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2-Chloro-5-(Trifuoromethyl)Benzenesufonyl Chloridel
Linshang Chemical
|
HS Code |
592721 |
| Chemical Formula | C7H3Cl2F3O2S |
| Molar Mass | 279.06 g/mol |
| Appearance | Solid (usually white or off - white) |
| Physical State At Room Temp | Solid |
| Boiling Point | Data may vary, typically high due to polar groups |
| Melting Point | Data may vary |
| Solubility In Water | Low, as it is an organic sulfonyl chloride |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Density | Data may vary |
| Odor | Pungent, characteristic of sulfonyl chlorides |
| Reactivity | Reactive towards nucleophiles, can undergo substitution reactions |
| Hazard Class | Corrosive, harmful if inhaled, swallowed or in contact with skin |
As an accredited 2-Chloro-5-(Trifuoromethyl)Benzenesufonyl Chloridel factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - kg bottle of 2 - chloro - 5 - (trifluoromethyl)benzenesulfonyl chloride, well - sealed. |
| Storage | 2 - Chloro - 5 - (trifluoromethyl)benzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It must be kept in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and reaction with moisture or air. Store it separately from incompatible substances like bases and reducing agents. |
| Shipping | 2 - chloro - 5 - (trifluoromethyl)benzenesulfonyl chloride is shipped in sealed, corrosion - resistant containers. It must be transported under cool, dry conditions, following strict hazardous chemical shipping regulations to ensure safety. |
Competitive 2-Chloro-5-(Trifuoromethyl)Benzenesufonyl Chloridel prices that fit your budget—flexible terms and customized quotes for every order.
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What is the main use of 2-chloro-5- (trifuoromethyl) benzenesufonyl Chloride?
2-Chloro-5- (trifluoromethyl) benzenesulfonyl chloride, which has a wide range of uses. In the field of organic synthesis, it is often a key reagent.
One of them can be used to prepare various sulfonamide compounds. Gain sulfonyl chloride groups have high reactivity and can undergo nucleophilic substitution reactions with many amino-containing compounds. If they meet with aliphatic amines or aromatic amines, the two can react smoothly to form sulfonamides with diverse structures. This sulfonamide substance has a wide range of uses in the field of medicine. Many drug molecules contain this group, or have antibacterial and anti-inflammatory effects, making great contributions to human health.
Second, it also has important applications in materials science. It can be reacted with a specific polymer monomer to introduce its structure into the polymer chain. In this way, the surface properties of the polymer material may be changed, such as improving the corrosion resistance and water resistance of the material. Because it contains trifluoromethyl, it has unique electronic effects and spatial effects, which can give the material special properties.
Third, for the synthesis of pesticides, 2-chloro-5- (trifluoromethyl) benzenesulfonyl chloride is also indispensable. By reacting with other organic compounds, pesticide products with high-efficiency insecticidal, weeding and other functions can be prepared. These pesticides play an important role in ensuring crop growth and improving grain yield.
In conclusion, 2-chloro-5- (trifluoromethyl) benzenesulfonyl chloride plays an important role in many fields such as organic synthesis, materials science, and pesticide manufacturing, and has made great contributions to the development of various fields.
One of them can be used to prepare various sulfonamide compounds. Gain sulfonyl chloride groups have high reactivity and can undergo nucleophilic substitution reactions with many amino-containing compounds. If they meet with aliphatic amines or aromatic amines, the two can react smoothly to form sulfonamides with diverse structures. This sulfonamide substance has a wide range of uses in the field of medicine. Many drug molecules contain this group, or have antibacterial and anti-inflammatory effects, making great contributions to human health.
Second, it also has important applications in materials science. It can be reacted with a specific polymer monomer to introduce its structure into the polymer chain. In this way, the surface properties of the polymer material may be changed, such as improving the corrosion resistance and water resistance of the material. Because it contains trifluoromethyl, it has unique electronic effects and spatial effects, which can give the material special properties.
Third, for the synthesis of pesticides, 2-chloro-5- (trifluoromethyl) benzenesulfonyl chloride is also indispensable. By reacting with other organic compounds, pesticide products with high-efficiency insecticidal, weeding and other functions can be prepared. These pesticides play an important role in ensuring crop growth and improving grain yield.
In conclusion, 2-chloro-5- (trifluoromethyl) benzenesulfonyl chloride plays an important role in many fields such as organic synthesis, materials science, and pesticide manufacturing, and has made great contributions to the development of various fields.
What are the physical properties of 2-chloro-5- (trifuoromethyl) benzenesufonyl Chloride
2-Chloro-5- (trifluoromethyl) benzenesulfonyl chloride, the properties of this substance are quite critical, and it is related to many chemical costs.
Looking at its physical properties, under room temperature, it often appears as a colorless to slightly yellow liquid, with a uniform state and a certain fluidity. Its appearance is clean, and there is no obvious impurity suspension or precipitation.
Smell it, there is a pungent smell emitted. This smell is unique and strong because of the characteristics of chlorine and trifluoromethyl groups in its molecular structure. This kind of smell reminds the operator to take precautions, because it may irritate the respiratory tract, eyes and other parts of the human body.
When it comes to the melting point, it has been determined by many experiments that it is between -10 ° C and -5 ° C. This low-temperature melting point indicates that the substance can change from solid to liquid at a relatively low temperature. The boiling point is in the range of 135 ° C - 145 ° C. In this temperature range, the liquid boils and the substance changes from liquid to gaseous. Such melting boiling point characteristics are of great significance in the separation and purification of chemical operations.
Furthermore, its density is about 1.6 - 1.7 g/cm ³, which is significantly higher than that of water. If it is accidentally spilled in water, it will sink to the bottom of the water. This density characteristic also needs to be carefully considered when storing and transporting.
In terms of solubility, 2-chloro-5- (trifluoromethyl) benzenesulfonyl chloride is insoluble in water, but it exhibits good solubility in most organic solvents, such as dichloromethane, chloroform, toluene, etc. This solubility property provides a basis for the selection of solvents in organic synthesis reactions.
In addition, this substance is more sensitive to air and humidity. If exposed to air for a long time or in contact with moisture, it is prone to chemical reactions, resulting in quality changes and affecting the use efficiency. Therefore, when storing, it is necessary to ensure that the environment is dry and well sealed to maintain the stability of its physical properties.
Looking at its physical properties, under room temperature, it often appears as a colorless to slightly yellow liquid, with a uniform state and a certain fluidity. Its appearance is clean, and there is no obvious impurity suspension or precipitation.
Smell it, there is a pungent smell emitted. This smell is unique and strong because of the characteristics of chlorine and trifluoromethyl groups in its molecular structure. This kind of smell reminds the operator to take precautions, because it may irritate the respiratory tract, eyes and other parts of the human body.
When it comes to the melting point, it has been determined by many experiments that it is between -10 ° C and -5 ° C. This low-temperature melting point indicates that the substance can change from solid to liquid at a relatively low temperature. The boiling point is in the range of 135 ° C - 145 ° C. In this temperature range, the liquid boils and the substance changes from liquid to gaseous. Such melting boiling point characteristics are of great significance in the separation and purification of chemical operations.
Furthermore, its density is about 1.6 - 1.7 g/cm ³, which is significantly higher than that of water. If it is accidentally spilled in water, it will sink to the bottom of the water. This density characteristic also needs to be carefully considered when storing and transporting.
In terms of solubility, 2-chloro-5- (trifluoromethyl) benzenesulfonyl chloride is insoluble in water, but it exhibits good solubility in most organic solvents, such as dichloromethane, chloroform, toluene, etc. This solubility property provides a basis for the selection of solvents in organic synthesis reactions.
In addition, this substance is more sensitive to air and humidity. If exposed to air for a long time or in contact with moisture, it is prone to chemical reactions, resulting in quality changes and affecting the use efficiency. Therefore, when storing, it is necessary to ensure that the environment is dry and well sealed to maintain the stability of its physical properties.
What are the chemical properties of 2-chloro-5- (trifuoromethyl) benzenesufonyl Chloride
2-Chloro-5- (trifluoromethyl) benzenesulfonyl chloride, which has many chemical properties. It is a key intermediate in organic synthesis and is widely used in drugs, pesticides, materials and other fields.
In terms of its physical properties, it is either solid or liquid at room temperature, and its color varies depending on purity, or it is colorless to light yellow. Due to the presence of chlorine atoms, trifluoromethyl and sulfonyl chloride groups, the molecular polarity is significant, which affects its solubility. It has good solubility in organic solvents such as dichloromethane, chloroform, toluene, etc., but poor solubility in water. Due to the large difference between its molecular structure and the polarity of water molecules, it is not easy to form hydrogen bonds.
Chemical properties are abnormal. Sulfonyl chloride (-SO 2O Cl) has high activity and is easily hydrolyzed in water, releasing hydrogen chloride gas, and this hydrolysis reaction is violent. It can react with alcohols to form sulfonates. This reaction needs to be carried out under suitable catalysts and reaction conditions. The purpose of controlling the reaction process and product purity can be achieved by adjusting the reaction temperature, time and proportion of reactants. When it encounters amines, it is easy to undergo ammonolysis and form sulfonamides. Such products are of great significance in the field of medicinal chemistry. Many drug molecules contain sulfonamide groups.
The chlorine atom in 2-chloro-5- (trifluoromethyl) benzenesulfonyl chloride is also reactive due to the electronic effect of benzene ring and other groups. It can participate in the nucleophilic substitution reaction. When encountering nucleophilic reagents, chlorine atoms can be replaced, thereby deriving compounds with diverse structures.
Its chemical properties are active and it is widely used in organic synthesis. However, caution should be taken when operating. Because its hydrolysis product hydrogen chloride is corrosive and irritating, safety procedures should be followed when using it, and protective measures should be taken.
In terms of its physical properties, it is either solid or liquid at room temperature, and its color varies depending on purity, or it is colorless to light yellow. Due to the presence of chlorine atoms, trifluoromethyl and sulfonyl chloride groups, the molecular polarity is significant, which affects its solubility. It has good solubility in organic solvents such as dichloromethane, chloroform, toluene, etc., but poor solubility in water. Due to the large difference between its molecular structure and the polarity of water molecules, it is not easy to form hydrogen bonds.
Chemical properties are abnormal. Sulfonyl chloride (-SO 2O Cl) has high activity and is easily hydrolyzed in water, releasing hydrogen chloride gas, and this hydrolysis reaction is violent. It can react with alcohols to form sulfonates. This reaction needs to be carried out under suitable catalysts and reaction conditions. The purpose of controlling the reaction process and product purity can be achieved by adjusting the reaction temperature, time and proportion of reactants. When it encounters amines, it is easy to undergo ammonolysis and form sulfonamides. Such products are of great significance in the field of medicinal chemistry. Many drug molecules contain sulfonamide groups.
The chlorine atom in 2-chloro-5- (trifluoromethyl) benzenesulfonyl chloride is also reactive due to the electronic effect of benzene ring and other groups. It can participate in the nucleophilic substitution reaction. When encountering nucleophilic reagents, chlorine atoms can be replaced, thereby deriving compounds with diverse structures.
Its chemical properties are active and it is widely used in organic synthesis. However, caution should be taken when operating. Because its hydrolysis product hydrogen chloride is corrosive and irritating, safety procedures should be followed when using it, and protective measures should be taken.
What is the preparation method of 2-chloro-5- (trifuoromethyl) benzenesufonyl Chloride
The method of preparing 2-chloro-5- (trifluoromethyl) benzenesulfonyl chloride is a key process in organic synthesis. In the past, to prepare this substance, the following steps were often followed.
First take 2-chloro-5- (trifluoromethyl) benzene as the starting material. This raw material is put into the reactor and dissolved in an appropriate solvent, commonly used such as dichloromethane, chloroform, etc. Such solvents have good solubility and chemical stability, and do not interfere in the reaction environment.
Then, slowly introduce sulfonating reagents into the system. In the past, fuming sulfuric acid was mostly used as a sulfonating agent because of its strong sulfonation ability. However, fuming sulfuric acid is highly corrosive, and the operation needs to be extremely cautious. Under low temperature conditions, such as 0-5 ° C, fuming sulfuric acid is added dropwise to the solution containing raw materials, and stirred while adding. This is to make the reaction proceed uniformly and prevent local overheating from causing side reactions.
After the sulfonation reaction is completed, the resulting product is 2-chloro-5- (trifluoromethyl) benzenesulfonic acid. Subsequently, it is converted to sulfonyl chloride. Chlorination reagents such as sulfoxide chloride (SOCl ²) or phosphorus pentachloride (PCl) are commonly used in this step. If sulfoxide chloride is used, an appropriate amount of catalyst, such as N, N-dimethylformamide (DMF), can be added to the reaction to promote the reaction. Heat up to an appropriate temperature, such as 50-80 ° C, and react for several hours. Sulfoxide chloride reacts with sulfonic acid to form sulfonyl chloride, and sulfur dioxide and hydrogen chloride gas escape at the same time. This gas is properly collected and processed to avoid polluting the environment.
After the reaction is completed, the unreacted raw materials, by-products and impurities are removed by distillation, recrystallization and other purification methods to obtain pure 2-chloro-5- (trifluoromethyl) benzenesulfonyl chloride. Although this preparation method has been proved feasible in practice, some reagents are dangerous and cumbersome to operate. In the future, safer and more efficient new methods may need to be explored to meet the needs of the development of organic synthesis.
First take 2-chloro-5- (trifluoromethyl) benzene as the starting material. This raw material is put into the reactor and dissolved in an appropriate solvent, commonly used such as dichloromethane, chloroform, etc. Such solvents have good solubility and chemical stability, and do not interfere in the reaction environment.
Then, slowly introduce sulfonating reagents into the system. In the past, fuming sulfuric acid was mostly used as a sulfonating agent because of its strong sulfonation ability. However, fuming sulfuric acid is highly corrosive, and the operation needs to be extremely cautious. Under low temperature conditions, such as 0-5 ° C, fuming sulfuric acid is added dropwise to the solution containing raw materials, and stirred while adding. This is to make the reaction proceed uniformly and prevent local overheating from causing side reactions.
After the sulfonation reaction is completed, the resulting product is 2-chloro-5- (trifluoromethyl) benzenesulfonic acid. Subsequently, it is converted to sulfonyl chloride. Chlorination reagents such as sulfoxide chloride (SOCl ²) or phosphorus pentachloride (PCl) are commonly used in this step. If sulfoxide chloride is used, an appropriate amount of catalyst, such as N, N-dimethylformamide (DMF), can be added to the reaction to promote the reaction. Heat up to an appropriate temperature, such as 50-80 ° C, and react for several hours. Sulfoxide chloride reacts with sulfonic acid to form sulfonyl chloride, and sulfur dioxide and hydrogen chloride gas escape at the same time. This gas is properly collected and processed to avoid polluting the environment.
After the reaction is completed, the unreacted raw materials, by-products and impurities are removed by distillation, recrystallization and other purification methods to obtain pure 2-chloro-5- (trifluoromethyl) benzenesulfonyl chloride. Although this preparation method has been proved feasible in practice, some reagents are dangerous and cumbersome to operate. In the future, safer and more efficient new methods may need to be explored to meet the needs of the development of organic synthesis.
What are the precautions for 2-chloro-5- (trifuoromethyl) benzenesufonyl Chloride during use?
2-Chloro-5- (trifluoromethyl) benzenesulfonyl chloride is a commonly used reagent in organic synthesis. When using, many matters need to be paid attention to.
First, it is related to safety. This substance is corrosive and can cause serious burns when it comes into contact with the skin and eyes. Therefore, when operating, protective equipment is essential, such as wearing protective clothing, protective gloves, protective glasses and masks to ensure safety. And it should be operated in a well-ventilated place. If it is inadvertently touched, it should be rinsed with plenty of water immediately and seek medical treatment.
Second, it involves storage. It should be stored in a cool, dry and ventilated place, away from fire and heat sources, and avoid moisture and heat. Due to its active chemical properties, improper storage is prone to deterioration or danger. It should be stored separately from oxidants and bases, and should not be mixed to prevent reactions.
Third, it is related to the reaction conditions. In organic synthesis reactions, its reactivity is quite high, and the control of reaction conditions is extremely critical. Temperature, solvent, catalyst and other factors have a significant impact on the reaction process and product yield and purity. The reaction conditions need to be precisely adjusted according to the specific reaction to achieve the desired reaction effect. For example, some reactions need to be carried out at low temperature to prevent side reactions from occurring; while specific reactions require specific solvents to promote the smooth progress of the reaction.
Fourth, the operation process also needs to be cautious. When taking it, the action should be precise and rapid to prevent spillage. The reaction operation should strictly follow the standard process, and details such as stirring rate and feeding sequence should not be ignored. After the reaction is completed, the separation and purification of the product should also follow appropriate methods to obtain high-purity products.
First, it is related to safety. This substance is corrosive and can cause serious burns when it comes into contact with the skin and eyes. Therefore, when operating, protective equipment is essential, such as wearing protective clothing, protective gloves, protective glasses and masks to ensure safety. And it should be operated in a well-ventilated place. If it is inadvertently touched, it should be rinsed with plenty of water immediately and seek medical treatment.
Second, it involves storage. It should be stored in a cool, dry and ventilated place, away from fire and heat sources, and avoid moisture and heat. Due to its active chemical properties, improper storage is prone to deterioration or danger. It should be stored separately from oxidants and bases, and should not be mixed to prevent reactions.
Third, it is related to the reaction conditions. In organic synthesis reactions, its reactivity is quite high, and the control of reaction conditions is extremely critical. Temperature, solvent, catalyst and other factors have a significant impact on the reaction process and product yield and purity. The reaction conditions need to be precisely adjusted according to the specific reaction to achieve the desired reaction effect. For example, some reactions need to be carried out at low temperature to prevent side reactions from occurring; while specific reactions require specific solvents to promote the smooth progress of the reaction.
Fourth, the operation process also needs to be cautious. When taking it, the action should be precise and rapid to prevent spillage. The reaction operation should strictly follow the standard process, and details such as stirring rate and feeding sequence should not be ignored. After the reaction is completed, the separation and purification of the product should also follow appropriate methods to obtain high-purity products.
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