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2-Chloro-5-Trifluoromethyl Bromobenzene
Linshang Chemical
|
HS Code |
554955 |
| Chemical Formula | C7H3BrClF3 |
| Molecular Weight | 273.45 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 197 - 199 °C |
| Melting Point | N/A |
| Density | 1.748 g/mL at 25 °C |
| Flash Point | 78.9 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ether, chloroform |
| Vapor Pressure | N/A |
| Refractive Index | 1.483 - 1.485 |
As an accredited 2-Chloro-5-Trifluoromethyl Bromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 5 - trifluoromethyl bromobenzene packaged in a sealed glass bottle. |
| Storage | 2 - chloro - 5 - trifluoromethyl bromobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition points. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, strong acids, and bases to prevent potential chemical reactions. Regularly check storage conditions to ensure safety. |
| Shipping | 2 - chloro - 5 - trifluoromethyl Bromobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict chemical transportation regulations to ensure safety during transit, avoiding exposure to incompatible substances. |
Competitive 2-Chloro-5-Trifluoromethyl Bromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Chloro-5-Trifluoromethyl Bromobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-5-Trifluoromethyl Bromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-5-trifluoromethyl Bromobenzene?
2-Chloro-5-trifluoromethyl bromobenzene is also an organic compound. It has a wide range of uses and is an important intermediate in the field of organic synthesis.
Because of its special structure, it contains functional groups such as chlorine, bromine and trifluoromethyl, which can be derived from various chemical reactions. In the synthesis of medicine, it is often a key starting material. After appropriate reaction steps, it may be able to construct molecular structures with specific physiological activities to prepare various drugs.
It also plays an important role in the creation of pesticides. With it as a base, chemically modified and transformed, or pesticide products with high insecticidal, bactericidal or herbicidal properties can be synthesized. Due to the introduction of trifluoromethyl, it can often improve the stability, fat solubility and biological activity of compounds, so it is very popular in the field of pesticides.
In addition, in the field of materials science, 2-chloro-5-trifluoromethyl bromobenzene may also have its uses. Or it can participate in the preparation of special polymer materials, endowing the materials with excellent properties such as weather resistance and chemical corrosion resistance, and demonstrating its value in high-end fields such as aerospace and electronics.
In short, 2-chloro-5-trifluoromethyl bromobenzene has important uses in many fields such as medicine, pesticides, and materials, and is an important cornerstone of organic synthetic chemistry.
Because of its special structure, it contains functional groups such as chlorine, bromine and trifluoromethyl, which can be derived from various chemical reactions. In the synthesis of medicine, it is often a key starting material. After appropriate reaction steps, it may be able to construct molecular structures with specific physiological activities to prepare various drugs.
It also plays an important role in the creation of pesticides. With it as a base, chemically modified and transformed, or pesticide products with high insecticidal, bactericidal or herbicidal properties can be synthesized. Due to the introduction of trifluoromethyl, it can often improve the stability, fat solubility and biological activity of compounds, so it is very popular in the field of pesticides.
In addition, in the field of materials science, 2-chloro-5-trifluoromethyl bromobenzene may also have its uses. Or it can participate in the preparation of special polymer materials, endowing the materials with excellent properties such as weather resistance and chemical corrosion resistance, and demonstrating its value in high-end fields such as aerospace and electronics.
In short, 2-chloro-5-trifluoromethyl bromobenzene has important uses in many fields such as medicine, pesticides, and materials, and is an important cornerstone of organic synthetic chemistry.
2-chloro-5-trifluoromethyl the physical properties of Bromobenzene
2-Chloro-5-trifluoromethyl bromobenzene is also an organic compound. It has specific physical properties, which are described in detail by you today.
Looking at its appearance, under room temperature and pressure, 2-chloro-5-trifluoromethyl bromobenzene is in a colorless to light yellow liquid state, clear and transparent, like a beautiful jade without flaws. Its taste has a special aromatic smell, but this smell should not be smelled lightly, because it may be harmful to the human body.
Talking about the boiling point, it is about 190-195 ° C. When the temperature gradually rises, the compound changes from liquid to gas state, and the molecules break free from each other and run freely in space. The characteristics of the boiling point allow it to precisely control its state changes according to temperature in separation, purification and other experiments or industrial operations.
In terms of melting point, it is about -20 ° C. When the temperature drops to this point, the molecular motion gradually slows down, and they are arranged in an orderly manner close to each other, then solidify from liquid to solid. The melting point data can help the experimenter understand the conditions for its phase transition. When storing and transporting, the appropriate temperature environment can be selected according to this to ensure its morphological stability.
2-chloro-5-trifluoromethylbromobenzene has a higher density than water, about 1.7g/cm ³. If it is mixed with water, it will sink to the bottom of the water, such as a stone entering the water. This density characteristic can be used in the separation of mixtures to achieve preliminary separation by means of density difference.
Solubility is also an important physical property. It is insoluble in water, because water is a polar molecule, while 2-chloro-5-trifluoromethyl bromobenzene has a weaker polarity. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in a variety of organic solvents, such as ethanol, ether, dichloromethane, etc. In organic synthesis reactions, organic solvents are often used as reaction mediums. This solubility facilitates the reaction, allowing the reactants to mix evenly and accelerating the reaction process.
In addition, its vapor pressure is low, indicating that its volatilization rate is relatively slow at room temperature. This property should be paid attention to when storing. Although it evaporates slowly, it still needs to be sealed and stored to prevent it from spreading in the air, causing loss or causing safety problems.
The physical properties of 2-chloro-5-trifluoromethyl bromobenzene have their own uses. They are all key factors to consider in the fields of organic chemistry experiments and industrial production. It helps researchers and producers to properly handle this substance and exert its due effect.
Looking at its appearance, under room temperature and pressure, 2-chloro-5-trifluoromethyl bromobenzene is in a colorless to light yellow liquid state, clear and transparent, like a beautiful jade without flaws. Its taste has a special aromatic smell, but this smell should not be smelled lightly, because it may be harmful to the human body.
Talking about the boiling point, it is about 190-195 ° C. When the temperature gradually rises, the compound changes from liquid to gas state, and the molecules break free from each other and run freely in space. The characteristics of the boiling point allow it to precisely control its state changes according to temperature in separation, purification and other experiments or industrial operations.
In terms of melting point, it is about -20 ° C. When the temperature drops to this point, the molecular motion gradually slows down, and they are arranged in an orderly manner close to each other, then solidify from liquid to solid. The melting point data can help the experimenter understand the conditions for its phase transition. When storing and transporting, the appropriate temperature environment can be selected according to this to ensure its morphological stability.
2-chloro-5-trifluoromethylbromobenzene has a higher density than water, about 1.7g/cm ³. If it is mixed with water, it will sink to the bottom of the water, such as a stone entering the water. This density characteristic can be used in the separation of mixtures to achieve preliminary separation by means of density difference.
Solubility is also an important physical property. It is insoluble in water, because water is a polar molecule, while 2-chloro-5-trifluoromethyl bromobenzene has a weaker polarity. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in a variety of organic solvents, such as ethanol, ether, dichloromethane, etc. In organic synthesis reactions, organic solvents are often used as reaction mediums. This solubility facilitates the reaction, allowing the reactants to mix evenly and accelerating the reaction process.
In addition, its vapor pressure is low, indicating that its volatilization rate is relatively slow at room temperature. This property should be paid attention to when storing. Although it evaporates slowly, it still needs to be sealed and stored to prevent it from spreading in the air, causing loss or causing safety problems.
The physical properties of 2-chloro-5-trifluoromethyl bromobenzene have their own uses. They are all key factors to consider in the fields of organic chemistry experiments and industrial production. It helps researchers and producers to properly handle this substance and exert its due effect.
2-chloro-5-trifluoromethyl the chemistry of Bromobenzene
2-Chloro-5-trifluoromethyl bromobenzene is a genus of organohalogenated aromatic hydrocarbons. Its chemical properties are very interesting and of great significance in the field of organic synthesis.
In this compound, both the chlorine atom and the bromine atom are halogen atoms, giving it a specific reactivity. Halogen atoms can change the electron cloud density of the benzene ring due to their electronegativity. Bromine atoms are relatively large, and the steric resistance effect is more significant, and the electronegativity of chlorine atoms cannot be ignored.
In nucleophilic substitution reactions, halogen atoms can be used as leaving groups. Because bromine atoms tend to leave slightly larger than chlorine atoms, nucleophilic reagents are more likely to attack the carbon atoms attached to bromine atoms, causing bromine ions to leave, thereby forming new compounds For example, when reacting with nucleophiles such as sodium alcohol, corresponding ether compounds may be formed.
Because it contains trifluoromethyl, this group has strong electron-absorbing properties, which can greatly reduce the electron cloud density of the benzene ring, making it more difficult for the benzene ring to undergo electrophilic substitution. However, in the nucleophilic substitution, it can stabilize the negative ion intermediates generated during the reaction, making the nucleophilic substitution reaction easier to proceed.
In addition, the compound may participate in metal-catalyzed reactions, such as palladium-catalyzed coupling reactions. In such reactions, halogen atoms can form intermediates with metals, and then couple with other organic compounds to build more complex organic molecular structures.
In terms of physical properties, it is usually a colorless to light yellow liquid, with a certain boiling point and melting point due to factors such as intermolecular forces and relative molecular mass. And because it contains halogen atoms and trifluoromethyl, it is soluble in organic solvents or has special characteristics, and is generally soluble in common organic solvents, such as dichloromethane and tetrahydrofuran.
2-chloro-5-trifluoromethyl bromobenzene has unique chemical properties and has potential application value in many fields of organic synthesis. It is an important chemical raw material in organic chemistry research and related industrial production.
In this compound, both the chlorine atom and the bromine atom are halogen atoms, giving it a specific reactivity. Halogen atoms can change the electron cloud density of the benzene ring due to their electronegativity. Bromine atoms are relatively large, and the steric resistance effect is more significant, and the electronegativity of chlorine atoms cannot be ignored.
In nucleophilic substitution reactions, halogen atoms can be used as leaving groups. Because bromine atoms tend to leave slightly larger than chlorine atoms, nucleophilic reagents are more likely to attack the carbon atoms attached to bromine atoms, causing bromine ions to leave, thereby forming new compounds For example, when reacting with nucleophiles such as sodium alcohol, corresponding ether compounds may be formed.
Because it contains trifluoromethyl, this group has strong electron-absorbing properties, which can greatly reduce the electron cloud density of the benzene ring, making it more difficult for the benzene ring to undergo electrophilic substitution. However, in the nucleophilic substitution, it can stabilize the negative ion intermediates generated during the reaction, making the nucleophilic substitution reaction easier to proceed.
In addition, the compound may participate in metal-catalyzed reactions, such as palladium-catalyzed coupling reactions. In such reactions, halogen atoms can form intermediates with metals, and then couple with other organic compounds to build more complex organic molecular structures.
In terms of physical properties, it is usually a colorless to light yellow liquid, with a certain boiling point and melting point due to factors such as intermolecular forces and relative molecular mass. And because it contains halogen atoms and trifluoromethyl, it is soluble in organic solvents or has special characteristics, and is generally soluble in common organic solvents, such as dichloromethane and tetrahydrofuran.
2-chloro-5-trifluoromethyl bromobenzene has unique chemical properties and has potential application value in many fields of organic synthesis. It is an important chemical raw material in organic chemistry research and related industrial production.
What are the preparation methods of 2-chloro-5-trifluoromethyl Bromobenzene?
2-Chloro-5-trifluoromethyl bromide benzene is also an organic compound. There are many common methods for its preparation.
First, 2-chloro-5-trifluoromethyl aniline is used as the starting material. First, it reacts with sodium nitrite and hydrobromide to undergo diazotization. In this process, in a low temperature environment, sodium nitrite interacts with hydrobromide to form nitrous acid, and aniline reacts with it to form diazonium salts. Then, when the diazonium salts are in the presence of catalysts such as cuprous bromide, the Sandmeier reaction occurs, and the diazonium groups are replaced by bromine atoms, thereby preparing 2-chloro-5-trifluoromethyl bromide benzene.
Second, 2-chloro-5-trifluoromethylbenzoic acid is used as the starting material. First, it is converted into an acyl chloride, which can be achieved by co-heating with reagents such as dichlorosulfoxide. The acyl chloride is then combined with hydrogen bromide and reducing agents such as red phosphorus. After a series of reactions, decarboxylation and bromination are achieved, and the final product is obtained.
Third, a suitable aromatic hydrocarbon is used as the starting material, and chlorine atoms and bromine atoms and trifluoromethyl atoms are gradually introduced through a halogenation reaction. For example, chlorination of aromatic hydrocarbons is carried out first, and chlorine gas or other chlorinated reagents are used, and chlorine atoms are introduced under the action of suitable catalysts such Then the bromination reaction is carried out, and bromine atoms are introduced under the action of bromine and other bromine reagents under the catalyst. Finally, through a specific trifluoromethylation reaction, such as the use of trifluoromethylation reagents, such as trifluoromethylmagnesium halide, trifluoromethyl is introduced, and 2-chloro-5-trifluoromethylbromobenzene is prepared by multi-step reaction.
All methods have their own advantages and disadvantages. In actual preparation, the appropriate method should be selected according to the availability of raw materials, the difficulty of reaction conditions, and the consideration of cost.
First, 2-chloro-5-trifluoromethyl aniline is used as the starting material. First, it reacts with sodium nitrite and hydrobromide to undergo diazotization. In this process, in a low temperature environment, sodium nitrite interacts with hydrobromide to form nitrous acid, and aniline reacts with it to form diazonium salts. Then, when the diazonium salts are in the presence of catalysts such as cuprous bromide, the Sandmeier reaction occurs, and the diazonium groups are replaced by bromine atoms, thereby preparing 2-chloro-5-trifluoromethyl bromide benzene.
Second, 2-chloro-5-trifluoromethylbenzoic acid is used as the starting material. First, it is converted into an acyl chloride, which can be achieved by co-heating with reagents such as dichlorosulfoxide. The acyl chloride is then combined with hydrogen bromide and reducing agents such as red phosphorus. After a series of reactions, decarboxylation and bromination are achieved, and the final product is obtained.
Third, a suitable aromatic hydrocarbon is used as the starting material, and chlorine atoms and bromine atoms and trifluoromethyl atoms are gradually introduced through a halogenation reaction. For example, chlorination of aromatic hydrocarbons is carried out first, and chlorine gas or other chlorinated reagents are used, and chlorine atoms are introduced under the action of suitable catalysts such Then the bromination reaction is carried out, and bromine atoms are introduced under the action of bromine and other bromine reagents under the catalyst. Finally, through a specific trifluoromethylation reaction, such as the use of trifluoromethylation reagents, such as trifluoromethylmagnesium halide, trifluoromethyl is introduced, and 2-chloro-5-trifluoromethylbromobenzene is prepared by multi-step reaction.
All methods have their own advantages and disadvantages. In actual preparation, the appropriate method should be selected according to the availability of raw materials, the difficulty of reaction conditions, and the consideration of cost.
2-chloro-5-trifluoromethyl Bromobenzene what to look out for when storing and shipping
2-Chloro-5-trifluoromethyl bromobenzene is also an organic compound. During storage and transportation, many matters must not be ignored.
Let's talk about storage first. This compound may be harmful to the environment, so it should be stored in a cool and ventilated special warehouse. The temperature of the warehouse should not be too high to prevent it from dangerous changes due to heat, generally not exceeding 37 ° C. It should be stored separately from oxidants and edible chemicals, and must not be mixed. If it is mixed with oxidants, in case of triggering conditions, it is prone to violent chemical reactions, causing fires, explosions and other disasters; if it is mixed with edible chemicals, it may cause pollution and endanger humans and animals. And the warehouse needs to be equipped with suitable materials to contain leaks, in case of leaks, and can be properly disposed of in time.
Let's talk about transportation. During transportation, the packaging must be complete to ensure that there is no risk of leakage. During transportation, the speed of the vehicle should not be too fast, nor should it be braked abruptly to avoid damage to the packaging due to vibration and collision. Transportation vehicles should follow the specified route and do not stop in densely populated areas, residential areas, etc., to prevent accidents from endangering many lives. At the same time, transportation personnel need to be professionally trained to be familiar with the dangerous characteristics of this compound and emergency treatment methods. Once there is a leak on the way, they can quickly act according to the plan to reduce the harm.
Therefore, when storing and transporting 2-chloro-5-trifluoromethylbromobenzene, the above points should be carefully followed to ensure safety and avoid disasters.
Let's talk about storage first. This compound may be harmful to the environment, so it should be stored in a cool and ventilated special warehouse. The temperature of the warehouse should not be too high to prevent it from dangerous changes due to heat, generally not exceeding 37 ° C. It should be stored separately from oxidants and edible chemicals, and must not be mixed. If it is mixed with oxidants, in case of triggering conditions, it is prone to violent chemical reactions, causing fires, explosions and other disasters; if it is mixed with edible chemicals, it may cause pollution and endanger humans and animals. And the warehouse needs to be equipped with suitable materials to contain leaks, in case of leaks, and can be properly disposed of in time.
Let's talk about transportation. During transportation, the packaging must be complete to ensure that there is no risk of leakage. During transportation, the speed of the vehicle should not be too fast, nor should it be braked abruptly to avoid damage to the packaging due to vibration and collision. Transportation vehicles should follow the specified route and do not stop in densely populated areas, residential areas, etc., to prevent accidents from endangering many lives. At the same time, transportation personnel need to be professionally trained to be familiar with the dangerous characteristics of this compound and emergency treatment methods. Once there is a leak on the way, they can quickly act according to the plan to reduce the harm.
Therefore, when storing and transporting 2-chloro-5-trifluoromethylbromobenzene, the above points should be carefully followed to ensure safety and avoid disasters.
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