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2-Chloro-5-Iodo-1-Methoxybenzene
Linshang Chemical
|
HS Code |
168863 |
| Chemical Formula | C7H6ClIO |
| Molecular Weight | 270.48 |
| Appearance | Solid (usually) |
| Solubility In Water | Low (organic halide and ether - low water solubility) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 2-Chloro-5-Iodo-1-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 5 - iodo - 1 - methoxybenzene packaged in a sealed glass bottle. |
| Storage | 2 - Chloro - 5 - iodo - 1 - methoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Since it is a chemical, store it separately from incompatible substances, like oxidizing agents and strong bases, to prevent chemical reactions. |
| Shipping | 2 - chloro - 5 - iodo - 1 - methoxybenzene is shipped in sealed, corrosion - resistant containers. They are carefully packed to prevent breakage and ensure safe transit, following all relevant chemical shipping regulations. |
Competitive 2-Chloro-5-Iodo-1-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the Chinese name of 2-chloro-5-iodo-1-methoxybenzene?
2-Chloro-5-iodine-1-methoxybenzene is a kind of naming for organic compounds. This naming is based on chemical naming rules, depending on the type and position of each atom and functional group in the compound.
"2-chloro" means that there is a chlorine atom connected to the second position of the benzene ring; "5-iodine" means that there is an iodine atom connected to the fifth position of the benzene ring; "1-methoxy" means that the first position of the benzene ring is connected to the methoxy group (-OCH 🥰). The naming of organic compounds
is an extremely important matter in the field of chemistry. Precise naming allows chemists to communicate information about the relevant properties, structures and reactions of compounds accurately and without confusion. In the words of 2-chloro-5-iodine-1-methoxybenzene, according to this naming, we can clearly know the specific positions and types of substituents on the benzene ring structure of the compound, so as to have a preliminary inference about the chemical properties and possible reactions of the compound.
In the naming of this compound, the parts are arranged in an orderly manner, the positions of the substituents are clearly identified by numbers, and the types of substituents are indicated by words, which is in line with the general naming convention in the chemical community. This specification has been developed and improved for a long time and is followed by chemists around the world. It has made great contributions to promoting the progress and exchange of chemistry.
"2-chloro" means that there is a chlorine atom connected to the second position of the benzene ring; "5-iodine" means that there is an iodine atom connected to the fifth position of the benzene ring; "1-methoxy" means that the first position of the benzene ring is connected to the methoxy group (-OCH 🥰). The naming of organic compounds
is an extremely important matter in the field of chemistry. Precise naming allows chemists to communicate information about the relevant properties, structures and reactions of compounds accurately and without confusion. In the words of 2-chloro-5-iodine-1-methoxybenzene, according to this naming, we can clearly know the specific positions and types of substituents on the benzene ring structure of the compound, so as to have a preliminary inference about the chemical properties and possible reactions of the compound.
In the naming of this compound, the parts are arranged in an orderly manner, the positions of the substituents are clearly identified by numbers, and the types of substituents are indicated by words, which is in line with the general naming convention in the chemical community. This specification has been developed and improved for a long time and is followed by chemists around the world. It has made great contributions to promoting the progress and exchange of chemistry.
What are the main uses of 2-chloro-5-iodo-1-methoxybenzene?
2-Chloro-5-iodine-1-methoxybenzene has a wide range of uses. It is often used as a key intermediate in the field of organic synthesis. Due to the characteristics of chlorine, iodine and methoxy in its structure, it can be derived from many chemical reactions.
First, it can be used for the coupling reaction of halogenated aromatic hydrocarbons. Chlorine and iodine atoms have different activities and can selectively participate in the coupling with selected reagents according to the reaction conditions. For example, under the condition of palladium catalysis, it is coupled with specific alkenyl halides or aryl halides to form carbon-carbon bonds, which lays the foundation for the synthesis of complex aromatic hydrocarbon skeletons. This is of great significance in the fields of medicinal chemistry and materials science.
Second, the presence of methoxy groups can affect the electron cloud density of benzene rings. In electrophilic substitution reactions, it can guide the reaction check point and prepare derivatives with specific structures. And methoxy groups can be converted by chemical means to expand the structural diversity of compounds.
Furthermore, in the field of pharmaceutical research and development, this is used as a starting material, modified by multi-step reactions, or molecules with specific biological activities can be obtained. Because of its unique structure, it may be able to fit specific biological targets, providing opportunities for the creation of new drugs.
In material synthesis, materials with special optoelectronic properties can be prepared through the derivatization of 2-chloro-5-iodine-1-methoxybenzene. If the molecule is properly designed and reacted, it can become the structural unit of organic semiconductor materials, which can be used in organic Light Emitting Diodes, field effect transistors and other devices.
First, it can be used for the coupling reaction of halogenated aromatic hydrocarbons. Chlorine and iodine atoms have different activities and can selectively participate in the coupling with selected reagents according to the reaction conditions. For example, under the condition of palladium catalysis, it is coupled with specific alkenyl halides or aryl halides to form carbon-carbon bonds, which lays the foundation for the synthesis of complex aromatic hydrocarbon skeletons. This is of great significance in the fields of medicinal chemistry and materials science.
Second, the presence of methoxy groups can affect the electron cloud density of benzene rings. In electrophilic substitution reactions, it can guide the reaction check point and prepare derivatives with specific structures. And methoxy groups can be converted by chemical means to expand the structural diversity of compounds.
Furthermore, in the field of pharmaceutical research and development, this is used as a starting material, modified by multi-step reactions, or molecules with specific biological activities can be obtained. Because of its unique structure, it may be able to fit specific biological targets, providing opportunities for the creation of new drugs.
In material synthesis, materials with special optoelectronic properties can be prepared through the derivatization of 2-chloro-5-iodine-1-methoxybenzene. If the molecule is properly designed and reacted, it can become the structural unit of organic semiconductor materials, which can be used in organic Light Emitting Diodes, field effect transistors and other devices.
What are the physical properties of 2-chloro-5-iodo-1-methoxybenzene?
2-Chloro-5-iodine-1-methoxybenzene is a kind of organic compound. Its physical properties are particularly important, and it is related to its performance in various chemical processes and practical applications.
First of all, under room temperature, 2-chloro-5-iodine-1-methoxybenzene is mostly colorless to pale yellow liquid, with a clear appearance. This color feature is quite useful for intuitive identification and preliminary cognition of the compound.
Second of its melting point. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. However, the data on the melting point of this compound may vary, and it is probably in a specific low temperature range, and the specific value needs to be determined by precise experiments. The boiling point is related to the temperature limit of liquid to gaseous state. The boiling point of 2-chloro-5-iodine-1-methoxybenzene is also a specific value, usually in a relatively high temperature range. This characteristic makes it exhibit corresponding behavior in operations such as heating and evaporation.
Furthermore, its density is also an important physical property. In terms of density, the mass of the substance per unit volume is also. The density of 2-chloro-5-iodine-1-methoxybenzene is higher than that of water, and it will appear to sink in the liquid mixed system. This characteristic should be paid attention to when separating and purifying.
In terms of solubility, 2-chloro-5-iodine-1-methoxybenzene has good solubility in organic solvents such as ethanol, ether, dichloromethane, etc. Due to the principle of similar miscibility, its organic structure is compatible with the intermolecular forces of organic solvents, so it is miscible. However, the solubility in water is minimal. Water is a polar molecule, and the non-polar structure of this compound is quite different. The molecular interaction is weak, resulting in insolubility.
In terms of volatility, 2-chloro-5-iodine-1-methoxybenzene is volatile to a certain extent. In an open system, it will gradually evaporate into the air. This characteristic needs to be protected during storage and use to avoid its dissipation and impact on the environment and people.
These physical properties are an indispensable consideration for the study and application of 2-chloro-5-iodine-1-methoxybenzene, which helps to understand its behavior and provides a solid foundation for related chemical operations and industrial applications.
First of all, under room temperature, 2-chloro-5-iodine-1-methoxybenzene is mostly colorless to pale yellow liquid, with a clear appearance. This color feature is quite useful for intuitive identification and preliminary cognition of the compound.
Second of its melting point. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. However, the data on the melting point of this compound may vary, and it is probably in a specific low temperature range, and the specific value needs to be determined by precise experiments. The boiling point is related to the temperature limit of liquid to gaseous state. The boiling point of 2-chloro-5-iodine-1-methoxybenzene is also a specific value, usually in a relatively high temperature range. This characteristic makes it exhibit corresponding behavior in operations such as heating and evaporation.
Furthermore, its density is also an important physical property. In terms of density, the mass of the substance per unit volume is also. The density of 2-chloro-5-iodine-1-methoxybenzene is higher than that of water, and it will appear to sink in the liquid mixed system. This characteristic should be paid attention to when separating and purifying.
In terms of solubility, 2-chloro-5-iodine-1-methoxybenzene has good solubility in organic solvents such as ethanol, ether, dichloromethane, etc. Due to the principle of similar miscibility, its organic structure is compatible with the intermolecular forces of organic solvents, so it is miscible. However, the solubility in water is minimal. Water is a polar molecule, and the non-polar structure of this compound is quite different. The molecular interaction is weak, resulting in insolubility.
In terms of volatility, 2-chloro-5-iodine-1-methoxybenzene is volatile to a certain extent. In an open system, it will gradually evaporate into the air. This characteristic needs to be protected during storage and use to avoid its dissipation and impact on the environment and people.
These physical properties are an indispensable consideration for the study and application of 2-chloro-5-iodine-1-methoxybenzene, which helps to understand its behavior and provides a solid foundation for related chemical operations and industrial applications.
What are the chemical properties of 2-chloro-5-iodo-1-methoxybenzene?
2-Chloro-5-iodine-1-methoxybenzene is one of the organic compounds. In its molecular structure, above the benzene ring, the chlorine atom occupies two positions, the iodine atom occupies five positions, and the methoxy group occupies one position. This unique structure endows it with numerous chemical properties.
First talk about its substitution reaction. The benzene ring has an electron cloud density and is vulnerable to attack by electrophilic reagents. Because the methoxy group is the power supply group, the electron cloud density of the benzene ring and the para-position can increase, and it is more prone to electrophilic substitution. In case of halogenating agents, new substituents can be introduced in the ortho and para-positions. However, the existence of chlorine and iodine also affects the reaction activity and positional
Let's talk about its redox properties. Although there are no typical groups that are easy to oxidize or reduce, under certain conditions, the benzene ring can be oxidized to cause structural changes. In case of strong reducing agents, halogen atoms may be reduced and removed.
In terms of hydrolysis, methoxy groups can be hydrolyzed under the action of strong acids or strong bases to form phenolic hydroxyl groups. Chlorine and iodine atoms can be replaced under suitable nucleophilic reagents and conditions to form new derivatives.
And because of its halogen-containing atoms, it can participate in coupling reactions. For example, with metal-containing organic reagents, under the action of catalysts, carbon-carbon bonds can be formed, and molecular structures can be expanded. It has a wide range of uses in the field of organic synthesis. The chemical properties of this compound depend on its structure and are of great significance in various fields such as organic synthesis and medicinal chemistry. It can be used as an intermediate to prepare a variety of complex organic compounds.
First talk about its substitution reaction. The benzene ring has an electron cloud density and is vulnerable to attack by electrophilic reagents. Because the methoxy group is the power supply group, the electron cloud density of the benzene ring and the para-position can increase, and it is more prone to electrophilic substitution. In case of halogenating agents, new substituents can be introduced in the ortho and para-positions. However, the existence of chlorine and iodine also affects the reaction activity and positional
Let's talk about its redox properties. Although there are no typical groups that are easy to oxidize or reduce, under certain conditions, the benzene ring can be oxidized to cause structural changes. In case of strong reducing agents, halogen atoms may be reduced and removed.
In terms of hydrolysis, methoxy groups can be hydrolyzed under the action of strong acids or strong bases to form phenolic hydroxyl groups. Chlorine and iodine atoms can be replaced under suitable nucleophilic reagents and conditions to form new derivatives.
And because of its halogen-containing atoms, it can participate in coupling reactions. For example, with metal-containing organic reagents, under the action of catalysts, carbon-carbon bonds can be formed, and molecular structures can be expanded. It has a wide range of uses in the field of organic synthesis. The chemical properties of this compound depend on its structure and are of great significance in various fields such as organic synthesis and medicinal chemistry. It can be used as an intermediate to prepare a variety of complex organic compounds.
What are 2-chloro-5-iodo-1-methoxybenzene synthesis methods?
To prepare 2-chloro-5-iodine-1-methoxybenzene, the following numbers can be used.
First, 1-methoxy-2-chlorobenzene is used as the starting material. Because methoxy is an ortho-para-localization group, chlorine is also an ortho-para-localization group, and the methoxy localization effect is stronger. First, the iodization reaction of 1-methoxy-2-chlorobenzene can be carried out. Iodine elemental substance can be used with appropriate oxidants such as hydrogen peroxide or nitric acid, etc., and reacted in a suitable solvent such as glacial acetic acid. The oxidizing agent can convert the iodine element into an electrophilic reagent and attack the benzene ring. Due to the positioning of the methoxy group, the iodine atom mainly enters the para-position of the methoxy group to obtain 2-chloro-5-iodine-1-methoxylbenzene.
Second, 1-methoxylbenzene is used as the starting material. It is first chlorinated and reacted with chlorine gas in the presence of a suitable catalyst such as ferric chloride. The chlorine atom mainly enters the ortho-position and para-position of the methoxy group to form a mixture of 2-chloro-1-methoxylbenzene and 4-chloro-1-methoxylbenzene. By appropriate separation means such as distillation, column chromatography, etc., 2-chloro-1-methoxybenzene is separated, and then the iodization reaction is carried out according to the above method of using 1-methoxy-2-chlorobenzene as raw material, and the target product can also be obtained.
Third, phenol is used as the starting material. Phenol is methylated first, and dimethyl sulfate and sodium hydroxide can be used to convert phenolic hydroxyl groups into methoxy groups to obtain 1-methoxybenzene. According to the subsequent steps of the second method above, chlorination is first carried out, then separation, and finally iodization to obtain 2-chloro-5-iodine-1-methoxybenzene.
All methods have advantages and disadvantages. In actual preparation, factors such as raw material cost, reaction conditions, and difficulty in product separation should be comprehensively considered, and the good one should be selected and used.
First, 1-methoxy-2-chlorobenzene is used as the starting material. Because methoxy is an ortho-para-localization group, chlorine is also an ortho-para-localization group, and the methoxy localization effect is stronger. First, the iodization reaction of 1-methoxy-2-chlorobenzene can be carried out. Iodine elemental substance can be used with appropriate oxidants such as hydrogen peroxide or nitric acid, etc., and reacted in a suitable solvent such as glacial acetic acid. The oxidizing agent can convert the iodine element into an electrophilic reagent and attack the benzene ring. Due to the positioning of the methoxy group, the iodine atom mainly enters the para-position of the methoxy group to obtain 2-chloro-5-iodine-1-methoxylbenzene.
Second, 1-methoxylbenzene is used as the starting material. It is first chlorinated and reacted with chlorine gas in the presence of a suitable catalyst such as ferric chloride. The chlorine atom mainly enters the ortho-position and para-position of the methoxy group to form a mixture of 2-chloro-1-methoxylbenzene and 4-chloro-1-methoxylbenzene. By appropriate separation means such as distillation, column chromatography, etc., 2-chloro-1-methoxybenzene is separated, and then the iodization reaction is carried out according to the above method of using 1-methoxy-2-chlorobenzene as raw material, and the target product can also be obtained.
Third, phenol is used as the starting material. Phenol is methylated first, and dimethyl sulfate and sodium hydroxide can be used to convert phenolic hydroxyl groups into methoxy groups to obtain 1-methoxybenzene. According to the subsequent steps of the second method above, chlorination is first carried out, then separation, and finally iodization to obtain 2-chloro-5-iodine-1-methoxybenzene.
All methods have advantages and disadvantages. In actual preparation, factors such as raw material cost, reaction conditions, and difficulty in product separation should be comprehensively considered, and the good one should be selected and used.
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