be kept away from oxidants, acids, alkalis and other substances, because of their active chemical properties, contact with the above substances, or cause severe chemical reactions, which will bring serious consequences.
When transporting, there are also many key points. Vehicles must meet safety standards and have reliable fire and explosion-proof devices. The loading and unloading process must be handled with care, and it is strictly forbidden to drop and heavy pressure to prevent package damage. During transportation, drivers should be vigilant, drive cautiously, and avoid intense operations such as sudden braking and sharp turns. At the same time, they should drive according to the specified route to avoid sensitive areas such as water source reserves and densely populated areas.
Transportation and storage personnel need to be professionally trained and familiar with the characteristics of 2-chloro-4-methyl-1-trifluoromethylbenzene and emergency treatment methods. In the event of a leak or other accident, they can respond quickly and correctly to reduce losses and hazards. In this way, the safety of 2-chloro-4-methyl-1-trifluoromethylbenzene during storage and transportation is guaranteed.
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