Linshang Chemical
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2-Chloro-6-Fluorobromobenzene
Linshang Chemical
|
HS Code |
566142 |
| Chemical Formula | C6H3BrClF |
| Molar Mass | 225.44 g/mol |
| Appearance | Liquid (usually) |
| Boiling Point | Approx. 190 - 200 °C |
| Density | Approx. 1.8 - 2.0 g/cm³ (estimated) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Low at room temperature |
| Flash Point | Approx. 75 - 85 °C (estimated) |
| Odor | Typical halogenated - aromatic odor (pungent) |
As an accredited 2-Chloro-6-Fluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2 - chloro - 6 - fluorobromobenzene in a tightly - sealed glass bottle. |
| Storage | 2 - chloro - 6 - fluorobromobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to prevent potential reactions. |
| Shipping | 2 - chloro - 6 - fluorobromobenzene is shipped in sealed, corrosion - resistant containers. It must be transported in accordance with hazardous chemical regulations, ensuring proper labeling and secure handling to prevent leakage during transit. |
Competitive 2-Chloro-6-Fluorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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As a leading 2-Chloro-6-Fluorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 2-chloro-6-fluorobromobenzene?
2-Chloro-6-fluorobromobenzene is also an organic compound. It has the properties of halogenated aromatics, and the halogen atom has a great influence on its chemical properties.
First of all, its nucleophilic substitution. Because the halogen atom has electron-absorbing properties, the electron cloud density of the benzene ring decreases, but the activity of different halogen atoms is different. Bromine atoms are larger than chlorine and fluorine atoms, and the bond energy of C-Br is relatively small. Therefore, when nucleophilic substitution occurs, bromine atoms are more likely to leave. In case of nucleophilic reagents, such as sodium alcohol, amines, etc., the check point where the bromine atom is located is easily attacked by nucle For example, in the presence of sodium alcohol, the corresponding ethers can be formed; when reacted with amines, nitrogen-containing derivatives can be obtained.
The electrophilic substitution of the benzene ring is discussed. Although the halogen atom is a blunt group, the electrophilic substitution of the benzene ring can still occur under certain conditions. Due to the localization effect of fluorine, chlorine and bromine, the electron cloud density of the ortho and para-position is relatively high, and the electrophilic reagents are easy to attack the ortho and para-position. However, due to the steric resistance, the proportion of ortho-substitution products may vary depending on the specific reagents and conditions. In case of nitrifying reagents, nitro groups can be introduced into the benzene ring to obtain nitro substitutes.
This compound itself is difficult to oxidize by ordinary oxidants, but if there are oxidizable groups attached to the benzene ring, or there are other situations. In reduction reactions, halogen atoms can be reduced and removed under the action of specific reducing agents, such as metal zinc and acid systems, or halogen atoms can be removed gradually.
In addition, the physical properties of 2-chloro-6-fluorobromobenzene are also related to its chemical properties. It is an organic halide, which is mostly insoluble in water and easily soluble in organic solvents. This property must be taken into account when selecting the reaction solvent and separating the product.
First of all, its nucleophilic substitution. Because the halogen atom has electron-absorbing properties, the electron cloud density of the benzene ring decreases, but the activity of different halogen atoms is different. Bromine atoms are larger than chlorine and fluorine atoms, and the bond energy of C-Br is relatively small. Therefore, when nucleophilic substitution occurs, bromine atoms are more likely to leave. In case of nucleophilic reagents, such as sodium alcohol, amines, etc., the check point where the bromine atom is located is easily attacked by nucle For example, in the presence of sodium alcohol, the corresponding ethers can be formed; when reacted with amines, nitrogen-containing derivatives can be obtained.
The electrophilic substitution of the benzene ring is discussed. Although the halogen atom is a blunt group, the electrophilic substitution of the benzene ring can still occur under certain conditions. Due to the localization effect of fluorine, chlorine and bromine, the electron cloud density of the ortho and para-position is relatively high, and the electrophilic reagents are easy to attack the ortho and para-position. However, due to the steric resistance, the proportion of ortho-substitution products may vary depending on the specific reagents and conditions. In case of nitrifying reagents, nitro groups can be introduced into the benzene ring to obtain nitro substitutes.
This compound itself is difficult to oxidize by ordinary oxidants, but if there are oxidizable groups attached to the benzene ring, or there are other situations. In reduction reactions, halogen atoms can be reduced and removed under the action of specific reducing agents, such as metal zinc and acid systems, or halogen atoms can be removed gradually.
In addition, the physical properties of 2-chloro-6-fluorobromobenzene are also related to its chemical properties. It is an organic halide, which is mostly insoluble in water and easily soluble in organic solvents. This property must be taken into account when selecting the reaction solvent and separating the product.
What are the main uses of 2-chloro-6-fluorobromobenzene?
2-Chloro-6-fluorobromobenzene is also an organic compound. It has a wide range of uses and is used in various fields.
First, in the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of drugs. Due to its unique chemical structure, it can introduce various functional groups through specific chemical reactions to build complex drug molecular structures. By ingeniously designing the reaction path, using 2-chloro-6-fluorobrobenzene as the starting material, it can synthesize compounds with specific biological activities, which is expected to develop new drugs for the treatment of diseases such as diseases and contribute to human health and well-being.
Second, in the field of materials science, it also has important uses. It can be used as a raw material for the synthesis of special polymer materials. By polymerizing with other monomers, the polymer materials are endowed with unique properties, such as improving the thermal stability, mechanical properties and chemical stability of the materials. These materials with excellent properties can be used in high-end fields such as aerospace, electronics and electrical appliances, meeting the strict demand for high-performance materials in related fields.
Third, in the field of pesticide chemistry, 2-chloro-6-fluorobromobenzene also plays an important role. It can be used as an important intermediate for the synthesis of high-efficiency and low-toxicity pesticides. Through rational molecular design and reaction synthesis, pesticide products with high efficacy in killing crop pests and less harm to the environment and non-target organisms are prepared, providing strong support for the sustainable development of agriculture.
In short, 2-chloro-6-fluorobromobenzene has shown important uses in many fields such as medicine, materials, and pesticides due to its unique chemical structure, which is of great significance for promoting scientific and technological progress and industrial development in related fields.
First, in the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of drugs. Due to its unique chemical structure, it can introduce various functional groups through specific chemical reactions to build complex drug molecular structures. By ingeniously designing the reaction path, using 2-chloro-6-fluorobrobenzene as the starting material, it can synthesize compounds with specific biological activities, which is expected to develop new drugs for the treatment of diseases such as diseases and contribute to human health and well-being.
Second, in the field of materials science, it also has important uses. It can be used as a raw material for the synthesis of special polymer materials. By polymerizing with other monomers, the polymer materials are endowed with unique properties, such as improving the thermal stability, mechanical properties and chemical stability of the materials. These materials with excellent properties can be used in high-end fields such as aerospace, electronics and electrical appliances, meeting the strict demand for high-performance materials in related fields.
Third, in the field of pesticide chemistry, 2-chloro-6-fluorobromobenzene also plays an important role. It can be used as an important intermediate for the synthesis of high-efficiency and low-toxicity pesticides. Through rational molecular design and reaction synthesis, pesticide products with high efficacy in killing crop pests and less harm to the environment and non-target organisms are prepared, providing strong support for the sustainable development of agriculture.
In short, 2-chloro-6-fluorobromobenzene has shown important uses in many fields such as medicine, materials, and pesticides due to its unique chemical structure, which is of great significance for promoting scientific and technological progress and industrial development in related fields.
What is 2-chloro-6-fluorobromobenzene synthesis method?
To prepare 2-chloro-6-fluorobromobenzene, the following method can be used.
First take benzene as the starting material and use ferric chloride as the catalyst to make benzene and chlorine substitution reaction to obtain chlorobenzene. This reaction needs to be carried out at a suitable temperature and atmosphere to ensure that the reaction proceeds in the direction of generating chlorobenzene. The reaction formula is:\ (C_ {6} H_ {6} + Cl_ {2}\ xrightarrow [] {FeCl_ {3}} C_ {6} H_ {5} Cl + HCl\). Next, chlorobenzene is placed in a specific reaction system, a fluorine source is introduced, such as potassium fluoride, etc., and a suitable catalyst and reaction conditions are used to cause a fluorination reaction to replace the chlorine atom at a specific position on the benzene ring to generate 2-chloro-6-fluorobenzene. This step requires fine regulation of reaction temperature, pressure and reactant ratio to improve the yield of the target product.
Finally, using 2-chloro-6-fluorobenzene as the substrate, under the catalysis of liquid bromine and suitable catalysts such as iron powder, bromine atoms are introduced into the benzene ring, and finally 2-chloro-6-fluorobromobenzene is obtained. The reaction formula is:\ (C_ {6} H_ {3} ClF_ {2} + Br_ {2}\ xrightarrow [] {Fe} C_ {6} H_ {2} ClFBr + HBr\).
Throughout the synthesis process, each step of the reaction requires attention to the control of reaction conditions, including temperature, catalyst dosage, reactant ratio, etc., and the product should be purified to remove impurities to obtain high-purity 2-chloro-6-fluorobromobenzene.
First take benzene as the starting material and use ferric chloride as the catalyst to make benzene and chlorine substitution reaction to obtain chlorobenzene. This reaction needs to be carried out at a suitable temperature and atmosphere to ensure that the reaction proceeds in the direction of generating chlorobenzene. The reaction formula is:\ (C_ {6} H_ {6} + Cl_ {2}\ xrightarrow [] {FeCl_ {3}} C_ {6} H_ {5} Cl + HCl\). Next, chlorobenzene is placed in a specific reaction system, a fluorine source is introduced, such as potassium fluoride, etc., and a suitable catalyst and reaction conditions are used to cause a fluorination reaction to replace the chlorine atom at a specific position on the benzene ring to generate 2-chloro-6-fluorobenzene. This step requires fine regulation of reaction temperature, pressure and reactant ratio to improve the yield of the target product.
Finally, using 2-chloro-6-fluorobenzene as the substrate, under the catalysis of liquid bromine and suitable catalysts such as iron powder, bromine atoms are introduced into the benzene ring, and finally 2-chloro-6-fluorobromobenzene is obtained. The reaction formula is:\ (C_ {6} H_ {3} ClF_ {2} + Br_ {2}\ xrightarrow [] {Fe} C_ {6} H_ {2} ClFBr + HBr\).
Throughout the synthesis process, each step of the reaction requires attention to the control of reaction conditions, including temperature, catalyst dosage, reactant ratio, etc., and the product should be purified to remove impurities to obtain high-purity 2-chloro-6-fluorobromobenzene.
What are the precautions in storage and transportation of 2-chloro-6-fluorobromobenzene?
2-Chloro-6-fluorobromobenzene is an organic compound. When storing and transporting, the following matters must be paid attention to:
First, the choice of storage place is crucial. Find a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, in case of open flame or hot topic, it may cause the risk of combustion. This compound may be sensitive to air and moisture, so the humidity and air circulation of the storage environment need to be properly regulated to prevent its deterioration.
Second, the packaging must be tight and reliable. Appropriate packaging materials, such as sealed glass bottles or metal drums, need to be used to ensure that there is no risk of leakage during storage and transportation. Leakage will not only cause material loss, but also cause pollution to the environment and even endanger personal safety.
Third, during storage and transportation, it should be stored and transported in isolation from oxidants, strong alkalis and other substances. 2-chloro-6-fluorobromobenzene and these substances are prone to chemical reactions, or form unstable products, which can lead to hazards such as violent reactions and explosions.
Fourth, when handling, the operation should be gentle and must not be handled brutally. Because it is a fragile packaging container, if it is subjected to violent impact or vibration, the packaging is easily damaged, resulting in material leakage.
Fifth, the storage area and transportation tools should be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of a fire or leakage accident, response measures can be taken quickly to reduce losses and hazards. For leaks, appropriate methods should be used to collect and deal with them according to their characteristics to avoid their spread.
Sixth, relevant operators must be professionally trained and familiar with the characteristics, hazards and emergency treatment methods of 2-chloro-6-fluorobromobenzene. During storage and transportation, strictly follow the operating procedures and take personal protection, such as wearing appropriate protective gloves, protective glasses and gas masks.
First, the choice of storage place is crucial. Find a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, in case of open flame or hot topic, it may cause the risk of combustion. This compound may be sensitive to air and moisture, so the humidity and air circulation of the storage environment need to be properly regulated to prevent its deterioration.
Second, the packaging must be tight and reliable. Appropriate packaging materials, such as sealed glass bottles or metal drums, need to be used to ensure that there is no risk of leakage during storage and transportation. Leakage will not only cause material loss, but also cause pollution to the environment and even endanger personal safety.
Third, during storage and transportation, it should be stored and transported in isolation from oxidants, strong alkalis and other substances. 2-chloro-6-fluorobromobenzene and these substances are prone to chemical reactions, or form unstable products, which can lead to hazards such as violent reactions and explosions.
Fourth, when handling, the operation should be gentle and must not be handled brutally. Because it is a fragile packaging container, if it is subjected to violent impact or vibration, the packaging is easily damaged, resulting in material leakage.
Fifth, the storage area and transportation tools should be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of a fire or leakage accident, response measures can be taken quickly to reduce losses and hazards. For leaks, appropriate methods should be used to collect and deal with them according to their characteristics to avoid their spread.
Sixth, relevant operators must be professionally trained and familiar with the characteristics, hazards and emergency treatment methods of 2-chloro-6-fluorobromobenzene. During storage and transportation, strictly follow the operating procedures and take personal protection, such as wearing appropriate protective gloves, protective glasses and gas masks.
2-chloro-6-fluorobromobenzene impact on the environment and people
2-Chloro-6-fluorobromobenzene is also an organic compound. Its impact on the environment and the human body has been carefully observed.
At the environmental end, 2-chloro-6-fluorobromobenzene is quite stable and is not easy to decompose quickly in the natural environment. If it is released into the atmosphere, it will be widely distributed by atmospheric circulation. In water bodies, due to its hydrophobicity, or adsorption on suspended particles, it settles to the bottom of the water, causing sediment to be contaminated. In the soil, it either stays on the surface, or slowly penetrates into the deep layer, affecting the ecology of soil microorganisms. And because of its special chemical structure, or accumulates in organisms. Aquatic organisms such as fish and shrimp, if they are in water containing this compound for a long time, they will accumulate in the body and pass along the food chain, endangering high-level organisms.
As for personal effects, 2-chloro-6-fluorobromobenzene may be ingested into the human body through respiratory tract, skin contact and diet. After entering the body, it may interfere with the normal physiological functions of the human body. Halogen atoms contained in it can interact with biological macromolecules such as proteins and nucleic acids in the body, destroying their structure and function. Long-term exposure may damage the nervous system, causing headaches, dizziness, fatigue, and even neurological dysfunction. It also has potential harm to organs such as the liver and kidneys, or affects their metabolic and detoxification functions, causing abnormal liver and kidney function. In addition, in view of its chemical properties, or a certain carcinogenicity, although the relevant research is not complete, the latent risk cannot be ignored. In conclusion, 2-chloro-6-fluorobromobenzene poses a potential threat to the environment and humans, and should be handled with caution.
At the environmental end, 2-chloro-6-fluorobromobenzene is quite stable and is not easy to decompose quickly in the natural environment. If it is released into the atmosphere, it will be widely distributed by atmospheric circulation. In water bodies, due to its hydrophobicity, or adsorption on suspended particles, it settles to the bottom of the water, causing sediment to be contaminated. In the soil, it either stays on the surface, or slowly penetrates into the deep layer, affecting the ecology of soil microorganisms. And because of its special chemical structure, or accumulates in organisms. Aquatic organisms such as fish and shrimp, if they are in water containing this compound for a long time, they will accumulate in the body and pass along the food chain, endangering high-level organisms.
As for personal effects, 2-chloro-6-fluorobromobenzene may be ingested into the human body through respiratory tract, skin contact and diet. After entering the body, it may interfere with the normal physiological functions of the human body. Halogen atoms contained in it can interact with biological macromolecules such as proteins and nucleic acids in the body, destroying their structure and function. Long-term exposure may damage the nervous system, causing headaches, dizziness, fatigue, and even neurological dysfunction. It also has potential harm to organs such as the liver and kidneys, or affects their metabolic and detoxification functions, causing abnormal liver and kidney function. In addition, in view of its chemical properties, or a certain carcinogenicity, although the relevant research is not complete, the latent risk cannot be ignored. In conclusion, 2-chloro-6-fluorobromobenzene poses a potential threat to the environment and humans, and should be handled with caution.
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