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2-Chloro-4-(Trifluoromethyl)Benzenesulphonyl Chloride
Linshang Chemical
|
HS Code |
141697 |
| Chemical Formula | C7H3Cl2F3O2S |
| Molecular Weight | 279.06 |
| Appearance | Typically a colorless to pale yellow liquid |
| Odor | Pungent odor |
| Boiling Point | Around 270 - 275 °C |
| Solubility | Soluble in many organic solvents like dichloromethane, toluene |
| Reactivity | Highly reactive towards nucleophiles due to the presence of sulfonyl chloride group |
| Hazard Class | Corrosive, can cause severe skin and eye damage |
As an accredited 2-Chloro-4-(Trifluoromethyl)Benzenesulphonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 4 - (trifluoromethyl)benzenesulphonyl Chloride in sealed glass bottles. |
| Storage | 2 - chloro - 4 - (trifluoromethyl)benzenesulphonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container, preferably in a corrosion - resistant material due to its reactive and potentially corrosive nature. Store it separately from incompatible substances like bases, reducing agents, and moisture - sensitive compounds to prevent unwanted reactions. |
| Shipping | 2 - chloro - 4 - (trifluoromethyl)benzenesulphonyl chloride is a chemical. Shipping should be in accordance with hazardous materials regulations. It must be properly packaged to prevent leaks, and transported with appropriate safety documentation. |
Competitive 2-Chloro-4-(Trifluoromethyl)Benzenesulphonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 2-chloro-4- (trifluoromethyl) benzenesulphonyl Chloride
2-Chloro-4- (trifluoromethyl) benzenesulfonyl chloride is an important chemical substance in the field of organic synthesis. In terms of physical properties, it is mostly colorless to light yellow liquid at room temperature, has a pungent odor, is volatile in the air, and can be dissolved in most organic solvents, such as dichloromethane, chloroform, and toluene.
In terms of chemical properties, the sulfonyl chloride group (-SO 2O Cl) is very active, and its chlorine atom is easily replaced by nucleophiles. When exposed to water, the hydrolysis reaction will occur rapidly, generating the corresponding sulfonic acid and hydrogen chloride gas. The reaction is as follows: 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride + H2O O → 2-chloro-4- (trifluoromethyl) benzenesulfonic acid + HCl. This hydrolysis reaction is rapid and exothermic, and special attention should be paid during operation.
In addition, because it contains trifluoromethyl (-CF 🥰), this group has strong electron absorption, which reduces the electron cloud density of the benzene ring, which in turn affects the electrophilic substitution reaction activity on the benzene ring. For example, when performing electrophilic substitution reactions on aromatic rings, compared with benzene derivatives without trifluoromethyl substitution, the reaction conditions may be more severe, and the reaction check point will also be affected by the positioning effect of trifluoromethyl, mainly in the meta position.
In addition, it can be esterified with alcohols in the presence of bases to form sulfonates. Reacting with amines, sulfonamides can be formed. These reactions are often used in organic synthesis to construct various functional molecules containing sulfonyl groups, and are widely used in many fields such as medicine, pesticides, and materials science.
When handling 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride, due to its hydrolysis and irritation, it must be carried out in a dry and well-ventilated place, and the operator should take protective measures to prevent contact and inhalation.
In terms of chemical properties, the sulfonyl chloride group (-SO 2O Cl) is very active, and its chlorine atom is easily replaced by nucleophiles. When exposed to water, the hydrolysis reaction will occur rapidly, generating the corresponding sulfonic acid and hydrogen chloride gas. The reaction is as follows: 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride + H2O O → 2-chloro-4- (trifluoromethyl) benzenesulfonic acid + HCl. This hydrolysis reaction is rapid and exothermic, and special attention should be paid during operation.
In addition, because it contains trifluoromethyl (-CF 🥰), this group has strong electron absorption, which reduces the electron cloud density of the benzene ring, which in turn affects the electrophilic substitution reaction activity on the benzene ring. For example, when performing electrophilic substitution reactions on aromatic rings, compared with benzene derivatives without trifluoromethyl substitution, the reaction conditions may be more severe, and the reaction check point will also be affected by the positioning effect of trifluoromethyl, mainly in the meta position.
In addition, it can be esterified with alcohols in the presence of bases to form sulfonates. Reacting with amines, sulfonamides can be formed. These reactions are often used in organic synthesis to construct various functional molecules containing sulfonyl groups, and are widely used in many fields such as medicine, pesticides, and materials science.
When handling 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride, due to its hydrolysis and irritation, it must be carried out in a dry and well-ventilated place, and the operator should take protective measures to prevent contact and inhalation.
What are the common uses of 2-chloro-4- (trifluoromethyl) benzenesulphonyl Chloride
2-Chloro-4- (trifluoromethyl) benzenesulfonyl chloride, which has strong properties and wide uses, is commonly used in the field of organic synthesis, and is a key intermediate for the preparation of many fluorinated organic compounds.
First, in pharmaceutical chemistry, it can be used to construct molecular structures with specific biological activities. Because of its fluoride atom, it can significantly change the lipophilic, metabolic stability and biological activity of drug molecules. For example, when synthesizing some antiviral and antitumor drugs, this is used as the starting material, and a sulfonyl chloride group is introduced through multi-step reaction to shape the unique spatial structure and electron cloud distribution of drug molecules, achieving the expected pharmacological effect.
Second, in the field of materials science, it is often used to prepare high-performance fluoropolymer materials. React with polymer monomers containing hydroxyl or amino groups to form sulfonamide or sulfonate bonds, giving the material excellent thermal stability, chemical stability and weather resistance. Such as the preparation of high-end coatings, engineering plastics, to improve the material's resistance to harsh environments, it is widely used in aerospace, automotive industry and other fields that require strict material properties.
Third, in the field of pesticide chemistry, as an important intermediate to participate in the synthesis of new pesticides. Fluorinated pesticides often have the characteristics of high efficiency, low toxicity and environmental friendliness. Based on 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride, by reacting with various amines and alcohols, pesticides, fungicides and herbicides with unique mechanisms of action can be created to help agricultural production pest control.
First, in pharmaceutical chemistry, it can be used to construct molecular structures with specific biological activities. Because of its fluoride atom, it can significantly change the lipophilic, metabolic stability and biological activity of drug molecules. For example, when synthesizing some antiviral and antitumor drugs, this is used as the starting material, and a sulfonyl chloride group is introduced through multi-step reaction to shape the unique spatial structure and electron cloud distribution of drug molecules, achieving the expected pharmacological effect.
Second, in the field of materials science, it is often used to prepare high-performance fluoropolymer materials. React with polymer monomers containing hydroxyl or amino groups to form sulfonamide or sulfonate bonds, giving the material excellent thermal stability, chemical stability and weather resistance. Such as the preparation of high-end coatings, engineering plastics, to improve the material's resistance to harsh environments, it is widely used in aerospace, automotive industry and other fields that require strict material properties.
Third, in the field of pesticide chemistry, as an important intermediate to participate in the synthesis of new pesticides. Fluorinated pesticides often have the characteristics of high efficiency, low toxicity and environmental friendliness. Based on 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride, by reacting with various amines and alcohols, pesticides, fungicides and herbicides with unique mechanisms of action can be created to help agricultural production pest control.
What is the synthesis method of 2-chloro-4- (trifluoromethyl) benzenesulphonyl Chloride
The synthesis of 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride is an important topic in the field of organic synthesis. This compound has a wide range of uses and is often used as an intermediate in organic synthesis. It plays a key role in many fields such as medicinal chemistry and materials science.
Synthesis of this compound can follow the classical organic synthesis path. First, 2-chloro-4- (trifluoromethyl) benzene is used as a starting material and sulfonated to react with fuming sulfuric acid or chlorosulfonic acid. In this step, the activity of the sulfonating agent and the reaction conditions are crucial. Fuming sulfuric acid usually undergoes electrophilic substitution with substrate molecules at appropriate temperatures (e.g. low to medium temperature range, about 0-50 ° C), introducing sulfonic acid groups at specific locations in the benzene ring. The reaction temperature needs to be closely monitored to prevent excessive sulfonation or other side reactions.
The resulting 2-chloro-4- (trifluoromethyl) benzene sulfonic acid can be further converted into the corresponding sulfonyl chloride. In general, chlorination is carried out using chlorination reagents such as phosphorus pentachloride (PCl) or dichlorosulfoxide (SOCl ²). In the case of dichlorosulfoxide, which reacts with sulfonic acid, it can be carried out under mild conditions. In the reaction system, dichlorosulfoxide is both a chlorination reagent and a solvent. The sulfur dioxide and hydrogen chloride gases generated by the reaction are easy to escape, which promotes the forward progress of the reaction. Usually, the reaction is stirred at the reflux temperature for several hours until the reaction is complete. After the reaction is completed, the pure 2-chloro-4 - (trifluoromethyl) benzenesulfonyl chloride product can be obtained by conventional separation and purification methods such as distillation, extraction, and column chromatography.
In addition, attention should be paid to safe operation during the reaction process. Reagents such as fuming sulfuric acid and dichlorosulfoxide are highly corrosive and irritating. The operation should be in a well-ventilated environment and wear suitable protective equipment to ensure the safety of the experimenters.
Synthesis of this compound can follow the classical organic synthesis path. First, 2-chloro-4- (trifluoromethyl) benzene is used as a starting material and sulfonated to react with fuming sulfuric acid or chlorosulfonic acid. In this step, the activity of the sulfonating agent and the reaction conditions are crucial. Fuming sulfuric acid usually undergoes electrophilic substitution with substrate molecules at appropriate temperatures (e.g. low to medium temperature range, about 0-50 ° C), introducing sulfonic acid groups at specific locations in the benzene ring. The reaction temperature needs to be closely monitored to prevent excessive sulfonation or other side reactions.
The resulting 2-chloro-4- (trifluoromethyl) benzene sulfonic acid can be further converted into the corresponding sulfonyl chloride. In general, chlorination is carried out using chlorination reagents such as phosphorus pentachloride (PCl) or dichlorosulfoxide (SOCl ²). In the case of dichlorosulfoxide, which reacts with sulfonic acid, it can be carried out under mild conditions. In the reaction system, dichlorosulfoxide is both a chlorination reagent and a solvent. The sulfur dioxide and hydrogen chloride gases generated by the reaction are easy to escape, which promotes the forward progress of the reaction. Usually, the reaction is stirred at the reflux temperature for several hours until the reaction is complete. After the reaction is completed, the pure 2-chloro-4 - (trifluoromethyl) benzenesulfonyl chloride product can be obtained by conventional separation and purification methods such as distillation, extraction, and column chromatography.
In addition, attention should be paid to safe operation during the reaction process. Reagents such as fuming sulfuric acid and dichlorosulfoxide are highly corrosive and irritating. The operation should be in a well-ventilated environment and wear suitable protective equipment to ensure the safety of the experimenters.
What are the precautions for 2-chloro-4- (trifluoromethyl) benzenesulphonyl Chloride in storage and transportation?
2-Chloro-4- (trifluoromethyl) benzenesulfonyl chloride is a commonly used reagent in organic synthesis. When storing and transporting these chemicals, many key matters must be paid attention to to to ensure safety.
The first to bear the brunt, when storing, be sure to choose a cool, dry and well-ventilated place. Due to its active nature, high temperature and humid environments can easily cause it to deteriorate or cause dangerous reactions. If heated, the compound may accelerate decomposition, generating harmful gases, or even triggering the risk of explosion. Therefore, the warehouse temperature should be maintained at a low level, and the humidity should also be strictly controlled.
Secondly, this reagent is highly corrosive and poses potential hazards to both humans and the environment. Storage containers must be made of corrosion-resistant materials, such as glass or specific plastic materials, and must be tightly sealed to prevent leakage. Once leaked, not only will it erode the surrounding items, but the volatile gas may also endanger human health and pollute the environment.
Furthermore, during transportation, relevant regulations must be strictly followed. Packaging must be sturdy and reliable, able to withstand a certain degree of collision and vibration, to avoid leakage of reagents due to package damage. At the same time, transportation vehicles should be equipped with necessary emergency treatment equipment, such as fire extinguishers, leakage emergency treatment tools, etc. Transport personnel also need to undergo professional training, familiar with the characteristics of the chemical and emergency response methods.
In addition, whether it is stored or transported, it should be stored and transported separately from oxidants, alkalis and other substances to prevent violent chemical reactions. Due to its active chemical properties, contact with these substances is likely to cause uncontrollable reactions, endangering personnel safety and environmental safety.
In short, the storage and transportation of 2-chloro-4 - (trifluoromethyl) benzenesulfonyl chloride should be treated with caution in terms of environmental conditions, packaging materials, personnel training, etc., and must not be taken lightly, so as to ensure the safety and order of the whole process.
The first to bear the brunt, when storing, be sure to choose a cool, dry and well-ventilated place. Due to its active nature, high temperature and humid environments can easily cause it to deteriorate or cause dangerous reactions. If heated, the compound may accelerate decomposition, generating harmful gases, or even triggering the risk of explosion. Therefore, the warehouse temperature should be maintained at a low level, and the humidity should also be strictly controlled.
Secondly, this reagent is highly corrosive and poses potential hazards to both humans and the environment. Storage containers must be made of corrosion-resistant materials, such as glass or specific plastic materials, and must be tightly sealed to prevent leakage. Once leaked, not only will it erode the surrounding items, but the volatile gas may also endanger human health and pollute the environment.
Furthermore, during transportation, relevant regulations must be strictly followed. Packaging must be sturdy and reliable, able to withstand a certain degree of collision and vibration, to avoid leakage of reagents due to package damage. At the same time, transportation vehicles should be equipped with necessary emergency treatment equipment, such as fire extinguishers, leakage emergency treatment tools, etc. Transport personnel also need to undergo professional training, familiar with the characteristics of the chemical and emergency response methods.
In addition, whether it is stored or transported, it should be stored and transported separately from oxidants, alkalis and other substances to prevent violent chemical reactions. Due to its active chemical properties, contact with these substances is likely to cause uncontrollable reactions, endangering personnel safety and environmental safety.
In short, the storage and transportation of 2-chloro-4 - (trifluoromethyl) benzenesulfonyl chloride should be treated with caution in terms of environmental conditions, packaging materials, personnel training, etc., and must not be taken lightly, so as to ensure the safety and order of the whole process.
What are the effects of 2-chloro-4- (trifluoromethyl) benzenesulphonyl Chloride on the environment and human health?
2-Chloro-4- (trifluoromethyl) benzenesulfonyl chloride has an impact on both the environment and human health.
First talk about its harm to the environment. If this chemical is released into the environment, it will remain in soil and water bodies. Because of its stable chemical structure, it is difficult to be degraded naturally. In the soil, it may change the soil quality, affect the soil microbial community, hinder the absorption of nutrients by plant roots, cause plant growth to be hindered, and even wither. Inflow into water bodies can endanger aquatic organisms. After fish are exposed, it may cause damage to the gills and affect respiration; it may also interfere with its nervous system, make it behave abnormally, and affect population reproduction. And this substance will also accumulate in the food chain. After ingestion by low-level organisms, it will be transmitted through the food chain, and the concentration will gradually increase in high-level organisms, threatening the balance of the entire ecosystem.
Let's talk about the impact on human health. It is highly irritating. If it is accidentally touched with the skin, it will cause redness, swelling, pain, and in severe cases, it may cause burns and ulceration, leaving scars. If it comes into contact with the eyes, it can be especially harmful, which can damage the cornea, affect vision, and even cause blindness. If it inhales its volatile gas, it will irritate the respiratory tract, cause symptoms such as cough, asthma, breathing difficulties, and long-term exposure or cause chronic respiratory diseases, such as bronchitis, emphysema, etc. In addition, oral ingestion can damage the digestive system, causing nausea, vomiting, abdominal pain, diarrhea, etc., and may also cause damage to vital organs such as the liver and kidneys, affecting their normal function.
Therefore, when producing and using substances containing 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride, it is necessary to operate with caution, take protective measures, and properly dispose of waste to reduce its harm to the environment and human health.
First talk about its harm to the environment. If this chemical is released into the environment, it will remain in soil and water bodies. Because of its stable chemical structure, it is difficult to be degraded naturally. In the soil, it may change the soil quality, affect the soil microbial community, hinder the absorption of nutrients by plant roots, cause plant growth to be hindered, and even wither. Inflow into water bodies can endanger aquatic organisms. After fish are exposed, it may cause damage to the gills and affect respiration; it may also interfere with its nervous system, make it behave abnormally, and affect population reproduction. And this substance will also accumulate in the food chain. After ingestion by low-level organisms, it will be transmitted through the food chain, and the concentration will gradually increase in high-level organisms, threatening the balance of the entire ecosystem.
Let's talk about the impact on human health. It is highly irritating. If it is accidentally touched with the skin, it will cause redness, swelling, pain, and in severe cases, it may cause burns and ulceration, leaving scars. If it comes into contact with the eyes, it can be especially harmful, which can damage the cornea, affect vision, and even cause blindness. If it inhales its volatile gas, it will irritate the respiratory tract, cause symptoms such as cough, asthma, breathing difficulties, and long-term exposure or cause chronic respiratory diseases, such as bronchitis, emphysema, etc. In addition, oral ingestion can damage the digestive system, causing nausea, vomiting, abdominal pain, diarrhea, etc., and may also cause damage to vital organs such as the liver and kidneys, affecting their normal function.
Therefore, when producing and using substances containing 2-chloro-4- (trifluoromethyl) benzenesulfonyl chloride, it is necessary to operate with caution, take protective measures, and properly dispose of waste to reduce its harm to the environment and human health.
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