Linshang Chemical
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2-Chloro-5-Fluorobromobenzene
Linshang Chemical
|
HS Code |
243187 |
| Chemical Formula | C6H3BrClF |
| Molecular Weight | 225.44 |
| Appearance | Liquid (expected, based on similar compounds) |
| Solubility In Water | Low (due to non - polar nature of benzene ring and hydrophobic halogens) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Low (due to relatively high molecular weight and intermolecular forces) |
| Hazard Class | Harmful (halogenated organics can be toxic) |
As an accredited 2-Chloro-5-Fluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 5 - fluorobromobenzene packaged in a sealed glass bottle. |
| Storage | 2 - chloro - 5 - fluorobromobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store it in a tightly sealed container, preferably made of corrosion - resistant materials like glass. Label the container clearly with its name and hazard information to prevent misidentification. |
| Shipping | 2 - chloro - 5 - fluorobromobenzene is shipped in tightly sealed, corrosion - resistant containers. It must be labeled clearly as a hazardous chemical. Shipment follows strict regulations to ensure safety during transit. |
Competitive 2-Chloro-5-Fluorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What is the chemistry of 2-chloro-5-fluorobromobenzene?
2-Chloro-5-fluorobromobenzene is one of the organohalogenated aromatic hydrocarbons. It has unique chemical properties and is crucial in the field of organic synthesis.
Let's talk about its reactivity first. Due to the difference in electronegativity of halogen atoms, the activities of bromine, chlorine and fluorine atoms in this compound are different. Usually, bromine atoms are relatively active, and in nucleophilic substitution reactions, they are more likely to be attacked and left by nucleophiles. For example, under appropriate basic conditions and the presence of nucleophiles, bromine atoms can be replaced by nucleophiles such as alkoxides and amines to generate new organic compounds. This is a common means of constructing carbon-heteroatomic bonds.
Although chlorine atoms are less active than bromine atoms, they can also participate in the reaction under certain conditions. For example, under the action of high temperature, strong polar solvents and suitable catalysts, chlorine atoms can undergo nucleophilic substitution, providing the possibility for the synthesis of various organic molecules.
Fluorine atoms are relatively stable due to their extremely high electronegativity, large carbon-fluorine bond energy, and are difficult to be replaced under normal conditions. However, with the help of some special reagents and reaction conditions, such as the use of reagents with strong nucleophilicity and specific structures, or in fluorine-containing transition metal catalytic systems, carbon-fluorine bonds can also be activated and transformed, thereby introducing fluorine-containing functional groups and endowing the products with unique physical and chemical properties, such as improving the lipid solubility and stability of compounds.
The coexistence of multiple halogen atoms in 2-chloro-5-fluorobromobenzene brings complexity and diversity to its reaction. Different halogen atoms can be selectively converted by rationally designing the reaction sequence and conditions according to needs, creating conditions for the synthesis of complex organic compounds with specific functions. It is widely used in medicinal chemistry, materials science and other fields.
Let's talk about its reactivity first. Due to the difference in electronegativity of halogen atoms, the activities of bromine, chlorine and fluorine atoms in this compound are different. Usually, bromine atoms are relatively active, and in nucleophilic substitution reactions, they are more likely to be attacked and left by nucleophiles. For example, under appropriate basic conditions and the presence of nucleophiles, bromine atoms can be replaced by nucleophiles such as alkoxides and amines to generate new organic compounds. This is a common means of constructing carbon-heteroatomic bonds.
Although chlorine atoms are less active than bromine atoms, they can also participate in the reaction under certain conditions. For example, under the action of high temperature, strong polar solvents and suitable catalysts, chlorine atoms can undergo nucleophilic substitution, providing the possibility for the synthesis of various organic molecules.
Fluorine atoms are relatively stable due to their extremely high electronegativity, large carbon-fluorine bond energy, and are difficult to be replaced under normal conditions. However, with the help of some special reagents and reaction conditions, such as the use of reagents with strong nucleophilicity and specific structures, or in fluorine-containing transition metal catalytic systems, carbon-fluorine bonds can also be activated and transformed, thereby introducing fluorine-containing functional groups and endowing the products with unique physical and chemical properties, such as improving the lipid solubility and stability of compounds.
The coexistence of multiple halogen atoms in 2-chloro-5-fluorobromobenzene brings complexity and diversity to its reaction. Different halogen atoms can be selectively converted by rationally designing the reaction sequence and conditions according to needs, creating conditions for the synthesis of complex organic compounds with specific functions. It is widely used in medicinal chemistry, materials science and other fields.
What are the common uses of 2-chloro-5-fluorobromobenzene?
2-Chloro-5-fluorobromobenzene is an important intermediate commonly used in the field of organic synthesis, and is widely used in medicine, pesticides, materials and other industries. Its common preparation routes are as follows:
First, halogenation reaction. Using 2-chloro-5-fluorobenzene as the starting material, 2-chloro-5-fluorobromobenzene can be prepared by bromination reaction. This reaction is often carried out with liquid bromine as the brominating reagent in the presence of appropriate catalysts (such as iron powder, iron tribromide, etc.). Iron reacts with bromine to form iron tribromide, which acts as a catalyst to replace hydrogen atoms at specific positions on the benzene ring with bromine atoms. During the reaction process, the electron cloud distribution of the benzene ring is affected by the chlorine atom and the fluorine atom, so that the bromine atom mainly replaces a specific position to form the target product.
Second, the diazotization reaction. First, 2-chloro-5-fluoroaniline is reacted to form a diazonium salt, and then interacts with reagents such as cuprous bromide, and the diazonium group is replaced by a bromine atom to obtain 2-chloro-5-fluorobromobenzene. The diazotization reaction needs to be carried out under low temperature and acidic conditions to ensure the stability of the diazonium salt. The generated diazonium salt has high reactivity, and under the action of suitable reagents, the substitution reaction can occur smoothly to
Third, the Grignard reagent method. Using 2-chloro-5-fluorobromobenzene-related halogens as raw materials, Grignard reagents are prepared by reacting with magnesium, and then reacting with bromine-containing compounds to achieve the synthesis of 2-chloro-5-fluorobromobenzene. Grignard reagents have high activity and can undergo nucleophilic substitution reactions with many halogen-containing compounds. In this reaction, magnesium atoms in Grignard reagents form strong coordination with halogen atoms, which enhances the nucleophilicity of carbon atoms and prompts them to react with bromine-containing compounds to form target products. This method needs to be operated in an anhydrous and oxygen-free environment to prevent Grignard reagents from decomposing in contact with water and oxygen.
First, halogenation reaction. Using 2-chloro-5-fluorobenzene as the starting material, 2-chloro-5-fluorobromobenzene can be prepared by bromination reaction. This reaction is often carried out with liquid bromine as the brominating reagent in the presence of appropriate catalysts (such as iron powder, iron tribromide, etc.). Iron reacts with bromine to form iron tribromide, which acts as a catalyst to replace hydrogen atoms at specific positions on the benzene ring with bromine atoms. During the reaction process, the electron cloud distribution of the benzene ring is affected by the chlorine atom and the fluorine atom, so that the bromine atom mainly replaces a specific position to form the target product.
Second, the diazotization reaction. First, 2-chloro-5-fluoroaniline is reacted to form a diazonium salt, and then interacts with reagents such as cuprous bromide, and the diazonium group is replaced by a bromine atom to obtain 2-chloro-5-fluorobromobenzene. The diazotization reaction needs to be carried out under low temperature and acidic conditions to ensure the stability of the diazonium salt. The generated diazonium salt has high reactivity, and under the action of suitable reagents, the substitution reaction can occur smoothly to
Third, the Grignard reagent method. Using 2-chloro-5-fluorobromobenzene-related halogens as raw materials, Grignard reagents are prepared by reacting with magnesium, and then reacting with bromine-containing compounds to achieve the synthesis of 2-chloro-5-fluorobromobenzene. Grignard reagents have high activity and can undergo nucleophilic substitution reactions with many halogen-containing compounds. In this reaction, magnesium atoms in Grignard reagents form strong coordination with halogen atoms, which enhances the nucleophilicity of carbon atoms and prompts them to react with bromine-containing compounds to form target products. This method needs to be operated in an anhydrous and oxygen-free environment to prevent Grignard reagents from decomposing in contact with water and oxygen.
What are 2-chloro-5-fluorobromobenzene synthesis methods?
The common methods for making 2-chloro-5-fluorobromobenzene are as follows.
One is halogenation reaction. Fluorobenzene is used as the starting material and chlorinated first to obtain chlorine-containing fluorobenzene derivatives. This process requires the selection of suitable chlorination reagents, such as chlorine gas. Under the action of catalysts such as ferric chloride, chlorine atoms are selectively introduced into specific positions in the benzene ring. Then the bromination reaction is carried out, and bromine is selected. Catalyzed by appropriate catalysts such as iron powder, bromine atoms can be introduced into the benzene ring, and finally 2-chloro-5-fluorobromobenzene can be obtained. In this path, the control of chlorination and bromination conditions is extremely critical, and factors such as temperature, reagent dosage, reaction time, etc. will affect the selectivity and yield of the product.
The second can start from benzene and construct the target product through a multi-step reaction. First, the fluorination reaction of benzene is carried out, and fluorine atoms are introduced. There are various fluorination methods, such as selecting a suitable fluorine-containing reagent to react with benzene under specific conditions. Then chlorination and bromination are carried out in sequence. It is also necessary to precisely control the reaction conditions of each step to ensure that the substituents are introduced at the desired positions. Although this approach is a little complicated, it can better control the positions of different substituents on the benzene ring.
Third, the reaction can be participated in by organometallic reagents. The fluorine-containing organometallic reagents are reacted with halogenated benzene derivatives through a series of transformations to achieve the arrangement and combination of chlorine, fluorine and bromine atoms at specific positions in the benzene ring. This method requires strict reaction conditions and needs to be carried out in specific environments such as anhydrous and anaerobic, and the preparation and use of organometallic reagents also need to be handled with caution.
All kinds of synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively weigh factors such as the availability of raw materials, cost, and difficulty of reaction conditions to choose the optimal synthesis path.
One is halogenation reaction. Fluorobenzene is used as the starting material and chlorinated first to obtain chlorine-containing fluorobenzene derivatives. This process requires the selection of suitable chlorination reagents, such as chlorine gas. Under the action of catalysts such as ferric chloride, chlorine atoms are selectively introduced into specific positions in the benzene ring. Then the bromination reaction is carried out, and bromine is selected. Catalyzed by appropriate catalysts such as iron powder, bromine atoms can be introduced into the benzene ring, and finally 2-chloro-5-fluorobromobenzene can be obtained. In this path, the control of chlorination and bromination conditions is extremely critical, and factors such as temperature, reagent dosage, reaction time, etc. will affect the selectivity and yield of the product.
The second can start from benzene and construct the target product through a multi-step reaction. First, the fluorination reaction of benzene is carried out, and fluorine atoms are introduced. There are various fluorination methods, such as selecting a suitable fluorine-containing reagent to react with benzene under specific conditions. Then chlorination and bromination are carried out in sequence. It is also necessary to precisely control the reaction conditions of each step to ensure that the substituents are introduced at the desired positions. Although this approach is a little complicated, it can better control the positions of different substituents on the benzene ring.
Third, the reaction can be participated in by organometallic reagents. The fluorine-containing organometallic reagents are reacted with halogenated benzene derivatives through a series of transformations to achieve the arrangement and combination of chlorine, fluorine and bromine atoms at specific positions in the benzene ring. This method requires strict reaction conditions and needs to be carried out in specific environments such as anhydrous and anaerobic, and the preparation and use of organometallic reagents also need to be handled with caution.
All kinds of synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively weigh factors such as the availability of raw materials, cost, and difficulty of reaction conditions to choose the optimal synthesis path.
2-chloro-5-fluorobromobenzene What are the precautions during storage and transportation?
2-Chloro-5-fluorobromobenzene is an organic compound. When storing and transporting, many key matters must be paid attention to to to ensure safety.
First, it is related to storage. This compound should be stored in a cool and well-ventilated place. It must not be placed in a high temperature environment to prevent it from evaporating or even dangerous reactions due to excessive temperature. Because it is an organic halide, it is very sensitive to temperature, and high temperature is very likely to promote its decomposition. Furthermore, it is necessary to ensure that the storage place is dry and must not be damp. Because it encounters water or moisture, it may cause reactions such as hydrolysis, resulting in quality damage. At the same time, it should be stored separately from oxidants, strong alkalis and other substances. The halogen atoms in this compound are highly active. If they come into contact with oxidizing agents, there may be a risk of violent reaction; when they meet strong bases, they may also replace or eliminate reactions. When storing, it should also be placed in a closed container to prevent volatilization from escaping and causing pollution to the environment. Second, to avoid reaction with air components.
Second, when transporting, the packaging must be tight and reliable. Appropriate packaging materials should be selected, such as special glass bottles and reinforced by plastic film winding, or special metal containers should be used to ensure that they will not be damaged by collision and vibration during transportation. Transportation vehicles need to be equipped with good ventilation equipment. If the compound evaporates during transportation, it can be discharged in time to reduce danger. Transport personnel must be professionally trained and familiar with the characteristics of 2-chloro-5-fluorobromobenzene and emergency treatment methods. In the event of an unexpected situation such as leakage, they can respond quickly and properly. Moreover, fire and heat sources should be strictly avoided during transportation, because of their flammability and the possibility of thermal decomposition. Close to fire sources can easily cause fires or explosions.
First, it is related to storage. This compound should be stored in a cool and well-ventilated place. It must not be placed in a high temperature environment to prevent it from evaporating or even dangerous reactions due to excessive temperature. Because it is an organic halide, it is very sensitive to temperature, and high temperature is very likely to promote its decomposition. Furthermore, it is necessary to ensure that the storage place is dry and must not be damp. Because it encounters water or moisture, it may cause reactions such as hydrolysis, resulting in quality damage. At the same time, it should be stored separately from oxidants, strong alkalis and other substances. The halogen atoms in this compound are highly active. If they come into contact with oxidizing agents, there may be a risk of violent reaction; when they meet strong bases, they may also replace or eliminate reactions. When storing, it should also be placed in a closed container to prevent volatilization from escaping and causing pollution to the environment. Second, to avoid reaction with air components.
Second, when transporting, the packaging must be tight and reliable. Appropriate packaging materials should be selected, such as special glass bottles and reinforced by plastic film winding, or special metal containers should be used to ensure that they will not be damaged by collision and vibration during transportation. Transportation vehicles need to be equipped with good ventilation equipment. If the compound evaporates during transportation, it can be discharged in time to reduce danger. Transport personnel must be professionally trained and familiar with the characteristics of 2-chloro-5-fluorobromobenzene and emergency treatment methods. In the event of an unexpected situation such as leakage, they can respond quickly and properly. Moreover, fire and heat sources should be strictly avoided during transportation, because of their flammability and the possibility of thermal decomposition. Close to fire sources can easily cause fires or explosions.
2-chloro-5-fluorobromobenzene impact on the environment and human health
2-Chloro-5-fluorobromobenzene is one of the organohalogenated aromatic hydrocarbons. The impact of this substance on the environment and human health cannot be ignored, as detailed below.
In terms of the environment, 2-chloro-5-fluorobromobenzene has considerable stability and is difficult to degrade in the natural environment. Once released into the environment, it can persist for a long time, causing pollution to spread. If it enters the soil or adsorbs on soil particles, it hinders the uptake of nutrients and moisture by plants, inhibits plant growth, causes crop production, and accumulates and transmits through the food chain, threatening higher trophic organisms.
When entering water, 2-chloro-5-fluorobromobenzene may affect aquatic organisms. Its toxicity can cause abnormal behavior, growth inhibition, reproduction obstruction, and even death of aquatic organisms. Destroy the balance of aquatic ecology, affect the self-purification ability of water bodies, change water quality, and pose a serious threat to the stability and health of aquatic ecosystems.
In human health, 2-chloro-5-fluorobrobenzene may enter the body through contact with the respiratory tract, digestive tract and skin. After entering the body, or concentrate in adipose tissue and liver. Long-term exposure can damage multiple systems of the human body. Damage to the nervous system, causing headaches, dizziness, fatigue, memory loss and other neurological symptoms; damage to the liver and kidneys, affecting their normal metabolism and excretion functions, and in severe cases can cause abnormal liver and kidney function; or potentially carcinogenic, interfering with the growth and differentiation of normal human cells, increasing the risk of cancer.
In short, 2-chloro-5-fluorobromobenzene has potential hazards to both the environment and human health. Therefore, when producing, using and disposing of this substance, strict protection and management measures should be taken to reduce its impact on the environment and human body, and protect the ecological environment and public health.
In terms of the environment, 2-chloro-5-fluorobromobenzene has considerable stability and is difficult to degrade in the natural environment. Once released into the environment, it can persist for a long time, causing pollution to spread. If it enters the soil or adsorbs on soil particles, it hinders the uptake of nutrients and moisture by plants, inhibits plant growth, causes crop production, and accumulates and transmits through the food chain, threatening higher trophic organisms.
When entering water, 2-chloro-5-fluorobromobenzene may affect aquatic organisms. Its toxicity can cause abnormal behavior, growth inhibition, reproduction obstruction, and even death of aquatic organisms. Destroy the balance of aquatic ecology, affect the self-purification ability of water bodies, change water quality, and pose a serious threat to the stability and health of aquatic ecosystems.
In human health, 2-chloro-5-fluorobrobenzene may enter the body through contact with the respiratory tract, digestive tract and skin. After entering the body, or concentrate in adipose tissue and liver. Long-term exposure can damage multiple systems of the human body. Damage to the nervous system, causing headaches, dizziness, fatigue, memory loss and other neurological symptoms; damage to the liver and kidneys, affecting their normal metabolism and excretion functions, and in severe cases can cause abnormal liver and kidney function; or potentially carcinogenic, interfering with the growth and differentiation of normal human cells, increasing the risk of cancer.
In short, 2-chloro-5-fluorobromobenzene has potential hazards to both the environment and human health. Therefore, when producing, using and disposing of this substance, strict protection and management measures should be taken to reduce its impact on the environment and human body, and protect the ecological environment and public health.
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