Linshang Chemical
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2-Chloro-4-(Trifluoromethoxy)Iodobenzene
Linshang Chemical
|
HS Code |
704604 |
| Chemical Formula | C7H3ClF3IO |
| Molecular Weight | 320.45 |
| Appearance | liquid (usually) |
| Stability | should be stored away from heat, light, and oxidizing agents |
As an accredited 2-Chloro-4-(Trifluoromethoxy)Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 4 - (trifluoromethoxy)iodobenzene in a sealed glass bottle. |
| Storage | Store 2 - chloro - 4 - (trifluoromethoxy)iodobenzene in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent exposure to air and moisture. Since it's a chemical, store it separately from incompatible substances, such as oxidizing agents, in a dedicated chemical storage cabinet for safety. |
| Shipping | 2 - chloro - 4 - (trifluoromethoxy)iodobenzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling, handling, and transportation to prevent any spills or risks. |
Competitive 2-Chloro-4-(Trifluoromethoxy)Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the physical properties of 2-chloro-4- (trifluoromethoxy) iodobenzene?
2-Chloro-4- (trifluoromethoxy) iodobenzene is one of the organic compounds. Its physical properties are quite unique.
Looking at its appearance, under normal temperature and pressure, it often appears colorless to light yellow liquid, which makes it have specific performance and use in many substances. It has a certain volatility, but its volatility is not very high. In general environments, it can be slowly emitted in a specific space.
There is no extremely accurate ancient book on the melting point, but it is deduced from the theory of similar structural compounds, or it is in a relatively low temperature range, making it difficult to be solid at room temperature. In terms of boiling point, according to the characteristics of similar compounds, or boiling at a certain temperature range, between about [X] ° C and [X] ° C. This temperature range also determines the conditions required for separation operations such as distillation.
The density of this compound is higher than that of water, so if it is mixed with water, it will sink underwater. This property needs to be carefully considered during separation and related reaction operations. Its solubility is also a key physical property. It may have good solubility in organic solvents such as ethanol and ether, but it has little solubility in water. This is because its molecular structure contains fluorine, chlorine and other halogen atoms and iodine atoms, resulting in its certain hydrophobicity.
Furthermore, the odor of 2-chloro-4- (trifluoromethoxy) iodobenzene, although there is no exact ancient book in detail, may have a special irritating odor depending on its structure and the common conditions of similar compounds. This odor may have a certain irritating effect on the human respiratory tract and other parts, and needs to be protected during operation and use.
In summary, the physical properties of 2-chloro-4- (trifluoromethoxy) iodobenzene are of great significance in many aspects such as preparation, separation, storage and application, which need to be deeply explored and grasped.
Looking at its appearance, under normal temperature and pressure, it often appears colorless to light yellow liquid, which makes it have specific performance and use in many substances. It has a certain volatility, but its volatility is not very high. In general environments, it can be slowly emitted in a specific space.
There is no extremely accurate ancient book on the melting point, but it is deduced from the theory of similar structural compounds, or it is in a relatively low temperature range, making it difficult to be solid at room temperature. In terms of boiling point, according to the characteristics of similar compounds, or boiling at a certain temperature range, between about [X] ° C and [X] ° C. This temperature range also determines the conditions required for separation operations such as distillation.
The density of this compound is higher than that of water, so if it is mixed with water, it will sink underwater. This property needs to be carefully considered during separation and related reaction operations. Its solubility is also a key physical property. It may have good solubility in organic solvents such as ethanol and ether, but it has little solubility in water. This is because its molecular structure contains fluorine, chlorine and other halogen atoms and iodine atoms, resulting in its certain hydrophobicity.
Furthermore, the odor of 2-chloro-4- (trifluoromethoxy) iodobenzene, although there is no exact ancient book in detail, may have a special irritating odor depending on its structure and the common conditions of similar compounds. This odor may have a certain irritating effect on the human respiratory tract and other parts, and needs to be protected during operation and use.
In summary, the physical properties of 2-chloro-4- (trifluoromethoxy) iodobenzene are of great significance in many aspects such as preparation, separation, storage and application, which need to be deeply explored and grasped.
What are the chemical properties of 2-chloro-4- (trifluoromethoxy) iodobenzene
2-Chloro-4- (trifluoromethoxy) iodobenzene, which is an organic halide containing chlorine, iodine and trifluoromethoxy, has unique chemical properties and is of great significance for organic synthesis.
Let's talk about the activity of halogen atoms first. Although its chlorine atom is in an aromatic ring, due to the electron-absorbing effect of ortho-iodine and para-trifluoromethoxy, the electron cloud density decreases, and its activity is slightly higher than that of ordinary aromatic chlorine, which can participate in nucleophilic substitution reactions. Under suitable conditions, it can react with nucleophilic reagents such as alkoxides and amines, and the chlorine atom is replaced by corresponding groups, thereby synthesizing new aromatic hydrocarbon derivatives containing different substituents and expanding the structural diversity of compounds.
The activity of i Aryl iodine performs well in metal-catalyzed coupling reactions, such as palladium-catalyzed Suzuki coupling and Stille coupling reactions. In these reactions, iodobenzene derivatives react with organoboron reagents and organotin reagents under palladium catalysts and bases to form carbon-carbon bonds, synthesizing polyaryl compounds with conjugated structures, which are widely used in materials science, such as the preparation of organic optoelectronic materials.
Trifluoromethoxy is a strong electron-absorbing group, which greatly affects the distribution of benzene ring electron cloud, reduces the density of benzene ring electron cloud, enhances the electrophilic substitution reaction activity of compounds, and affects the reaction regioselectivity. Due to their strong electron absorption, electrophilic reagents tend to attack the meta-sites with relatively high electron cloud density in the benzene ring, which provides a direction for the synthesis of aromatic hydrocarbons with specific substitution modes.
In addition, there are interactions between different functional groups in 2-chloro-4- (trifluoromethoxy) iodobenzene molecules. The electron-absorbing effect of trifluoromethoxy enhances the atomic activity of chlorine and iodine; conversely, chlorine and iodine atoms also have subtle effects on the surrounding electronic environment of trifluoromethoxy, affecting the overall chemical activity and reaction selectivity of the molecule. These properties make it a valuable synthetic building block in the field of organic synthesis, especially in the construction of complex aromatic derivatives.
Let's talk about the activity of halogen atoms first. Although its chlorine atom is in an aromatic ring, due to the electron-absorbing effect of ortho-iodine and para-trifluoromethoxy, the electron cloud density decreases, and its activity is slightly higher than that of ordinary aromatic chlorine, which can participate in nucleophilic substitution reactions. Under suitable conditions, it can react with nucleophilic reagents such as alkoxides and amines, and the chlorine atom is replaced by corresponding groups, thereby synthesizing new aromatic hydrocarbon derivatives containing different substituents and expanding the structural diversity of compounds.
The activity of i Aryl iodine performs well in metal-catalyzed coupling reactions, such as palladium-catalyzed Suzuki coupling and Stille coupling reactions. In these reactions, iodobenzene derivatives react with organoboron reagents and organotin reagents under palladium catalysts and bases to form carbon-carbon bonds, synthesizing polyaryl compounds with conjugated structures, which are widely used in materials science, such as the preparation of organic optoelectronic materials.
Trifluoromethoxy is a strong electron-absorbing group, which greatly affects the distribution of benzene ring electron cloud, reduces the density of benzene ring electron cloud, enhances the electrophilic substitution reaction activity of compounds, and affects the reaction regioselectivity. Due to their strong electron absorption, electrophilic reagents tend to attack the meta-sites with relatively high electron cloud density in the benzene ring, which provides a direction for the synthesis of aromatic hydrocarbons with specific substitution modes.
In addition, there are interactions between different functional groups in 2-chloro-4- (trifluoromethoxy) iodobenzene molecules. The electron-absorbing effect of trifluoromethoxy enhances the atomic activity of chlorine and iodine; conversely, chlorine and iodine atoms also have subtle effects on the surrounding electronic environment of trifluoromethoxy, affecting the overall chemical activity and reaction selectivity of the molecule. These properties make it a valuable synthetic building block in the field of organic synthesis, especially in the construction of complex aromatic derivatives.
What is the synthesis method of 2-chloro-4- (trifluoromethoxy) iodobenzene?
To prepare 2-chloro-4- (trifluoromethoxy) iodobenzene, the following ancient method can be followed.
First take an appropriate starting material and use a chlorine-containing aromatic hydrocarbon derivative as the base. This aromatic hydrocarbon derivative needs to reserve a substituted group at a specific position in order to subsequently introduce the desired functional group. In this case, suitable chlorobenzene derivatives can be selected, which should contain a leavable group in the ortho or para-position of the chlorine atom, such as a halogen atom or a sulfonate group, so that the subsequent reaction can proceed smoothly.
Then introduce a trifluoromethoxy group. It is often reacted with trifluoromethoxylation reagents, such as potassium trifluoromethoxy. Under suitable reaction conditions, such as in a polar aprotic solvent, at a certain temperature and in the presence of a base, trifluoromethoxy negative ions can attack the leavable groups on aromatic derivatives. After nucleophilic substitution, trifluoromethoxy is successfully introduced to obtain a chlorobenzene intermediate containing trifluoromethoxy.
The last step is to introduce an iodine atom. An iodine substitution reagent, such as potassium iodide, can be used in combination with an appropriate oxidizing agent, such as hydrogen peroxide or nitric acid. Under mild reaction conditions, the iodizing reagent is reacted with the above intermediates. Under the action of oxidants, iodine ions are oxidized into active iodine species, which then replace hydrogen atoms at specific positions on aromatics. After a series of reaction processes, 2-chloro-4- (trifluoromethoxy) iodobenzene is finally formed.
During the reaction process, the reaction conditions need to be carefully controlled, including temperature, reaction time, reagent dosage, etc. The intermediates in each step of the reaction need to be properly separated and purified. Traditional separation methods such as column chromatography and recrystallization can be used to ensure the purity and yield of the final product. In this way, the target product 2-chloro-4- (trifluoromethoxy) iodobenzene can be obtained.
First take an appropriate starting material and use a chlorine-containing aromatic hydrocarbon derivative as the base. This aromatic hydrocarbon derivative needs to reserve a substituted group at a specific position in order to subsequently introduce the desired functional group. In this case, suitable chlorobenzene derivatives can be selected, which should contain a leavable group in the ortho or para-position of the chlorine atom, such as a halogen atom or a sulfonate group, so that the subsequent reaction can proceed smoothly.
Then introduce a trifluoromethoxy group. It is often reacted with trifluoromethoxylation reagents, such as potassium trifluoromethoxy. Under suitable reaction conditions, such as in a polar aprotic solvent, at a certain temperature and in the presence of a base, trifluoromethoxy negative ions can attack the leavable groups on aromatic derivatives. After nucleophilic substitution, trifluoromethoxy is successfully introduced to obtain a chlorobenzene intermediate containing trifluoromethoxy.
The last step is to introduce an iodine atom. An iodine substitution reagent, such as potassium iodide, can be used in combination with an appropriate oxidizing agent, such as hydrogen peroxide or nitric acid. Under mild reaction conditions, the iodizing reagent is reacted with the above intermediates. Under the action of oxidants, iodine ions are oxidized into active iodine species, which then replace hydrogen atoms at specific positions on aromatics. After a series of reaction processes, 2-chloro-4- (trifluoromethoxy) iodobenzene is finally formed.
During the reaction process, the reaction conditions need to be carefully controlled, including temperature, reaction time, reagent dosage, etc. The intermediates in each step of the reaction need to be properly separated and purified. Traditional separation methods such as column chromatography and recrystallization can be used to ensure the purity and yield of the final product. In this way, the target product 2-chloro-4- (trifluoromethoxy) iodobenzene can be obtained.
What is the main use of 2-chloro-4- (trifluoromethoxy) iodobenzene?
2-Chloro-4- (trifluoromethoxy) iodobenzene is also an important intermediate in organic synthesis. It has a wide range of uses in the field of organic synthesis.
First and arylation reaction, this compound can be coupled with many nucleophiles to form carbon-carbon or carbon-hetero atomic bonds. For example, with carbon-containing nucleophiles, it can be coupled with palladium-catalyzed coupling reactions to construct aromatic compounds with specific structures. This is crucial in the creation of drug molecules with novel structures and biological activities in medicinal chemistry. In many drug development processes, through such coupling reactions, the required functional groups can be precisely introduced to optimize the activity, selectivity and pharmacokinetic properties of drug molecules.
Furthermore, in the field of materials science, it can be used to prepare materials with special optoelectronic properties. Through subsequent reactions, a specific conjugate structure is introduced, which can modulate the electronic transport and fluorescence emission properties of the material. In the fields of organic Light Emitting Diode (OLED), organic solar cells and other fields, the development of such materials with specific structures is of great significance, which can improve the performance and efficiency of devices.
In addition, in the field of pesticide chemistry, 2-chloro-4- (trifluoromethoxy) iodobenzene is also used. Pesticide molecules synthesized from it as a starting material through a series of reactions may have unique insecticidal and bactericidal activities. By modifying its structure, the mechanism of action, shelf life and environmental friendliness of pesticides can be regulated to meet the needs of modern agriculture for high-efficiency, low-toxicity and environmentally friendly pesticides.
In conclusion, 2-chloro-4- (trifluoromethoxy) iodobenzene has an active halogen atom and a unique trifluoromethoxy functional group. It is a key starting material and intermediate in many fields such as organic synthesis, medicinal chemistry, materials science and pesticide chemistry. It plays a significant role in promoting the development of various fields.
First and arylation reaction, this compound can be coupled with many nucleophiles to form carbon-carbon or carbon-hetero atomic bonds. For example, with carbon-containing nucleophiles, it can be coupled with palladium-catalyzed coupling reactions to construct aromatic compounds with specific structures. This is crucial in the creation of drug molecules with novel structures and biological activities in medicinal chemistry. In many drug development processes, through such coupling reactions, the required functional groups can be precisely introduced to optimize the activity, selectivity and pharmacokinetic properties of drug molecules.
Furthermore, in the field of materials science, it can be used to prepare materials with special optoelectronic properties. Through subsequent reactions, a specific conjugate structure is introduced, which can modulate the electronic transport and fluorescence emission properties of the material. In the fields of organic Light Emitting Diode (OLED), organic solar cells and other fields, the development of such materials with specific structures is of great significance, which can improve the performance and efficiency of devices.
In addition, in the field of pesticide chemistry, 2-chloro-4- (trifluoromethoxy) iodobenzene is also used. Pesticide molecules synthesized from it as a starting material through a series of reactions may have unique insecticidal and bactericidal activities. By modifying its structure, the mechanism of action, shelf life and environmental friendliness of pesticides can be regulated to meet the needs of modern agriculture for high-efficiency, low-toxicity and environmentally friendly pesticides.
In conclusion, 2-chloro-4- (trifluoromethoxy) iodobenzene has an active halogen atom and a unique trifluoromethoxy functional group. It is a key starting material and intermediate in many fields such as organic synthesis, medicinal chemistry, materials science and pesticide chemistry. It plays a significant role in promoting the development of various fields.
What are the precautions for 2-chloro-4- (trifluoromethoxy) iodobenzene in storage and transportation?
2-Chloro-4- (trifluoromethoxy) iodobenzene is an organic compound, and many things should be paid attention to during storage and transportation.
First of all, storage, this compound should be placed in a cool, dry and well-ventilated place. Because it is quite sensitive to heat, if it is heated or decomposes, it is necessary to keep away from heat and fire sources. And because it has certain chemical activity, it must be separated from oxidizing agents, reducing agents and other incompatible substances to prevent chemical reactions. The storage place should keep the temperature stable and the humidity should not be too high, because moisture may affect its chemical stability. At the same time, the storage container must be well sealed to prevent leakage and contact with air and moisture.
As for transportation, the first thing to ensure is that the packaging is strong and sealed. Commonly used packaging materials should be able to withstand certain external shocks and temperature changes, so as not to leak the compound. During transportation, it should not be mixed with other substances that may react. The means of transportation should also maintain a suitable temperature and humidity environment, avoid direct sunlight and violent vibration. And the transporter needs to be familiar with the characteristics of the compound and emergency treatment methods, and can respond quickly and correctly in the event of leakage and other accidents.
In this way, when storing and transporting 2-chloro-4 - (trifluoromethoxy) iodobenzene, pay careful attention to the above things to ensure its safety and avoid harm.
First of all, storage, this compound should be placed in a cool, dry and well-ventilated place. Because it is quite sensitive to heat, if it is heated or decomposes, it is necessary to keep away from heat and fire sources. And because it has certain chemical activity, it must be separated from oxidizing agents, reducing agents and other incompatible substances to prevent chemical reactions. The storage place should keep the temperature stable and the humidity should not be too high, because moisture may affect its chemical stability. At the same time, the storage container must be well sealed to prevent leakage and contact with air and moisture.
As for transportation, the first thing to ensure is that the packaging is strong and sealed. Commonly used packaging materials should be able to withstand certain external shocks and temperature changes, so as not to leak the compound. During transportation, it should not be mixed with other substances that may react. The means of transportation should also maintain a suitable temperature and humidity environment, avoid direct sunlight and violent vibration. And the transporter needs to be familiar with the characteristics of the compound and emergency treatment methods, and can respond quickly and correctly in the event of leakage and other accidents.
In this way, when storing and transporting 2-chloro-4 - (trifluoromethoxy) iodobenzene, pay careful attention to the above things to ensure its safety and avoid harm.
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