Linshang Chemical
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2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride
Linshang Chemical
|
HS Code |
127854 |
| Chemical Formula | C7H3Cl2FO |
| Molar Mass | 193.00 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 203 - 205 °C |
| Density | 1.499 g/cm³ |
| Flash Point | 86 °C |
| Solubility | Soluble in organic solvents like dichloromethane |
| Odor | Pungent |
| Reactivity | Reactive towards nucleophiles |
| Hazard | Corrosive, causes burns to skin and eyes |
As an accredited 2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 2 - chloro - 6 - fluorobenzene - 1 - carbonyl chloride in sealed, corrosion - resistant containers. |
| Storage | 2 - Chloro - 6 - fluorobenzene - 1 - carbonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It must be kept in a tightly sealed container to prevent moisture and air ingress, as it can react with water and oxygen. Store it separately from incompatible substances like bases, alcohols, and amines to avoid potential hazardous reactions. |
| Shipping | 2 - chloro - 6 - fluorobenzene - 1 - carbonyl chloride is a hazardous chemical. Shipping requires proper packaging in accordance with regulations, likely in corrosion - resistant containers, and must be labeled clearly for its dangerous nature. |
Competitive 2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemistry of 2-chloro-6-fluorobenzene-1-carbonyl Chloride?
2-Chloro-6-fluorobenzene-1-formyl chloride, this is an organic compound with unique chemical properties and is crucial in the field of organic synthesis.
Looking at its chemical activity, the formyl chloride group (-COCl) is active and has strong electrophilicity. This property makes it very easy to react with many nucleophiles, such as alcohols, amines, and water.
When it encounters an alcohol, an alcoholysis reaction occurs, and the chlorine atom of formyl chloride is replaced by the alkoxy group of the alcohol to form the corresponding ester. This process is like an ingenious atom "exchange game". With its active nature, formyl chloride "surrenders" its own chlorine atoms and accepts the alkoxy group of alcohol, thus transforming it into a new ester compound. For example, if it reacts with ethanol, it will produce 2-chloro-6-fluorobenzoate ethyl ester.
When it meets an amine, it will trigger an aminolysis reaction. The chlorine atom is replaced by an amine group to form a corresponding amide. The amine group, with its nucleophilicity, "targets" the chlorine atom of formyl chloride to complete the substitution and create an amide product. If it reacts with methylamine, 2-chloro-6-fluorobenzamide will be formed.
As for contact with water, the hydrolysis reaction occurs immediately, and the formyl chloride is converted into the corresponding carboxylic acid and hydrogen chloride. This is like a "decomposition and reorganization". Under the action of water, the formyl chloride falls apart and reorganizes into carboxylic acid and hydrogen chloride. After the hydrolysis of 2-chloro-6-fluorobenzene-1-formyl chloride, 2-chloro-6-fluorobenzoic acid and hydrogen chloride gas are obtained.
Looking at the fluorine atoms and chlorine atoms, they have a significant impact on the electron cloud density distribution of the benzene ring. Both fluorine and chlorine have electron-absorbing effects, which reduce the electron cloud density of the benzene ring. As a result, the electrophilic substitution reaction activity on the benzene ring decreases. However, due to the difference in electron-absorbing ability between the two, fluorine has stronger electron-absorbing ability, so it will affect the regioselectivity of the reaction to a certain extent. For example, in the nucleophilic substitution reaction, the nucleophilic reagents are more inclined to attack the position with relatively high electron cloud density, and the reactivity at different positions is different due to the influence of fluorine and chlorine atoms.
In addition, 2-chloro-6-fluorobenzene-1-formyl chloride contains chlorine, fluorine and other halogen atoms, and can also participate in some reactions involving the conversion of halogen atoms. For example, under certain conditions, chlorine atoms or fluorine atoms can be replaced by other groups to achieve diverse modifications of molecular structures, providing rich possibilities for organic synthesis, and has broad application prospects in many fields such as drug synthesis and material chemistry.
Looking at its chemical activity, the formyl chloride group (-COCl) is active and has strong electrophilicity. This property makes it very easy to react with many nucleophiles, such as alcohols, amines, and water.
When it encounters an alcohol, an alcoholysis reaction occurs, and the chlorine atom of formyl chloride is replaced by the alkoxy group of the alcohol to form the corresponding ester. This process is like an ingenious atom "exchange game". With its active nature, formyl chloride "surrenders" its own chlorine atoms and accepts the alkoxy group of alcohol, thus transforming it into a new ester compound. For example, if it reacts with ethanol, it will produce 2-chloro-6-fluorobenzoate ethyl ester.
When it meets an amine, it will trigger an aminolysis reaction. The chlorine atom is replaced by an amine group to form a corresponding amide. The amine group, with its nucleophilicity, "targets" the chlorine atom of formyl chloride to complete the substitution and create an amide product. If it reacts with methylamine, 2-chloro-6-fluorobenzamide will be formed.
As for contact with water, the hydrolysis reaction occurs immediately, and the formyl chloride is converted into the corresponding carboxylic acid and hydrogen chloride. This is like a "decomposition and reorganization". Under the action of water, the formyl chloride falls apart and reorganizes into carboxylic acid and hydrogen chloride. After the hydrolysis of 2-chloro-6-fluorobenzene-1-formyl chloride, 2-chloro-6-fluorobenzoic acid and hydrogen chloride gas are obtained.
Looking at the fluorine atoms and chlorine atoms, they have a significant impact on the electron cloud density distribution of the benzene ring. Both fluorine and chlorine have electron-absorbing effects, which reduce the electron cloud density of the benzene ring. As a result, the electrophilic substitution reaction activity on the benzene ring decreases. However, due to the difference in electron-absorbing ability between the two, fluorine has stronger electron-absorbing ability, so it will affect the regioselectivity of the reaction to a certain extent. For example, in the nucleophilic substitution reaction, the nucleophilic reagents are more inclined to attack the position with relatively high electron cloud density, and the reactivity at different positions is different due to the influence of fluorine and chlorine atoms.
In addition, 2-chloro-6-fluorobenzene-1-formyl chloride contains chlorine, fluorine and other halogen atoms, and can also participate in some reactions involving the conversion of halogen atoms. For example, under certain conditions, chlorine atoms or fluorine atoms can be replaced by other groups to achieve diverse modifications of molecular structures, providing rich possibilities for organic synthesis, and has broad application prospects in many fields such as drug synthesis and material chemistry.
What are the common uses of 2-chloro-6-fluorobenzene-1-carbonyl Chloride?
2-Chloro-6-fluorobenzoyl chloride, which has a wide range of uses and is often a key intermediate in the field of organic synthesis.
First, it is used to create medicine. Such as the preparation of specific targeted drugs, with its unique chemical structure, it precisely binds to the specific targets of diseased cells to exert therapeutic effects. In the synthesis of some antibacterial drugs, 2-chloro-6-fluorobenzoyl chloride participates in the reaction, giving the drug the ability to inhibit and kill specific bacteria, escorting human health.
Second, it also plays an important role in the synthesis of pesticides. It can produce high-efficiency insecticides, which can interfere with the nervous system or physiological and metabolic processes of pests by virtue of their chemical properties, so as to achieve the purpose of pest control, ensure the harvest of crops, and maintain the stable development of agriculture.
Third, in the field of materials science, its use should not be underestimated. It can be used to synthesize special polymer materials, which have unique properties, such as excellent heat resistance, corrosion resistance, etc. In the aerospace field, such materials can be used to manufacture parts of aircraft, enhancing the performance and service life of aircraft.
Furthermore, in the synthesis of dyes, 2-chloro-6-fluorobenzoyl chloride, as an important raw material, can synthesize dyes with bright colors and excellent fastness, meet the needs of high-quality dyes in textile, printing and dyeing industries, and add brilliant colors to people's lives.
Overall, 2-chloro-6-fluorobenzoyl chloride plays an indispensable role in many fields, promoting the development and progress of various industries.
First, it is used to create medicine. Such as the preparation of specific targeted drugs, with its unique chemical structure, it precisely binds to the specific targets of diseased cells to exert therapeutic effects. In the synthesis of some antibacterial drugs, 2-chloro-6-fluorobenzoyl chloride participates in the reaction, giving the drug the ability to inhibit and kill specific bacteria, escorting human health.
Second, it also plays an important role in the synthesis of pesticides. It can produce high-efficiency insecticides, which can interfere with the nervous system or physiological and metabolic processes of pests by virtue of their chemical properties, so as to achieve the purpose of pest control, ensure the harvest of crops, and maintain the stable development of agriculture.
Third, in the field of materials science, its use should not be underestimated. It can be used to synthesize special polymer materials, which have unique properties, such as excellent heat resistance, corrosion resistance, etc. In the aerospace field, such materials can be used to manufacture parts of aircraft, enhancing the performance and service life of aircraft.
Furthermore, in the synthesis of dyes, 2-chloro-6-fluorobenzoyl chloride, as an important raw material, can synthesize dyes with bright colors and excellent fastness, meet the needs of high-quality dyes in textile, printing and dyeing industries, and add brilliant colors to people's lives.
Overall, 2-chloro-6-fluorobenzoyl chloride plays an indispensable role in many fields, promoting the development and progress of various industries.
What is the preparation method of 2-chloro-6-fluorobenzene-1-carbonyl Chloride?
The method of preparing 2-chloro-6-fluorobenzoyl chloride follows the following path. At the beginning, 2-chloro-6-fluorobenzoic acid is used as a raw material. This acid can be converted into the target product 2-chloro-6-fluorobenzoyl chloride through a specific halogenation reaction.
The commonly used halogenation reagent is thionyl chloride ($SOCl_2 $). The reaction of 2-chloro-6-fluorobenzoic acid with thionyl chloride is quite effective. During the reaction, 2-chloro-6-fluorobenzoic acid is placed in a suitable reaction vessel, and thionyl chloride is added in a certain proportion. Usually, a slight excess of thionyl chloride is required to promote the reaction to be complete.
In order to accelerate the reaction, heating is often required. Generally, the reaction can be carried out at a reflux temperature, which varies according to the specific conditions of the reaction system, roughly near the boiling point of thionyl chloride. During the reaction, thionyl chloride reacts with the carboxyl group in 2-chloro-6-fluorobenzoic acid, and the hydroxyl group in the carboxyl group is replaced by a chlorine atom to form 2-chloro-6-fluorobenzoyl chloride, and the sulfur dioxide and hydrogen chloride gas escape system is generated at the same time.
After the reaction is completed, the product can be separated and purified by distillation and other means. First, atmospheric distillation is performed to remove the unreacted thionyl chloride, which is easy to evaporate because of its relatively low boiling point. Then, vacuum distillation is performed to obtain pure 2-chloro-6-fluorobenzoyl chloride. Because vacuum distillation can reduce the boiling point of the substance and avoid the decomposition of the target product at high temperature, the purity and yield of the product can be improved.
In addition, phosphorus trichloride ($PCl_3 $) can also be used as a halogenation reagent. Mix 2-chloro-6-fluorobenzoic acid with phosphorus trichloride in an appropriate ratio. This reaction is relatively mild and does not require high temperature reflux. After the reaction is completed, 2-chloro-6-fluorobenzoyl chloride can also be obtained by distillation and purification through stratification, washing, drying and other steps. However, when using phosphorus trichloride, it is necessary to pay attention to its toxicity and corrosiveness, and the operation should be done with caution in a well-ventilated environment.
The commonly used halogenation reagent is thionyl chloride ($SOCl_2 $). The reaction of 2-chloro-6-fluorobenzoic acid with thionyl chloride is quite effective. During the reaction, 2-chloro-6-fluorobenzoic acid is placed in a suitable reaction vessel, and thionyl chloride is added in a certain proportion. Usually, a slight excess of thionyl chloride is required to promote the reaction to be complete.
In order to accelerate the reaction, heating is often required. Generally, the reaction can be carried out at a reflux temperature, which varies according to the specific conditions of the reaction system, roughly near the boiling point of thionyl chloride. During the reaction, thionyl chloride reacts with the carboxyl group in 2-chloro-6-fluorobenzoic acid, and the hydroxyl group in the carboxyl group is replaced by a chlorine atom to form 2-chloro-6-fluorobenzoyl chloride, and the sulfur dioxide and hydrogen chloride gas escape system is generated at the same time.
After the reaction is completed, the product can be separated and purified by distillation and other means. First, atmospheric distillation is performed to remove the unreacted thionyl chloride, which is easy to evaporate because of its relatively low boiling point. Then, vacuum distillation is performed to obtain pure 2-chloro-6-fluorobenzoyl chloride. Because vacuum distillation can reduce the boiling point of the substance and avoid the decomposition of the target product at high temperature, the purity and yield of the product can be improved.
In addition, phosphorus trichloride ($PCl_3 $) can also be used as a halogenation reagent. Mix 2-chloro-6-fluorobenzoic acid with phosphorus trichloride in an appropriate ratio. This reaction is relatively mild and does not require high temperature reflux. After the reaction is completed, 2-chloro-6-fluorobenzoyl chloride can also be obtained by distillation and purification through stratification, washing, drying and other steps. However, when using phosphorus trichloride, it is necessary to pay attention to its toxicity and corrosiveness, and the operation should be done with caution in a well-ventilated environment.
What are the precautions for 2-chloro-6-fluorobenzene-1-carbonyl Chloride in storage and transportation?
2-Chloro-6-fluorobenzoyl chloride is a chemical substance, and many important things need to be paid attention to during storage and transportation.
First of all, storage is lively, and it should be stored in a cool, dry and well-ventilated place. Because it is afraid of moisture and moisture is easy to cause hydrolysis and isochange, the warehouse must be moisture-proof, and the humidity should be controlled at a low level. And because it is sensitive to heat, high temperature can cause decomposition or accelerate reactions, causing danger, so the temperature should be maintained at a low temperature, usually not exceeding 25 ° C. And keep away from fire and heat sources to prevent explosion. This substance is corrosive and toxic. It should be stored separately from oxidants, alkalis, alcohols, etc., and must not be mixed to prevent severe reactions.
Besides transportation, it is necessary to ensure that the container is well sealed and there is no risk of leakage during transportation. Packaging materials should be corrosion-resistant and resistant to the erosion of this substance. Transportation vehicles should be selected and equipped with corresponding fire and leak emergency treatment equipment. During driving, drivers should drive slowly to avoid sudden braking, bumps, and damage to the container. Transportation personnel also need to be professionally trained and familiar with the characteristics of the substance and emergency treatment methods. When loading and unloading, handle it with care, and strictly prohibit touching or dragging to prevent the package from breaking. During transportation, it is also necessary to drive according to the specified route, away from sensitive areas such as densely populated areas and water sources. Only in this way can we ensure the safety of 2-chloro-6-fluorobenzoyl chloride during storage and transportation, avoid accidents, and protect the safety of personnel and the environment.
First of all, storage is lively, and it should be stored in a cool, dry and well-ventilated place. Because it is afraid of moisture and moisture is easy to cause hydrolysis and isochange, the warehouse must be moisture-proof, and the humidity should be controlled at a low level. And because it is sensitive to heat, high temperature can cause decomposition or accelerate reactions, causing danger, so the temperature should be maintained at a low temperature, usually not exceeding 25 ° C. And keep away from fire and heat sources to prevent explosion. This substance is corrosive and toxic. It should be stored separately from oxidants, alkalis, alcohols, etc., and must not be mixed to prevent severe reactions.
Besides transportation, it is necessary to ensure that the container is well sealed and there is no risk of leakage during transportation. Packaging materials should be corrosion-resistant and resistant to the erosion of this substance. Transportation vehicles should be selected and equipped with corresponding fire and leak emergency treatment equipment. During driving, drivers should drive slowly to avoid sudden braking, bumps, and damage to the container. Transportation personnel also need to be professionally trained and familiar with the characteristics of the substance and emergency treatment methods. When loading and unloading, handle it with care, and strictly prohibit touching or dragging to prevent the package from breaking. During transportation, it is also necessary to drive according to the specified route, away from sensitive areas such as densely populated areas and water sources. Only in this way can we ensure the safety of 2-chloro-6-fluorobenzoyl chloride during storage and transportation, avoid accidents, and protect the safety of personnel and the environment.
2-chloro-6-fluorobenzene-1-carbonyl Chloride Effects on the Environment and Human Health
2-Chloro-6-fluorobenzoyl chloride has a significant impact on the environment and human health.
First of all, its harm to the environment. If this chemical is accidentally released in nature, it can be dispersed by air and water. In the soil, it may change the chemical properties of the soil, affect the absorption of nutrients by plant roots, cause plant growth to be hindered, or stunted and yield to be sharply reduced. If it enters the water body, it will poison aquatic organisms and destroy the balance of aquatic ecosystems. Many aquatic organisms are sensitive to chemicals, and its presence may cause the death of organisms such as fish, shrimp and shellfish, which in turn affects the entire aquatic food chain. Furthermore, it volatilizes in the atmosphere, or participates in photochemical reactions, generating harmful smog, which deteriorates air quality and affects regional climate and environmental quality.
As for the impact on human health, it should not be underestimated. It is corrosive. If it comes into contact with the skin, it will cause serious burns, make the skin red, swollen, painful, and even ulcerated. It is difficult to heal, or leave permanent scars. If it is not carefully entered into the eyes, it will cause great damage to the eyes. In light cases, it will cause eye pain, tears, blurred vision, and in severe cases, blindness. If inhaled, its volatile aerosol will irritate the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term exposure to this environment may damage lung function and increase the risk of respiratory diseases such as bronchitis and emphysema. What's more, this substance may be potentially carcinogenic. Long-term exposure to genetic material or damage to body cells can cause genetic mutations, which can then induce cancer and seriously threaten human life and health.
Therefore, when using and handling 2-chloro-6-fluorobenzoyl chloride, strict protective measures must be taken and properly disposed of to reduce its harm to the environment and human health.
First of all, its harm to the environment. If this chemical is accidentally released in nature, it can be dispersed by air and water. In the soil, it may change the chemical properties of the soil, affect the absorption of nutrients by plant roots, cause plant growth to be hindered, or stunted and yield to be sharply reduced. If it enters the water body, it will poison aquatic organisms and destroy the balance of aquatic ecosystems. Many aquatic organisms are sensitive to chemicals, and its presence may cause the death of organisms such as fish, shrimp and shellfish, which in turn affects the entire aquatic food chain. Furthermore, it volatilizes in the atmosphere, or participates in photochemical reactions, generating harmful smog, which deteriorates air quality and affects regional climate and environmental quality.
As for the impact on human health, it should not be underestimated. It is corrosive. If it comes into contact with the skin, it will cause serious burns, make the skin red, swollen, painful, and even ulcerated. It is difficult to heal, or leave permanent scars. If it is not carefully entered into the eyes, it will cause great damage to the eyes. In light cases, it will cause eye pain, tears, blurred vision, and in severe cases, blindness. If inhaled, its volatile aerosol will irritate the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term exposure to this environment may damage lung function and increase the risk of respiratory diseases such as bronchitis and emphysema. What's more, this substance may be potentially carcinogenic. Long-term exposure to genetic material or damage to body cells can cause genetic mutations, which can then induce cancer and seriously threaten human life and health.
Therefore, when using and handling 2-chloro-6-fluorobenzoyl chloride, strict protective measures must be taken and properly disposed of to reduce its harm to the environment and human health.
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