Linshang Chemical
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2-Chloro-5-(1-Hydroxy-3-Oxo-2,3-Dihydro-1H-Isoindol-1-Yl)Benzenesulfonamide
Linshang Chemical
|
HS Code |
747145 |
| Chemical Formula | C14H9ClN2O5S |
| Molar Mass | 364.75 g/mol |
| Solubility In Water | Expected to be low due to non - polar aromatic rings and relatively large molecular size |
| Solubility In Organic Solvents | Likely soluble in polar organic solvents like DMSO, DMF based on functional groups |
| Pka | No general data available, acidic due to sulfonamide group but exact pKa would depend on environment |
| Logp | Positive value expected as it has hydrophobic aromatic regions |
As an accredited 2-Chloro-5-(1-Hydroxy-3-Oxo-2,3-Dihydro-1H-Isoindol-1-Yl)Benzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 5 - (1 - hydroxy - 3 - oxo - 2,3 - dihydro - 1H - isoindol - 1 - yl)benzenesulfonamide in sealed plastic bags. |
| Storage | Store 2 - chloro - 5 - (1 - hydroxy - 3 - oxo - 2,3 - dihydro - 1H - isoindol - 1 - yl)benzenesulfonamide in a cool, dry place, away from direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and potential reactions with air components. Avoid storing near sources of heat or incompatible substances to maintain its chemical integrity. |
| Shipping | 2 - chloro - 5 - (1 - hydroxy - 3 - oxo - 2,3 - dihydro - 1H - isoindol - 1 - yl)benzenesulfonamide is shipped in well - sealed containers, following strict chemical transport regulations. Packaging ensures protection from environmental factors during transit. |
Competitive 2-Chloro-5-(1-Hydroxy-3-Oxo-2,3-Dihydro-1H-Isoindol-1-Yl)Benzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a trusted 2-Chloro-5-(1-Hydroxy-3-Oxo-2,3-Dihydro-1H-Isoindol-1-Yl)Benzenesulfonamide manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-5-(1-Hydroxy-3-Oxo-2,3-Dihydro-1H-Isoindol-1-Yl)Benzenesulfonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2-chloro-5- (1-hydroxy-3-oxo-2, 3-dihydro-1h-isoindol-1-yl) benzenesulfonamide
2-Chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl) benzenesulfonamide, which is an organic compound. Looking at its chemical structure, it contains chlorine atoms, sulfonamide groups and isoindolone structural fragments, which endows it with unique chemical properties.
In terms of its physical properties, it is mostly solid at room temperature. Due to the existence of van der Waals forces and hydrogen bonds between molecules, the molecules are closely arranged. However, its specific melting point and boiling point need to be accurately determined by experiments, and the influence of surrounding groups on the intermolecular forces is quite complicated.
When it comes to chemical activity, chlorine atoms have high activity and can participate in nucleophilic substitution reactions. The chlorine atoms above the aromatic ring are affected by the distribution of the surrounding electron cloud, which makes the electron cloud density of the benzene ring change, and it is easy to be attacked by nucleophilic reagents, and then substituted. In the sulfonamide group, the electronegativity difference between nitrogen atom and oxygen atom is large, which makes it have a certain polarity, which can participate in the formation of hydrogen bonds and can also react with acids and bases. The carbonyl group of the structural part of isoindolone is electrophilic and can undergo addition reactions with nucleophilic reagents; the hydroxyl group can participate in esterification, dehydration and other reactions.
In addition, the compound may have a certain solubility in organic solvents, but the specific solubility varies depending on the type of solvent. Polar solvents may have better solubility because their molecules have a certain polarity. Its stability is also affected by factors such as temperature, light, pH, etc. Under high temperature, strong light or specific acid-base conditions, reactions such as decomposition and isomerization may occur.
In terms of its physical properties, it is mostly solid at room temperature. Due to the existence of van der Waals forces and hydrogen bonds between molecules, the molecules are closely arranged. However, its specific melting point and boiling point need to be accurately determined by experiments, and the influence of surrounding groups on the intermolecular forces is quite complicated.
When it comes to chemical activity, chlorine atoms have high activity and can participate in nucleophilic substitution reactions. The chlorine atoms above the aromatic ring are affected by the distribution of the surrounding electron cloud, which makes the electron cloud density of the benzene ring change, and it is easy to be attacked by nucleophilic reagents, and then substituted. In the sulfonamide group, the electronegativity difference between nitrogen atom and oxygen atom is large, which makes it have a certain polarity, which can participate in the formation of hydrogen bonds and can also react with acids and bases. The carbonyl group of the structural part of isoindolone is electrophilic and can undergo addition reactions with nucleophilic reagents; the hydroxyl group can participate in esterification, dehydration and other reactions.
In addition, the compound may have a certain solubility in organic solvents, but the specific solubility varies depending on the type of solvent. Polar solvents may have better solubility because their molecules have a certain polarity. Its stability is also affected by factors such as temperature, light, pH, etc. Under high temperature, strong light or specific acid-base conditions, reactions such as decomposition and isomerization may occur.
What are the uses of 2-chloro-5- (1-hydroxy-3-oxo-2, 3-dihydro-1h-isoindol-1-yl) benzenesulfonamide
2-Chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl) benzenesulfonamide, although this substance is not ancient, but according to today's pharmacological theory, its uses may be various.
In the field of pharmacy, such compounds are often involved in the treatment of diseases. First, it may be useful in the genus of anti-inflammatory. Inflammation, the body's defense response to damaging factors, but if it is overdone, it will harm itself. This compound may regulate inflammation-related signaling pathways, inhibit the release of inflammatory mediators, such as inhibiting the production of interleukin, tumor necrosis factor, etc., thereby reducing the inflammatory response, and may be used as a palliative aid in inflammatory diseases such as arthritis and enteritis.
Second, it also has potential applications in the field of anti-tumor. The proliferation and survival of tumor cells are related to many intracellular signaling. The substance may target specific molecular targets of tumor cells, interfere with the growth cycle of tumor cells, and induce apoptosis. For example, it acts on some key kinases to block abnormal signaling of tumor cells and inhibit their wanton proliferation, providing a possible path for the treatment of tumors.
Third, it may also be effective in neurological diseases. Neurological diseases such as Alzheimer's disease and Parkinson's disease are related to neuroinflammation, oxidative stress and abnormal protein aggregation. The properties of this compound may regulate the microenvironment of nerve cells, reduce neuroinflammation, inhibit oxidative stress damage, protect nerve cells, and hope to improve the dysfunction of the nervous system.
Fourth, it may play a role in immune regulation. If the immune system is unbalanced, it can cause autoimmune diseases, etc. The substance may regulate the activity and function of immune cells, correct immune imbalance, help the immune system restore homeostasis, and be beneficial to the treatment of autoimmune diseases such as systemic lupus erythematosus.
In summary, although 2-chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl) benzenesulfonamide is a new research substance, it has potential uses in many fields such as anti-inflammatory, anti-tumor, nervous system diseases and immune regulation, or a new opportunity for future disease treatment.
In the field of pharmacy, such compounds are often involved in the treatment of diseases. First, it may be useful in the genus of anti-inflammatory. Inflammation, the body's defense response to damaging factors, but if it is overdone, it will harm itself. This compound may regulate inflammation-related signaling pathways, inhibit the release of inflammatory mediators, such as inhibiting the production of interleukin, tumor necrosis factor, etc., thereby reducing the inflammatory response, and may be used as a palliative aid in inflammatory diseases such as arthritis and enteritis.
Second, it also has potential applications in the field of anti-tumor. The proliferation and survival of tumor cells are related to many intracellular signaling. The substance may target specific molecular targets of tumor cells, interfere with the growth cycle of tumor cells, and induce apoptosis. For example, it acts on some key kinases to block abnormal signaling of tumor cells and inhibit their wanton proliferation, providing a possible path for the treatment of tumors.
Third, it may also be effective in neurological diseases. Neurological diseases such as Alzheimer's disease and Parkinson's disease are related to neuroinflammation, oxidative stress and abnormal protein aggregation. The properties of this compound may regulate the microenvironment of nerve cells, reduce neuroinflammation, inhibit oxidative stress damage, protect nerve cells, and hope to improve the dysfunction of the nervous system.
Fourth, it may play a role in immune regulation. If the immune system is unbalanced, it can cause autoimmune diseases, etc. The substance may regulate the activity and function of immune cells, correct immune imbalance, help the immune system restore homeostasis, and be beneficial to the treatment of autoimmune diseases such as systemic lupus erythematosus.
In summary, although 2-chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl) benzenesulfonamide is a new research substance, it has potential uses in many fields such as anti-inflammatory, anti-tumor, nervous system diseases and immune regulation, or a new opportunity for future disease treatment.
What is the synthesis method of 2-chloro-5- (1-hydroxy-3-oxo-2, 3-dihydro-1h-isoindol-1-yl) benzenesulfonamide
To prepare 2-chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl) benzenesulfonamide, the method is as follows:
Appropriate starting materials are taken first, often based on compounds containing benzene rings. For example, a specific substituted benzenesulfonyl chloride reacts with a precursor containing an isoindole structure. The isoindole precursor needs to have suitable substituents for subsequent generation of 1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl moiety in the target structure.
During the reaction, in a suitable reaction vessel, an organic solvent such as dichloromethane, N, N-dimethylformamide, etc. is added to assist the dissolution of the raw materials and promote the reaction. Add an appropriate amount of bases, such as triethylamine, pyridine, etc. The function of bases is to neutralize the acid generated by the reaction and promote the forward progress of the reaction.
Temperature-controlled reaction, the temperature depends on the raw material and reaction characteristics, usually between room temperature and tens of degrees Celsius. The reaction lasts for several hours, during which the reaction process is monitored by thin-layer chromatography. When the raw materials are exhausted or the expected reaction degree is reached, the reaction is terminated.
After that, the reaction solution is post-processed. First, it is extracted with water and an organic solvent, and the organic phase is collected after stratification. Desiccants such as anhydrous sodium sulfate are removed from water, the desiccant is filtered, and the organic solvent is removed by vacuum distillation to obtain a crude product.
The crude product is purified by column chromatography, recrystallization, etc. According to the physical and chemical properties of the product and impurities, a suitable eluent or solvent is selected to obtain pure 2-chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl) benzenesulfonamide. During the operation, pay attention to the control of conditions in each step to ensure the yield and purity of the product.
Appropriate starting materials are taken first, often based on compounds containing benzene rings. For example, a specific substituted benzenesulfonyl chloride reacts with a precursor containing an isoindole structure. The isoindole precursor needs to have suitable substituents for subsequent generation of 1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl moiety in the target structure.
During the reaction, in a suitable reaction vessel, an organic solvent such as dichloromethane, N, N-dimethylformamide, etc. is added to assist the dissolution of the raw materials and promote the reaction. Add an appropriate amount of bases, such as triethylamine, pyridine, etc. The function of bases is to neutralize the acid generated by the reaction and promote the forward progress of the reaction.
Temperature-controlled reaction, the temperature depends on the raw material and reaction characteristics, usually between room temperature and tens of degrees Celsius. The reaction lasts for several hours, during which the reaction process is monitored by thin-layer chromatography. When the raw materials are exhausted or the expected reaction degree is reached, the reaction is terminated.
After that, the reaction solution is post-processed. First, it is extracted with water and an organic solvent, and the organic phase is collected after stratification. Desiccants such as anhydrous sodium sulfate are removed from water, the desiccant is filtered, and the organic solvent is removed by vacuum distillation to obtain a crude product.
The crude product is purified by column chromatography, recrystallization, etc. According to the physical and chemical properties of the product and impurities, a suitable eluent or solvent is selected to obtain pure 2-chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl) benzenesulfonamide. During the operation, pay attention to the control of conditions in each step to ensure the yield and purity of the product.
What is the market outlook for 2-chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1h-isoindol-1-yl) benzenesulfonamide
2-Chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl) benzenesulfonamide is a rather complex organic compound. Looking at its market prospects, it needs to be examined in detail from multiple dimensions.
In the field of medicine, such compounds containing specific functional groups often have unique biological activities. Or they can be used as potential drug lead compounds, which are expected to be used to create new drugs after in-depth research and optimization. Nowadays, pharmaceutical research and development has a strong demand for compounds with novel structures and activities. If this compound can demonstrate significant pharmacological activities, such as anti-tumor, antibacterial, anti-inflammatory and other effects, and has good pharmacokinetic properties, it may be able to occupy a place in the drug market. However, the road of pharmaceutical research and development is full of obstacles, requiring rigorous clinical trials, high costs, and long cycles. It is difficult to determine whether it can be successfully marketed in the end.
In the chemical industry, it may be used as a synthetic intermediate. With its structural characteristics, it may be able to participate in a series of organic synthesis reactions to prepare other high-value-added fine chemicals. The chemical industry has a constant demand for characteristic intermediates. If large-scale stable production can be achieved and the cost is controllable, it may find its own value in the chemical industry chain. However, chemical production also needs to take into account environmental protection and safety, and needs to follow many regulations and standards in order to ensure sustainable development.
Furthermore, the market competition situation cannot be ignored. Globally, the field of chemical synthesis is active in research and development, and similar structural compounds either exist in the market or are in the process of research and development. In order for this compound to emerge in the market, it needs to have unique advantages, such as better activity, lower cost, and more environmentally friendly production processes.
In summary, the market prospect of 2-chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl) benzenesulfonamide, although there are opportunities, it also faces many challenges. Only through in-depth research and development, rational planning of production and precise market positioning can it be possible to gain a place in the market.
In the field of medicine, such compounds containing specific functional groups often have unique biological activities. Or they can be used as potential drug lead compounds, which are expected to be used to create new drugs after in-depth research and optimization. Nowadays, pharmaceutical research and development has a strong demand for compounds with novel structures and activities. If this compound can demonstrate significant pharmacological activities, such as anti-tumor, antibacterial, anti-inflammatory and other effects, and has good pharmacokinetic properties, it may be able to occupy a place in the drug market. However, the road of pharmaceutical research and development is full of obstacles, requiring rigorous clinical trials, high costs, and long cycles. It is difficult to determine whether it can be successfully marketed in the end.
In the chemical industry, it may be used as a synthetic intermediate. With its structural characteristics, it may be able to participate in a series of organic synthesis reactions to prepare other high-value-added fine chemicals. The chemical industry has a constant demand for characteristic intermediates. If large-scale stable production can be achieved and the cost is controllable, it may find its own value in the chemical industry chain. However, chemical production also needs to take into account environmental protection and safety, and needs to follow many regulations and standards in order to ensure sustainable development.
Furthermore, the market competition situation cannot be ignored. Globally, the field of chemical synthesis is active in research and development, and similar structural compounds either exist in the market or are in the process of research and development. In order for this compound to emerge in the market, it needs to have unique advantages, such as better activity, lower cost, and more environmentally friendly production processes.
In summary, the market prospect of 2-chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl) benzenesulfonamide, although there are opportunities, it also faces many challenges. Only through in-depth research and development, rational planning of production and precise market positioning can it be possible to gain a place in the market.
2-Chloro-5- (1-hydroxy-3-oxo-2, 3-dihydro-1h-isoindol-1-yl) benzenesulfonamide
2-Chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl) benzenesulfonamide, this is a chemical substance, and its safety precautions need to be paid attention to in detail.
First, this substance may be toxic. During operation, you must wear suitable protective equipment, such as laboratory clothes, gloves and goggles, to prevent skin contact, inhalation or accidental ingestion. In case of inadvertent contact, rinse immediately with plenty of water and, if necessary, seek medical assistance immediately.
Second, operate in a well-ventilated area. Because it may evaporate harmful gases, good ventilation can reduce the concentration of harmful substances in the air and reduce the risk of inhalation. If conditions permit, it is advisable to operate in a fume hood.
Third, when storing, it should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Many chemical substances are exposed to heat, open flames or oxidants, which can easily cause fire or explosion. At the same time, it should be stored separately from other chemical substances to avoid mutual reaction.
Fourth, after the operation is completed, be sure to thoroughly clean the appliances and working areas used to prevent residual substances from affecting subsequent experiments or the environment. For the discarded substance, it should also be properly disposed of in accordance with relevant regulations, and must not be discarded at will.
In short, when treating chemicals such as 2-chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl) benzenesulfonamide, we should adhere to a rigorous scientific attitude and strictly follow safety operating procedures to ensure personal safety and environmental safety.
First, this substance may be toxic. During operation, you must wear suitable protective equipment, such as laboratory clothes, gloves and goggles, to prevent skin contact, inhalation or accidental ingestion. In case of inadvertent contact, rinse immediately with plenty of water and, if necessary, seek medical assistance immediately.
Second, operate in a well-ventilated area. Because it may evaporate harmful gases, good ventilation can reduce the concentration of harmful substances in the air and reduce the risk of inhalation. If conditions permit, it is advisable to operate in a fume hood.
Third, when storing, it should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Many chemical substances are exposed to heat, open flames or oxidants, which can easily cause fire or explosion. At the same time, it should be stored separately from other chemical substances to avoid mutual reaction.
Fourth, after the operation is completed, be sure to thoroughly clean the appliances and working areas used to prevent residual substances from affecting subsequent experiments or the environment. For the discarded substance, it should also be properly disposed of in accordance with relevant regulations, and must not be discarded at will.
In short, when treating chemicals such as 2-chloro-5- (1-hydroxy-3-oxo-2,3-dihydro-1H-isoindole-1-yl) benzenesulfonamide, we should adhere to a rigorous scientific attitude and strictly follow safety operating procedures to ensure personal safety and environmental safety.
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