2-Chloro-5-Methylbenzene-1,4-Diamine
Linshang Chemical
HS Code |
188930 |
Chemical Formula | C7H9ClN2 |
Molar Mass | 156.613 g/mol |
Appearance | Solid |
Physical State At Room Temp | Solid |
Melting Point | Data needed |
Boiling Point | Data needed |
Solubility In Water | Data needed |
Solubility In Organic Solvents | Data needed |
Density | Data needed |
Odor | Data needed |
Color | Data needed |
Pka | Data needed |
Flash Point | Data needed |
As an accredited 2-Chloro-5-Methylbenzene-1,4-Diamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 100g of 2 - chloro - 5 - methylbenzene - 1,4 - diamine packaged in a sealed plastic bag. |
Storage | 2 - chloro - 5 - methylbenzene - 1,4 - diamine should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture absorption and exposure to air, which could potentially lead to degradation or reaction. Label the storage container clearly for easy identification and safety. |
Shipping | 2 - chloro - 5 - methylbenzene - 1,4 - diamine should be shipped in accordance with strict chemical regulations. Use properly labeled, sealed containers to prevent leakage. Ensure transport in a well - ventilated vehicle, away from heat and ignition sources. |
Competitive 2-Chloro-5-Methylbenzene-1,4-Diamine prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 2-Chloro-5-Methylbenzene-1,4-Diamine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
On the benzene ring, there are chlorine atoms connected to the two positions, methyl is connected to the five positions, and one amino group is connected to the one and four positions. Chlorine atoms have electron-absorbing properties. Because their electronegativity is greater than that of carbon, they can affect the electron cloud density distribution of the benzene ring. The methyl group is the power supply subgroup, which can increase the electron cloud density of the benzene ring, especially in the adjacent and para-positions.
The two amino groups are connected to the one and four positions of the benzene ring. The amino group is also a power supply group, which can form a conjugate system with the benzene ring, causing electron cloud delocalization and affecting the properties of the compound. Overall, the chemical structure of 2-chloro-5-methylbenzene-1,4-diamine has unique physical and chemical properties due to the electronic effect and steric resistance of each group. It has potential applications in organic synthesis, materials science and other fields.
It is also of great significance in the field of medicinal chemistry. In the research and development of some new drugs, as key intermediates, they participate in the construction of drug molecules, and with the help of their special functional groups, they endow drugs with specific biological activities and pharmacological effects, helping to synthesize drugs with better curative effects and fewer side effects, and contributing to human health.
In addition, in the field of materials science, 2-chloro-5-methylbenzene-1,4-diamine has also emerged. When used in the preparation of special polymer materials, it can improve the mechanical properties and thermal stability of materials, so that the materials can be applied in high-end fields such as aerospace, electronics and electrical appliances, and meet the strict requirements for high performance of materials in these fields. Overall, it plays an indispensable role in many fields such as chemical engineering, medicine, and materials, promoting technological progress and development in various fields.
Looking at its properties, it is mostly solid at room temperature. The color of this compound is usually off-white to light yellow, with a bright color and is easy to distinguish. Its melting point is also a key physical property, about a specific temperature range. The value of this melting point has a profound impact on its morphological transformation in different environments.
Furthermore, the solubility cannot be ignored. In common organic solvents, such as ethanol and acetone, it exhibits a certain solubility and can dissolve with these solvents to form a uniform system. However, the solubility in water is relatively limited, only a small amount can be dissolved.
As for the density, it is relatively stable and is a specific value. This value reflects its mass per unit volume, which is an important consideration in many practical application scenarios.
In addition, the stability of this compound is also worthy of attention. Under normal conditions, it has a certain chemical stability, but when it encounters extreme conditions such as specific chemical reagents, high temperature or strong light, chemical reactions may occur, resulting in changes in its structure and properties.
These physical properties play an indispensable role in many fields such as organic synthesis, materials science, and drug development. Researchers must consider them carefully in order to make good use of this compound.
First, it can be prepared by reduction of the corresponding nitro compound. First, the nitro group is introduced through nitration reaction with suitable raw materials. For example, with 2-chloro-5-methyltoluene as the starting material, under appropriate nitrification conditions, such as in the mixed acid system of nitric acid and sulfuric acid, the reaction temperature, time and other factors are controlled to introduce nitro groups into the benzene ring at specific positions to generate 2-chloro-5-methyl-1,4-dinitrobenzene. Subsequently, the dinitro compound is reduced. There are many reduction methods, such as catalytic hydrogenation. In the presence of suitable catalysts, such as palladium carbon, platinum carbon, etc., hydrogen is introduced, and the nitro group can be gradually reduced to an amino group under a certain temperature and pressure, so as to obtain the target product 2-chloro-5-methylbenzene-1,4-diamine. The advantage of this method is that the reaction is relatively clean and the atomic utilization rate is high, but the reaction equipment is relatively high, and a suitable hydrogenation device is required.
Second, halogenation can be combined with aminolysis. First, chlorine atoms are introduced into the benzene ring to determine the substitution position of chlorine, and then ammonia or amine reagents are used to replace the halogen atoms at specific positions with amino groups. For example, with suitable benzene derivatives, chlorine atoms are introduced at specific positions through halogenation to obtain chlorine-containing intermediates. Afterwards, under appropriate reaction conditions, such as suitable solvents, temperatures, pressures, and catalysts, ammonia or amines are reacted with ammonia or amines to gradually introduce amino groups. This method can flexibly control the order and location of substituents, but attention should be paid to the precise control of reaction conditions to ensure the selectivity and yield of the reaction.
Third, diazotization and related conversion reactions can also be used. First, the intermediate containing amino group is prepared, the amino group is converted into diazonium salt, and then through the specific reaction of diazonium salt, chlorine atoms and methyl groups are introduced, and after a series of reactions, 2-chloro-5-methylbenzene-1,4-diamine is obtained. This method has relatively many steps and needs to strictly control the diazotization reaction and subsequent conversion reaction conditions. However, it has unique advantages for the construction of specific structures, and can achieve some substituent positions and structural requirements that are difficult to achieve by other methods.
Different synthesis methods have their own advantages and disadvantages. In practical applications, many factors such as raw material cost, difficulty of reaction conditions, product yield and purity need to be comprehensively considered to choose the most suitable synthesis path.
Those who bear the brunt, safety is of paramount importance. This substance is toxic and irritating to a certain extent, and can cause adverse consequences if it touches the skin, eyes or inhales its dust and vapor. Therefore, when using it, be sure to wear suitable protective equipment, such as gloves, protective glasses, masks and even protective clothing, to prevent direct contact with it. The operation should be carried out in a well-ventilated place. If it is used in a closed space, effective ventilation facilities should be set up to discharge volatile gas in time, reduce the concentration in the air, and avoid its inhalation hazards.
In addition, storage is also exquisite. It should be placed in a cool, dry and ventilated place, away from fire and heat sources. Do not mix with oxidants, acids and other co-storage, because it may cause violent reactions and cause danger. Storage containers must also be well sealed to prevent leakage and escape.
During use, it is also essential to strictly follow the operating procedures. Precisely control the dosage, according to experimental or production needs, measure with accurate gauges, and do not use in excess. If there is any spill, clean it immediately to prevent spread. And when operating, concentrate and do not be distracted by other things, causing misoperation to cause accidents.
In addition, after use, properly dispose of the remaining materials and waste. Do not dump at will, should be in accordance with relevant regulations, classified collection, handed over to professional institutions for treatment to prevent environmental pollution.
In short, the use of 2-chloro-5-methylbenzene-1,4-diamine, safety awareness should not be relaxed at all times, and all precautions should not be lost, so as to ensure the smooth operation process and avoid danger.

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