Linshang Chemical
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2-Chloro-5-Fluorobenzeneamine
Linshang Chemical
|
HS Code |
442582 |
| Chemical Formula | C6H5ClFN |
| Molar Mass | 145.56 g/mol |
| Appearance | Solid (usually) |
| Color | Typically white to off - white |
| Odor | Characteristic amine - like odor |
| Melting Point | Data may vary, but in a certain range |
| Boiling Point | Data may vary depending on conditions |
| Solubility In Water | Poorly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, dichloromethane |
| Density | Specific value depending on conditions |
| Pka | Value related to its acidic - basic properties |
| Flash Point | Value indicating flammability risk |
As an accredited 2-Chloro-5-Fluorobenzeneamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 2 - chloro - 5 - fluorobenzeneamine packaged in 100 - gram bottles. |
| Storage | 2 - chloro - 5 - fluorobenzeneamine should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store it in a tightly - sealed container to prevent moisture absorption and evaporation. Due to its potential toxicity, ensure the storage location is out of reach of children and unauthorized personnel. |
| Shipping | 2 - chloro - 5 - fluorobenzeneamine is shipped in tightly sealed, corrosion - resistant containers. It must be transported in accordance with hazardous chemical regulations, ensuring proper handling to prevent spills and exposure during transit. |
Competitive 2-Chloro-5-Fluorobenzeneamine prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Chloro-5-Fluorobenzeneamine in China?
As a trusted 2-Chloro-5-Fluorobenzeneamine manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-5-Fluorobenzeneamine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-5-fluorobenzeneamine?
2-Chloro-5-fluorobenzamide is a class of organic compounds. It has a wide range of uses and has important applications in many fields.
In the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of new drugs. Due to the introduction of chlorine and fluorine atoms on the benzene ring, the physical and chemical properties of the molecule, such as lipophilicity and stability, can be significantly changed, which in turn affects the interaction between the drug and the target. With this as a starting material, through a series of chemical reactions, molecular structures with specific pharmacological activities can be constructed, which can be used as antibacterial drugs or as a good drug for the treatment of nervous system diseases, contributing to the process of medical research and new drug development.
In the field of materials science, 2-chloro-5-fluorobenzamine also has certain value. It can participate in the synthesis of polymer materials and endow materials with unique properties. For example, introducing this structural unit into polymers can improve the electrical and optical properties of materials, or enhance their mechanical strength and chemical stability to meet the special needs of different engineering materials. It is used in electronic devices, optical instruments and many other fields.
In addition, in the fine chemical industry, it is often used as a raw material for the preparation of special chemicals. With its unique chemical structure, it can be converted into compounds with special functions through various reactions, such as special dyes, fragrances, additives, etc., providing assistance for the diversification of fine chemical products and enriching the various fine chemicals required by people's daily lives.
In short, although 2-chloro-5-fluorobenzamine is an organic small molecule, it plays an indispensable role in many fields such as medicine, materials, and fine chemicals, and is of great significance to promote the development of various industries.
In the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of new drugs. Due to the introduction of chlorine and fluorine atoms on the benzene ring, the physical and chemical properties of the molecule, such as lipophilicity and stability, can be significantly changed, which in turn affects the interaction between the drug and the target. With this as a starting material, through a series of chemical reactions, molecular structures with specific pharmacological activities can be constructed, which can be used as antibacterial drugs or as a good drug for the treatment of nervous system diseases, contributing to the process of medical research and new drug development.
In the field of materials science, 2-chloro-5-fluorobenzamine also has certain value. It can participate in the synthesis of polymer materials and endow materials with unique properties. For example, introducing this structural unit into polymers can improve the electrical and optical properties of materials, or enhance their mechanical strength and chemical stability to meet the special needs of different engineering materials. It is used in electronic devices, optical instruments and many other fields.
In addition, in the fine chemical industry, it is often used as a raw material for the preparation of special chemicals. With its unique chemical structure, it can be converted into compounds with special functions through various reactions, such as special dyes, fragrances, additives, etc., providing assistance for the diversification of fine chemical products and enriching the various fine chemicals required by people's daily lives.
In short, although 2-chloro-5-fluorobenzamine is an organic small molecule, it plays an indispensable role in many fields such as medicine, materials, and fine chemicals, and is of great significance to promote the development of various industries.
What are the physical properties of 2-chloro-5-fluorobenzeneamine?
2-Chloro-5-fluorobenzamine is one of the organic compounds. Its physical properties are quite characteristic and it is related to many applications.
This compound is mostly solid at room temperature, and its appearance is usually white to white-like crystalline powder. Looking at its color, the pure one is white. If it contains impurities, the color may vary. The texture is delicate and the touch is smooth.
The melting point is quite critical. Its melting point is about a specific temperature range, and this temperature range has a great impact on its purification, identification and application. When the temperature rises to the melting point, 2-chloro-5-fluorobenzamine gradually melts from a solid state to a liquid state. This transition process is an important consideration in many chemical process operations.
Solubility is also its significant physical property. In organic solvents, such as ethanol and ether, it has a certain solubility. For ethanol, polar organic solvents are also polar organic solvents. Due to its own structural characteristics, 2-chloro-5-fluorobenzamine can form a specific interaction with ethanol molecules, thereby dissolving it. In water, its solubility is relatively small, because the proportion of organic groups in the molecular structure is relatively large, and the force between it and water molecules is weak.
Density is also a property that cannot be ignored. Its density is determined by the molecular structure and the arrangement of molecules, which is of great significance to application scenarios involving the relationship between mass and volume. In terms of material measurement and reaction system ratio in chemical production, density data provides a basis for precise operation.
In addition, its volatility is low, and it is not easy to volatilize into gas escape at room temperature and pressure. This property can reduce losses and safety risks caused by volatilization during storage and use.
The physical properties of 2-chloro-5-fluorobenzamide are of great significance in the fields of organic synthesis, drug research and development, and lay the foundation for related work.
This compound is mostly solid at room temperature, and its appearance is usually white to white-like crystalline powder. Looking at its color, the pure one is white. If it contains impurities, the color may vary. The texture is delicate and the touch is smooth.
The melting point is quite critical. Its melting point is about a specific temperature range, and this temperature range has a great impact on its purification, identification and application. When the temperature rises to the melting point, 2-chloro-5-fluorobenzamine gradually melts from a solid state to a liquid state. This transition process is an important consideration in many chemical process operations.
Solubility is also its significant physical property. In organic solvents, such as ethanol and ether, it has a certain solubility. For ethanol, polar organic solvents are also polar organic solvents. Due to its own structural characteristics, 2-chloro-5-fluorobenzamine can form a specific interaction with ethanol molecules, thereby dissolving it. In water, its solubility is relatively small, because the proportion of organic groups in the molecular structure is relatively large, and the force between it and water molecules is weak.
Density is also a property that cannot be ignored. Its density is determined by the molecular structure and the arrangement of molecules, which is of great significance to application scenarios involving the relationship between mass and volume. In terms of material measurement and reaction system ratio in chemical production, density data provides a basis for precise operation.
In addition, its volatility is low, and it is not easy to volatilize into gas escape at room temperature and pressure. This property can reduce losses and safety risks caused by volatilization during storage and use.
The physical properties of 2-chloro-5-fluorobenzamide are of great significance in the fields of organic synthesis, drug research and development, and lay the foundation for related work.
What are the chemical properties of 2-chloro-5-fluorobenzeneamine?
2-Chloro-5-fluoroaniline is an organic compound. It has many chemical properties and is crucial in the field of organic synthesis.
Looking at its structure, chlorine and fluorine atoms are connected to the benzene ring, and the amino group is also on the benzene ring. Due to the presence of halogen atoms and amino groups, this compound exhibits unique reactivity.
As far as nucleophilic substitution is concerned, the chlorine atom on the benzene ring can be replaced by many nucleophilic reagents. For example, under suitable conditions, nucleophilic reagents such as hydroxyl groups and alkoxy groups can react with it to form new compounds. This is because the electronegativity of chlorine atoms and the conjugation effect of benzene rings make its carbon-chlorine bonds have a certain polarity and are more vulnerable to attack by nucleophilic
As for the electrophilic substitution reaction, the amino group is the donor group, which can increase the electron cloud density of the benzene ring, especially the amino ortho and para-position. Therefore, in the electrophilic substitution reaction, the electrophilic reagents are more inclined to attack the amino ortho and para-position. However, chlorine and fluorine atoms are electron-withdrawing groups, which will reduce the electron cloud density of the benzene ring. However, due to the relatively strong ability of the amino group to supply electricity, the benzene ring is still relatively active as a whole, and electrophilic substitution reactions such as nitrification, halogenation, and sulfonation can occur.
2-chloro-5-fluoroaniline can also participate in the coupling reaction For example, under the catalysis of transition metals, it is coupled with halogenated aromatics or other organic halides to form carbon-carbon bonds, thereby expanding the molecular structure, which is of great significance in the fields of drug synthesis and materials science.
In addition, its amino group is basic and can react with acids to form salts. This property allows it to improve solubility and reactivity by salt formation in some reaction systems, and also helps in the separation and purification of compounds.
2-chloro-5-fluoroaniline has become an important intermediate in organic synthesis due to its chemical properties, and is widely used in the preparation of compounds in many fields such as medicine, pesticides, and dyes.
Looking at its structure, chlorine and fluorine atoms are connected to the benzene ring, and the amino group is also on the benzene ring. Due to the presence of halogen atoms and amino groups, this compound exhibits unique reactivity.
As far as nucleophilic substitution is concerned, the chlorine atom on the benzene ring can be replaced by many nucleophilic reagents. For example, under suitable conditions, nucleophilic reagents such as hydroxyl groups and alkoxy groups can react with it to form new compounds. This is because the electronegativity of chlorine atoms and the conjugation effect of benzene rings make its carbon-chlorine bonds have a certain polarity and are more vulnerable to attack by nucleophilic
As for the electrophilic substitution reaction, the amino group is the donor group, which can increase the electron cloud density of the benzene ring, especially the amino ortho and para-position. Therefore, in the electrophilic substitution reaction, the electrophilic reagents are more inclined to attack the amino ortho and para-position. However, chlorine and fluorine atoms are electron-withdrawing groups, which will reduce the electron cloud density of the benzene ring. However, due to the relatively strong ability of the amino group to supply electricity, the benzene ring is still relatively active as a whole, and electrophilic substitution reactions such as nitrification, halogenation, and sulfonation can occur.
2-chloro-5-fluoroaniline can also participate in the coupling reaction For example, under the catalysis of transition metals, it is coupled with halogenated aromatics or other organic halides to form carbon-carbon bonds, thereby expanding the molecular structure, which is of great significance in the fields of drug synthesis and materials science.
In addition, its amino group is basic and can react with acids to form salts. This property allows it to improve solubility and reactivity by salt formation in some reaction systems, and also helps in the separation and purification of compounds.
2-chloro-5-fluoroaniline has become an important intermediate in organic synthesis due to its chemical properties, and is widely used in the preparation of compounds in many fields such as medicine, pesticides, and dyes.
What are 2-chloro-5-fluorobenzeneamine synthesis methods?
To prepare 2-chloro-5-fluorobenzamide, there are several common methods as follows.
First, it can be started from 2-chloro-5-fluorobenzoic acid. The acid is first heated with dichlorosulfoxide to convert it into the corresponding acid chloride. The acid chloride reacts with sodium azide in a suitable solvent to form an acyl azide. Then, through the Curtius rearrangement reaction, the isocyanate intermediate can be obtained. The intermediate is then treated with water or alcohol, and finally hydrolyzed or alcoholized to obtain 2-chloro-5-fluorobenzamide. Although this pathway step is complex, the reaction conditions of each step are relatively mild and the yield is acceptable.
Second, starting from 2-chloro-5-fluorobrobenzene. First, the Grignard reagent is prepared in anhydrous ether with magnesium chips, and then reacted with nitrile compounds, such as acetonitrile, to form ketones. The ketone is then reduced by reducing agents such as sodium borohydride or lithium aluminum hydride, and the target product 2-chloro-5-fluorobenzamide can also be obtained. In this way, it should be noted that the preparation conditions of Grignard reagent are strict, and the anhydrous and anaerobic environment is required, and the reducing agent and reaction conditions should be carefully selected according to the characteristics of the substrate.
Third, the amination reaction catalyzed by Using 2-chloro-5-fluorohalobenzene as a raw material, with a suitable amine source, such as ammonia or amine derivatives, under the catalysis of palladium catalysts, such as tetra (triphenylphosphine) palladium, etc., in the presence of bases. This method is efficient and convenient, but the catalyst cost is high, and the reaction equipment and operation requirements are also high. It is necessary to precisely control the reaction temperature, pressure and other conditions to obtain the ideal yield.
First, it can be started from 2-chloro-5-fluorobenzoic acid. The acid is first heated with dichlorosulfoxide to convert it into the corresponding acid chloride. The acid chloride reacts with sodium azide in a suitable solvent to form an acyl azide. Then, through the Curtius rearrangement reaction, the isocyanate intermediate can be obtained. The intermediate is then treated with water or alcohol, and finally hydrolyzed or alcoholized to obtain 2-chloro-5-fluorobenzamide. Although this pathway step is complex, the reaction conditions of each step are relatively mild and the yield is acceptable.
Second, starting from 2-chloro-5-fluorobrobenzene. First, the Grignard reagent is prepared in anhydrous ether with magnesium chips, and then reacted with nitrile compounds, such as acetonitrile, to form ketones. The ketone is then reduced by reducing agents such as sodium borohydride or lithium aluminum hydride, and the target product 2-chloro-5-fluorobenzamide can also be obtained. In this way, it should be noted that the preparation conditions of Grignard reagent are strict, and the anhydrous and anaerobic environment is required, and the reducing agent and reaction conditions should be carefully selected according to the characteristics of the substrate.
Third, the amination reaction catalyzed by Using 2-chloro-5-fluorohalobenzene as a raw material, with a suitable amine source, such as ammonia or amine derivatives, under the catalysis of palladium catalysts, such as tetra (triphenylphosphine) palladium, etc., in the presence of bases. This method is efficient and convenient, but the catalyst cost is high, and the reaction equipment and operation requirements are also high. It is necessary to precisely control the reaction temperature, pressure and other conditions to obtain the ideal yield.
2-chloro-5-fluorobenzeneamine need to pay attention to when storing and transporting
2-Chloro-5-fluorobenzamide is an organic compound. When storing and transporting, many matters need to be paid attention to.
When storing, the first environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. This is because the compound is heated or exposed to open flames, or there is a risk of combustion and explosion. The temperature of the warehouse should be controlled within a suitable range to prevent its properties from changing due to excessive temperature.
Furthermore, it should be stored separately from oxidants, acids, food chemicals, etc., and should not be mixed. Due to its active chemical properties, contact with oxidants, etc., or severe chemical reactions, resulting in danger. And suitable materials should be prepared to contain leaks to prevent accidental leakage and difficult to deal with in time.
When transporting, the packaging must be firm. According to its hazard characteristics, choose appropriate packaging materials and methods to ensure that no leakage is caused during transportation. During transportation, also ensure that the container does not leak, collapse, fall or damage.
Transportation vehicles should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. Driving routes should avoid sensitive areas such as densely populated areas and water source protection areas. Transportation personnel also need to undergo professional training, familiar with its hazard characteristics and emergency treatment methods, and pay close attention during transportation to ensure transportation safety.
When storing, the first environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. This is because the compound is heated or exposed to open flames, or there is a risk of combustion and explosion. The temperature of the warehouse should be controlled within a suitable range to prevent its properties from changing due to excessive temperature.
Furthermore, it should be stored separately from oxidants, acids, food chemicals, etc., and should not be mixed. Due to its active chemical properties, contact with oxidants, etc., or severe chemical reactions, resulting in danger. And suitable materials should be prepared to contain leaks to prevent accidental leakage and difficult to deal with in time.
When transporting, the packaging must be firm. According to its hazard characteristics, choose appropriate packaging materials and methods to ensure that no leakage is caused during transportation. During transportation, also ensure that the container does not leak, collapse, fall or damage.
Transportation vehicles should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. Driving routes should avoid sensitive areas such as densely populated areas and water source protection areas. Transportation personnel also need to undergo professional training, familiar with its hazard characteristics and emergency treatment methods, and pay close attention during transportation to ensure transportation safety.
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