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2-Chloro-5-Bromofluorobenzene
Linshang Chemical
|
HS Code |
750125 |
| Chemical Formula | C6H3BrClF |
| Molar Mass | 225.44 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approx. 190 - 192 °C |
| Density | Around 1.8 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like dichloromethane, ether |
| Flash Point | Approx. 75 °C |
| Odor | Pungent |
As an accredited 2-Chloro-5-Bromofluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle of 2 - chloro - 5 - bromofluorobenzene, securely sealed. |
| Storage | 2 - chloro - 5 - bromofluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, strong acids, and bases to prevent chemical reactions. Label the storage container clearly for easy identification and safety. |
| Shipping | 2 - chloro - 5 - bromofluorobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported by approved carriers following strict hazardous chemical shipping regulations to ensure safety during transit. |
Competitive 2-Chloro-5-Bromofluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What is the chemistry of 2-chloro-5-bromofluorobenzene?
2-Chloro-5-bromo fluorobenzene is also an organic compound. Among its molecules, above the benzene ring, there are chlorine atoms, bromine atoms and fluorine atoms attached. These three occupy positions, each has a fixed position, chlorine is at the two position, bromine is at the five position, and fluorine is also on the ring.
On its chemical properties, it has many characteristics due to halogen atoms. First, the nature of nucleophilic substitution. Due to the large electronegativity of halogen atoms, the electron cloud density of the benzene ring decreases, especially in the adjacent position, which is easy to be attacked by nucleophilic reagents. When the nucleophilic reagent approaches, the halogen atom can carry electrons away, and the nucleophilic reagent takes its place.
Second, the activity of halogen atoms is different Usually, the fluorine atom is slightly difficult to leave due to the high carbon-fluorine bond energy; the carbon-halogen bond energy formed by bromine and chlorine atom is slightly lower, and it is relatively easy to leave. In the substitution reaction, the activity of bromine and chlorine atoms is higher than that of fluorine.
Third, the aromaticity still exists. Although there are halogen atoms, the benzene ring conjugated system has not been greatly damaged, so it still has the commonality of aromatic compounds, such as electrophilic substitution reaction. However, the halogen atom is a blunt group, which will reduce the reactivity slightly compared with benzene.
Fourth, in the redox reaction, 2-chloro-5-bromobenzene also exhibits. Under suitable conditions, halogen atoms can be reduced and removed, or benzene rings can be oxidized, but such reactions require specific reagents and conditions to achieve.
On its chemical properties, it has many characteristics due to halogen atoms. First, the nature of nucleophilic substitution. Due to the large electronegativity of halogen atoms, the electron cloud density of the benzene ring decreases, especially in the adjacent position, which is easy to be attacked by nucleophilic reagents. When the nucleophilic reagent approaches, the halogen atom can carry electrons away, and the nucleophilic reagent takes its place.
Second, the activity of halogen atoms is different Usually, the fluorine atom is slightly difficult to leave due to the high carbon-fluorine bond energy; the carbon-halogen bond energy formed by bromine and chlorine atom is slightly lower, and it is relatively easy to leave. In the substitution reaction, the activity of bromine and chlorine atoms is higher than that of fluorine.
Third, the aromaticity still exists. Although there are halogen atoms, the benzene ring conjugated system has not been greatly damaged, so it still has the commonality of aromatic compounds, such as electrophilic substitution reaction. However, the halogen atom is a blunt group, which will reduce the reactivity slightly compared with benzene.
Fourth, in the redox reaction, 2-chloro-5-bromobenzene also exhibits. Under suitable conditions, halogen atoms can be reduced and removed, or benzene rings can be oxidized, but such reactions require specific reagents and conditions to achieve.
What are the main uses of 2-chloro-5-bromofluorobenzene?
2-Chloro-5-bromofluorobenzene is an important member of organic compounds. Its uses are quite extensive and will be described in detail today.
In the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of drugs. Due to its unique structure, it contains halogen atoms such as chlorine, bromine, and fluorine. It can be combined with many active groups by organic synthesis to generate drug molecules with specific pharmacological activities. For example, in the preparation of some antibacterial and antiviral drugs, 2-chloro-5-bromofluorobenzene may be used as one of the starting materials. After a series of reactions, the core skeleton of the drug is built, which is essential for improving the efficacy of the drug and optimizing the pharmacokinetic properties.
In the field of materials science, it also plays an important role. In the preparation of high-performance organic optoelectronic materials, the electronic and spatial effects of halogen atoms can regulate the electronic transport properties and luminescence properties of the materials. Such as the preparation of organic Light Emitting Diode (OLED) materials, the introduction of 2-chloro-5-bromofluorobenzene may improve the luminous efficiency and stability of the material, so that the OLED device presents better display performance.
Furthermore, in the field of pesticide chemistry, this compound has also been applied. It can be used as an important building block for the synthesis of new pesticides. Its structural characteristics can be used to design and synthesize pesticide varieties with high efficiency and environmental friendliness against specific pests. Due to its halogen atom properties, it may enhance the interaction between pesticide molecules and target check points in pests, and improve the biological activity and shelf life of pesticides.
Overall, 2-chloro-5-bromofluorobenzene has important uses in many fields such as medicine, materials, and pesticides, and has made great contributions to promoting the development of various fields.
In the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of drugs. Due to its unique structure, it contains halogen atoms such as chlorine, bromine, and fluorine. It can be combined with many active groups by organic synthesis to generate drug molecules with specific pharmacological activities. For example, in the preparation of some antibacterial and antiviral drugs, 2-chloro-5-bromofluorobenzene may be used as one of the starting materials. After a series of reactions, the core skeleton of the drug is built, which is essential for improving the efficacy of the drug and optimizing the pharmacokinetic properties.
In the field of materials science, it also plays an important role. In the preparation of high-performance organic optoelectronic materials, the electronic and spatial effects of halogen atoms can regulate the electronic transport properties and luminescence properties of the materials. Such as the preparation of organic Light Emitting Diode (OLED) materials, the introduction of 2-chloro-5-bromofluorobenzene may improve the luminous efficiency and stability of the material, so that the OLED device presents better display performance.
Furthermore, in the field of pesticide chemistry, this compound has also been applied. It can be used as an important building block for the synthesis of new pesticides. Its structural characteristics can be used to design and synthesize pesticide varieties with high efficiency and environmental friendliness against specific pests. Due to its halogen atom properties, it may enhance the interaction between pesticide molecules and target check points in pests, and improve the biological activity and shelf life of pesticides.
Overall, 2-chloro-5-bromofluorobenzene has important uses in many fields such as medicine, materials, and pesticides, and has made great contributions to promoting the development of various fields.
What are 2-chloro-5-bromofluorobenzene synthesis methods?
The method of preparing 2-chloro-5-bromofluorobenzene relies on the technique of organic synthesis. One method can start from fluorobenzene. First, brominate the fluorobenzene with a brominating agent, such as liquid bromine and iron bromide, to obtain 5-bromofluorobenzene. This reaction is based on the principle of electrophilic substitution. Bromine ions are attracted by the electron cloud of the benzene ring and form bonds at specific positions.
Then, 5-bromofluorobenzene is chlorinated with a chlorinating agent, such as chlorine gas and iron chloride. After controlling the reaction conditions, such as temperature, reagent ratio, reaction time, etc., the chlorine atom is substituted at just the second position, and the final product is 2-chloro-5-bromofluorobenzene. In this process, each step of the reaction needs to be carefully operated, because the activity and selectivity of the halogenation reaction need to be precisely controlled.
There are other methods, which can be started from suitable phenolic derivatives. First, the phenolic hydroxyl group is converted into an easy-to-leave group, and then through a series of reactions such as halogenation and fluorination, bromine, chlorine, and fluorine atoms are gradually introduced, and the target product can also be obtained. However, this path, steps may be more complicated, and the reaction sequence and conditions of each step need to be carefully planned to avoid the clump of side reactions and ensure the purity The method of preparing 2-chloro-5-bromofluorobenzene has its own advantages and disadvantages, and it is necessary to choose the appropriate one according to the actual needs and conditions.
Then, 5-bromofluorobenzene is chlorinated with a chlorinating agent, such as chlorine gas and iron chloride. After controlling the reaction conditions, such as temperature, reagent ratio, reaction time, etc., the chlorine atom is substituted at just the second position, and the final product is 2-chloro-5-bromofluorobenzene. In this process, each step of the reaction needs to be carefully operated, because the activity and selectivity of the halogenation reaction need to be precisely controlled.
There are other methods, which can be started from suitable phenolic derivatives. First, the phenolic hydroxyl group is converted into an easy-to-leave group, and then through a series of reactions such as halogenation and fluorination, bromine, chlorine, and fluorine atoms are gradually introduced, and the target product can also be obtained. However, this path, steps may be more complicated, and the reaction sequence and conditions of each step need to be carefully planned to avoid the clump of side reactions and ensure the purity The method of preparing 2-chloro-5-bromofluorobenzene has its own advantages and disadvantages, and it is necessary to choose the appropriate one according to the actual needs and conditions.
What are the precautions in storage and transportation of 2-chloro-5-bromofluorobenzene?
2-Chloro-5-bromofluorobenzene is also an organic compound. When storing and transporting, be sure to pay attention to many matters to ensure safety.
First storage, this compound should be placed in a cool and ventilated warehouse. Cover because of its nature or affected by temperature and humidity, high temperature or humidity, it is easy to cause deterioration or cause danger. The warehouse temperature should be controlled within an appropriate range, not too high, to prevent it from evaporating or chemical reactions. And it must be kept away from fire and heat sources, both of which can cause it to burn or even explode, endangering the safety of the surrounding area.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to its lively chemical properties, it is very likely that a violent chemical reaction will occur when it encounters the above-mentioned objects, resulting in serious consequences. At the same time, the storage area should be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time to reduce harm.
As for transportation, there are also many details. Before transportation, make sure that the packaging is complete and well sealed. If the packaging is damaged, 2-chloro-5-bromofluorobenzene is easy to leak, pollute the environment and endanger personal safety. During transportation, make sure that the container does not leak, collapse, fall, or damage. The transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment.
In addition, when transporting, you should follow the specified route and do not stop in densely populated areas and residential areas. In the event of an accident, the harm will be magnified in densely populated areas, causing incalculable losses. And transportation personnel must also have professional knowledge, familiar with the characteristics of this compound and emergency treatment methods, in case of emergencies, they can properly deal with it.
In short, 2-chloro-5-bromofluorobenzene must strictly follow relevant regulations and requirements during storage and transportation, and act with caution, so as to ensure the safety of personnel and the environment is not damaged.
First storage, this compound should be placed in a cool and ventilated warehouse. Cover because of its nature or affected by temperature and humidity, high temperature or humidity, it is easy to cause deterioration or cause danger. The warehouse temperature should be controlled within an appropriate range, not too high, to prevent it from evaporating or chemical reactions. And it must be kept away from fire and heat sources, both of which can cause it to burn or even explode, endangering the safety of the surrounding area.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to its lively chemical properties, it is very likely that a violent chemical reaction will occur when it encounters the above-mentioned objects, resulting in serious consequences. At the same time, the storage area should be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time to reduce harm.
As for transportation, there are also many details. Before transportation, make sure that the packaging is complete and well sealed. If the packaging is damaged, 2-chloro-5-bromofluorobenzene is easy to leak, pollute the environment and endanger personal safety. During transportation, make sure that the container does not leak, collapse, fall, or damage. The transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment.
In addition, when transporting, you should follow the specified route and do not stop in densely populated areas and residential areas. In the event of an accident, the harm will be magnified in densely populated areas, causing incalculable losses. And transportation personnel must also have professional knowledge, familiar with the characteristics of this compound and emergency treatment methods, in case of emergencies, they can properly deal with it.
In short, 2-chloro-5-bromofluorobenzene must strictly follow relevant regulations and requirements during storage and transportation, and act with caution, so as to ensure the safety of personnel and the environment is not damaged.
2-chloro-5-bromofluorobenzene impact on the environment and human health
2-Chloro-5-bromofluorobenzene is a genus of organohalogenated aromatic hydrocarbons. Its impact on the environment and human health is of particular concern.
At the environmental end, 2-chloro-5-bromofluorobenzene has high chemical stability and is not easily degraded by natural processes, so it is easy to accumulate in the environment. If released into soil, it can seep into groundwater, causing water pollution and endangering water sources. In aquatic ecosystems, this substance may harm aquatic organisms and cause biodiversity loss. Aquatic animals may be hindered by physiological disorders, development and reproduction. And there is a risk of biomagnification in the food chain, from low-level organisms to high-level organisms, the concentration is gradually increasing, and the harm is even greater.
As for human health, 2-chloro-5-bromofluorobenzene may damage multiple organ systems after being exposed to the body through respiration, diet or skin contact. It may irritate the respiratory tract, cause cough, asthma and other diseases, long-term exposure, or even increase the risk of respiratory diseases. In the nervous system, it may cause dizziness, fatigue, insomnia, etc., interfere with nerve conduction, affect cognition and normal function of the nervous system. Studies have also shown that it has potential carcinogenicity, long-term exposure, or cause cell mutation, causing cancer. And because it is fat-soluble, it is easy to accumulate in human adipose tissue, and gradually accumulate and cause harm, which is endless.
In conclusion, 2-chloro-5-bromofluorobenzene poses significant hazards to the environment and human health, and should be strictly controlled in all aspects of production, use and disposal to reduce its adverse effects on ecology and human health.
At the environmental end, 2-chloro-5-bromofluorobenzene has high chemical stability and is not easily degraded by natural processes, so it is easy to accumulate in the environment. If released into soil, it can seep into groundwater, causing water pollution and endangering water sources. In aquatic ecosystems, this substance may harm aquatic organisms and cause biodiversity loss. Aquatic animals may be hindered by physiological disorders, development and reproduction. And there is a risk of biomagnification in the food chain, from low-level organisms to high-level organisms, the concentration is gradually increasing, and the harm is even greater.
As for human health, 2-chloro-5-bromofluorobenzene may damage multiple organ systems after being exposed to the body through respiration, diet or skin contact. It may irritate the respiratory tract, cause cough, asthma and other diseases, long-term exposure, or even increase the risk of respiratory diseases. In the nervous system, it may cause dizziness, fatigue, insomnia, etc., interfere with nerve conduction, affect cognition and normal function of the nervous system. Studies have also shown that it has potential carcinogenicity, long-term exposure, or cause cell mutation, causing cancer. And because it is fat-soluble, it is easy to accumulate in human adipose tissue, and gradually accumulate and cause harm, which is endless.
In conclusion, 2-chloro-5-bromofluorobenzene poses significant hazards to the environment and human health, and should be strictly controlled in all aspects of production, use and disposal to reduce its adverse effects on ecology and human health.
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