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2-Chloro-4-Nitro-1-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
675585 |
| Chemical Formula | C7H3ClF3NO2 |
| Molar Mass | 225.55 g/mol |
| Appearance | Solid (usually a powder or crystalline solid) |
| Color | Off - white to light yellow |
| Odor | May have a characteristic chemical odor |
| Melting Point | 37 - 41 °C |
| Boiling Point | 230 - 232 °C |
| Density | 1.609 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like dichloromethane, chloroform |
As an accredited 2-Chloro-4-Nitro-1-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2 - chloro - 4 - nitro - 1 - (trifluoromethyl)benzene packaged in a sealed glass bottle. |
| Storage | 2 - chloro - 4 - nitro - 1 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Separate it from oxidizing agents, reducing agents, and bases to prevent chemical reactions. Store in accordance with local regulations for hazardous chemicals. |
| Shipping | 2 - chloro - 4 - nitro - 1 - (trifluoromethyl)benzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical regulations, with proper labeling and handling to ensure safe transportation. |
Competitive 2-Chloro-4-Nitro-1-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 2-chloro-4-nitro-1- (trifluoromethyl) benzene?
2-Chloro-4-nitro-1- (trifluoromethyl) benzene, this is an organic compound with unique chemical properties.
First, the properties of halogenated aromatics, due to the presence of chlorine atoms, the activity of chlorine atoms enables them to participate in many nucleophilic substitution reactions. In alkali, hydroxyl negative ions or other nucleophilic reagents can attack the benzene ring, and chlorine atoms can leave to form products containing hydroxyl groups or other substituents. This reaction is often used in organic synthesis to form new carbon-heteroatom bonds, and a variety of functionalized aromatic compounds can be prepared.
Second, the influence of nitro groups. Nitro is a strong electron-absorbing group, which decreases the electron cloud density of the benzene ring, and decreases the electrophilic substitution activity of the benzene ring, especially the electron cloud density of the ortho and para-sites. However, at the same time, nitro makes the ortho and para-sites of the benzene ring more prone to nucleophilic substitution. Nitro itself can be reduced under specific conditions. For example, in systems such as iron and hydrochloric acid, hydrogen and catalysts, nitro can be gradually reduced to amino groups. Amino is an important functional group, which is widely used in the synthesis of medicine, dyes and other fields.
Third, the characteristics of trifluoromethyl. Trifluoromethyl has strong electron-absorbing properties and high stability, which significantly affects molecular physical and chemical properties. Because of its strong electron-absorbing properties, it further reduces the electron cloud density of the benzene And the presence of trifluoromethyl enhances the fat solubility of the compound, which has a great impact on its pharmacokinetic properties such as absorption and distribution in vivo. This group is often introduced in the research and development of pesticides and medicines to optimize molecular properties.
Fourth, aromaticity. The compound has a benzene ring structure, has typical aromaticity, and can undergo aromatic-specific reactions, such as the Fu-gram reaction (but due to the strong electron absorption of nitro and trifluoromethyl, the reaction conditions may be different from benzene). In addition, electrophilic substitution reactions such as halogenation, nitrification, and sulfonation can also occur, but due to the existing substituent localization effects, the reaction check point and product ratio need to be carefully considered.
In conclusion, 2-chloro-4-nitro-1 - (trifluoromethyl) benzene is rich in chemical properties and has important application value in the fields of organic synthesis, materials science, and drug development.
First, the properties of halogenated aromatics, due to the presence of chlorine atoms, the activity of chlorine atoms enables them to participate in many nucleophilic substitution reactions. In alkali, hydroxyl negative ions or other nucleophilic reagents can attack the benzene ring, and chlorine atoms can leave to form products containing hydroxyl groups or other substituents. This reaction is often used in organic synthesis to form new carbon-heteroatom bonds, and a variety of functionalized aromatic compounds can be prepared.
Second, the influence of nitro groups. Nitro is a strong electron-absorbing group, which decreases the electron cloud density of the benzene ring, and decreases the electrophilic substitution activity of the benzene ring, especially the electron cloud density of the ortho and para-sites. However, at the same time, nitro makes the ortho and para-sites of the benzene ring more prone to nucleophilic substitution. Nitro itself can be reduced under specific conditions. For example, in systems such as iron and hydrochloric acid, hydrogen and catalysts, nitro can be gradually reduced to amino groups. Amino is an important functional group, which is widely used in the synthesis of medicine, dyes and other fields.
Third, the characteristics of trifluoromethyl. Trifluoromethyl has strong electron-absorbing properties and high stability, which significantly affects molecular physical and chemical properties. Because of its strong electron-absorbing properties, it further reduces the electron cloud density of the benzene And the presence of trifluoromethyl enhances the fat solubility of the compound, which has a great impact on its pharmacokinetic properties such as absorption and distribution in vivo. This group is often introduced in the research and development of pesticides and medicines to optimize molecular properties.
Fourth, aromaticity. The compound has a benzene ring structure, has typical aromaticity, and can undergo aromatic-specific reactions, such as the Fu-gram reaction (but due to the strong electron absorption of nitro and trifluoromethyl, the reaction conditions may be different from benzene). In addition, electrophilic substitution reactions such as halogenation, nitrification, and sulfonation can also occur, but due to the existing substituent localization effects, the reaction check point and product ratio need to be carefully considered.
In conclusion, 2-chloro-4-nitro-1 - (trifluoromethyl) benzene is rich in chemical properties and has important application value in the fields of organic synthesis, materials science, and drug development.
What are the common uses of 2-chloro-4-nitro-1- (trifluoromethyl) benzene?
2-Chloro-4-nitro-1- (trifluoromethyl) benzene is also an organic compound. It has a wide range of common uses and is an important intermediate in the field of organic synthesis.
First, it can be used to prepare many drugs. It has a unique structure and can introduce specific functional groups through a series of chemical reactions to build molecules with pharmacological activity. For example, through appropriate reactions, it can be converted into pharmaceutical ingredients with antibacterial, anti-inflammatory and other effects.
Second, it also plays an important role in the creation of pesticides. It can be chemically modified to give it insecticidal, weeding and other properties. Because it contains trifluoromethyl, such structures can often enhance the biological activity and stability of the compound, so that the pesticide can play a more effective role in the field, and the effective period is longer.
Furthermore, in the field of materials science, materials with special properties can be synthesized from this raw material. For example, polymer materials with specific optical and electrical properties can be synthesized for electronic devices, optical thin films, etc. The presence of chlorine atoms, nitro groups and trifluoromethyl groups can affect the intermolecular forces and electron cloud distribution of the material, thus endowing the material with unique properties.
The common method for preparing this compound is to use the corresponding aromatic compound as the starting material and achieve it through reaction steps such as halogenation, nitrification, and trifluoromethylation. Each step of the reaction requires precise control of the reaction conditions, such as temperature, reagent dosage, reaction time, etc., to ensure the selectivity and yield of the reaction. In this way, 2-chloro-4-nitro-1- (trifluoromethyl) benzene can be effectively obtained, thus laying the foundation for its subsequent extensive application.
First, it can be used to prepare many drugs. It has a unique structure and can introduce specific functional groups through a series of chemical reactions to build molecules with pharmacological activity. For example, through appropriate reactions, it can be converted into pharmaceutical ingredients with antibacterial, anti-inflammatory and other effects.
Second, it also plays an important role in the creation of pesticides. It can be chemically modified to give it insecticidal, weeding and other properties. Because it contains trifluoromethyl, such structures can often enhance the biological activity and stability of the compound, so that the pesticide can play a more effective role in the field, and the effective period is longer.
Furthermore, in the field of materials science, materials with special properties can be synthesized from this raw material. For example, polymer materials with specific optical and electrical properties can be synthesized for electronic devices, optical thin films, etc. The presence of chlorine atoms, nitro groups and trifluoromethyl groups can affect the intermolecular forces and electron cloud distribution of the material, thus endowing the material with unique properties.
The common method for preparing this compound is to use the corresponding aromatic compound as the starting material and achieve it through reaction steps such as halogenation, nitrification, and trifluoromethylation. Each step of the reaction requires precise control of the reaction conditions, such as temperature, reagent dosage, reaction time, etc., to ensure the selectivity and yield of the reaction. In this way, 2-chloro-4-nitro-1- (trifluoromethyl) benzene can be effectively obtained, thus laying the foundation for its subsequent extensive application.
What are the synthesis methods of 2-chloro-4-nitro-1- (trifluoromethyl) benzene?
The synthesis of 2-chloro-4-nitro-1- (trifluoromethyl) benzene is an important topic in the field of organic synthetic chemistry. This compound has unique structure and properties, and is widely used in many fields such as medicine, pesticides and materials science. Today I will describe the synthesis method for you in detail.
First, trifluoromethylbenzene is used as the starting material, and nitro groups can be introduced through nitrification reaction. Usually a mixed acid of concentrated nitric acid and concentrated sulfuric acid is used as the nitrifying reagent. At a suitable temperature and reaction time, trifluoromethylbenzene undergoes electrophilic substitution reaction with mixed acid, and nitro groups are introduced at specific positions in the benzene ring to generate 4-nitro-1- (trifluoromethyl) benzene. This step requires strict control of temperature and acid mixing ratio to prevent the formation of polynitrification products.
Then, 4-nitro-1- (trifluoromethyl) benzene is chlorinated. Chlorine gas can be used as a chlorination reagent. Under the presence of light or initiator, chlorine gas undergoes a radical substitution reaction with 4-nitro-1- (trifluoromethyl) benzene, and chlorine atoms are introduced at suitable positions in the benzene ring to obtain the target product 2-chloro-4-nitro-1- (trifluoromethyl) benzene. Other chlorinated reagents such as N-chlorosuccinimide (NCS) can also be used, and the reaction conditions of these reagents are relatively mild and the selectivity is better.
Second, m-chlorotrifluoromethylbenzene can also be used as the starting material. The nitration reaction is carried out first. Similar to the above nitration, m-chlorotrifluoromethylbenzene is treated with mixed acid, so that the nitro group is introduced into the benzene ring to obtain 2-chloro-4-nitro-1- (trifluoromethyl) benzene. This route can achieve the synthesis goal due to different starting material structures, reaction selectivity and conditions.
Furthermore, part of the synthesis route will first construct a benzene ring skeleton containing trifluoromethyl, chlorine and nitro. For example, through a multi-step reaction, the corresponding functional groups are gradually introduced with suitable raw materials, and a series of reactions such as nucleophilic substitution and electrophilic substitution are carried out to finally synthesize 2-chloro-4-nitro-1- (trifluoromethyl) benzene. Although this approach has many steps, it can flexibly adjust the position of functional groups and the reaction sequence, which may have unique advantages for improving the purity and yield of the product.
Synthesis of 2-chloro-4-nitro-1- (trifluoromethyl) benzene has various methods, each with its own advantages and disadvantages. In practical applications, the appropriate synthesis route should be carefully selected according to the availability of starting materials, the difficulty of controlling the reaction conditions, and the requirements of product purity and yield.
First, trifluoromethylbenzene is used as the starting material, and nitro groups can be introduced through nitrification reaction. Usually a mixed acid of concentrated nitric acid and concentrated sulfuric acid is used as the nitrifying reagent. At a suitable temperature and reaction time, trifluoromethylbenzene undergoes electrophilic substitution reaction with mixed acid, and nitro groups are introduced at specific positions in the benzene ring to generate 4-nitro-1- (trifluoromethyl) benzene. This step requires strict control of temperature and acid mixing ratio to prevent the formation of polynitrification products.
Then, 4-nitro-1- (trifluoromethyl) benzene is chlorinated. Chlorine gas can be used as a chlorination reagent. Under the presence of light or initiator, chlorine gas undergoes a radical substitution reaction with 4-nitro-1- (trifluoromethyl) benzene, and chlorine atoms are introduced at suitable positions in the benzene ring to obtain the target product 2-chloro-4-nitro-1- (trifluoromethyl) benzene. Other chlorinated reagents such as N-chlorosuccinimide (NCS) can also be used, and the reaction conditions of these reagents are relatively mild and the selectivity is better.
Second, m-chlorotrifluoromethylbenzene can also be used as the starting material. The nitration reaction is carried out first. Similar to the above nitration, m-chlorotrifluoromethylbenzene is treated with mixed acid, so that the nitro group is introduced into the benzene ring to obtain 2-chloro-4-nitro-1- (trifluoromethyl) benzene. This route can achieve the synthesis goal due to different starting material structures, reaction selectivity and conditions.
Furthermore, part of the synthesis route will first construct a benzene ring skeleton containing trifluoromethyl, chlorine and nitro. For example, through a multi-step reaction, the corresponding functional groups are gradually introduced with suitable raw materials, and a series of reactions such as nucleophilic substitution and electrophilic substitution are carried out to finally synthesize 2-chloro-4-nitro-1- (trifluoromethyl) benzene. Although this approach has many steps, it can flexibly adjust the position of functional groups and the reaction sequence, which may have unique advantages for improving the purity and yield of the product.
Synthesis of 2-chloro-4-nitro-1- (trifluoromethyl) benzene has various methods, each with its own advantages and disadvantages. In practical applications, the appropriate synthesis route should be carefully selected according to the availability of starting materials, the difficulty of controlling the reaction conditions, and the requirements of product purity and yield.
What should I pay attention to when storing and transporting 2-chloro-4-nitro-1- (trifluoromethyl) benzene?
2-Chloro-4-nitro-1- (trifluoromethyl) benzene is an organic compound. When storing and transporting, many matters need to be paid attention to.
First, the storage place must be dry and cool. This compound is afraid of moisture and moisture, and the humid environment can easily lead to its deterioration, which can damage the quality and performance. A cool place can reduce the risk of decomposition or other adverse reactions due to excessive temperature.
Second, when storing and transporting, it must be strictly protected from water vapor intrusion. Reactions such as water vapor or hydrolysis can damage its chemical structure. Therefore, the packaging must be tight to prevent water vapor penetration.
Furthermore, this compound is toxic and irritating, and leakage must be prevented during storage and transportation. If there is a leak, take effective measures to clean it up quickly to prevent endangering the environment and personal safety.
Also, when transporting, choose the appropriate packaging and transportation method in accordance with relevant regulations. Follow regulatory requirements to ensure the safety of the transportation process and avoid accidents caused by improper transportation.
In addition, the storage place should be kept away from fire sources, heat sources and oxidants. In case of open flame, hot topic or contact with oxidant, this compound has the risk of combustion and explosion.
When storing and transporting 2-chloro-4-nitro-1 - (trifluoromethyl) benzene, careful consideration must be given to various factors such as environment, packaging, safety, and strict adherence to relevant procedures to ensure its safety and quality.
First, the storage place must be dry and cool. This compound is afraid of moisture and moisture, and the humid environment can easily lead to its deterioration, which can damage the quality and performance. A cool place can reduce the risk of decomposition or other adverse reactions due to excessive temperature.
Second, when storing and transporting, it must be strictly protected from water vapor intrusion. Reactions such as water vapor or hydrolysis can damage its chemical structure. Therefore, the packaging must be tight to prevent water vapor penetration.
Furthermore, this compound is toxic and irritating, and leakage must be prevented during storage and transportation. If there is a leak, take effective measures to clean it up quickly to prevent endangering the environment and personal safety.
Also, when transporting, choose the appropriate packaging and transportation method in accordance with relevant regulations. Follow regulatory requirements to ensure the safety of the transportation process and avoid accidents caused by improper transportation.
In addition, the storage place should be kept away from fire sources, heat sources and oxidants. In case of open flame, hot topic or contact with oxidant, this compound has the risk of combustion and explosion.
When storing and transporting 2-chloro-4-nitro-1 - (trifluoromethyl) benzene, careful consideration must be given to various factors such as environment, packaging, safety, and strict adherence to relevant procedures to ensure its safety and quality.
What are the effects of 2-chloro-4-nitro-1- (trifluoromethyl) benzene on the environment and the human body?
2-Chloro-4-nitro-1- (trifluoromethyl) benzene, the impact of this substance on the environment and human body cannot be ignored.
First, the impact of the environment. It has a certain chemical stability and is difficult to decompose rapidly in the natural environment, or cause long-term residues. If it flows into the soil, it can change the physical and chemical properties of the soil, affect the structure and function of the soil microbial community, and then interfere with the material cycle and energy conversion of the soil ecosystem. If it hinders the decomposition of organic matter in the soil, it will reduce soil fertility and affect plant growth. If it enters the water body, it will cause water pollution, because of its toxicity or harm to aquatic organisms. Plankton, fish, etc. may be harmed by it, destroying the aquatic ecological balance and affecting the self-purification ability of the water body.
As for the impact on the human body, it should not be underestimated. After inhalation, skin contact or accidental ingestion into the human body, this compound may cause damage to many systems in the human body. In the nervous system, or interfere with the transmission of neurotransmitters, causing dizziness, headache, fatigue, memory loss and other symptoms. To the respiratory system, or irritate the respiratory mucosa, causing cough, asthma, long-term exposure may even damage lung function. Its nitro and chlorine atoms and other structures may be potentially carcinogenic. Long-term exposure may increase the risk of cancer in the human body. And the substance may also affect the human endocrine system, interfere with hormone balance, and have adverse effects on physiological processes such as reproduction and development. Therefore, 2-chloro-4-nitro-1- (trifluoromethyl) benzene must be treated with caution and its harm to the environment and human body must be strictly prevented and controlled.
First, the impact of the environment. It has a certain chemical stability and is difficult to decompose rapidly in the natural environment, or cause long-term residues. If it flows into the soil, it can change the physical and chemical properties of the soil, affect the structure and function of the soil microbial community, and then interfere with the material cycle and energy conversion of the soil ecosystem. If it hinders the decomposition of organic matter in the soil, it will reduce soil fertility and affect plant growth. If it enters the water body, it will cause water pollution, because of its toxicity or harm to aquatic organisms. Plankton, fish, etc. may be harmed by it, destroying the aquatic ecological balance and affecting the self-purification ability of the water body.
As for the impact on the human body, it should not be underestimated. After inhalation, skin contact or accidental ingestion into the human body, this compound may cause damage to many systems in the human body. In the nervous system, or interfere with the transmission of neurotransmitters, causing dizziness, headache, fatigue, memory loss and other symptoms. To the respiratory system, or irritate the respiratory mucosa, causing cough, asthma, long-term exposure may even damage lung function. Its nitro and chlorine atoms and other structures may be potentially carcinogenic. Long-term exposure may increase the risk of cancer in the human body. And the substance may also affect the human endocrine system, interfere with hormone balance, and have adverse effects on physiological processes such as reproduction and development. Therefore, 2-chloro-4-nitro-1- (trifluoromethyl) benzene must be treated with caution and its harm to the environment and human body must be strictly prevented and controlled.
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