Linshang Chemical
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2-Chloro-5-Nitrobenzenesulphonyl Chloride
Linshang Chemical
|
HS Code |
989351 |
| Chemical Formula | C6H3Cl2NO4S |
| Molar Mass | 260.06 g/mol |
| Appearance | Yellow to orange solid |
| Melting Point | 82 - 86 °C |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Odor | Pungent |
| Hazard Class | Corrosive |
As an accredited 2-Chloro-5-Nitrobenzenesulphonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2 - chloro - 5 - nitrobenzenesulphonyl chloride packaged in a sealed glass bottle. |
| Storage | 2 - Chloro - 5 - nitrobenzenesulphonyl chloride should be stored in a cool, dry, well - ventilated area. It must be kept away from heat sources, flames, and incompatible substances like bases, reducing agents, and moisture. Store it in a tightly - sealed container, preferably in a corrosion - resistant material, to prevent leakage and degradation. Label the storage clearly for easy identification and safety. |
| Shipping | 2 - chloro - 5 - nitrobenzenesulphonyl chloride is a hazardous chemical. Shipping requires proper packaging in accordance with regulations. It must be labeled clearly for its dangerous nature and transported by carriers licensed for such chemicals. |
Competitive 2-Chloro-5-Nitrobenzenesulphonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What is the chemistry of 2-chloro-5-nitrobenzenesulphonyl Chloride?
2-Chloro-5-nitrobenzenesulfonyl chloride, this is an organic compound. It has active chemical properties and has a wide range of uses in the field of organic synthesis.
In terms of its chemical properties, the sulfonyl chloride group (-SO 2O Cl) is active and prone to nucleophilic substitution. When exposed to water, it is easy to hydrolyze to form 2-chloro-5-nitrobenzenesulfonic acid and hydrogen chloride. The reaction is violent and irreversible, because its hydrolysis product hydrogen chloride escapes from the system, it promotes the reaction to proceed continuously. This hydrolysis reaction can also occur slowly in humid air, so care should be taken to isolate water vapor when storing.
Its nitro group (-NO ³) is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring, so that the electrophilic substitution activity on the benzene ring is weakened, the ortho-para-site effect is suppressed, and the meso-site substitution is more likely to occur. Although the chlorine atom (-Cl) is an ortho-site group, its electron-giving ability is relatively weak, and the electrophilic substitution activity is also restricted to a certain extent by the nitro group.
In the nucleophilic substitution reaction, the chlorine atom of the sulfonyl chloride group is easily replaced by various nucleophilic reagents. If it reacts with alcohols, sulfonates can be formed; if it reacts with amines, sulfonamides can Such reaction conditions are relatively mild, and by selecting suitable nucleophiles and reaction conditions, a variety of functionalized products can be synthesized, which is of great significance in the fields of medicinal chemistry and materials science.
Because the molecule contains chlorine atoms, nitro groups and sulfonyl chloride groups at the same time, the molecule can be modified and modified through multi-step reactions to construct complex organic structures. However, because many groups in the structure have strong reactivity, the reaction needs to be precisely controlled to achieve the desired synthesis target and avoid side reactions.
In terms of its chemical properties, the sulfonyl chloride group (-SO 2O Cl) is active and prone to nucleophilic substitution. When exposed to water, it is easy to hydrolyze to form 2-chloro-5-nitrobenzenesulfonic acid and hydrogen chloride. The reaction is violent and irreversible, because its hydrolysis product hydrogen chloride escapes from the system, it promotes the reaction to proceed continuously. This hydrolysis reaction can also occur slowly in humid air, so care should be taken to isolate water vapor when storing.
Its nitro group (-NO ³) is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring, so that the electrophilic substitution activity on the benzene ring is weakened, the ortho-para-site effect is suppressed, and the meso-site substitution is more likely to occur. Although the chlorine atom (-Cl) is an ortho-site group, its electron-giving ability is relatively weak, and the electrophilic substitution activity is also restricted to a certain extent by the nitro group.
In the nucleophilic substitution reaction, the chlorine atom of the sulfonyl chloride group is easily replaced by various nucleophilic reagents. If it reacts with alcohols, sulfonates can be formed; if it reacts with amines, sulfonamides can Such reaction conditions are relatively mild, and by selecting suitable nucleophiles and reaction conditions, a variety of functionalized products can be synthesized, which is of great significance in the fields of medicinal chemistry and materials science.
Because the molecule contains chlorine atoms, nitro groups and sulfonyl chloride groups at the same time, the molecule can be modified and modified through multi-step reactions to construct complex organic structures. However, because many groups in the structure have strong reactivity, the reaction needs to be precisely controlled to achieve the desired synthesis target and avoid side reactions.
What are the physical properties of 2-chloro-5-nitrobenzenesulphonyl Chloride?
2-Chloro-5-nitrobenzenesulfonyl chloride is an important compound in organic chemistry. Its physical properties are quite remarkable. Looking at its morphology, it is mostly solid at room temperature and pressure, and often appears in the form of crystals. The crystals are usually fine in texture and have a specific crystal structure, laying the foundation for subsequent research and application.
When it comes to color, it often appears white to light yellow. The color characteristics may vary due to differences in purity, but it falls roughly within this range.
Smell the odor, which is irritating. This irritating odor originates from the characteristics of chlorine atoms, nitro groups and sulfonyl chloride groups in its molecular structure. This smell reminds users to be cautious and take protective measures when touching.
Its melting point also has a specific value, about [specific melting point value]. This melting point characteristic is of great significance for its separation, purification and reaction control under specific temperature conditions. When the temperature rises to the melting point, the substance gradually melts from a solid state to a liquid state. This process requires precise temperature control to ensure the smooth progress of the reaction or operation.
In terms of boiling point, it is about [specific boiling point value]. The existence of boiling point indicates that under a specific pressure, heated to this temperature, 2-chloro-5-nitrobenzenesulfonyl chloride will change from a liquid state to a gas state. Knowing the boiling point, in the separation process such as distillation and fractionation, the appropriate temperature can be set accordingly to achieve effective separation of the substance from other impurities or reactants.
In terms of solubility, in common organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc., it shows a certain solubility, while in water, the solubility is poor. This difference in solubility is a key consideration in the solvent selection, product separation and purification steps of organic synthesis reactions. Selecting a suitable organic solvent can make the substance evenly dispersed in the reaction system and promote the efficient occurrence of the reaction. During separation and purification, according to the difference in solubility, it can be precisely separated from the reaction mixture by means of extraction.
The physical properties of 2-chloro-5-nitrobenzenesulfonyl chloride play a decisive role in its application and research in the fields of organic synthesis, medicinal chemistry and materials science. Scientists need to be familiar with these properties in order to use the compound rationally and carry out various innovative experiments and production activities.
When it comes to color, it often appears white to light yellow. The color characteristics may vary due to differences in purity, but it falls roughly within this range.
Smell the odor, which is irritating. This irritating odor originates from the characteristics of chlorine atoms, nitro groups and sulfonyl chloride groups in its molecular structure. This smell reminds users to be cautious and take protective measures when touching.
Its melting point also has a specific value, about [specific melting point value]. This melting point characteristic is of great significance for its separation, purification and reaction control under specific temperature conditions. When the temperature rises to the melting point, the substance gradually melts from a solid state to a liquid state. This process requires precise temperature control to ensure the smooth progress of the reaction or operation.
In terms of boiling point, it is about [specific boiling point value]. The existence of boiling point indicates that under a specific pressure, heated to this temperature, 2-chloro-5-nitrobenzenesulfonyl chloride will change from a liquid state to a gas state. Knowing the boiling point, in the separation process such as distillation and fractionation, the appropriate temperature can be set accordingly to achieve effective separation of the substance from other impurities or reactants.
In terms of solubility, in common organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc., it shows a certain solubility, while in water, the solubility is poor. This difference in solubility is a key consideration in the solvent selection, product separation and purification steps of organic synthesis reactions. Selecting a suitable organic solvent can make the substance evenly dispersed in the reaction system and promote the efficient occurrence of the reaction. During separation and purification, according to the difference in solubility, it can be precisely separated from the reaction mixture by means of extraction.
The physical properties of 2-chloro-5-nitrobenzenesulfonyl chloride play a decisive role in its application and research in the fields of organic synthesis, medicinal chemistry and materials science. Scientists need to be familiar with these properties in order to use the compound rationally and carry out various innovative experiments and production activities.
What are the common uses of 2-chloro-5-nitrobenzenesulphonyl Chloride?
2-Chloro-5-nitrobenzenesulfonyl chloride is an important chemical raw material in organic synthesis. It has many common uses, so let me tell you one by one.
First, it is often used as a key intermediate in the field of pharmaceutical synthesis. Taking the preparation of some antibacterial and anti-inflammatory drugs as an example, with its special chemical structure, it can undergo subtle chemical reactions with other compounds to build a specific skeleton of drug molecules. Through carefully designed reaction paths, using the activity of chlorine atoms and nitro groups, it can react with compounds containing specific functional groups by nucleophilic substitution, electrophilic addition, etc., and then shape the drug molecule structure with the required pharmacological activity.
Second, it also plays a key role in the creation of pesticides. It can participate in the synthesis of high-efficiency and low-toxicity pesticide varieties. For example, by reacting with compounds containing nitrogen and phosphorus, pesticide ingredients with unique insecticidal, bactericidal or herbicidal properties are generated. Through its chemical activity, the target and mode of action of pesticide molecules are changed, and the control effect of pesticides on specific pests and diseases is improved, while reducing the harm to the environment and non-target organisms.
Third, in dye synthesis, 2-chloro-5-nitrobenzenesulfonyl chloride is also an indispensable thing. It can be used as an important starting material for the synthesis of new dyes. After a series of reactions, it endows the dyes with excellent color properties and dyeing fastness. Using its sulfonyl chloride group to react with compounds containing different chromophore groups, colorful and stable dye molecules are constructed, which are widely used in textiles, printing and dyeing and other industries.
Fourth, in the field of materials science, it can also be used to synthesize functional polymer materials. Introduce it into the polymer chain segment to endow the material with special properties such as antibacterial and antioxidant. By polymerizing with polymer monomers, the material can add new functional properties on the basis of maintaining the original properties, and expand the application range of the material, such as for the preparation of special packaging materials, medical polymer materials, etc.
In summary, 2-chloro-5-nitrobenzenesulfonyl chloride has a wide range of important uses in many fields due to its unique chemical structure and reactivity, and plays an important role in promoting the development of related industries.
First, it is often used as a key intermediate in the field of pharmaceutical synthesis. Taking the preparation of some antibacterial and anti-inflammatory drugs as an example, with its special chemical structure, it can undergo subtle chemical reactions with other compounds to build a specific skeleton of drug molecules. Through carefully designed reaction paths, using the activity of chlorine atoms and nitro groups, it can react with compounds containing specific functional groups by nucleophilic substitution, electrophilic addition, etc., and then shape the drug molecule structure with the required pharmacological activity.
Second, it also plays a key role in the creation of pesticides. It can participate in the synthesis of high-efficiency and low-toxicity pesticide varieties. For example, by reacting with compounds containing nitrogen and phosphorus, pesticide ingredients with unique insecticidal, bactericidal or herbicidal properties are generated. Through its chemical activity, the target and mode of action of pesticide molecules are changed, and the control effect of pesticides on specific pests and diseases is improved, while reducing the harm to the environment and non-target organisms.
Third, in dye synthesis, 2-chloro-5-nitrobenzenesulfonyl chloride is also an indispensable thing. It can be used as an important starting material for the synthesis of new dyes. After a series of reactions, it endows the dyes with excellent color properties and dyeing fastness. Using its sulfonyl chloride group to react with compounds containing different chromophore groups, colorful and stable dye molecules are constructed, which are widely used in textiles, printing and dyeing and other industries.
Fourth, in the field of materials science, it can also be used to synthesize functional polymer materials. Introduce it into the polymer chain segment to endow the material with special properties such as antibacterial and antioxidant. By polymerizing with polymer monomers, the material can add new functional properties on the basis of maintaining the original properties, and expand the application range of the material, such as for the preparation of special packaging materials, medical polymer materials, etc.
In summary, 2-chloro-5-nitrobenzenesulfonyl chloride has a wide range of important uses in many fields due to its unique chemical structure and reactivity, and plays an important role in promoting the development of related industries.
What is the synthesis method of 2-chloro-5-nitrobenzenesulphonyl Chloride?
The preparation of 2-chloro-5-nitrobenzenesulfonyl chloride can start from common benzene derivatives. With benzene as the group, benzene is first sulfonated. This is to use concentrated sulfuric acid or fuming sulfuric acid as the sulfonating agent. Under heating conditions, benzene interacts with the sulfonating agent, and the hydrogen on the benzene ring is replaced by the sulfonic acid group (-SOH) to form benzenesulfonic acid.
Then, the benzenesulfonic acid is nitrified. In this step, the mixed acid of concentrated nitric acid and concentrated sulfuric acid is used as the nitrification reagent. At a suitable temperature, the nitro group (-NO _ 2) is introduced into the benzenesulfonic acid benzene ring. Because the sulfonic acid group is the meta-locator group,
Next, 5-nitrobenzenesulfonic acid is chlorinated. Phosphorus pentachloride (PCl) or sulfoxide chloride (SOCl) is used as a chlorination agent, and the hydroxyl group (-OH) of the sulfonic acid group in 5-nitrobenzenesulfonic acid is replaced by a chlorine atom to obtain 5-nitrobenzenesulfonyl chloride.
Finally, 5-nitrobenzenesulfonyl chloride is chlorinated. In the presence of suitable catalysts such as iron powder or ferric chloride, chlorine gas is used as a chlorination reagent to introduce chlorine atoms on the benzene ring. Due to the fact that both nitro and sulfonyl chloride are meta-sites, and the two interact together, the chlorine atoms mainly enter the two meta-sites, and finally form 2-chloro-5-nitrobenzenesulfonyl chloride. Each step of the reaction requires precise control of reaction conditions, such as temperature, reactant ratio, reaction time, etc., to achieve higher yield and purity.
Then, the benzenesulfonic acid is nitrified. In this step, the mixed acid of concentrated nitric acid and concentrated sulfuric acid is used as the nitrification reagent. At a suitable temperature, the nitro group (-NO _ 2) is introduced into the benzenesulfonic acid benzene ring. Because the sulfonic acid group is the meta-locator group,
Next, 5-nitrobenzenesulfonic acid is chlorinated. Phosphorus pentachloride (PCl) or sulfoxide chloride (SOCl) is used as a chlorination agent, and the hydroxyl group (-OH) of the sulfonic acid group in 5-nitrobenzenesulfonic acid is replaced by a chlorine atom to obtain 5-nitrobenzenesulfonyl chloride.
Finally, 5-nitrobenzenesulfonyl chloride is chlorinated. In the presence of suitable catalysts such as iron powder or ferric chloride, chlorine gas is used as a chlorination reagent to introduce chlorine atoms on the benzene ring. Due to the fact that both nitro and sulfonyl chloride are meta-sites, and the two interact together, the chlorine atoms mainly enter the two meta-sites, and finally form 2-chloro-5-nitrobenzenesulfonyl chloride. Each step of the reaction requires precise control of reaction conditions, such as temperature, reactant ratio, reaction time, etc., to achieve higher yield and purity.
What are the precautions for 2-chloro-5-nitrobenzenesulphonyl Chloride in storage and transportation?
2-Chloro-5-nitrobenzenesulfonyl chloride is a chemical substance. When storing and transporting, extra care must be taken to avoid dangerous disasters.
First, the storage place should be cool and dry, avoiding heat and moisture. This substance is prone to react when heated or wet, or cause qualitative change or be dangerous. Covering heat and moisture can promote its chemical changes, damage its quality, and may cause the escape of harmful gases, endangering the surrounding area.
Second, it must be isolated from oxidizing agents, reducing agents, alkalis, etc. Because of its active chemical properties, it is easy to react violently when it encounters with them, and even risk combustion and explosion. Therefore, classified storage, strict compliance with the regulations, security.
Third, the storage place must be well ventilated. If the ventilation is not smooth, in case of material leakage, harmful gas accumulation, human health and the environment are a serious threat. Good ventilation can quickly disperse harmful gases, reduce their concentration, and reduce the danger to intangible.
Fourth, during transportation, the packaging must be tight. Use appropriate packaging materials to ensure that there is no vibration, collision, and friction during transportation. If the packaging is damaged and the material leaks, it will harm the transportation personnel and the surrounding environment.
Fifth, the transportation personnel must be professionally trained to understand its characteristics, hazards, and emergency response methods. In case of emergencies, one can respond calmly, take correct measures, control the situation, and reduce losses.
In short, the storage and transportation of 2-chloro-5-nitrobenzenesulfonyl chloride is related to safety, and it is necessary to follow regulations and be cautious in order to ensure that everything goes smoothly and is safe and harmless.
First, the storage place should be cool and dry, avoiding heat and moisture. This substance is prone to react when heated or wet, or cause qualitative change or be dangerous. Covering heat and moisture can promote its chemical changes, damage its quality, and may cause the escape of harmful gases, endangering the surrounding area.
Second, it must be isolated from oxidizing agents, reducing agents, alkalis, etc. Because of its active chemical properties, it is easy to react violently when it encounters with them, and even risk combustion and explosion. Therefore, classified storage, strict compliance with the regulations, security.
Third, the storage place must be well ventilated. If the ventilation is not smooth, in case of material leakage, harmful gas accumulation, human health and the environment are a serious threat. Good ventilation can quickly disperse harmful gases, reduce their concentration, and reduce the danger to intangible.
Fourth, during transportation, the packaging must be tight. Use appropriate packaging materials to ensure that there is no vibration, collision, and friction during transportation. If the packaging is damaged and the material leaks, it will harm the transportation personnel and the surrounding environment.
Fifth, the transportation personnel must be professionally trained to understand its characteristics, hazards, and emergency response methods. In case of emergencies, one can respond calmly, take correct measures, control the situation, and reduce losses.
In short, the storage and transportation of 2-chloro-5-nitrobenzenesulfonyl chloride is related to safety, and it is necessary to follow regulations and be cautious in order to ensure that everything goes smoothly and is safe and harmless.
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