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2-Chloro-4-(Trifluoromethyl)Benzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
725512 |
| Chemical Formula | C7H3Cl2F3O2S |
| Molecular Weight | 279.06 |
| Appearance | Typically a colorless to pale yellow liquid |
| Boiling Point | Data varies, around [specific boiling point if known] °C |
| Melting Point | Data varies, around [specific melting point if known] °C |
| Density | Data varies, around [specific density if known] g/cm³ |
| Solubility | Soluble in some organic solvents |
| Pungency | Has a pungent odor |
| Reactivity | Reactive with nucleophiles |
| Hazard | Corrosive, can cause burns to skin and eyes |
As an accredited 2-Chloro-4-(Trifluoromethyl)Benzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 4 - (trifluoromethyl)benzenesulfonyl chloride in sealed, corrosion - resistant container. |
| Storage | 2 - chloro - 4 - (trifluoromethyl)benzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and moisture as it is reactive. Store in a tightly sealed container to prevent leakage and exposure to air. It should be segregated from incompatible substances like bases, reducing agents, and water - reactive materials to avoid dangerous reactions. |
| Shipping | 2 - chloro - 4 - (trifluoromethyl)benzenesulfonyl chloride is a chemical. Shipping should be in accordance with hazardous chemical regulations, using well - sealed containers and proper labeling for safe transportation. |
Competitive 2-Chloro-4-(Trifluoromethyl)Benzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 2-Chloro-4-(Trifluoromethyl)Benzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 2-chloro-4- (trifluoromethyl) benzenesulfonyl Chloride?
2-Chloro-4- (trifluoromethyl) benzenesulfonyl chloride, which is widely used. In the field of organic synthesis, it is a crucial intermediate.
One of them can be used to create various fluorobenzenesulfonamides. Due to the unique properties of fluorine atoms, such as high electronegativity and small atomic radius, fluorine-containing compounds often have specific physiological activities and physicochemical properties. Using this substance as a starting material, it can react with ammonia or amines to generate corresponding sulfonamides. Such sulfonamides are often used as active ingredients in pharmaceutical chemistry, or in the field of pesticides to prepare highly efficient and low-toxic pesticides.
Second, it also has important uses in materials science. It can be introduced into the structure of polymer materials through chemical reactions. Due to the existence of fluorine-containing groups, it can significantly improve the weather resistance, chemical corrosion resistance and surface properties of polymer materials. For example, it can be used to prepare special coatings, which can make the coatings have excellent waterproof, oil-proof and anti-fouling properties.
Third, for the preparation of fine chemicals, 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride is also indispensable. It can be used to synthesize surfactants with specific structures. Due to its fluorine-containing structure, such surfactants exhibit excellent performance in reducing surface tension, and have unique application value in some special industrial application scenarios, such as electronic cleaning, textile printing and dyeing aids, etc.
Fourth, in the study of organic synthesis methodology, as a reaction substrate, its participation in the reaction can be deeply explored to develop novel and efficient organic synthesis pathways. Many chemical researchers have focused on the reaction mechanism of this substance, aiming to expand the boundaries of organic synthesis chemistry and provide new ideas and methods for the synthesis of more complex organic compounds.
One of them can be used to create various fluorobenzenesulfonamides. Due to the unique properties of fluorine atoms, such as high electronegativity and small atomic radius, fluorine-containing compounds often have specific physiological activities and physicochemical properties. Using this substance as a starting material, it can react with ammonia or amines to generate corresponding sulfonamides. Such sulfonamides are often used as active ingredients in pharmaceutical chemistry, or in the field of pesticides to prepare highly efficient and low-toxic pesticides.
Second, it also has important uses in materials science. It can be introduced into the structure of polymer materials through chemical reactions. Due to the existence of fluorine-containing groups, it can significantly improve the weather resistance, chemical corrosion resistance and surface properties of polymer materials. For example, it can be used to prepare special coatings, which can make the coatings have excellent waterproof, oil-proof and anti-fouling properties.
Third, for the preparation of fine chemicals, 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride is also indispensable. It can be used to synthesize surfactants with specific structures. Due to its fluorine-containing structure, such surfactants exhibit excellent performance in reducing surface tension, and have unique application value in some special industrial application scenarios, such as electronic cleaning, textile printing and dyeing aids, etc.
Fourth, in the study of organic synthesis methodology, as a reaction substrate, its participation in the reaction can be deeply explored to develop novel and efficient organic synthesis pathways. Many chemical researchers have focused on the reaction mechanism of this substance, aiming to expand the boundaries of organic synthesis chemistry and provide new ideas and methods for the synthesis of more complex organic compounds.
What are the synthesis methods of 2-chloro-4- (trifluoromethyl) benzenesulfonyl Chloride
There are several methods for synthesizing 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride. One method can also start from the corresponding aromatic hydrocarbon. First, take the benzene containing a specific substituent, and use a chlorination reagent, such as chlorine gas. Under the catalysis of an appropriate catalyst, such as iron powder or ferric chloride, the chlorination reaction is carried out to introduce chlorine atoms into the benzene ring. Then, the benzene ring is sulfonated by a sulfonating reagent, such as fuming sulfuric acid, to obtain the corresponding sulfonic acid. Then, the sulfonic acid can be converted into a sulfonyl chloride by chlorination reagents such as sulfoxide chloride. And during the reaction process, factors such as temperature, proportion of reactants and reaction time need to be carefully regulated.
Another method, which can be started from other suitable organic compounds. The benzene ring skeleton is first constructed through a series of reactions, and chlorine atoms and trifluoromethyl are introduced at the same time, followed by sulfonation and chlorination steps to form the target product. In this process, the conditions of each step of the reaction, such as the choice of solvent, the level of reaction temperature, and the type and amount of catalyst, all have a significant impact on the yield and selectivity of the reaction. Careful exploration is required to achieve the best reaction effect, so that the target product can be produced efficiently and with high purity.
Another method, which can be started from other suitable organic compounds. The benzene ring skeleton is first constructed through a series of reactions, and chlorine atoms and trifluoromethyl are introduced at the same time, followed by sulfonation and chlorination steps to form the target product. In this process, the conditions of each step of the reaction, such as the choice of solvent, the level of reaction temperature, and the type and amount of catalyst, all have a significant impact on the yield and selectivity of the reaction. Careful exploration is required to achieve the best reaction effect, so that the target product can be produced efficiently and with high purity.
What are the physical properties of 2-chloro-4- (trifluoromethyl) benzenesulfonyl Chloride
2-Chloro-4- (trifluoromethyl) benzenesulfonyl chloride, this material is particularly important and is related to many chemical applications.
Its appearance is often colorless to yellowish liquid, and it has obvious fluidity. Smell, the smell is pungent, this pungent smell needs to be carefully handled during operation to prevent damage to the nose and throat.
The characteristics of the boiling point are also key. Its boiling point is in a specific range. During the heating process, when it reaches this temperature limit, it gradually changes from liquid to gaseous state. This boiling point value is an important basis for separation and purification in chemical processes.
Melting point cannot be ignored. When the temperature drops to a certain value, the substance solidifies from a liquid state to a solid state. This melting point is of great significance for the setting of storage and transportation conditions. If the temperature is not properly controlled, or its state is changed, it will affect the quality.
In terms of solubility, it has a certain solubility in organic solvents, such as some aromatic hydrocarbons and halogenated hydrocarbon solvents. This property is convenient for use as a reaction medium in synthetic reactions, so that the reactants can be better mixed and contacted, and the reaction can be carried out. In water, its solubility is very small, and contact with water or chemical reaction can produce acidic substances. This point needs to be carefully considered when dealing with waste or wastewater containing this substance.
The density is a fixed value. In the measurement and batching process of chemical production, the density data is used to accurately calculate the material dosage and ensure that the reaction proceeds as expected.
Chemical activity, in which chlorine atoms and sulfonyl chloride groups have high reactivity. It is easy to replace with nucleophiles and can introduce various functional groups for the synthesis of complex organic compounds. It is widely used in fine chemical fields such as medicine and pesticides.
However, due to its chemical activity, it is necessary to avoid water, heat and oxidants during storage to prevent dangerous chemical reactions and ensure the safety of production, storage and transportation.
Its appearance is often colorless to yellowish liquid, and it has obvious fluidity. Smell, the smell is pungent, this pungent smell needs to be carefully handled during operation to prevent damage to the nose and throat.
The characteristics of the boiling point are also key. Its boiling point is in a specific range. During the heating process, when it reaches this temperature limit, it gradually changes from liquid to gaseous state. This boiling point value is an important basis for separation and purification in chemical processes.
Melting point cannot be ignored. When the temperature drops to a certain value, the substance solidifies from a liquid state to a solid state. This melting point is of great significance for the setting of storage and transportation conditions. If the temperature is not properly controlled, or its state is changed, it will affect the quality.
In terms of solubility, it has a certain solubility in organic solvents, such as some aromatic hydrocarbons and halogenated hydrocarbon solvents. This property is convenient for use as a reaction medium in synthetic reactions, so that the reactants can be better mixed and contacted, and the reaction can be carried out. In water, its solubility is very small, and contact with water or chemical reaction can produce acidic substances. This point needs to be carefully considered when dealing with waste or wastewater containing this substance.
The density is a fixed value. In the measurement and batching process of chemical production, the density data is used to accurately calculate the material dosage and ensure that the reaction proceeds as expected.
Chemical activity, in which chlorine atoms and sulfonyl chloride groups have high reactivity. It is easy to replace with nucleophiles and can introduce various functional groups for the synthesis of complex organic compounds. It is widely used in fine chemical fields such as medicine and pesticides.
However, due to its chemical activity, it is necessary to avoid water, heat and oxidants during storage to prevent dangerous chemical reactions and ensure the safety of production, storage and transportation.
What are the chemical properties of 2-chloro-4- (trifluoromethyl) benzenesulfonyl Chloride
2-Chloro-4- (trifluoromethyl) benzenesulfonyl chloride, which has strong properties and special chemical properties, is an important raw material for organic synthesis.
Looking at its chemical structure, the chlorine atom and trifluoromethyl are co-attached to the benzene ring, and the sulfonyl chloride group is attached on one side. This structure gives it unique chemical properties. Its activity is quite high, and the sulfur atom in the sulfonyl chloride group is in a high valence state and has strong electrophilicity. When encountering nucleophilic reagents, such as alcohols and amines, it is easy to initiate nucleophilic substitution reactions, and chlorine atoms are easily replaced, thereby constructing a variety of sulfur-containing organic compounds. They are often used as key intermediates in the creation of medicines and pesticides. By reacting with different nucleophilic reagents, various functional groups can be introduced, and compounds with complex structures and specific biological activities can be derived.
Furthermore, due to the presence of chlorine atoms and trifluoromethyl on the benzene ring, the electron cloud density and steric resistance of the benzene ring are affected. Trifluoromethyl has strong electron absorption, which decreases the electron cloud density of the benzene ring, changes the activity of the electrophilic substitution reaction of the benzene ring, and affects the reactivity of ortho and para groups at the same time. The chlorine atom also has an effect on the distribution of benzene ring electron cloud, and the synergy between the two makes the reaction selectivity and activity of this compound different from that of ordinary benzene sulfonyl chloride.
In terms of physical properties, it is mostly colorless to light yellow liquid at room temperature, with a pungent smell and strong irritation to the eyes, skin and respiratory tract. Because of its fluorine atom, some of its physical properties are different from traditional sulfonyl chloride, such as solubility. It has good solubility in organic solvents such as dichloromethane and chloroform, but it is easy to hydrolyze in water. During hydrolysis, the sulfonyl chloride group reacts with water to release hydrogen chloride gas, and the solution is more acidic. This hydrolysis property needs to be treated with caution when storing and using.
Looking at its chemical structure, the chlorine atom and trifluoromethyl are co-attached to the benzene ring, and the sulfonyl chloride group is attached on one side. This structure gives it unique chemical properties. Its activity is quite high, and the sulfur atom in the sulfonyl chloride group is in a high valence state and has strong electrophilicity. When encountering nucleophilic reagents, such as alcohols and amines, it is easy to initiate nucleophilic substitution reactions, and chlorine atoms are easily replaced, thereby constructing a variety of sulfur-containing organic compounds. They are often used as key intermediates in the creation of medicines and pesticides. By reacting with different nucleophilic reagents, various functional groups can be introduced, and compounds with complex structures and specific biological activities can be derived.
Furthermore, due to the presence of chlorine atoms and trifluoromethyl on the benzene ring, the electron cloud density and steric resistance of the benzene ring are affected. Trifluoromethyl has strong electron absorption, which decreases the electron cloud density of the benzene ring, changes the activity of the electrophilic substitution reaction of the benzene ring, and affects the reactivity of ortho and para groups at the same time. The chlorine atom also has an effect on the distribution of benzene ring electron cloud, and the synergy between the two makes the reaction selectivity and activity of this compound different from that of ordinary benzene sulfonyl chloride.
In terms of physical properties, it is mostly colorless to light yellow liquid at room temperature, with a pungent smell and strong irritation to the eyes, skin and respiratory tract. Because of its fluorine atom, some of its physical properties are different from traditional sulfonyl chloride, such as solubility. It has good solubility in organic solvents such as dichloromethane and chloroform, but it is easy to hydrolyze in water. During hydrolysis, the sulfonyl chloride group reacts with water to release hydrogen chloride gas, and the solution is more acidic. This hydrolysis property needs to be treated with caution when storing and using.
What are the precautions for 2-chloro-4- (trifluoromethyl) benzenesulfonyl Chloride during storage and transportation?
2-Chloro-4- (trifluoromethyl) benzenesulfonyl chloride, this is a chemical substance, and many matters need to be paid attention to when storing and transporting.
Let's talk about storage first. This substance should be placed in a cool, dry and well-ventilated place. Because of its active nature, it is easy to change when heated, so it should not be near fire or heat sources to avoid decomposition or even cause danger. It needs to be stored separately from oxidants and alkalis, etc., and must not be mixed. Because this substance encounters them or reacts violently. The storage place should have suitable materials to contain the leakage, in case of leakage, it can be dealt with in time to avoid disaster.
Then transport. When transporting, the packaging must be tight to ensure that there is no risk of leakage. The transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During driving, it should be protected from exposure to the sun, rain and high temperature. When transporting by road, it should be driven according to the specified route, and do not stop in residential areas and densely populated areas. When transporting by rail, it should not be slipped away. When loading and unloading, the operator must wear suitable protective equipment, be careful, and handle lightly to avoid collision and friction, so as to prevent material leakage caused by package damage.
In conclusion, the storage and transportation of 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride must strictly follow relevant norms and requirements, and must not be negligent, so as to ensure safety.
Let's talk about storage first. This substance should be placed in a cool, dry and well-ventilated place. Because of its active nature, it is easy to change when heated, so it should not be near fire or heat sources to avoid decomposition or even cause danger. It needs to be stored separately from oxidants and alkalis, etc., and must not be mixed. Because this substance encounters them or reacts violently. The storage place should have suitable materials to contain the leakage, in case of leakage, it can be dealt with in time to avoid disaster.
Then transport. When transporting, the packaging must be tight to ensure that there is no risk of leakage. The transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During driving, it should be protected from exposure to the sun, rain and high temperature. When transporting by road, it should be driven according to the specified route, and do not stop in residential areas and densely populated areas. When transporting by rail, it should not be slipped away. When loading and unloading, the operator must wear suitable protective equipment, be careful, and handle lightly to avoid collision and friction, so as to prevent material leakage caused by package damage.
In conclusion, the storage and transportation of 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride must strictly follow relevant norms and requirements, and must not be negligent, so as to ensure safety.
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