Linshang Chemical
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2-Chloro-4-(Trifluoromethoxy)Bromobenzene
Linshang Chemical
|
HS Code |
203019 |
| Chemical Formula | C7H3BrClF3O |
| Molecular Weight | 273.45 |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Data may vary, around [X] °C under normal pressure (specific value needs experimental determination) |
| Melting Point | Data may vary, around [X] °C (specific value needs experimental determination) |
| Density | Data may vary, around [X] g/cm³ (specific value needs experimental determination) |
| Solubility In Water | Low solubility, hydrophobic |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Data may vary, relatively low at room temperature |
| Flash Point | Data may vary, needs experimental determination |
As an accredited 2-Chloro-4-(Trifluoromethoxy)Bromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 4 - (trifluoromethoxy)bromobenzene in a sealed, labeled bottle. |
| Storage | 2 - chloro - 4 - (trifluoromethoxy)bromobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent evaporation and contamination. Label the container clearly with its name, properties, and handling precautions. |
| Shipping | 2 - chloro - 4 - (trifluoromethoxy)bromobenzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous material regulations, with proper labeling and secure packaging to prevent leaks during transit. |
Competitive 2-Chloro-4-(Trifluoromethoxy)Bromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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What is the main use of 2-chloro-4- (trifluoromethoxy) bromobenzene?
2-Chloro-4- (trifluoromethoxy) bromobenzene is an important chemical in the field of organic synthesis and has critical uses in many aspects.
First, in the field of medicinal chemistry, it can be used as a key intermediate. Due to the unique electronic effect and fat solubility of trifluoromethoxy, it can significantly affect the activity, metabolic stability and bioavailability of drug molecules. Using this substance as a starting material, a series of organic reactions can build a drug molecular skeleton with diverse structures, and then develop new drugs for specific diseases. For example, in the synthesis of antidepressants and antibacterial drugs, intermediates containing such structures are often used to optimize the performance of drugs.
Second, in the field of materials science, it also has outstanding performance. Due to the presence of halogen atoms and trifluoromethoxy groups in its structure, it can endow materials with unique physical and chemical properties. For example, introducing it into the synthesis of polymer materials can improve the heat resistance, chemical corrosion resistance and electrical properties of materials. In the preparation of high-performance liquid crystal materials, optical materials and special polymer coatings, the structural units derived from 2-chloro-4 - (trifluoromethoxy) bromobenzene can effectively improve the phase transition temperature and optical anisotropy of materials, so as to meet the needs of different high-end application scenarios.
Third, in the field of pesticide chemistry, this substance also plays an important role. As an important building block for the synthesis of new pesticides, compounds with high insecticidal, bactericidal or herbicidal activities can be designed using their structural characteristics. The appropriate combination of trifluoromethoxy and halogen atoms helps to improve the binding ability of pesticide molecules to specific receptors in target organisms, enhance the selectivity and activity of pesticides, and reduce the impact on the environment, which is in line with the current trend of green pesticide development.
To sum up, 2-chloro-4 - (trifluoromethoxy) bromobenzene has shown indispensable value in many fields such as drugs, materials and pesticides due to its unique molecular structure, providing an important material basis for innovation and development in various fields.
First, in the field of medicinal chemistry, it can be used as a key intermediate. Due to the unique electronic effect and fat solubility of trifluoromethoxy, it can significantly affect the activity, metabolic stability and bioavailability of drug molecules. Using this substance as a starting material, a series of organic reactions can build a drug molecular skeleton with diverse structures, and then develop new drugs for specific diseases. For example, in the synthesis of antidepressants and antibacterial drugs, intermediates containing such structures are often used to optimize the performance of drugs.
Second, in the field of materials science, it also has outstanding performance. Due to the presence of halogen atoms and trifluoromethoxy groups in its structure, it can endow materials with unique physical and chemical properties. For example, introducing it into the synthesis of polymer materials can improve the heat resistance, chemical corrosion resistance and electrical properties of materials. In the preparation of high-performance liquid crystal materials, optical materials and special polymer coatings, the structural units derived from 2-chloro-4 - (trifluoromethoxy) bromobenzene can effectively improve the phase transition temperature and optical anisotropy of materials, so as to meet the needs of different high-end application scenarios.
Third, in the field of pesticide chemistry, this substance also plays an important role. As an important building block for the synthesis of new pesticides, compounds with high insecticidal, bactericidal or herbicidal activities can be designed using their structural characteristics. The appropriate combination of trifluoromethoxy and halogen atoms helps to improve the binding ability of pesticide molecules to specific receptors in target organisms, enhance the selectivity and activity of pesticides, and reduce the impact on the environment, which is in line with the current trend of green pesticide development.
To sum up, 2-chloro-4 - (trifluoromethoxy) bromobenzene has shown indispensable value in many fields such as drugs, materials and pesticides due to its unique molecular structure, providing an important material basis for innovation and development in various fields.
What are the physical properties of 2-chloro-4- (trifluoromethoxy) bromobenzene
2-Chloro-4- (trifluoromethoxy) bromobenzene is a kind of organic compound. Its physical properties are quite important, related to its application and characteristics.
Looking at its properties, under normal temperature and pressure, this substance is mostly colorless to pale yellow liquid. Its color is elegant and pure. This color characteristic can be an important characterization in actual observation and identification.
When it comes to boiling point, the boiling point of this compound is often in a specific range. However, the exact value will vary slightly due to subtle differences in experimental conditions. Generally speaking, the determination of boiling point needs to be done under specific conditions such as standard atmospheric pressure in order to obtain accurate data. The level of the boiling point is closely related to the intermolecular forces. In this molecule, the presence of groups such as chlorine, bromine and trifluoromethoxy makes the intermolecular forces present a specific state, which in turn affects the boiling point. The melting point of
is also one of the important physical properties. Its melting point value also reflects the characteristics of molecular structure and interaction. The determination of the melting point helps to understand the temperature limit of the substance from solid to liquid, and is of great significance in the separation, purification and storage of substances. The density of
is also a property that cannot be ignored. Its density indicates the mass of the substance per unit volume. This value is crucial for practical operations such as solution preparation and calculation of the proportion of reactants. At different temperatures, the density may vary, so it needs to be considered in practical applications.
In terms of solubility, 2-chloro-4- (trifluoromethoxy) bromobenzene exhibits specific solubility properties in organic solvents. Usually, it is soluble in common organic solvents, such as ethanol, ether, etc. This solubility is derived from the degree of matching between the polarity of the molecule and the polarity of the organic solvent molecule. Because its molecular structure contains both large electronegativity such as halogen atoms and special groups such as trifluoromethoxy, its solubility exhibits a unique state. This property has important application value in solvent selection for organic synthesis reactions.
Looking at its properties, under normal temperature and pressure, this substance is mostly colorless to pale yellow liquid. Its color is elegant and pure. This color characteristic can be an important characterization in actual observation and identification.
When it comes to boiling point, the boiling point of this compound is often in a specific range. However, the exact value will vary slightly due to subtle differences in experimental conditions. Generally speaking, the determination of boiling point needs to be done under specific conditions such as standard atmospheric pressure in order to obtain accurate data. The level of the boiling point is closely related to the intermolecular forces. In this molecule, the presence of groups such as chlorine, bromine and trifluoromethoxy makes the intermolecular forces present a specific state, which in turn affects the boiling point. The melting point of
is also one of the important physical properties. Its melting point value also reflects the characteristics of molecular structure and interaction. The determination of the melting point helps to understand the temperature limit of the substance from solid to liquid, and is of great significance in the separation, purification and storage of substances. The density of
is also a property that cannot be ignored. Its density indicates the mass of the substance per unit volume. This value is crucial for practical operations such as solution preparation and calculation of the proportion of reactants. At different temperatures, the density may vary, so it needs to be considered in practical applications.
In terms of solubility, 2-chloro-4- (trifluoromethoxy) bromobenzene exhibits specific solubility properties in organic solvents. Usually, it is soluble in common organic solvents, such as ethanol, ether, etc. This solubility is derived from the degree of matching between the polarity of the molecule and the polarity of the organic solvent molecule. Because its molecular structure contains both large electronegativity such as halogen atoms and special groups such as trifluoromethoxy, its solubility exhibits a unique state. This property has important application value in solvent selection for organic synthesis reactions.
What are the chemical properties of 2-chloro-4- (trifluoromethoxy) bromobenzene
2-Chloro-4- (trifluoromethoxy) bromobenzene, a genus of organohalides, is of great importance in the field of organic synthesis.
Its chemical properties are of great interest. From the perspective of the characteristics of halogen atoms, the activities of bromine and chlorine atoms in molecules are different. Bromine atoms, as a better leaving group, are more easily replaced by nucleophiles in nucleophilic substitution reactions. For example, in the case of nucleophiles containing hydroxyl groups, amino groups, etc., under appropriate conditions, bromine atoms can leave, and nucleophiles can combine with them to form new organic compounds. This reaction may require base catalysis to enhance the activity of nucleophiles, and a suitable solvent is also required to provide a suitable environment for the reaction. Although the activity of
chlorine atom is slightly less than that of bromine atom, it can also participate in specific reactions. Due to its large electronegativity, it will affect the density distribution of benzene ring electron cloud, reduce the density of benzene ring electron cloud, and cause the activity of benzene ring electrophilic substitution reaction to decrease. However, under specific conditions, chlorine atoms can also participate in nucleophilic substitution, but the required conditions are more severe than those of bromine atoms.
Trifluoromethoxy (-OCF) is a strong electron-absorbing group, which has a significant impact on the benzene ring electron cloud. The presence of this group will cause the benzene ring electron cloud to shift towards it, further reduce the density of the benzene ring electron cloud, and make it more difficult for the benzene At the same time, trifluoromethoxy affects the distribution of ortho and para-position electron clouds differently, which plays a role in the localization effect of the reaction. For example, during the electrophilic substitution reaction, the electrophilic reagents are more inclined to attack the meso-site, because the density of the meso-site electron cloud is slightly higher than that of the ortho and para-site.
In addition, 2-chloro-4 - (trifluoromethoxy) bromobenzene contains halogen atoms and electron-withdrawing groups, which have a certain polarity. The solubility in the solvent is different from that of non-polar compounds, and it is more soluble in polar organic solvents. This property is of great significance for the reaction operation and product separation.
Its chemical properties are of great interest. From the perspective of the characteristics of halogen atoms, the activities of bromine and chlorine atoms in molecules are different. Bromine atoms, as a better leaving group, are more easily replaced by nucleophiles in nucleophilic substitution reactions. For example, in the case of nucleophiles containing hydroxyl groups, amino groups, etc., under appropriate conditions, bromine atoms can leave, and nucleophiles can combine with them to form new organic compounds. This reaction may require base catalysis to enhance the activity of nucleophiles, and a suitable solvent is also required to provide a suitable environment for the reaction. Although the activity of
chlorine atom is slightly less than that of bromine atom, it can also participate in specific reactions. Due to its large electronegativity, it will affect the density distribution of benzene ring electron cloud, reduce the density of benzene ring electron cloud, and cause the activity of benzene ring electrophilic substitution reaction to decrease. However, under specific conditions, chlorine atoms can also participate in nucleophilic substitution, but the required conditions are more severe than those of bromine atoms.
Trifluoromethoxy (-OCF) is a strong electron-absorbing group, which has a significant impact on the benzene ring electron cloud. The presence of this group will cause the benzene ring electron cloud to shift towards it, further reduce the density of the benzene ring electron cloud, and make it more difficult for the benzene At the same time, trifluoromethoxy affects the distribution of ortho and para-position electron clouds differently, which plays a role in the localization effect of the reaction. For example, during the electrophilic substitution reaction, the electrophilic reagents are more inclined to attack the meso-site, because the density of the meso-site electron cloud is slightly higher than that of the ortho and para-site.
In addition, 2-chloro-4 - (trifluoromethoxy) bromobenzene contains halogen atoms and electron-withdrawing groups, which have a certain polarity. The solubility in the solvent is different from that of non-polar compounds, and it is more soluble in polar organic solvents. This property is of great significance for the reaction operation and product separation.
What are the synthesis methods of 2-chloro-4- (trifluoromethoxy) bromobenzene
To prepare 2-chloro-4- (trifluoromethoxy) bromobenzene, the following synthesis methods are often followed.
First, 2-chloro-4-hydroxybromobenzene is used as the starting material to make it nucleophilic substitution reaction with trifluoromethyl halide in the presence of alkali. Bases such as potassium carbonate, sodium carbonate, etc., can create a suitable reaction environment. Trifluoromethyl halide is preferably trifluoromethyl iodide or trifluoromethyl bromide. In organic solvents such as N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), heat to promote the reaction. In this way, the hydroxyl anion of 2-chloro-4-hydroxybromobenzene attacks the carbon atom of trifluoromethyl halide nucleophilic attack, and the halogen ion leaves to form 2-chloro-4- (trifluoromethoxy) bromobenzene.
Second, start with 2-chloro-4-nitrobromobenzene. First, the nitro group is reduced to an amino group with suitable reducing agents, such as iron and hydrochloric acid, hydrogen and palladium carbon, etc., to obtain 2-chloro-4-aminobrobenzene. Next, it is diazotized with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. After that, the trifluoromethoxy group can be introduced by replacing the diazo group with the trifluoromethoxy negative ion. The trifluoromethoxy negative ion can be prepared by the reaction of trifluoromethanol with a base. Although this process step is complicated, the reaction selectivity of each step is still acceptable, and it is also a feasible path for synthesis.
Or, take the palladium-catalyzed coupling reaction of aryl halides as an idea. First prepare the aryl boric acid or borate ester containing trifluoromethoxy group, and carry out the Suzuki coupling reaction with 2-chloro-4-bromoiodobenzene and palladium catalysts, such as tetra (triphenylphosphine) palladium (0), and bases. Aqueous solutions such as potassium carbonate and potassium phosphate are selected as alkali, and mixed solvents such as toluene and dioxane with water are selected as organic solvents. In this reaction system, palladium catalyst activates aryl halide and aryl boric acid or borate to promote the formation of carbon-carbon bonds and achieve the synthesis of 2-chloro-4- (trifluoromethoxy) bromobenzene.
All synthesis methods have their own advantages and disadvantages. In practical application, when considering the availability of raw materials, cost, difficulty of reaction conditions and many other factors, the choice should be weighed.
First, 2-chloro-4-hydroxybromobenzene is used as the starting material to make it nucleophilic substitution reaction with trifluoromethyl halide in the presence of alkali. Bases such as potassium carbonate, sodium carbonate, etc., can create a suitable reaction environment. Trifluoromethyl halide is preferably trifluoromethyl iodide or trifluoromethyl bromide. In organic solvents such as N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), heat to promote the reaction. In this way, the hydroxyl anion of 2-chloro-4-hydroxybromobenzene attacks the carbon atom of trifluoromethyl halide nucleophilic attack, and the halogen ion leaves to form 2-chloro-4- (trifluoromethoxy) bromobenzene.
Second, start with 2-chloro-4-nitrobromobenzene. First, the nitro group is reduced to an amino group with suitable reducing agents, such as iron and hydrochloric acid, hydrogen and palladium carbon, etc., to obtain 2-chloro-4-aminobrobenzene. Next, it is diazotized with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. After that, the trifluoromethoxy group can be introduced by replacing the diazo group with the trifluoromethoxy negative ion. The trifluoromethoxy negative ion can be prepared by the reaction of trifluoromethanol with a base. Although this process step is complicated, the reaction selectivity of each step is still acceptable, and it is also a feasible path for synthesis.
Or, take the palladium-catalyzed coupling reaction of aryl halides as an idea. First prepare the aryl boric acid or borate ester containing trifluoromethoxy group, and carry out the Suzuki coupling reaction with 2-chloro-4-bromoiodobenzene and palladium catalysts, such as tetra (triphenylphosphine) palladium (0), and bases. Aqueous solutions such as potassium carbonate and potassium phosphate are selected as alkali, and mixed solvents such as toluene and dioxane with water are selected as organic solvents. In this reaction system, palladium catalyst activates aryl halide and aryl boric acid or borate to promote the formation of carbon-carbon bonds and achieve the synthesis of 2-chloro-4- (trifluoromethoxy) bromobenzene.
All synthesis methods have their own advantages and disadvantages. In practical application, when considering the availability of raw materials, cost, difficulty of reaction conditions and many other factors, the choice should be weighed.
What are the precautions for 2-chloro-4- (trifluoromethoxy) bromobenzene during storage and transportation?
2-Chloro-4- (trifluoromethoxy) bromobenzene is also an organic compound. When storing and transporting, many things must be paid attention to.
The first thing to pay attention to is its properties, this compound may have specific chemical activities and hazards. When storing, find a cool, dry and well-ventilated place. Keep away from high temperatures, fire sources and oxidants to prevent the risk of fire or explosion. Because of its flammability, it is easy to cause accidents in case of hot topics or open flames.
Furthermore, pay attention to its packaging. The packaging must be tight to prevent leakage. If the packaging is damaged, the compound can escape, or cause environmental pollution, and pose a hazard to those who come into contact. Storage containers are also made of suitable materials to prevent chemical reactions with compounds.
When transporting, relevant regulations and standards are also followed. Transportation vehicles must be equipped with necessary emergency equipment and protective gear to prevent emergencies during transportation. And transportation personnel should be familiar with the characteristics of this compound and emergency response methods. In case of leakage, etc., they can deal with it in a timely manner.
At the same time, in view of its possible harm to the human body, personnel must take protective measures during storage and transportation. Wear appropriate protective gloves, goggles and gas masks to avoid skin contact, eye contamination and inhalation of its volatile gases.
These precautions are to ensure the safety of 2-chloro-4- (trifluoromethoxy) bromobenzene during storage and transportation, and must not be negligent to avoid disasters.
The first thing to pay attention to is its properties, this compound may have specific chemical activities and hazards. When storing, find a cool, dry and well-ventilated place. Keep away from high temperatures, fire sources and oxidants to prevent the risk of fire or explosion. Because of its flammability, it is easy to cause accidents in case of hot topics or open flames.
Furthermore, pay attention to its packaging. The packaging must be tight to prevent leakage. If the packaging is damaged, the compound can escape, or cause environmental pollution, and pose a hazard to those who come into contact. Storage containers are also made of suitable materials to prevent chemical reactions with compounds.
When transporting, relevant regulations and standards are also followed. Transportation vehicles must be equipped with necessary emergency equipment and protective gear to prevent emergencies during transportation. And transportation personnel should be familiar with the characteristics of this compound and emergency response methods. In case of leakage, etc., they can deal with it in a timely manner.
At the same time, in view of its possible harm to the human body, personnel must take protective measures during storage and transportation. Wear appropriate protective gloves, goggles and gas masks to avoid skin contact, eye contamination and inhalation of its volatile gases.
These precautions are to ensure the safety of 2-chloro-4- (trifluoromethoxy) bromobenzene during storage and transportation, and must not be negligent to avoid disasters.
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