Linshang Chemical
PRODUCTS
2-Chloro-4-(Trifluoromethyl)Benzeneboronic Acid
Linshang Chemical
|
HS Code |
537711 |
| Chemical Formula | C7H5BClF3O2 |
| Appearance | Solid (Typical) |
| Purity | Typically High Purity (e.g., 95%+) |
| Melting Point | Data Dependent on Purity |
| Solubility In Water | Low |
| Solubility In Organic Solvents | Soluble in Some Organic Solvents like THF, Dichloromethane |
| Stability | Stable under Normal Conditions, but Sensitive to Strong Bases and Oxidizing Agents |
As an accredited 2-Chloro-4-(Trifluoromethyl)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 4 - (trifluoromethyl)benzeneboronic acid in a sealed plastic bottle. |
| Storage | 2 - Chloro - 4 - (trifluoromethyl)benzeneboronic acid should be stored in a cool, dry place away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent moisture absorption, as boronic acids can react with water. Store separately from incompatible substances, like strong oxidizing agents and bases, to avoid potential chemical reactions. |
| Shipping | 2 - chloro - 4 - (trifluoromethyl)benzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. Packaging ensures protection from moisture and physical damage during transit to maintain its chemical integrity. |
Competitive 2-Chloro-4-(Trifluoromethyl)Benzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Chloro-4-(Trifluoromethyl)Benzeneboronic Acid in China?
As a trusted 2-Chloro-4-(Trifluoromethyl)Benzeneboronic Acid manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-4-(Trifluoromethyl)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main application fields of 2-chloro-4- (trifluoromethyl) benzeneboronic Acid
2-Chloro-4- (trifluoromethyl) phenylboronic acid, an important reagent in organic synthesis, is widely used in many fields.
In the field of medicinal chemistry, its application is quite critical. Through the Suzuki-Miyaura coupling reaction, etc., complex drug molecular skeletons can be constructed. It can often be found in the synthesis of many anti-cancer and antiviral drugs. Because it can be efficiently coupled with halogenated aromatics, it provides an effective means for introducing specific functional groups and constructing pharmacophore, enabling chemists to design and synthesize new drugs with specific biological activities.
The field of materials science is also an important application. In the preparation of organic optoelectronic materials, 2-chloro-4- (trifluoromethyl) phenylboronic acid can participate in the construction of conjugated polymers. By coupling and polymerizing with other monomers, the materials are endowed with unique optical and electrical properties, such as high fluorescence efficiency and good charge transfer ability, which are expected to be applied to organic Light Emitting Diode (OLED), organic solar cells and other optoelectronic devices.
Furthermore, its role in the synthesis of fine chemical products should not be underestimated. It can be used to synthesize fine chemicals such as dyes and fragrances with special structures. With the help of its participation in the coupling reaction, the molecular structure can be precisely regulated to achieve optimization and customization of product color, aroma and other properties, and improve the quality and added value of fine chemical products.
In summary, 2-chloro-4- (trifluoromethyl) phenylboronic acid has shown important application value in many fields such as medicine, materials and fine chemicals due to its unique chemical properties, providing a powerful chemical tool for the development of various fields.
In the field of medicinal chemistry, its application is quite critical. Through the Suzuki-Miyaura coupling reaction, etc., complex drug molecular skeletons can be constructed. It can often be found in the synthesis of many anti-cancer and antiviral drugs. Because it can be efficiently coupled with halogenated aromatics, it provides an effective means for introducing specific functional groups and constructing pharmacophore, enabling chemists to design and synthesize new drugs with specific biological activities.
The field of materials science is also an important application. In the preparation of organic optoelectronic materials, 2-chloro-4- (trifluoromethyl) phenylboronic acid can participate in the construction of conjugated polymers. By coupling and polymerizing with other monomers, the materials are endowed with unique optical and electrical properties, such as high fluorescence efficiency and good charge transfer ability, which are expected to be applied to organic Light Emitting Diode (OLED), organic solar cells and other optoelectronic devices.
Furthermore, its role in the synthesis of fine chemical products should not be underestimated. It can be used to synthesize fine chemicals such as dyes and fragrances with special structures. With the help of its participation in the coupling reaction, the molecular structure can be precisely regulated to achieve optimization and customization of product color, aroma and other properties, and improve the quality and added value of fine chemical products.
In summary, 2-chloro-4- (trifluoromethyl) phenylboronic acid has shown important application value in many fields such as medicine, materials and fine chemicals due to its unique chemical properties, providing a powerful chemical tool for the development of various fields.
What are the synthesis methods of 2-chloro-4- (trifluoromethyl) benzeneboronic Acid
The common methods for synthesizing 2-chloro-4- (trifluoromethyl) phenylboronic acid are as follows.
One is the method of related derivation of Suzuki-Miyaura reaction. The halogenated aromatics containing the corresponding substituents are used as raw materials to react with borate esters in palladium catalysts, bases and suitable solvent systems. For example, 2-chloro-4- (trifluoromethyl) bromobenzene and pinacol borane are used as starting materials. In toluene and other organic solvents, palladium acetate, tri-tert-butylphosphine and bases such as potassium carbonate are added, and the reaction is heated and stirred. In this process, the halogen atom of the halogenated aromatic hydrocarbon is coupled with the borate ester, and the target product 2-chloro-4- (trifluoromethyl) phenylboronic acid can be obtained after hydrolysis. The reaction conditions are mild and the selectivity is good. However, the cost of the palladium catalyst is higher, and the requirements for the reaction equipment and operation are also stricter.
Second, it can be prepared by the Grignard reagent method. First, the Grignard reagent is prepared by reacting 2-chloro-4- (trifluoromethyl) chlorobenzene with magnesium chips in anhydrous ether or tetrahydrofuran solvent. After the reaction, it is reacted with borate esters such as trimethyl borate. After the reaction is completed, the target product can be obtained by The raw materials of this method are relatively easy to obtain and the cost is controllable. Rangers reagent is extremely sensitive to water and oxygen, and the reaction requires strict anhydrous and anaerobic operation, which requires harsh requirements on the reaction environment.
Third, it is synthesized by the metal lithium reagent method. Lithium reagents such as 2-chloro-4- (trifluoromethyl) chlorobenzene and butyl lithium react in an anhydrous solvent at low temperature to form a lithiated intermediate, which is then reacted with borate ester, and then hydrolyzed to obtain the product. This method has high reactivity and can be carried out under milder conditions. However, the price of lithium reagents is higher, and the reaction requires strict control of temperature and other conditions, which is difficult to operate.
One is the method of related derivation of Suzuki-Miyaura reaction. The halogenated aromatics containing the corresponding substituents are used as raw materials to react with borate esters in palladium catalysts, bases and suitable solvent systems. For example, 2-chloro-4- (trifluoromethyl) bromobenzene and pinacol borane are used as starting materials. In toluene and other organic solvents, palladium acetate, tri-tert-butylphosphine and bases such as potassium carbonate are added, and the reaction is heated and stirred. In this process, the halogen atom of the halogenated aromatic hydrocarbon is coupled with the borate ester, and the target product 2-chloro-4- (trifluoromethyl) phenylboronic acid can be obtained after hydrolysis. The reaction conditions are mild and the selectivity is good. However, the cost of the palladium catalyst is higher, and the requirements for the reaction equipment and operation are also stricter.
Second, it can be prepared by the Grignard reagent method. First, the Grignard reagent is prepared by reacting 2-chloro-4- (trifluoromethyl) chlorobenzene with magnesium chips in anhydrous ether or tetrahydrofuran solvent. After the reaction, it is reacted with borate esters such as trimethyl borate. After the reaction is completed, the target product can be obtained by The raw materials of this method are relatively easy to obtain and the cost is controllable. Rangers reagent is extremely sensitive to water and oxygen, and the reaction requires strict anhydrous and anaerobic operation, which requires harsh requirements on the reaction environment.
Third, it is synthesized by the metal lithium reagent method. Lithium reagents such as 2-chloro-4- (trifluoromethyl) chlorobenzene and butyl lithium react in an anhydrous solvent at low temperature to form a lithiated intermediate, which is then reacted with borate ester, and then hydrolyzed to obtain the product. This method has high reactivity and can be carried out under milder conditions. However, the price of lithium reagents is higher, and the reaction requires strict control of temperature and other conditions, which is difficult to operate.
What are the physical properties of 2-chloro-4- (trifluoromethyl) benzeneboronic Acid
2-Chloro-4- (trifluoromethyl) phenylboronic acid is an important reagent in organic synthesis. Its physical properties are unique and are described as follows:
Looking at its properties, under room temperature, this substance is often white to white solid powder with fine texture. This form is easy to weigh and use, and provides convenience in various chemical reaction operations.
When it comes to the melting point, it is about a certain temperature range. This property is of great significance for its identification and purity judgment. By measuring the melting point, the purity of the substance can be preliminarily known. If the melting point is consistent with the theoretical value and the melting range is narrow, it indicates that the purity is quite high; conversely, if the melting point deviates or the melting range is wide, it may imply the presence of impurities.
Solubility is also one of the key physical properties. In common organic solvents, such as dichloromethane, tetrahydrofuran, etc., it exhibits a certain solubility. This property makes it possible to choose a suitable solvent according to the reaction requirements, so that the substance can be fully dissolved, thus promoting the smooth progress of the reaction. In dichloromethane, it can be uniformly dispersed, providing a good homogeneous environment for the reaction; in tetrahydrofuran, it can also effectively contact and collide with other reactants, promoting the occurrence of chemical reactions.
In addition to its stability, under normal storage conditions, this substance has certain stability. However, care should be taken to avoid contact with strong oxidizing agents, strong bases and other substances. Because its structure contains active parts such as boron-oxygen bonds and chlorine atoms, when it encounters strong oxidants, it may initiate oxidation reactions and cause structural changes; when it encounters strong bases, the boron-oxygen bonds may be destroyed, which in turn affects its chemical properties and reactivity. Therefore, when storing, it should be placed in a dry, cool and well-ventilated place, away from the above dangerous substances.
Looking at its properties, under room temperature, this substance is often white to white solid powder with fine texture. This form is easy to weigh and use, and provides convenience in various chemical reaction operations.
When it comes to the melting point, it is about a certain temperature range. This property is of great significance for its identification and purity judgment. By measuring the melting point, the purity of the substance can be preliminarily known. If the melting point is consistent with the theoretical value and the melting range is narrow, it indicates that the purity is quite high; conversely, if the melting point deviates or the melting range is wide, it may imply the presence of impurities.
Solubility is also one of the key physical properties. In common organic solvents, such as dichloromethane, tetrahydrofuran, etc., it exhibits a certain solubility. This property makes it possible to choose a suitable solvent according to the reaction requirements, so that the substance can be fully dissolved, thus promoting the smooth progress of the reaction. In dichloromethane, it can be uniformly dispersed, providing a good homogeneous environment for the reaction; in tetrahydrofuran, it can also effectively contact and collide with other reactants, promoting the occurrence of chemical reactions.
In addition to its stability, under normal storage conditions, this substance has certain stability. However, care should be taken to avoid contact with strong oxidizing agents, strong bases and other substances. Because its structure contains active parts such as boron-oxygen bonds and chlorine atoms, when it encounters strong oxidants, it may initiate oxidation reactions and cause structural changes; when it encounters strong bases, the boron-oxygen bonds may be destroyed, which in turn affects its chemical properties and reactivity. Therefore, when storing, it should be placed in a dry, cool and well-ventilated place, away from the above dangerous substances.
Precautions for storing 2-chloro-4- (trifluoromethyl) benzeneboronic Acid
2-Chloro-4- (trifluoromethyl) phenylboronic acid, this is a key reagent in organic synthesis. During storage, there are many precautions that need to be taken with caution.
Bear the brunt and pay attention to the environmental conditions of storage. This reagent must be stored in a dry place because it is highly hygroscopic. If the ambient humidity is high, it may cause the reagent to get damp, which in turn affects its purity and reactivity. As the ancients said: "If water is wet, it is perishable." A humid environment is just like a "corrosive agent" for a reagent. Therefore, a dry storage space should be selected, or a desiccant should be added to the storage container.
Furthermore, temperature is also a key factor. It should be stored in a low temperature environment, usually 2-8 ° C. Excessive temperature can easily cause the reagent to decompose and deteriorate. Just like under high temperature, many things are prone to lose their original state. It is necessary to avoid reagents from being heated and away from heat sources, such as heating and heating equipment.
At the same time, the choice of storage containers should not be ignored. When choosing a container with good sealing performance, it is necessary to prevent the reagent from coming into too much contact with the air. Oxygen, carbon dioxide and other components in the air may react with the reagent. Just like a closed box, it can protect the treasure from external intrusion. Therefore, the container should be sealed quickly after use to prevent air from entering.
In addition, care should be taken to avoid mixing with other chemicals. This reagent may react chemically with certain substances, causing danger. It needs to be stored separately from incompatible chemicals to ensure the safety of storage.
When storing 2-chloro-4 - (trifluoromethyl) phenylboronic acid, careful attention should be paid to environmental humidity, temperature, storage container and chemical mixing, so as to ensure its quality and performance, and play its due role in organic synthesis reactions.
Bear the brunt and pay attention to the environmental conditions of storage. This reagent must be stored in a dry place because it is highly hygroscopic. If the ambient humidity is high, it may cause the reagent to get damp, which in turn affects its purity and reactivity. As the ancients said: "If water is wet, it is perishable." A humid environment is just like a "corrosive agent" for a reagent. Therefore, a dry storage space should be selected, or a desiccant should be added to the storage container.
Furthermore, temperature is also a key factor. It should be stored in a low temperature environment, usually 2-8 ° C. Excessive temperature can easily cause the reagent to decompose and deteriorate. Just like under high temperature, many things are prone to lose their original state. It is necessary to avoid reagents from being heated and away from heat sources, such as heating and heating equipment.
At the same time, the choice of storage containers should not be ignored. When choosing a container with good sealing performance, it is necessary to prevent the reagent from coming into too much contact with the air. Oxygen, carbon dioxide and other components in the air may react with the reagent. Just like a closed box, it can protect the treasure from external intrusion. Therefore, the container should be sealed quickly after use to prevent air from entering.
In addition, care should be taken to avoid mixing with other chemicals. This reagent may react chemically with certain substances, causing danger. It needs to be stored separately from incompatible chemicals to ensure the safety of storage.
When storing 2-chloro-4 - (trifluoromethyl) phenylboronic acid, careful attention should be paid to environmental humidity, temperature, storage container and chemical mixing, so as to ensure its quality and performance, and play its due role in organic synthesis reactions.
What is the market price range for 2-chloro-4- (trifluoromethyl) benzeneboronic Acid?
2-Chloro-4- (trifluoromethyl) phenylboronic acid, the price of this substance in the market, it is difficult to generalize. The fluctuation of its price is caused by many reasons.
Looking at the method of its preparation, the complexity of the process, and the rarity of the materials used are all variables of the price. If its synthesis requires special reagents, or goes through multiple fine processes, the cost will be high, and the price will also rise. If it is based on rare materials, or requires strict reaction conditions, the cost is high, and the price is low.
Furthermore, the trend of supply and demand determines its price. If there are many people in the market, but the supply is small, the merchant will raise the price due to the situation to obtain huge profits. On the contrary, if there is an oversupply, it is a quick sale, and the price may drop.
The difference in origin also affects the price. In different places, due to the abundance of resources, the price of manpower, and the difference in taxes, the cost varies, and the price varies.
In addition, the state of market competition also plays a role in its price. There are many products of the same type, and merchants compete for market share or reduce prices in order to obtain it. If there is no competing product, or because of its uniqueness, the price is slightly higher.
Under normal circumstances, the price of this product in the market may range from tens to hundreds of yuan per gram. However, this is only an approximation. To know the exact price, you need to consult the relevant chemical raw material suppliers in detail, and obtain the exact price according to their quality, quantity, and current market conditions.
Looking at the method of its preparation, the complexity of the process, and the rarity of the materials used are all variables of the price. If its synthesis requires special reagents, or goes through multiple fine processes, the cost will be high, and the price will also rise. If it is based on rare materials, or requires strict reaction conditions, the cost is high, and the price is low.
Furthermore, the trend of supply and demand determines its price. If there are many people in the market, but the supply is small, the merchant will raise the price due to the situation to obtain huge profits. On the contrary, if there is an oversupply, it is a quick sale, and the price may drop.
The difference in origin also affects the price. In different places, due to the abundance of resources, the price of manpower, and the difference in taxes, the cost varies, and the price varies.
In addition, the state of market competition also plays a role in its price. There are many products of the same type, and merchants compete for market share or reduce prices in order to obtain it. If there is no competing product, or because of its uniqueness, the price is slightly higher.
Under normal circumstances, the price of this product in the market may range from tens to hundreds of yuan per gram. However, this is only an approximation. To know the exact price, you need to consult the relevant chemical raw material suppliers in detail, and obtain the exact price according to their quality, quantity, and current market conditions.
Scan to WhatsApp
