2-Chloro-6-Fluorobenzeneboronic Acid

Linshang Chemical

Specifications

HS Code

838962

Chemical Formula C6H5BClFO2
Molar Mass 175.366 g/mol
Appearance White to off - white solid
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
Melting Point 105 - 109 °C
Boiling Point Decomposes before boiling
Pka Typical for boronic acids around 8 - 9
Density Approximately 1.48 g/cm³
Stability Air - sensitive, moisture - sensitive

As an accredited 2-Chloro-6-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 2 - chloro - 6 - fluorobenzeneboronic Acid: 100g in a sealed, chemical - resistant plastic bottle.
Storage 2 - Chloro - 6 - fluorobenzeneboronic acid should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly sealed container to prevent moisture absorption, as boronic acids can react with water. Store it separately from incompatible substances like strong oxidizing agents and bases to avoid potential chemical reactions that could compromise its integrity.
Shipping 2 - chloro - 6 - fluorobenzeneboronic acid is shipped in well - sealed containers, following strict chemical transport regulations. Packaging safeguards against breakage, and shipping is coordinated to ensure safe transit at proper temperatures and handling.
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2-Chloro-6-Fluorobenzeneboronic Acid 2-Chloro-6-Fluorobenzeneboronic Acid
General Information
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Frequently Asked Questions

As a leading 2-Chloro-6-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 2-chloro-6-fluorobenzeneboronic Acid?
2-Chloro-6-fluorophenylboronic acid is a crucial reagent in organic synthesis. Its chemical properties are unique and it plays a key role in many reactions.
This compound is acidic because it contains a boric acid group (-B (OH) -2). Boron atoms in the boric acid group have empty orbits and can accept electron pairs, so they exhibit Lewis acidity. This acidic property allows it to interact with electron-rich species, such as compounds with lone pairs of electrons such as nitrogen and oxygen. In organic synthesis, this acidity often reacts with bases to form corresponding borates, which may lay the foundation for subsequent reactions. The chlorine atoms and fluorine atoms of 2-chloro-6-fluorophenylboronic acid also give them different activities. Chlorine atoms are relatively active and can participate in nucleophilic substitution reactions. Under appropriate conditions, nucleophilic testers can attack the carbon atoms attached to chlorine atoms, causing chlorine atoms to be replaced, thereby realizing the modification and transformation of molecular structures. Although fluorine atoms are extremely electronegative and have stable carbon-fluorine bonds, due to their special electronic effects, they can affect the electron cloud density distribution of the benzene ring and have an effect on the reactivity and selectivity of the whole molecule. In some reactions, the presence of fluorine atoms may prompt the reaction to proceed in a specific direction, resulting in the formation of specific regionally selective products.
In addition, the benzene ring of 2-chloro-6-fluorophenylboronic acid provides a conjugated system, which makes the molecule have certain stability and electron delocalization characteristics. This conjugated system not only affects the physical properties of the molecule, such as melting point, boiling point, etc., but also affects its chemical properties. The conjugation effect can make the electron cloud distribution on the benzene ring more uniform, so that the substituents at different positions on the benzene ring interact with each other, which in turn affects the activity of the reaction at each position. The chemical properties of 2-chloro-6-fluorophenylboronic acid are rich and diverse, and the acidity, halogen atom activity and benzene ring conjugation effect are intertwined, which shows broad application prospects in the field of organic synthesis and provides an effective way for the preparation of various complex organic compounds.
What are the main uses of 2-chloro-6-fluorobenzeneboronic Acid?
2-Chloro-6-fluorophenylboronic acid has a wide range of uses. In the field of organic synthesis, it is a key intermediate for the construction of complex organic molecular structures.
First, in the field of medicinal chemistry, it is often used to create new drugs. Because aryl boronic acid compounds can interact with biological macromolecules in a specific way, by rationally designing and modifying molecules containing 2-chloro-6-fluorophenylboronic acid structural units, drug molecules with specific pharmacological activities can be obtained. In the process of drug development such as anti-tumor and anti-viral drugs, it may play an important role and provide new opportunities for conquering related diseases.
Second, in the field of materials science, it also has important applications. In the preparation of optoelectronic functional materials, the introduction of this substance can adjust the electronic structure and optical properties of the material. For example, it is used to synthesize new organic semiconductor materials. Such materials can improve the performance of devices such as organic Light Emitting Diode (OLED) and organic solar cells, such as enhancing luminous efficiency and improving photoelectric conversion efficiency, etc., and facilitate the development of new high-performance materials.
Third, in organometallic catalytic reactions, 2-chloro-6-fluorophenylboronic acid is often used as a substrate to participate in many reactions, such as Suzuki-Miyaura coupling reaction. This reaction is a classic method for constructing carbon-carbon bonds. By coupling with different halogenated aromatics or olefin halides under the action of suitable catalysts and bases, a variety of biaryl or alkenyl aromatics can be efficiently synthesized, which greatly enriches the variety of organic compounds and contributes to the development of organic synthesis chemistry.
What are the synthetic methods of 2-chloro-6-fluorobenzeneboronic Acid?
The synthesis method of 2-chloro-6-fluorobromobenzene boronic acid often involves several routes, and each method has its own length and shortness. The appropriate method should be selected according to the specific situation and needs.
One is the metallization method of halogenated aromatic hydrocarbons. First, 2-chloro-6-fluorobromobenzene is used as the starting material, and it interacts with a strong base such as butyl lithium at low temperature to cause it to metallize and generate the corresponding aryl lithium reagent. This aryl lithium reagent has very high activity, and then quickly reacts with borate esters, such as trimethyl borate. After hydrolysis, 2-chloro-6-fluorophenylboronic acid can be obtained. The advantage of this method is that the reaction route is relatively straight and the product purity is quite high. However, reagents such as butyllithium are extremely active and require strict reaction conditions. They must be operated in an anhydrous and oxygen-free environment, and the cost is also high.
The second is the palladium catalytic coupling method. Using 2-chloro-6-fluorohalobenzene and diphenacol borate as raw materials, under the catalysis of palladium catalyst, such as tetra (triphenylphosphine) palladium (0), the coupling reaction occurs in a suitable base and organic solvent. The base can be selected from potassium carbonate, etc., and toluene, dioxane, etc. are commonly used in organic solvents. In this reaction, the halogen atom of halobenzene is coupled with the boron atom of borate ester by the action of palladium catalyst. After the reaction is completed, the target product is obtained after separation and purification. The advantage of this method is that the reaction conditions are relatively mild, the equipment requirements are not as strict as the former, and the raw materials are easier to obtain. However, the disadvantage is that the catalyst is expensive, and the separation and recovery of the catalyst after the reaction are more complicated, or affect the production cost.
There is also a Grignard reagent method. The Grignard reagent is prepared by the reaction of 2-chloro-6-fluorohalobenzene and magnesium chips in anhydrous ether or tetrahydrofuran and other solvents. Grignard's reagent is also active, and then reacts with borate ester to obtain 2-chloro-6-fluorophenylboronic acid after hydrolysis. The advantage of this method is that the raw materials are common and the cost is relatively low. However, the preparation of Grignard's reagent requires an anhydrous environment, and careful temperature control during the reaction process, otherwise side reactions will easily occur, affecting the yield and purity of the product.
2-chloro-6-fluorobenzeneboronic Acid to pay attention to when storing and transporting
2-Chloro-6-fluorophenylboronic acid is an important reagent in organic synthesis. When storing and transporting, there are indeed many key matters that need to be paid attention to.
Let's talk about storage first. Because of its certain chemical activity, it is highly susceptible to environmental factors, so it needs to be stored in a dry place. Moisture can easily cause hydrolysis and deterioration. If the storage place is humid, water molecules will interact with the reagent, changing its chemical structure, thereby reducing its purity and reactivity. It should be placed in a sealed container, which can effectively isolate external moisture. In addition, the temperature should not be ignored, and it should be stored in a low temperature environment, usually 2-8 ° C. If the temperature is too high, it may trigger the chemical reaction of the reagent itself, causing it to decompose or polymerize, which will affect the quality.
Let's talk about transportation. During transportation, it is necessary to ensure that the packaging is firm. Because of its lively nature, if the packaging is damaged, not only the reagent itself will be affected, but also it may cause harm to the surrounding environment. At the same time, it is necessary to avoid mixing with oxidizing agents, acids, alkalis and other substances. The chemical properties of this reagent determine that when it comes into contact with these substances, it is very likely that violent chemical reactions will occur, and even dangerous accidents will occur. The transportation process should also be kept as smooth as possible to avoid vibration and collision, so as to prevent
In conclusion, when storing and transporting 2-chloro-6-fluorophenylboronic acid, it is necessary to pay attention to moisture resistance, temperature control, ensure that the packaging is stable and avoid contact with incompatible substances, so as to ensure its quality and safety.
What is the market price range for 2-chloro-6-fluorobenzeneboronic Acid?
The market price range of 2-chloro-6-fluorophenylboronic acid is difficult to say exactly. The price of the product is influenced by many factors, just like the price of many things, and cannot be determined by a single reason.
The first to bear the brunt is the market supply and demand. If there are many people who want it, and the supply is small, the price will tend to increase; on the contrary, if the supply exceeds the demand, the price will easily drop. This is a common sense of business, and it has never changed.
Furthermore, the price of raw materials is also the key. If the price of the raw materials required for its synthesis is high, the price of the finished product will also be difficult to lower; if the price of raw materials falls, the price of the product may be lowered.
The difficulty of the preparation process also affects the price. If the process is complicated, requires superb skills and sophisticated equipment, and is time-consuming and laborious, the cost will increase, and the price will also rise; if the process is simple, the cost may be reduced, and the price is expected to be close to the people.
In addition, the number of manufacturers and the competitive situation also affect the price. There are many manufacturers, and the competition is fierce. In order to compete for the market, there may be price reductions; if there are few manufacturers and they are almost monopolized, the pricing power is in the hands of a few, and the price may remain high.
There are also quality points. Those with high quality may be higher than those with ordinary prices. Because quality is related to the wide range of uses and the quality of the effect, it affects the price.
According to past market conditions, the price of this compound may fluctuate between tens of yuan and hundreds of yuan per gram. However, this is only a rough figure, and the market is changing rapidly, making it difficult to predict accurately. To know the exact price, it is recommended to consult the chemical product supplier in detail, or check the recent transaction price on the chemical trading platform to obtain a relatively accurate figure.