Linshang Chemical
PRODUCTS
2-Chloro-5-(Trifluoromethyl)Benzeneboronic Acid
Linshang Chemical
|
HS Code |
386568 |
| Chemical Formula | C7H5BClF3O2 |
| Molecular Weight | 224.47 |
| Appearance | Typically a solid (white to off - white powder) |
| Purity | Often available in high purity, e.g., 95%+ |
| Solubility | Soluble in some organic solvents like dichloromethane |
| Melting Point | Around 120 - 125 °C |
| Acidity | Boronic acid group can act as a weak acid |
| Reactivity | Reactive in cross - coupling reactions |
As an accredited 2-Chloro-5-(Trifluoromethyl)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 5 - (trifluoromethyl)benzeneboronic acid in sealed chemical - grade packaging. |
| Storage | 2 - chloro - 5 - (trifluoromethyl)benzeneboronic acid should be stored in a cool, dry place, away from heat sources and direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and exposure to air, which could lead to degradation. Store it separately from incompatible substances, like strong oxidizing agents and bases, to avoid chemical reactions. |
| Shipping | 2 - chloro - 5 - (trifluoromethyl)benzeneboronic acid is shipped in well - sealed containers, compliant with chemical transportation regulations. Shipment ensures protection from moisture and physical damage during transit. |
Competitive 2-Chloro-5-(Trifluoromethyl)Benzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Chloro-5-(Trifluoromethyl)Benzeneboronic Acid in China?
As a trusted 2-Chloro-5-(Trifluoromethyl)Benzeneboronic Acid manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-5-(Trifluoromethyl)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 2-chloro-5- (trifluoromethyl) benzeneboronic Acid?
2-Chloro-5- (trifluoromethyl) phenylboronic acid, this substance has a wide range of uses in organic synthesis.
First, it is often a key player in the construction of carbon-carbon bonds. Through the Suzuki-Miyaura coupling reaction, it can be cleverly combined with halogenated aromatics, halogenated olefins, etc. In this reaction, the boron atom in 2-chloro-5- (trifluoromethyl) phenylboronic acid and the halogenated compound realize the exquisite construction of carbon-carbon bonds with the help of palladium catalysts and bases. With this reaction, many aromatic hydrocarbon derivatives with special structures can be synthesized. In the field of medicinal chemistry, it can lay the foundation for the creation of new drug molecules; in the field of materials science, it is helpful to prepare organic optoelectronic materials with unique properties.
Second, in the path of drug research and development, the chlorine atom, trifluoromethyl and boric acid groups contained in the molecule endow it with unique physical, chemical and biological activities. Chlorine atoms and trifluoromethyl can adjust the lipid solubility and electrical properties of molecules, affecting the ability of drugs to bind to targets; boric acid groups can interact with specific molecules in organisms, such as reversibly covalent bonds with sugar molecules. Therefore, it can be used as a key intermediate for the synthesis of compounds with specific pharmacological activities, providing the possibility for the search for new therapeutic drugs.
Third, in the field of material synthesis, the macromolecular structures constructed by the coupling reactions in which they participate can exhibit special optical and electrical properties. For example, the preparation of fluorine-containing polymer materials with conjugated structures may emerge in organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices because of their special structures or can improve the charge transfer efficiency and luminous efficiency of materials.
First, it is often a key player in the construction of carbon-carbon bonds. Through the Suzuki-Miyaura coupling reaction, it can be cleverly combined with halogenated aromatics, halogenated olefins, etc. In this reaction, the boron atom in 2-chloro-5- (trifluoromethyl) phenylboronic acid and the halogenated compound realize the exquisite construction of carbon-carbon bonds with the help of palladium catalysts and bases. With this reaction, many aromatic hydrocarbon derivatives with special structures can be synthesized. In the field of medicinal chemistry, it can lay the foundation for the creation of new drug molecules; in the field of materials science, it is helpful to prepare organic optoelectronic materials with unique properties.
Second, in the path of drug research and development, the chlorine atom, trifluoromethyl and boric acid groups contained in the molecule endow it with unique physical, chemical and biological activities. Chlorine atoms and trifluoromethyl can adjust the lipid solubility and electrical properties of molecules, affecting the ability of drugs to bind to targets; boric acid groups can interact with specific molecules in organisms, such as reversibly covalent bonds with sugar molecules. Therefore, it can be used as a key intermediate for the synthesis of compounds with specific pharmacological activities, providing the possibility for the search for new therapeutic drugs.
Third, in the field of material synthesis, the macromolecular structures constructed by the coupling reactions in which they participate can exhibit special optical and electrical properties. For example, the preparation of fluorine-containing polymer materials with conjugated structures may emerge in organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices because of their special structures or can improve the charge transfer efficiency and luminous efficiency of materials.
What are the physical properties of 2-chloro-5- (trifluoromethyl) benzeneboronic Acid
2-Chloro-5- (trifluoromethyl) phenylboronic acid, its physical properties are as follows:
This compound is mostly in solid form at room temperature. Looking at its appearance, it is usually white to off-white crystalline powder with fine texture.
Melting point is one of the important physical properties of substances. The melting point of 2-chloro-5- (trifluoromethyl) phenylboronic acid is within a specific range. This value is of great significance for the identification and purification of the compound. By accurately measuring the melting point, its purity can be determined. If the melting point value is highly consistent with the theoretical value and the melting range is narrow, it indicates that the purity of the compound is quite high; conversely, if the melting range is wide, it means that there may be impurities.
Solubility is also a key physical property. It has a certain solubility in common organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). In dichloromethane, under moderate temperature and stirring conditions, it can dissolve to form a homogeneous solution. This property makes it possible for 2-chloro-5- (trifluoromethyl) phenylboronic acid to fully contact and mix with other reactants in the organic synthesis reaction medium using dichloromethane as the reaction medium, promoting the efficient progress of the reaction. In DMF, its solubility is relatively better, and the strong polarity of DMF helps to disperse the compound molecules and form a stable solution, which is extremely beneficial in some reactions or separation processes that require high solubility. However, its solubility in water is poor. Due to the strong hydrophobicity of benzene ring, chlorine atom, trifluoromethyl and other parts of its molecular structure, its solubility in water is greatly limited.
2-chloro-5- (trifluoromethyl) phenylboronic acid has a higher density than water. If it is put into water, it will sink to the bottom. This density characteristic is very important for judging its location and the choice of separation method in operations involving liquid-liquid separation.
In terms of stability, it has certain stability under normal storage conditions. However, it should be noted that it is more sensitive to humidity. In an environment with high humidity, reactions such as hydrolysis may occur, resulting in structural changes and affecting performance. Therefore, storage should be placed in a dry environment and sealed to prevent excessive contact with moisture.
This compound is mostly in solid form at room temperature. Looking at its appearance, it is usually white to off-white crystalline powder with fine texture.
Melting point is one of the important physical properties of substances. The melting point of 2-chloro-5- (trifluoromethyl) phenylboronic acid is within a specific range. This value is of great significance for the identification and purification of the compound. By accurately measuring the melting point, its purity can be determined. If the melting point value is highly consistent with the theoretical value and the melting range is narrow, it indicates that the purity of the compound is quite high; conversely, if the melting range is wide, it means that there may be impurities.
Solubility is also a key physical property. It has a certain solubility in common organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). In dichloromethane, under moderate temperature and stirring conditions, it can dissolve to form a homogeneous solution. This property makes it possible for 2-chloro-5- (trifluoromethyl) phenylboronic acid to fully contact and mix with other reactants in the organic synthesis reaction medium using dichloromethane as the reaction medium, promoting the efficient progress of the reaction. In DMF, its solubility is relatively better, and the strong polarity of DMF helps to disperse the compound molecules and form a stable solution, which is extremely beneficial in some reactions or separation processes that require high solubility. However, its solubility in water is poor. Due to the strong hydrophobicity of benzene ring, chlorine atom, trifluoromethyl and other parts of its molecular structure, its solubility in water is greatly limited.
2-chloro-5- (trifluoromethyl) phenylboronic acid has a higher density than water. If it is put into water, it will sink to the bottom. This density characteristic is very important for judging its location and the choice of separation method in operations involving liquid-liquid separation.
In terms of stability, it has certain stability under normal storage conditions. However, it should be noted that it is more sensitive to humidity. In an environment with high humidity, reactions such as hydrolysis may occur, resulting in structural changes and affecting performance. Therefore, storage should be placed in a dry environment and sealed to prevent excessive contact with moisture.
What are the synthesis methods of 2-chloro-5- (trifluoromethyl) benzeneboronic Acid
The common methods for synthesizing 2-chloro-5- (trifluoromethyl) phenylboronic acid are as follows.
One is the halogenated aromatic hydrocarbon metal reagent method. Using 2-chloro-5- (trifluoromethyl) bromobenzene as the starting material, it is reacted with metal magnesium in a low temperature environment to form Grignard reagent. This process needs to be carried out under severe conditions of anhydrous and oxygen-free. Because Grignard reagent is extremely active, it reacts quickly in contact with water and oxygen and fails. After the Grignard reagent is formed, it reacts with borate esters, such as trimethyl borate. After the reaction is completed, 2-chloro-5- (trifluoromethyl) phenylboronic acid can be obtained by hydrolysis.
The second is the palladium catalytic coupling method. Using 2-chloro-5- (trifluoromethyl) halobenzene and pinacol biborate as raw materials, under the action of palladium catalyst, such as tetra (triphenylphosphine) palladium, the reaction is carried out in a suitable solvent, such as dioxane. This reaction requires the addition of bases as additives. Common bases include potassium carbonate. The palladium catalyst can effectively promote the coupling reaction between halobenzene and pinacol biborate to form the corresponding borate intermediate. Subsequently, the intermediate is hydrolyzed to obtain the target product 2-chloro-5- (trifluoromethyl) phenylboronic acid. This method has the advantages of relatively mild reaction conditions and high selectivity, and is widely used in the field of organic synthesis.
Another lithium reagent method. First, 2-chloro-5- (trifluoromethyl) halobenzene reacts with lithium reagents such as butyl lithium to form lithium aromatic hydrocarbon intermediates. This intermediate is extremely active, followed by reaction with borate esters, and finally through hydrolysis steps, 2-chloro-5- (trifluoromethyl) phenylboronic acid can also be successfully synthesized. However, this method requires the use of active lithium reagents such as butyl lithium, which requires high reaction operation and must strictly control the reaction conditions to ensure the safety of the experiment and the smooth progress of the reaction.
One is the halogenated aromatic hydrocarbon metal reagent method. Using 2-chloro-5- (trifluoromethyl) bromobenzene as the starting material, it is reacted with metal magnesium in a low temperature environment to form Grignard reagent. This process needs to be carried out under severe conditions of anhydrous and oxygen-free. Because Grignard reagent is extremely active, it reacts quickly in contact with water and oxygen and fails. After the Grignard reagent is formed, it reacts with borate esters, such as trimethyl borate. After the reaction is completed, 2-chloro-5- (trifluoromethyl) phenylboronic acid can be obtained by hydrolysis.
The second is the palladium catalytic coupling method. Using 2-chloro-5- (trifluoromethyl) halobenzene and pinacol biborate as raw materials, under the action of palladium catalyst, such as tetra (triphenylphosphine) palladium, the reaction is carried out in a suitable solvent, such as dioxane. This reaction requires the addition of bases as additives. Common bases include potassium carbonate. The palladium catalyst can effectively promote the coupling reaction between halobenzene and pinacol biborate to form the corresponding borate intermediate. Subsequently, the intermediate is hydrolyzed to obtain the target product 2-chloro-5- (trifluoromethyl) phenylboronic acid. This method has the advantages of relatively mild reaction conditions and high selectivity, and is widely used in the field of organic synthesis.
Another lithium reagent method. First, 2-chloro-5- (trifluoromethyl) halobenzene reacts with lithium reagents such as butyl lithium to form lithium aromatic hydrocarbon intermediates. This intermediate is extremely active, followed by reaction with borate esters, and finally through hydrolysis steps, 2-chloro-5- (trifluoromethyl) phenylboronic acid can also be successfully synthesized. However, this method requires the use of active lithium reagents such as butyl lithium, which requires high reaction operation and must strictly control the reaction conditions to ensure the safety of the experiment and the smooth progress of the reaction.
What to pay attention to when storing 2-chloro-5- (trifluoromethyl) benzeneboronic Acid
When storing 2-chloro-5- (trifluoromethyl) phenylboronic acid, it is necessary to pay attention to many matters. This compound is more active in nature and is quite sensitive to environmental factors.
First, the control of temperature is crucial. It should be stored in a low temperature and stable place, usually 2-8 ° C. If the temperature is too high, it may cause its chemical reaction, cause its deterioration, and affect the quality and utility.
Second, the humidity should not be underestimated. It should be placed in a dry place, away from water vapor. Because it is prone to hydrolysis and other reactions in contact with water, resulting in structural changes and reduced activity.
Third, light will also affect it. The substance should be stored in a dark place, preferably in a brown bottle, to prevent adverse changes such as decomposition caused by light.
Fourth, the storage place must be away from fire sources, heat sources and strong oxidants. This compound has certain flammability and reactivity. In case of open flame, topic or strong oxidant, it may burn or explode.
In addition, the storage process should ensure that the packaging is tight to prevent contact with air to avoid oxidation and other reactions. After taking it, it needs to be sealed in time to prevent external factors from affecting the remaining substances. In this way, 2-chloro-5- (trifluoromethyl) phenylboronic acid can be properly preserved to maintain good performance.
First, the control of temperature is crucial. It should be stored in a low temperature and stable place, usually 2-8 ° C. If the temperature is too high, it may cause its chemical reaction, cause its deterioration, and affect the quality and utility.
Second, the humidity should not be underestimated. It should be placed in a dry place, away from water vapor. Because it is prone to hydrolysis and other reactions in contact with water, resulting in structural changes and reduced activity.
Third, light will also affect it. The substance should be stored in a dark place, preferably in a brown bottle, to prevent adverse changes such as decomposition caused by light.
Fourth, the storage place must be away from fire sources, heat sources and strong oxidants. This compound has certain flammability and reactivity. In case of open flame, topic or strong oxidant, it may burn or explode.
In addition, the storage process should ensure that the packaging is tight to prevent contact with air to avoid oxidation and other reactions. After taking it, it needs to be sealed in time to prevent external factors from affecting the remaining substances. In this way, 2-chloro-5- (trifluoromethyl) phenylboronic acid can be properly preserved to maintain good performance.
What are the common impurities of 2-chloro-5- (trifluoromethyl) benzeneboronic Acid
2-Chloro-5- (trifluoromethyl) phenylboronic acid is a commonly used reagent in organic synthesis, but it is susceptible to impurities during preparation and storage. The following impurities are more common:
1. ** Boric acid impurities **: During the synthesis process, due to incomplete reaction, unreacted boric acid, such as phenylboronic acid, may remain. This impurity is formed, or due to poor control of reaction conditions, the proportion of reactants is inappropriate. Its presence in the product may affect the purity of the product and subsequent reaction selectivity.
2. ** Halogenated aromatic hydrocarbon impurities **: If the raw material 2-chloro-5- (trifluoromethyl) chlorobenzene is not fully converted, it will remain in the product. Such impurities result from insufficient reaction conversion, or due to poor catalyst activity and short reaction time. They are in the product, or cause subsequent reactions to produce side reactions, reducing the yield of the target product.
3. ** Oxidation product impurities **: 2-chloro-5- (trifluoromethyl) phenylboronic acid has certain reductive properties. If it encounters air during storage, it is easy to be oxidized and form corresponding oxidation products. This oxidation process may be accelerated due to inappropriate storage environment humidity and temperature. The formation of oxidation products will cause the product to deteriorate, affecting its chemical properties and application performance.
4. ** Moisture **: Moisture is also one of the common impurities. It may be mixed in the synthesis, separation and storage. The presence of water content may initiate the hydrolysis of 2-chloro-5- (trifluoromethyl) phenylboronic acid to form other impurities, and may also affect the stability and reactivity of the product.
5. ** Metal ion impurities **: The catalysts and reaction equipment used in the synthesis, or the introduction of metal ion impurities, such as iron ions, copper ions, etc. Such metal ions may catalyze some side reactions to occur, affect the quality of the product, or react with the product to change the properties of the product.
In order to ensure the quality and properties of 2-chloro-5- (trifluoromethyl) phenylboronic acid, effective measures must be taken during the preparation, storage and use, such as optimizing the reaction conditions to improve the reaction conversion rate, strictly controlling the storage environment, and using appropriate purification methods to reduce the impurity content.
1. ** Boric acid impurities **: During the synthesis process, due to incomplete reaction, unreacted boric acid, such as phenylboronic acid, may remain. This impurity is formed, or due to poor control of reaction conditions, the proportion of reactants is inappropriate. Its presence in the product may affect the purity of the product and subsequent reaction selectivity.
2. ** Halogenated aromatic hydrocarbon impurities **: If the raw material 2-chloro-5- (trifluoromethyl) chlorobenzene is not fully converted, it will remain in the product. Such impurities result from insufficient reaction conversion, or due to poor catalyst activity and short reaction time. They are in the product, or cause subsequent reactions to produce side reactions, reducing the yield of the target product.
3. ** Oxidation product impurities **: 2-chloro-5- (trifluoromethyl) phenylboronic acid has certain reductive properties. If it encounters air during storage, it is easy to be oxidized and form corresponding oxidation products. This oxidation process may be accelerated due to inappropriate storage environment humidity and temperature. The formation of oxidation products will cause the product to deteriorate, affecting its chemical properties and application performance.
4. ** Moisture **: Moisture is also one of the common impurities. It may be mixed in the synthesis, separation and storage. The presence of water content may initiate the hydrolysis of 2-chloro-5- (trifluoromethyl) phenylboronic acid to form other impurities, and may also affect the stability and reactivity of the product.
5. ** Metal ion impurities **: The catalysts and reaction equipment used in the synthesis, or the introduction of metal ion impurities, such as iron ions, copper ions, etc. Such metal ions may catalyze some side reactions to occur, affect the quality of the product, or react with the product to change the properties of the product.
In order to ensure the quality and properties of 2-chloro-5- (trifluoromethyl) phenylboronic acid, effective measures must be taken during the preparation, storage and use, such as optimizing the reaction conditions to improve the reaction conversion rate, strictly controlling the storage environment, and using appropriate purification methods to reduce the impurity content.
Scan to WhatsApp
