Linshang Chemical
PRODUCTS
2-Chloro-4-Nitro-1-(Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
190793 |
| Chemical Formula | C7H3ClF3NO3 |
| Molar Mass | 241.55 g/mol |
| Appearance | Solid (usually) |
| Physical State At Room Temp | Solid |
| Color | Typically colorless to pale yellow |
| Odor | Characteristic organic odor |
| Melting Point | Data - specific value needed from reference |
| Boiling Point | Data - specific value needed from reference |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Density | Data - specific value needed from reference |
| Flash Point | Data - specific value needed from reference |
| Stability | Stable under normal conditions, but reactive with strong oxidizing/reducing agents |
| Hazard Class | Irritant, may be harmful if swallowed, inhaled or in contact with skin |
As an accredited 2-Chloro-4-Nitro-1-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2 - chloro - 4 - nitro - 1 - (trifluoromethoxy)benzene in sealed chemical - grade bottle. |
| Storage | 2 - Chloro - 4 - nitro - 1 - (trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and exposure to air and moisture, which could potentially cause decomposition or react with other substances. |
| Shipping | 2 - chloro - 4 - nitro - 1 - (trifluoromethoxy)benzene is shipped in sealed, corrosion - resistant containers. Special handling procedures are followed due to its chemical nature, ensuring safe transportation and compliance with regulations. |
Competitive 2-Chloro-4-Nitro-1-(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Chloro-4-Nitro-1-(Trifluoromethoxy)Benzene in China?
As a trusted 2-Chloro-4-Nitro-1-(Trifluoromethoxy)Benzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-4-Nitro-1-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 2-chloro-4-nitro-1- (trifluoromethoxy) benzene?
2-Chloro-4-nitro-1- (trifluoromethoxy) benzene is one of the organic compounds. Its physical properties are quite characteristic, and are described in detail below.
Looking at its properties, under normal conditions, it is mostly a colorless to light yellow liquid, or a crystalline solid, which varies depending on the environmental conditions. Its appearance is pure, the texture is uniform, and there is no impurity heterogeneity.
As for the melting point, according to relevant books and experimental records, it is about a specific range, but this value will also vary slightly due to differences in experimental conditions. If the ambient pressure and other factors are stable, its melting point is roughly within the reference range, which is one of the important indicators for identifying the compound.
Boiling point, under specific pressure conditions, will reach the corresponding temperature value. When the external pressure is standard atmospheric pressure, the substance will boil at a certain temperature, which is the boiling point. This characteristic also helps to separate and purify it from the mixture.
In terms of solubility, in organic solvents, it shows different degrees of solubility. Organic solvents such as common ethanol and ether can have a certain solubility and can form a uniform mixed system with them. However, in water, its solubility is very small, which is due to the characteristics of its molecular structure. The trifluoromethoxy group contained in the molecule makes it hydrophobic to a certain extent.
Density is also the key to its physical properties. Under normal temperature and pressure, the substance has a specific density value, which can be used to determine the purity and content of the substance by measuring the volume and mass in actual production and experiments.
In addition, the vapor pressure of the compound also varies at different temperatures. When the temperature increases, the vapor pressure increases, indicating that more molecules have a tendency to escape the liquid phase. This property needs to be carefully considered in the process of evaporation and distillation in chemical production.
2-chloro-4-nitro-1 - (trifluoromethoxy) benzene has various physical properties, and each property is related and affected. It is of great significance in many fields such as organic synthesis and chemical production, and needs to be carefully grasped and studied.
Looking at its properties, under normal conditions, it is mostly a colorless to light yellow liquid, or a crystalline solid, which varies depending on the environmental conditions. Its appearance is pure, the texture is uniform, and there is no impurity heterogeneity.
As for the melting point, according to relevant books and experimental records, it is about a specific range, but this value will also vary slightly due to differences in experimental conditions. If the ambient pressure and other factors are stable, its melting point is roughly within the reference range, which is one of the important indicators for identifying the compound.
Boiling point, under specific pressure conditions, will reach the corresponding temperature value. When the external pressure is standard atmospheric pressure, the substance will boil at a certain temperature, which is the boiling point. This characteristic also helps to separate and purify it from the mixture.
In terms of solubility, in organic solvents, it shows different degrees of solubility. Organic solvents such as common ethanol and ether can have a certain solubility and can form a uniform mixed system with them. However, in water, its solubility is very small, which is due to the characteristics of its molecular structure. The trifluoromethoxy group contained in the molecule makes it hydrophobic to a certain extent.
Density is also the key to its physical properties. Under normal temperature and pressure, the substance has a specific density value, which can be used to determine the purity and content of the substance by measuring the volume and mass in actual production and experiments.
In addition, the vapor pressure of the compound also varies at different temperatures. When the temperature increases, the vapor pressure increases, indicating that more molecules have a tendency to escape the liquid phase. This property needs to be carefully considered in the process of evaporation and distillation in chemical production.
2-chloro-4-nitro-1 - (trifluoromethoxy) benzene has various physical properties, and each property is related and affected. It is of great significance in many fields such as organic synthesis and chemical production, and needs to be carefully grasped and studied.
What are the chemical properties of 2-chloro-4-nitro-1- (trifluoromethoxy) benzene
2-Chloro-4-nitro-1- (trifluoromethoxy) benzene, this is an organic compound, and its chemical properties are very interesting.
Looking at its structure, chlorine atoms, nitro groups and trifluoromethoxy groups are all connected to the benzene ring. Chlorine atoms have certain electronegativity. In chemical reactions, they can change the electron cloud density distribution of the benzene ring, and the electron cloud density of the adjacent and para-sites of the benzene ring is relatively reduced. Therefore, during the electrophilic substitution reaction, new groups tend to enter the intermediate position.
Nitro is a strong electron-absorbing group, which can significantly reduce the electron cloud density of the benzene ring, which greatly reduces the activity of the benzene ring, and is not prone to electrophilic sub However, its existence makes the ortho and para-sites of the benzene ring more vulnerable to attack by nucleophiles. For example, under certain conditions, nucleophiles can replace chlorine atoms on the benzene ring, because the nitro group enhances the activity of chlorine atoms.
In the trifluoromethoxy group, the fluorine atom is extremely electronegative, resulting in the trifluoromethoxy group being also a strong electron-absorbing group. It interacts with the nitro group and chlorine atom, which further affects the distribution and activity of the electron cloud in the benzene ring.
This compound has a wide range of uses in the field of organic synthesis due to the many electron-withdrawing groups in its structure. It can be used as an intermediate to prepare various fluorine and nitrogen-containing organic compounds through a series of reactions such as nucleophilic substitution and reduction. It has important application value in the fields of medicine, pesticides, and materials science.
Looking at its structure, chlorine atoms, nitro groups and trifluoromethoxy groups are all connected to the benzene ring. Chlorine atoms have certain electronegativity. In chemical reactions, they can change the electron cloud density distribution of the benzene ring, and the electron cloud density of the adjacent and para-sites of the benzene ring is relatively reduced. Therefore, during the electrophilic substitution reaction, new groups tend to enter the intermediate position.
Nitro is a strong electron-absorbing group, which can significantly reduce the electron cloud density of the benzene ring, which greatly reduces the activity of the benzene ring, and is not prone to electrophilic sub However, its existence makes the ortho and para-sites of the benzene ring more vulnerable to attack by nucleophiles. For example, under certain conditions, nucleophiles can replace chlorine atoms on the benzene ring, because the nitro group enhances the activity of chlorine atoms.
In the trifluoromethoxy group, the fluorine atom is extremely electronegative, resulting in the trifluoromethoxy group being also a strong electron-absorbing group. It interacts with the nitro group and chlorine atom, which further affects the distribution and activity of the electron cloud in the benzene ring.
This compound has a wide range of uses in the field of organic synthesis due to the many electron-withdrawing groups in its structure. It can be used as an intermediate to prepare various fluorine and nitrogen-containing organic compounds through a series of reactions such as nucleophilic substitution and reduction. It has important application value in the fields of medicine, pesticides, and materials science.
What is the main use of 2-chloro-4-nitro-1- (trifluoromethoxy) benzene?
2-Chloro-4-nitro-1- (trifluoromethoxy) benzene is an organic compound. It has a wide range of uses in the field of medicinal chemistry and is often a key intermediate for the synthesis of various drug molecules with specific biological activities. Due to the unique electronic effects and spatial structure of trifluoromethoxy, chlorine atoms and nitro groups, it can endow the target drug with unique pharmacological properties, such as enhancing the binding ability of the drug to the target, enhancing the lipid solubility of the drug, promoting its absorption and distribution in the body, and then optimizing the efficacy and bioavailability of the drug.
In the field of pesticide chemistry, it also plays an important role. From this raw material, pesticide varieties with high insecticidal, bactericidal or herbicidal activities can be created. For example, by rationally designing the molecular structure, it can precisely act on the specific physiological processes of pests, bacteria or weeds to achieve high-efficiency, low-toxicity and environmentally friendly pesticide efficacy. The introduction of trifluoromethoxy can enhance the effect of compounds on the nervous system or cell membranes of certain pests, and improve the control effect and shelf life of pesticides.
In addition, in the field of materials science, 2-chloro-4-nitro-1- (trifluoromethoxy) benzene also has potential applications. Or it can be used to synthesize organic materials with special optical and electrical properties. Due to the fact that the functional groups in the molecular structure can affect the electron cloud distribution and energy level structure of materials, it is expected to prepare materials with unique properties in photoelectric conversion and photoluminescence, providing a material basis for the research and development of new organic optoelectronic devices.
In the field of pesticide chemistry, it also plays an important role. From this raw material, pesticide varieties with high insecticidal, bactericidal or herbicidal activities can be created. For example, by rationally designing the molecular structure, it can precisely act on the specific physiological processes of pests, bacteria or weeds to achieve high-efficiency, low-toxicity and environmentally friendly pesticide efficacy. The introduction of trifluoromethoxy can enhance the effect of compounds on the nervous system or cell membranes of certain pests, and improve the control effect and shelf life of pesticides.
In addition, in the field of materials science, 2-chloro-4-nitro-1- (trifluoromethoxy) benzene also has potential applications. Or it can be used to synthesize organic materials with special optical and electrical properties. Due to the fact that the functional groups in the molecular structure can affect the electron cloud distribution and energy level structure of materials, it is expected to prepare materials with unique properties in photoelectric conversion and photoluminescence, providing a material basis for the research and development of new organic optoelectronic devices.
What are the synthesis methods of 2-chloro-4-nitro-1- (trifluoromethoxy) benzene
To prepare 2-chloro-4-nitro-1 - (trifluoromethoxy) benzene, there are about two common methods.
First, 2-chloro-1-hydroxy-4-nitrobenzene is used as the starting material. This raw material reacts with trifluoromethyl halides, such as trifluoromethyl bromide or trifluoromethyl iodine, in the presence of bases, in a suitable solvent. The base can be selected from potassium carbonate, sodium carbonate, etc. The solvent can be N, N-dimethylformamide (DMF), dimethylsulfoxide (DMSO), etc. During the reaction, the alkali captures the hydrogen of the phenolic hydroxyl group to form a phenoxy anion, which enhances its nucleophilicity, and then undergoes a nucleophilic substitution reaction with the trifluoromethyl halide to form the target product 2-chloro-4-nitro-1 - (trifluoromethoxy) benzene. This reaction condition is relatively mild, but the acquisition of the starting material 2-chloro-1-hydroxy-4-nitrobenzene may require multiple steps and the cost may be higher.
Second, 1-chloro-2 - (trifluoromethoxy) benzene is used as the raw material. It is first nitrified and nitro is introduced. Nitrifying reagents are often mixed acids, that is, a mixture of concentrated sulfuric acid and concentrated nitric acid. At a suitable temperature, 1-chloro-2 - (trifluoromethoxy) benzene and mixed acids undergo electrophilic substitution, and the nitro group is mainly substituted in the chlorine atom para-position to form 2-chloro-4-nitro-1 - (trifluoromethoxy) benzene. The raw materials for this method are relatively easy to obtain, but the nitrification reaction needs to strictly control the reaction conditions, such as temperature and acid mixing ratio, to prevent excessive nitrification or other side reactions. Moreover, the mixed acid has strong corrosion and requires high equipment.
Preparation of 2-chloro-4-nitro-1 - (trifluoromethoxy) benzene, each method has advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, cost, reaction conditions and product purity requirements, and select an appropriate synthesis method.
First, 2-chloro-1-hydroxy-4-nitrobenzene is used as the starting material. This raw material reacts with trifluoromethyl halides, such as trifluoromethyl bromide or trifluoromethyl iodine, in the presence of bases, in a suitable solvent. The base can be selected from potassium carbonate, sodium carbonate, etc. The solvent can be N, N-dimethylformamide (DMF), dimethylsulfoxide (DMSO), etc. During the reaction, the alkali captures the hydrogen of the phenolic hydroxyl group to form a phenoxy anion, which enhances its nucleophilicity, and then undergoes a nucleophilic substitution reaction with the trifluoromethyl halide to form the target product 2-chloro-4-nitro-1 - (trifluoromethoxy) benzene. This reaction condition is relatively mild, but the acquisition of the starting material 2-chloro-1-hydroxy-4-nitrobenzene may require multiple steps and the cost may be higher.
Second, 1-chloro-2 - (trifluoromethoxy) benzene is used as the raw material. It is first nitrified and nitro is introduced. Nitrifying reagents are often mixed acids, that is, a mixture of concentrated sulfuric acid and concentrated nitric acid. At a suitable temperature, 1-chloro-2 - (trifluoromethoxy) benzene and mixed acids undergo electrophilic substitution, and the nitro group is mainly substituted in the chlorine atom para-position to form 2-chloro-4-nitro-1 - (trifluoromethoxy) benzene. The raw materials for this method are relatively easy to obtain, but the nitrification reaction needs to strictly control the reaction conditions, such as temperature and acid mixing ratio, to prevent excessive nitrification or other side reactions. Moreover, the mixed acid has strong corrosion and requires high equipment.
Preparation of 2-chloro-4-nitro-1 - (trifluoromethoxy) benzene, each method has advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, cost, reaction conditions and product purity requirements, and select an appropriate synthesis method.
What are the precautions for 2-chloro-4-nitro-1- (trifluoromethoxy) benzene in storage and transportation?
2-Chloro-4-nitro-1- (trifluoromethoxy) benzene is a highly toxic chemical. When storing and transporting, it is necessary to pay great attention to many matters.
When storing, the first thing to do is to choose a cool, dry and well-ventilated place. This substance is easy to decompose when heated, and if it is in a high temperature environment, it may be dangerous. Therefore, it must be kept away from fire and heat sources, just like avoiding water and fire. The temperature of the warehouse should be controlled within a specific range, and it must not be too high.
Furthermore, it must be stored separately from oxidizing agents, reducing agents, alkalis, etc. Because of its active chemical properties, contact with these substances is likely to cause violent chemical reactions, such as explosions, fires and other disasters. There should be obvious warning signs in the storage place to inform everyone that this is a dangerous chemical and should not be taken lightly.
When transporting, there are also many key points. First, the packaging must be tight and firm. Appropriate packaging materials must be used in accordance with relevant regulations to ensure that there will be no damage or leakage during transportation. Second, the transportation vehicle should be equipped with corresponding fire protection equipment and emergency treatment equipment. In case of an accident, rescue and treatment can be carried out quickly to reduce losses.
During transportation, drivers and escorts must strictly abide by the operating procedures and must not leave their duties without authorization. And the route should avoid sensitive places such as densely populated areas and water source protection areas. In the event of a spill accident, do not panic. Immediate emergency measures should be taken to evacuate the surrounding crowd, seal off the scene, and quickly report to the relevant departments.
In short, the storage and transportation of 2-chloro-4-nitro-1- (trifluoromethoxy) benzene is a matter of safety and cannot be sloppy. All parties need to be cautious and operate in accordance with regulations to ensure safety.
When storing, the first thing to do is to choose a cool, dry and well-ventilated place. This substance is easy to decompose when heated, and if it is in a high temperature environment, it may be dangerous. Therefore, it must be kept away from fire and heat sources, just like avoiding water and fire. The temperature of the warehouse should be controlled within a specific range, and it must not be too high.
Furthermore, it must be stored separately from oxidizing agents, reducing agents, alkalis, etc. Because of its active chemical properties, contact with these substances is likely to cause violent chemical reactions, such as explosions, fires and other disasters. There should be obvious warning signs in the storage place to inform everyone that this is a dangerous chemical and should not be taken lightly.
When transporting, there are also many key points. First, the packaging must be tight and firm. Appropriate packaging materials must be used in accordance with relevant regulations to ensure that there will be no damage or leakage during transportation. Second, the transportation vehicle should be equipped with corresponding fire protection equipment and emergency treatment equipment. In case of an accident, rescue and treatment can be carried out quickly to reduce losses.
During transportation, drivers and escorts must strictly abide by the operating procedures and must not leave their duties without authorization. And the route should avoid sensitive places such as densely populated areas and water source protection areas. In the event of a spill accident, do not panic. Immediate emergency measures should be taken to evacuate the surrounding crowd, seal off the scene, and quickly report to the relevant departments.
In short, the storage and transportation of 2-chloro-4-nitro-1- (trifluoromethoxy) benzene is a matter of safety and cannot be sloppy. All parties need to be cautious and operate in accordance with regulations to ensure safety.
Scan to WhatsApp
