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2-Chloro-6-Fluoro-N-Hydroxybenzenecarboximidoyl Chloride
Linshang Chemical
|
HS Code |
137992 |
| Name | 2-Chloro-6-Fluoro-N-Hydroxybenzenecarboximidoyl Chloride |
| Chemical Formula | C7H4Cl2FNO |
| Molecular Weight | 209.996 g/mol |
| Appearance | Solid (usually white or off - white) |
| Solubility | Soluble in some organic solvents like dichloromethane |
| Purity | Typically available in high purity grades (e.g., 95%+) |
| Odor | Pungent, characteristic odor |
| Stability | Should be stored in a cool, dry place away from moisture |
As an accredited 2-Chloro-6-Fluoro-N-Hydroxybenzenecarboximidoyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 6 - fluoro - N - hydroxybenzenecarboximidoyl Chloride in sealed glass vial. |
| Storage | 2 - chloro - 6 - fluoro - N - hydroxybenzenecarboximidoyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly sealed container to prevent contact with moisture, which could initiate decomposition. Store it separately from incompatible substances like oxidizing agents and bases to avoid potential reactions. |
| Shipping | 2 - chloro - 6 - fluoro - n - hydroxybenzenecarboximidoyl Chloride is a chemical. Shipping should follow strict hazardous materials regulations. It must be properly packaged to prevent leakage, with clear labels indicating its nature and safety precautions. |
Competitive 2-Chloro-6-Fluoro-N-Hydroxybenzenecarboximidoyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 2-chloro-6-fluoro-n-hydroxybenzenecarboximidoyl Chloride?
This is to explore the chemical structure of 2-chloro-6-fluoro-N-hydroxybenzoimide chloride. This compound belongs to the category of organic halides and nitrogen-containing compounds.
From the name, "2-chloro-6-fluoro-N-hydroxybenzoimide chloride", it can be seen that its structure is based on the benzene ring. Above the benzene ring, there is a chlorine atom (Cl) at position 2 and a fluorine atom (F) at position 6. "Benzoimide" indicates that the benzene ring is connected to an imidoyl group. In this imidoyl group, the carbon atom is connected to the nitrogen atom by a double bond. " N-hydroxyl "shows that the nitrogen atom is connected with a hydroxyl group (-OH). And" chlorine "shows that the carbon atom of the imide group is also connected with a chlorine atom.
As shown in the ancient drawing method, a regular hexagon is first drawn to represent the benzene ring. At its two corners, there is a symbol of the chlorine atom" Cl "and a symbol of the fluorine atom" F ". On one side of the benzene ring, there is a connected structure. This structure is first a carbon atom, which is connected to the benzene ring by a single bond. The carbon atom is then connected to the nitrogen atom by a double bond. The nitrogen atom is connected to the hydroxyl group, and the carbon atom is connected to the chlorine atom.
In this way, the chemical structure of 2-chloro-6-fluoro-N-hydroxybenzoimide chloride can be obtained. In this structure, the benzene ring gives it aromaticity, and the groups such as chlorine, fluorine, hydroxyl and imide chloride give the compound unique chemical activities and properties, and may have specific uses in organic synthesis and other fields.
From the name, "2-chloro-6-fluoro-N-hydroxybenzoimide chloride", it can be seen that its structure is based on the benzene ring. Above the benzene ring, there is a chlorine atom (Cl) at position 2 and a fluorine atom (F) at position 6. "Benzoimide" indicates that the benzene ring is connected to an imidoyl group. In this imidoyl group, the carbon atom is connected to the nitrogen atom by a double bond. " N-hydroxyl "shows that the nitrogen atom is connected with a hydroxyl group (-OH). And" chlorine "shows that the carbon atom of the imide group is also connected with a chlorine atom.
As shown in the ancient drawing method, a regular hexagon is first drawn to represent the benzene ring. At its two corners, there is a symbol of the chlorine atom" Cl "and a symbol of the fluorine atom" F ". On one side of the benzene ring, there is a connected structure. This structure is first a carbon atom, which is connected to the benzene ring by a single bond. The carbon atom is then connected to the nitrogen atom by a double bond. The nitrogen atom is connected to the hydroxyl group, and the carbon atom is connected to the chlorine atom.
In this way, the chemical structure of 2-chloro-6-fluoro-N-hydroxybenzoimide chloride can be obtained. In this structure, the benzene ring gives it aromaticity, and the groups such as chlorine, fluorine, hydroxyl and imide chloride give the compound unique chemical activities and properties, and may have specific uses in organic synthesis and other fields.
What are the main uses of 2-chloro-6-fluoro-n-hydroxybenzenecarboximidoyl Chloride?
2-Chloro-6-fluoro-N-hydroxybenzoimide chloride has a wide range of uses. In the field of organic synthesis, it is a key intermediate, and the preparation of many nitrogen-containing heterocyclic compounds and molecules with biological activity depends on it.
Taking the preparation of specific drug molecules as an example, 2-chloro-6-fluoro-N-hydroxybenzoimide chloride is often used to participate in the reaction, and it is combined with nitrogen-containing nucleophiles to construct the desired chemical structure to achieve the purpose of modifying activity and optimizing drug properties.
In the field of materials science, it also has important uses. It can be introduced into the polymer system by chemical reaction to impart novel properties to the material, such as improving the heat resistance, chemical stability or giving it special optical properties.
Furthermore, in the field of agricultural chemistry, it can be used as an intermediary for the synthesis of new pesticides. By reacting with other organic compounds, pesticides with high insecticidal, bactericidal or herbicidal properties can be generated, providing strong support for pest control and weed control in agricultural production.
In summary, 2-chloro-6-fluoro-N-hydroxybenzoimide chloride plays an important role in many fields such as organic synthesis, materials science and agricultural chemistry, and has a wide range of uses and key uses.
Taking the preparation of specific drug molecules as an example, 2-chloro-6-fluoro-N-hydroxybenzoimide chloride is often used to participate in the reaction, and it is combined with nitrogen-containing nucleophiles to construct the desired chemical structure to achieve the purpose of modifying activity and optimizing drug properties.
In the field of materials science, it also has important uses. It can be introduced into the polymer system by chemical reaction to impart novel properties to the material, such as improving the heat resistance, chemical stability or giving it special optical properties.
Furthermore, in the field of agricultural chemistry, it can be used as an intermediary for the synthesis of new pesticides. By reacting with other organic compounds, pesticides with high insecticidal, bactericidal or herbicidal properties can be generated, providing strong support for pest control and weed control in agricultural production.
In summary, 2-chloro-6-fluoro-N-hydroxybenzoimide chloride plays an important role in many fields such as organic synthesis, materials science and agricultural chemistry, and has a wide range of uses and key uses.
What is the synthesis method of 2-chloro-6-fluoro-n-hydroxybenzenecarboximidoyl Chloride?
To prepare 2-chloro-6-fluoro-N-hydroxybenzoimide chloride, the following ancient method can be used.
Take 2-chloro-6-fluorobenzoic acid as the starting material, which is the key thing. It is co-placed with dichlorosulfoxide in a round bottom flask, which is not only the reaction reagent but also the solvent. On top of the flask, a reflux condenser is connected to prevent the reaction from escaping. Gently heat in an oil bath and control the temperature in a moderate range, about 70 to 80 degrees Celsius. At this time, the two then react. The carboxyl group of 2-chloro-6-fluorobenzoic acid interacts with dichlorosulfoxide. Through the mechanism of substitution, the carboxyl group is converted into an acyl chloride group, and sulfur dioxide and hydrogen chloride gas are released at the same time. After the reaction is completed, by decompression distillation, the excess dichlorosulfoxide is removed to obtain 2-chloro-6-fluorobenzoyl chloride.
Then, take an appropriate amount of hydroxylamine hydrochloride and dissolve it in an appropriate amount of alcohol solvent, such as ethanol. Add an appropriate amount of base, such as sodium carbonate, to release free hydroxylamine. The prepared 2-chloro-6-fluorobenzoyl chloride is slowly dropped into the hydroxylamine solution, and the reaction temperature should be controlled at a low temperature, about 0 to 5 degrees Celsius. In this step, the acid chloride of benzoyl chloride reacts with the amino group of hydroxylamine to form 2-chloro-6-fluoro-N-hydroxybenzamide.
Finally, 2-chloro-6-fluoro-N-hydroxybenzamide is co-placed in the reaction vessel with phosphorus oxychloride, which is a dehydrating agent. After a little heating, in the reaction system, phosphorus oxychloride promotes the dehydration of N-hydroxybenzamide, and the hydroxyl group dehydrates the water from the hydrogen at the ortho position to form an imino group, and the oxygen of the hydroxyl group combines with the chlorine atom to obtain 2-chloro-6-fluoro-N-hydroxybenzimide chloride. After the reaction is completed, the pure product can be obtained by various separation and purification methods such as distillation, extraction, and column chromatography.
Take 2-chloro-6-fluorobenzoic acid as the starting material, which is the key thing. It is co-placed with dichlorosulfoxide in a round bottom flask, which is not only the reaction reagent but also the solvent. On top of the flask, a reflux condenser is connected to prevent the reaction from escaping. Gently heat in an oil bath and control the temperature in a moderate range, about 70 to 80 degrees Celsius. At this time, the two then react. The carboxyl group of 2-chloro-6-fluorobenzoic acid interacts with dichlorosulfoxide. Through the mechanism of substitution, the carboxyl group is converted into an acyl chloride group, and sulfur dioxide and hydrogen chloride gas are released at the same time. After the reaction is completed, by decompression distillation, the excess dichlorosulfoxide is removed to obtain 2-chloro-6-fluorobenzoyl chloride.
Then, take an appropriate amount of hydroxylamine hydrochloride and dissolve it in an appropriate amount of alcohol solvent, such as ethanol. Add an appropriate amount of base, such as sodium carbonate, to release free hydroxylamine. The prepared 2-chloro-6-fluorobenzoyl chloride is slowly dropped into the hydroxylamine solution, and the reaction temperature should be controlled at a low temperature, about 0 to 5 degrees Celsius. In this step, the acid chloride of benzoyl chloride reacts with the amino group of hydroxylamine to form 2-chloro-6-fluoro-N-hydroxybenzamide.
Finally, 2-chloro-6-fluoro-N-hydroxybenzamide is co-placed in the reaction vessel with phosphorus oxychloride, which is a dehydrating agent. After a little heating, in the reaction system, phosphorus oxychloride promotes the dehydration of N-hydroxybenzamide, and the hydroxyl group dehydrates the water from the hydrogen at the ortho position to form an imino group, and the oxygen of the hydroxyl group combines with the chlorine atom to obtain 2-chloro-6-fluoro-N-hydroxybenzimide chloride. After the reaction is completed, the pure product can be obtained by various separation and purification methods such as distillation, extraction, and column chromatography.
What are the physical properties of 2-chloro-6-fluoro-n-hydroxybenzenecarboximidoyl Chloride?
2-Chloro-6-fluoro-N-hydroxybenzoimide chloride, the physical properties of this substance are related to its appearance, melting point, boiling point, solubility and other characteristics.
Its appearance is often in solid form, mostly white to light yellow powder or crystalline form. Viewed in sunlight, it has a certain luster, fine and uniform. As for the melting point, it has been determined by many experiments to be about [X] ° C. At this temperature, its solid lattice structure gradually loosens, and the molecular thermal motion intensifies, so it transitions from solid to liquid. The boiling point is relatively high, about [X] ° C under normal pressure. At this temperature, the kinetic energy of the molecule is sufficient to overcome the intermolecular forces and escape from the liquid state to the gaseous state.
In terms of solubility, it exhibits good solubility in organic solvents such as dichloromethane, chloroform, and ether. Van der Waals forces or other weak interactions can be formed between the solvent molecules and the compound molecules, so that it is uniformly dispersed in the solvent. However, in water, its solubility is poor. Due to the lack of groups forming strong hydrogen bonds with water molecules in the molecular structure of the compound, and the large proportion of its hydrophobic part, it is difficult to dissolve in water. This property also makes it necessary to choose a suitable solvent system when separating, purifying, and participating in chemical reactions.
In addition, its density is slightly higher than that of common organic solvents, and the mass is relatively large when placed in the same volume container. At room temperature and pressure, the compound is relatively stable, and when exposed to high temperature, open flame or strong oxidizing agent, there is a certain reactivity or danger. The comprehensive performance of this physical property lays the foundation for its application in chemical industry, pharmaceutical synthesis and other fields, and also determines the operation specifications of its storage and transportation.
Its appearance is often in solid form, mostly white to light yellow powder or crystalline form. Viewed in sunlight, it has a certain luster, fine and uniform. As for the melting point, it has been determined by many experiments to be about [X] ° C. At this temperature, its solid lattice structure gradually loosens, and the molecular thermal motion intensifies, so it transitions from solid to liquid. The boiling point is relatively high, about [X] ° C under normal pressure. At this temperature, the kinetic energy of the molecule is sufficient to overcome the intermolecular forces and escape from the liquid state to the gaseous state.
In terms of solubility, it exhibits good solubility in organic solvents such as dichloromethane, chloroform, and ether. Van der Waals forces or other weak interactions can be formed between the solvent molecules and the compound molecules, so that it is uniformly dispersed in the solvent. However, in water, its solubility is poor. Due to the lack of groups forming strong hydrogen bonds with water molecules in the molecular structure of the compound, and the large proportion of its hydrophobic part, it is difficult to dissolve in water. This property also makes it necessary to choose a suitable solvent system when separating, purifying, and participating in chemical reactions.
In addition, its density is slightly higher than that of common organic solvents, and the mass is relatively large when placed in the same volume container. At room temperature and pressure, the compound is relatively stable, and when exposed to high temperature, open flame or strong oxidizing agent, there is a certain reactivity or danger. The comprehensive performance of this physical property lays the foundation for its application in chemical industry, pharmaceutical synthesis and other fields, and also determines the operation specifications of its storage and transportation.
What are the storage conditions for 2-chloro-6-fluoro-n-hydroxybenzenecarboximidoyl Chloride?
2-Chloro-6-fluoro-N-hydroxybenzoimide chloride, this is a rather special chemical substance. Its storage conditions need to follow specific regulations to ensure the stability and safety of the substance.
The first to bear the brunt should be stored in a cool place. Due to high temperature, it is easy to cause the substance to chemically react, or cause it to decompose and deteriorate. This substance must not be stored in a place directly exposed to the hot sun. It must be placed in a shady place to maintain the temperature at a low level, so as to protect the stability of its chemical properties.
Furthermore, a dry environment is indispensable. This chemical substance may be quite sensitive to moisture, and when exposed to water, it is easy to cause reactions such as hydrolysis, which will damage its quality. Therefore, the storage place must be dry, and the surrounding water vapor can be adsorbed with the help of desiccants and other substances to prevent moisture intrusion.
In addition, sealed storage is also key. Because it may be volatile or easily react with oxygen, carbon dioxide and other components in the air, sealed containers can effectively isolate external interference and protect them from various substances in the air. And the material of sealed containers should also be carefully selected, and chemical reactions with the substance should not occur, so as not to cause corrosion of the container and affect the quality of the substance.
When storing, it should also be kept away from fire sources and strong oxidants. This chemical substance may be flammable, and in case of open flames and hot topics, it may be at risk of combustion and explosion; and strong oxidants may also react violently with it, endangering safety. Therefore, fireworks are strictly prohibited in the storage area, and cannot be stored with strong oxidants.
Where the substance is stored, a clear warning label should be posted, indicating its danger and storage precautions, so that relevant personnel can clearly know, operate cautiously, and avoid accidents caused by accidental touch and misuse.
Follow the above storage conditions to properly store 2-chloro-6-fluoro-N-hydroxybenzoimide chloride, so that its quality and safety can be guaranteed.
The first to bear the brunt should be stored in a cool place. Due to high temperature, it is easy to cause the substance to chemically react, or cause it to decompose and deteriorate. This substance must not be stored in a place directly exposed to the hot sun. It must be placed in a shady place to maintain the temperature at a low level, so as to protect the stability of its chemical properties.
Furthermore, a dry environment is indispensable. This chemical substance may be quite sensitive to moisture, and when exposed to water, it is easy to cause reactions such as hydrolysis, which will damage its quality. Therefore, the storage place must be dry, and the surrounding water vapor can be adsorbed with the help of desiccants and other substances to prevent moisture intrusion.
In addition, sealed storage is also key. Because it may be volatile or easily react with oxygen, carbon dioxide and other components in the air, sealed containers can effectively isolate external interference and protect them from various substances in the air. And the material of sealed containers should also be carefully selected, and chemical reactions with the substance should not occur, so as not to cause corrosion of the container and affect the quality of the substance.
When storing, it should also be kept away from fire sources and strong oxidants. This chemical substance may be flammable, and in case of open flames and hot topics, it may be at risk of combustion and explosion; and strong oxidants may also react violently with it, endangering safety. Therefore, fireworks are strictly prohibited in the storage area, and cannot be stored with strong oxidants.
Where the substance is stored, a clear warning label should be posted, indicating its danger and storage precautions, so that relevant personnel can clearly know, operate cautiously, and avoid accidents caused by accidental touch and misuse.
Follow the above storage conditions to properly store 2-chloro-6-fluoro-N-hydroxybenzoimide chloride, so that its quality and safety can be guaranteed.
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