Linshang Chemical
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2-Chloro-5-Nitrobenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
595913 |
| Chemical Formula | C6H3Cl2NO4S |
| Molecular Weight | 256.06 |
| Appearance | Solid (usually a yellow - colored solid) |
| Melting Point | Typically in a certain temperature range, e.g., around 100 - 110°C (approximate, actual may vary) |
| Boiling Point | Decomposes before boiling in normal conditions |
| Solubility | Soluble in some organic solvents like dichloromethane, less soluble in water |
| Density | Specific density value (data may vary, need to be experimentally determined accurately) |
| Odor | Pungent, irritating odor |
| Stability | Stable under normal storage conditions, but reactive with strong bases and reducing agents |
| Hazard Class | Corrosive, can cause skin and eye damage |
As an accredited 2-Chloro-5-Nitrobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2 - chloro - 5 - nitrobenzenesulfonyl chloride packaged in a sealed glass bottle. |
| Storage | 2 - Chloro - 5 - nitrobenzenesulfonyl chloride should be stored in a cool, dry, and well - ventilated area. It must be kept away from heat, flames, and oxidizing agents. Store it in a tightly - sealed container, preferably made of corrosion - resistant material, to prevent leakage and contact with moisture, which could cause decomposition and release of harmful fumes. |
| Shipping | 2 - Chloro - 5 - nitrobenzenesulfonyl chloride is a hazardous chemical. Shipping requires proper packaging in accordance with regulations. It should be labeled clearly, transported by approved carriers, and handled with care to prevent spills and ensure safety. |
Competitive 2-Chloro-5-Nitrobenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What is the chemistry of 2-chloro-5-nitrobenzenesulfonyl Chloride?
2-Chloro-5-nitrobenzenesulfonyl chloride, this is an organic compound. Its chemical properties are unique and quite active.
Looking at its structure, it contains chlorine atoms, nitro groups and sulfonyl chloride groups. The chlorine atom is above the benzene ring and can participate in the nucleophilic substitution reaction. Because of its certain electronegativity, it can reduce the electron cloud density of the benzene ring, making the benzene ring more vulnerable to nucleophilic attack. Under appropriate conditions, the nucleophilic reagent can replace the chlorine atom to form new compounds.
Nitro is a strong electron-absorbing group, which not only affects the electron cloud distribution of the benzene ring, enhances the activity of the benzene ring electrophilic substitution reaction, but also increases The presence of nitro groups also allows the compound to be reduced to amino groups in some reduction reactions, and a series of amino-containing derivatives are derived, which are widely used in the field of organic synthesis.
And sulfonyl chloride (-SO ² Cl) is particularly active. It is very easy to hydrolyze in contact with water to generate corresponding sulfonic acids and hydrogen chloride. This hydrolysis reaction is very violent, so it is necessary to avoid water when storing and using. Sulfonyl chloride groups can also react with compounds such as alcohols and amines to form sulfonates and sulfonamides. When reacting with alcohols, the hydroxyl oxygen atoms of the alcohol attack the sulfur atoms of sulfonyl chloride, and the chlorine atoms leave to form sulfonates. The reaction with amines produces sulfonamides, which is an important way to prepare sulfonamides and is often involved in the synthesis of many drugs and functional materials.
The functional groups contained in 2-chloro-5-nitrobenzenesulfonyl chloride play an important role in the field of organic synthesis and can be used as a key intermediate for the preparation of various organic compounds with special structures and functions.
Looking at its structure, it contains chlorine atoms, nitro groups and sulfonyl chloride groups. The chlorine atom is above the benzene ring and can participate in the nucleophilic substitution reaction. Because of its certain electronegativity, it can reduce the electron cloud density of the benzene ring, making the benzene ring more vulnerable to nucleophilic attack. Under appropriate conditions, the nucleophilic reagent can replace the chlorine atom to form new compounds.
Nitro is a strong electron-absorbing group, which not only affects the electron cloud distribution of the benzene ring, enhances the activity of the benzene ring electrophilic substitution reaction, but also increases The presence of nitro groups also allows the compound to be reduced to amino groups in some reduction reactions, and a series of amino-containing derivatives are derived, which are widely used in the field of organic synthesis.
And sulfonyl chloride (-SO ² Cl) is particularly active. It is very easy to hydrolyze in contact with water to generate corresponding sulfonic acids and hydrogen chloride. This hydrolysis reaction is very violent, so it is necessary to avoid water when storing and using. Sulfonyl chloride groups can also react with compounds such as alcohols and amines to form sulfonates and sulfonamides. When reacting with alcohols, the hydroxyl oxygen atoms of the alcohol attack the sulfur atoms of sulfonyl chloride, and the chlorine atoms leave to form sulfonates. The reaction with amines produces sulfonamides, which is an important way to prepare sulfonamides and is often involved in the synthesis of many drugs and functional materials.
The functional groups contained in 2-chloro-5-nitrobenzenesulfonyl chloride play an important role in the field of organic synthesis and can be used as a key intermediate for the preparation of various organic compounds with special structures and functions.
What are the preparation methods of 2-chloro-5-nitrobenzenesulfonyl Chloride?
There are several common methods for preparing 2-chloro-5-nitrobenzenesulfonyl chloride.
First, it can be started from 2-chloro-5-nitrobenzenesulfonic acid. First, 2-chloro-5-nitrobenzenesulfonic acid is treated with an appropriate chlorination reagent, such as phosphorus pentachloride (PCl). 2-chloro-5-nitrobenzenesulfonic acid and phosphorus pentachloride are placed in a suitable reaction vessel in an appropriate ratio, usually in inert organic solvents such as dichloromethane and chloroform. This reaction needs to be stirred at an appropriate temperature, usually at room temperature to about 50 ° C, depending on the reaction process and phenomenon. Phosphorus pentachloride reacts with the sulfonic acid group, and the hydroxyl group of the sulfonic acid group is replaced by the chlorine atom to form 2-chloro-5-nitrobenzenesulfonyl chloride. After the reaction, the solvent is removed by distillation, and then the product is purified by appropriate methods such as reduced pressure distillation or recrystallization.
Second, 2-chloro-5-nitroaniline is used as raw material. First, 2-chloro-5-nitroaniline is converted into diazonium salt through diazotization reaction. Take 2-chloro-5-nitroaniline and react with sodium nitrite in an acidic medium such as hydrochloric acid solution at low temperature (0-5 ℃) to form diazonium salt. Subsequently, the diazonium salt is reacted with reagents such as sodium bisulfite and copper sulfate to undergo a transformation such as a Sandmeier reaction, so that the diazonium group is converted into a sulfonic acid group. After that, the resulting sulfonic acid is chlorinated with a chlorination reagent such as sulfite chloride (SOCl ²). The sulfonic acid product is mixed with sulfite chloride and reacted at a certain temperature. The sulfite chloride reacts with the sulfonic acid group to convert it into a sulfonyl chloride group to obtain 2-chloro-5-nitrobenzenesulfonyl chloride. After the reaction, the excess reagent needs to be distilled and then purified to obtain the pure product.
Third, start from 2-chloro-5-nitrotoluene. First, 2-chloro-5-nitrotoluene is sulfonated with a sulfonating agent such as fuming sulfuric acid, and the methyl ortho-or para-position is introduced into the sulfonic acid group to generate the 2-chloro-5-nitrobenzenesulfonic acid derivative. The reaction conditions, such as reaction temperature, concentration and dosage of fuming sulfuric acid, etc., are controlled to ensure that the main target sulfonic acid product is generated. Then, as previously described, the sulfonic acid group is converted to sulfonyl chloride with a chlorinating agent such as phosphorus pentachloride or thionyl chloride. After subsequent separation and purification operations, 2-chloro-5-nitrobenzenesulfonyl chloride can be obtained.
The above preparation methods each have their own advantages and disadvantages. In actual operation, it is necessary to comprehensively consider factors such as the availability of raw materials, cost, and controllability of reaction conditions, and choose the appropriate one.
First, it can be started from 2-chloro-5-nitrobenzenesulfonic acid. First, 2-chloro-5-nitrobenzenesulfonic acid is treated with an appropriate chlorination reagent, such as phosphorus pentachloride (PCl). 2-chloro-5-nitrobenzenesulfonic acid and phosphorus pentachloride are placed in a suitable reaction vessel in an appropriate ratio, usually in inert organic solvents such as dichloromethane and chloroform. This reaction needs to be stirred at an appropriate temperature, usually at room temperature to about 50 ° C, depending on the reaction process and phenomenon. Phosphorus pentachloride reacts with the sulfonic acid group, and the hydroxyl group of the sulfonic acid group is replaced by the chlorine atom to form 2-chloro-5-nitrobenzenesulfonyl chloride. After the reaction, the solvent is removed by distillation, and then the product is purified by appropriate methods such as reduced pressure distillation or recrystallization.
Second, 2-chloro-5-nitroaniline is used as raw material. First, 2-chloro-5-nitroaniline is converted into diazonium salt through diazotization reaction. Take 2-chloro-5-nitroaniline and react with sodium nitrite in an acidic medium such as hydrochloric acid solution at low temperature (0-5 ℃) to form diazonium salt. Subsequently, the diazonium salt is reacted with reagents such as sodium bisulfite and copper sulfate to undergo a transformation such as a Sandmeier reaction, so that the diazonium group is converted into a sulfonic acid group. After that, the resulting sulfonic acid is chlorinated with a chlorination reagent such as sulfite chloride (SOCl ²). The sulfonic acid product is mixed with sulfite chloride and reacted at a certain temperature. The sulfite chloride reacts with the sulfonic acid group to convert it into a sulfonyl chloride group to obtain 2-chloro-5-nitrobenzenesulfonyl chloride. After the reaction, the excess reagent needs to be distilled and then purified to obtain the pure product.
Third, start from 2-chloro-5-nitrotoluene. First, 2-chloro-5-nitrotoluene is sulfonated with a sulfonating agent such as fuming sulfuric acid, and the methyl ortho-or para-position is introduced into the sulfonic acid group to generate the 2-chloro-5-nitrobenzenesulfonic acid derivative. The reaction conditions, such as reaction temperature, concentration and dosage of fuming sulfuric acid, etc., are controlled to ensure that the main target sulfonic acid product is generated. Then, as previously described, the sulfonic acid group is converted to sulfonyl chloride with a chlorinating agent such as phosphorus pentachloride or thionyl chloride. After subsequent separation and purification operations, 2-chloro-5-nitrobenzenesulfonyl chloride can be obtained.
The above preparation methods each have their own advantages and disadvantages. In actual operation, it is necessary to comprehensively consider factors such as the availability of raw materials, cost, and controllability of reaction conditions, and choose the appropriate one.
What are the main uses of 2-chloro-5-nitrobenzenesulfonyl Chloride?
2-Chloro-5-nitrobenzenesulfonyl chloride is an important compound in organic chemistry. It has a wide range of uses and has significant effects in many fields.
In the field of pharmaceutical synthesis, it is often used as a key intermediate. The preparation process of many drugs depends on its participation in the reaction. With it, a specific chemical structure can be constructed, which in turn gives the drug the desired activity and efficacy. For example, some antibacterial drugs and drugs for the treatment of specific diseases are synthesized using 2-chloro-5-nitrobenzenesulfonyl chloride. By cleverly designing the reaction path, it can react with other compounds to precisely construct the core structure of the drug molecule, which is of great significance for drug development.
also plays an important role in the field of pesticides. It can be used to synthesize pesticides with high insecticidal, bactericidal or herbicidal properties. Combine with other chemicals in a specific reaction way to prepare pesticide products that have good control effects on crop diseases and pests. Due to its special chemical structure, it can effectively act on the specific physiological processes of pests or pathogens, inhibit their growth and reproduction, thereby ensuring the healthy growth of crops and improving crop yield and quality.
In the dye industry, 2-chloro-5-nitrobenzenesulfonyl chloride is also indispensable. It can be used as a raw material for the synthesis of special structural dyes. Through a series of chemical reactions, it is converted into dye intermediates with specific colors and properties, and then various dyes with bright colors and good fastness are prepared. These dyes are widely used in textiles, printing and dyeing and other industries to impart rich and diverse colors to fabrics, meeting the market demand for dyes of different colors and properties.
In the field of chemical research, due to its unique chemical properties, it is often used as a reagent to explore new chemical reaction pathways and mechanisms. Researchers use it to react with other compounds, observe reaction phenomena, and analyze the structure of products to reveal new chemical laws and reaction modes, and promote the continuous development and progress of organic chemistry.
In conclusion, 2-chloro-5-nitrobenzenesulfonyl chloride plays an irreplaceable and important role in many fields such as medicine, pesticides, dyes and chemical research, and is of great significance to promoting the development of related industries.
In the field of pharmaceutical synthesis, it is often used as a key intermediate. The preparation process of many drugs depends on its participation in the reaction. With it, a specific chemical structure can be constructed, which in turn gives the drug the desired activity and efficacy. For example, some antibacterial drugs and drugs for the treatment of specific diseases are synthesized using 2-chloro-5-nitrobenzenesulfonyl chloride. By cleverly designing the reaction path, it can react with other compounds to precisely construct the core structure of the drug molecule, which is of great significance for drug development.
also plays an important role in the field of pesticides. It can be used to synthesize pesticides with high insecticidal, bactericidal or herbicidal properties. Combine with other chemicals in a specific reaction way to prepare pesticide products that have good control effects on crop diseases and pests. Due to its special chemical structure, it can effectively act on the specific physiological processes of pests or pathogens, inhibit their growth and reproduction, thereby ensuring the healthy growth of crops and improving crop yield and quality.
In the dye industry, 2-chloro-5-nitrobenzenesulfonyl chloride is also indispensable. It can be used as a raw material for the synthesis of special structural dyes. Through a series of chemical reactions, it is converted into dye intermediates with specific colors and properties, and then various dyes with bright colors and good fastness are prepared. These dyes are widely used in textiles, printing and dyeing and other industries to impart rich and diverse colors to fabrics, meeting the market demand for dyes of different colors and properties.
In the field of chemical research, due to its unique chemical properties, it is often used as a reagent to explore new chemical reaction pathways and mechanisms. Researchers use it to react with other compounds, observe reaction phenomena, and analyze the structure of products to reveal new chemical laws and reaction modes, and promote the continuous development and progress of organic chemistry.
In conclusion, 2-chloro-5-nitrobenzenesulfonyl chloride plays an irreplaceable and important role in many fields such as medicine, pesticides, dyes and chemical research, and is of great significance to promoting the development of related industries.
2-chloro-5-nitrobenzenesulfonyl Chloride in Storage and Transportation
2-Chloro-5-nitrobenzenesulfonyl chloride is a commonly used reagent in organic synthesis. When storing and transporting it, special attention must be paid to all things to ensure safety.
When storing, the first environment is dry. Because of its hydrolysis, it is easy to react with water and cause quality damage, so it should be stored in a dry place and packaged tightly to prevent moisture from invading. The humidity of the warehouse should be controlled at a relatively low level, such as between 40% and 60%.
Temperature is also critical. This compound is easy to decompose when heated, and even cause danger. Therefore, it should be stored in a cool place. The temperature should be maintained below 25 ° C, preferably between 15 ° C and 20 ° C. Avoid direct sunlight, because light can promote its decomposition.
In addition, the storage place should be away from fire, heat sources and oxidants. Because it is an organic chloride, it is easy to react violently when exposed to strong oxidants, causing the risk of fire or explosion. When storing with other chemicals, it should be strictly classified to avoid mixed storage.
When transporting, the packaging material must be strong and durable, and can withstand certain external shocks and vibrations to prevent the container from being damaged. The packaging selected should comply with relevant regulations and standards to ensure safety during transportation.
Transport vehicles are also required to have good ventilation equipment to prevent danger due to local temperature rise and gas accumulation. Drivers and escorts should be familiar with the characteristics of the chemical and emergency disposal methods, and regularly check the condition of the goods during transportation, such as whether the packaging is damaged or leaked.
In case of leakage, the surrounding personnel should be evacuated immediately, the scene should be isolated, and fire should not be allowed to approach. Emergency personnel must wear professional protective equipment, such as gas masks, chemical protective clothing, etc., to avoid contact and inhalation of harmful substances.
In conclusion, 2-chloro-5-nitrobenzenesulfonyl chloride requires strict environmental conditions, packaging, and personnel handling during storage and transportation. Only by exercising caution and following relevant regulations can we ensure its safety and avoid accidents.
When storing, the first environment is dry. Because of its hydrolysis, it is easy to react with water and cause quality damage, so it should be stored in a dry place and packaged tightly to prevent moisture from invading. The humidity of the warehouse should be controlled at a relatively low level, such as between 40% and 60%.
Temperature is also critical. This compound is easy to decompose when heated, and even cause danger. Therefore, it should be stored in a cool place. The temperature should be maintained below 25 ° C, preferably between 15 ° C and 20 ° C. Avoid direct sunlight, because light can promote its decomposition.
In addition, the storage place should be away from fire, heat sources and oxidants. Because it is an organic chloride, it is easy to react violently when exposed to strong oxidants, causing the risk of fire or explosion. When storing with other chemicals, it should be strictly classified to avoid mixed storage.
When transporting, the packaging material must be strong and durable, and can withstand certain external shocks and vibrations to prevent the container from being damaged. The packaging selected should comply with relevant regulations and standards to ensure safety during transportation.
Transport vehicles are also required to have good ventilation equipment to prevent danger due to local temperature rise and gas accumulation. Drivers and escorts should be familiar with the characteristics of the chemical and emergency disposal methods, and regularly check the condition of the goods during transportation, such as whether the packaging is damaged or leaked.
In case of leakage, the surrounding personnel should be evacuated immediately, the scene should be isolated, and fire should not be allowed to approach. Emergency personnel must wear professional protective equipment, such as gas masks, chemical protective clothing, etc., to avoid contact and inhalation of harmful substances.
In conclusion, 2-chloro-5-nitrobenzenesulfonyl chloride requires strict environmental conditions, packaging, and personnel handling during storage and transportation. Only by exercising caution and following relevant regulations can we ensure its safety and avoid accidents.
What is the market price of 2-chloro-5-nitrobenzenesulfonyl Chloride?
2-Chloro-5-nitrobenzenesulfonyl chloride, the price of this substance in the market is difficult to determine. The change in its price is related to many reasons.
The first is the situation of raw materials. Its preparation requires specific raw materials. If the supply of raw materials changes, the price will follow. For example, if the production of raw materials decreases due to natural disasters, man-made disasters or policy adjustments, and the supply of raw materials is small but the demand remains unchanged, the price will rise. On the contrary, if the raw materials are abundant, the supply exceeds the demand, and the price may decline.
Furthermore, the preparation method and cost are also heavy. If there is a new method, it can reduce the cost and yield, and the market supply may increase or decrease. If the cost of the old method is high and the yield is low, the price will be difficult to drop.
Market demand is also the key. If the demand for this product in the chemical industry, medicine and other fields increases greatly, and the supply cannot respond quickly, the price will be high. If the demand is less and the supply is more, the price will fall.
The difference in the region also affects its price. In places with convenient transportation and industrial agglomeration, the price may be slightly lower due to low transportation and transaction costs. And in remote places, due to cost increases, the price may be higher.
The price varies depending on the season. In some seasons, due to the different production plans of downstream industries, the demand fluctuates and the price changes accordingly. Therefore, in order to know the exact market price of 2-chloro-5-nitrobenzenesulfonyl chloride, it is necessary to carefully investigate the situation of raw materials, preparation methods, market supply and demand, regional factors and changes in time, etc., and comprehensively analyze and judge, in order to obtain a more accurate price.
The first is the situation of raw materials. Its preparation requires specific raw materials. If the supply of raw materials changes, the price will follow. For example, if the production of raw materials decreases due to natural disasters, man-made disasters or policy adjustments, and the supply of raw materials is small but the demand remains unchanged, the price will rise. On the contrary, if the raw materials are abundant, the supply exceeds the demand, and the price may decline.
Furthermore, the preparation method and cost are also heavy. If there is a new method, it can reduce the cost and yield, and the market supply may increase or decrease. If the cost of the old method is high and the yield is low, the price will be difficult to drop.
Market demand is also the key. If the demand for this product in the chemical industry, medicine and other fields increases greatly, and the supply cannot respond quickly, the price will be high. If the demand is less and the supply is more, the price will fall.
The difference in the region also affects its price. In places with convenient transportation and industrial agglomeration, the price may be slightly lower due to low transportation and transaction costs. And in remote places, due to cost increases, the price may be higher.
The price varies depending on the season. In some seasons, due to the different production plans of downstream industries, the demand fluctuates and the price changes accordingly. Therefore, in order to know the exact market price of 2-chloro-5-nitrobenzenesulfonyl chloride, it is necessary to carefully investigate the situation of raw materials, preparation methods, market supply and demand, regional factors and changes in time, etc., and comprehensively analyze and judge, in order to obtain a more accurate price.
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