Linshang Chemical
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2-Chloro-6-Fluoronitrobenzene
Linshang Chemical
|
HS Code |
106811 |
| Chemical Formula | C6H3ClFNO2 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 225 - 227 °C |
| Melting Point | 23 - 25 °C |
| Density | 1.454 g/cm³ |
| Flash Point | 100 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Odor | Pungent odor |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 2-Chloro-6-Fluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 2 - chloro - 6 - fluoronitrobenzene packaged in 5 - kg containers. |
| Storage | 2 - Chloro - 6 - fluoronitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly closed container to prevent leakage. Due to its potential toxicity and reactivity, it should be separated from incompatible substances, and storage areas should be clearly labeled and under strict access control. |
| Shipping | 2 - chloro - 6 - fluoronitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported by approved carriers following strict regulations to ensure safety during transit due to its chemical nature. |
Competitive 2-Chloro-6-Fluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Chloro-6-Fluoronitrobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chloro-6-Fluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chloro-6-fluoronitrobenzene?
2-Chloro-6-fluoronitrobenzene, which is a crucial chemical raw material in the field of organic synthesis, has a wide range of uses.
First, in the field of pharmaceutical synthesis, its role is crucial. It can be used as a key intermediate for the preparation of a variety of specific drugs. For example, some antibacterial drugs, by carrying out a specific chemical reaction on 2-chloro-6-fluoronitrobenzene, ingeniously introduce other functional groups, and through multiple steps of exquisite synthesis, finally obtain drugs with strong antibacterial activity. Due to its special chemical structure, it can endow drugs with unique pharmacological properties, enhance the ability of drugs to combine with targets, and improve efficacy.
Second, it also plays a key role in the creation of pesticides. It can be used as a starting material to construct novel pesticide molecules through a series of complex organic reactions. Some high-efficiency insecticides are based on it and have been carefully designed and synthesized. Because of its chlorine, fluorine and other elements, it endows pesticides with good stability and biological activity, can effectively kill various pests, and has a relatively small impact on the environment, which is in line with the current trend of green pesticides.
Third, in the field of materials science, 2-chloro-6-fluoronitrobenzene also shows unique value. Can be used to synthesize special polymer materials. For example, by polymerizing it with specific monomers, polymers with special properties can be prepared. These polymers may have good heat resistance and corrosion resistance, and can be used in high-end fields such as aerospace and electronics to meet the needs of materials used in special environments.
To sum up, 2-chloro-6-fluoronitrobenzene has indispensable uses in many fields such as medicine, pesticides, and materials due to its unique chemical structure, which is of great significance for promoting the development of related industries.
First, in the field of pharmaceutical synthesis, its role is crucial. It can be used as a key intermediate for the preparation of a variety of specific drugs. For example, some antibacterial drugs, by carrying out a specific chemical reaction on 2-chloro-6-fluoronitrobenzene, ingeniously introduce other functional groups, and through multiple steps of exquisite synthesis, finally obtain drugs with strong antibacterial activity. Due to its special chemical structure, it can endow drugs with unique pharmacological properties, enhance the ability of drugs to combine with targets, and improve efficacy.
Second, it also plays a key role in the creation of pesticides. It can be used as a starting material to construct novel pesticide molecules through a series of complex organic reactions. Some high-efficiency insecticides are based on it and have been carefully designed and synthesized. Because of its chlorine, fluorine and other elements, it endows pesticides with good stability and biological activity, can effectively kill various pests, and has a relatively small impact on the environment, which is in line with the current trend of green pesticides.
Third, in the field of materials science, 2-chloro-6-fluoronitrobenzene also shows unique value. Can be used to synthesize special polymer materials. For example, by polymerizing it with specific monomers, polymers with special properties can be prepared. These polymers may have good heat resistance and corrosion resistance, and can be used in high-end fields such as aerospace and electronics to meet the needs of materials used in special environments.
To sum up, 2-chloro-6-fluoronitrobenzene has indispensable uses in many fields such as medicine, pesticides, and materials due to its unique chemical structure, which is of great significance for promoting the development of related industries.
What are the physical properties of 2-chloro-6-fluoronitrobenzene?
2-Chloro-6-fluoronitrobenzene is one of the organic compounds. It has many physical properties and is related to its use and reaction characteristics. Details are as follows.
Looking at its properties, at room temperature, 2-chloro-6-fluoronitrobenzene is in a white to light yellow crystalline powder form. This form is very critical in actual operation and storage. Because it is powdery, it is easy to disperse and can provide a larger reaction area in some reactions. However, attention should also be paid to prevent dust flying, so as not to cause safety problems.
As for the melting point, it is about 35-39 ° C. The characteristics of the melting point can be used to identify the purity of the substance. If the substance contains impurities, the melting point will often change, or decrease, or the melting range will become wider. Therefore, in production and research, measuring the melting point is a common means to detect its purity.
In terms of boiling point, it is about 237-238 ° C. The boiling point determines the temperature at which the substance changes from liquid to gaseous. Knowing the boiling point is of great significance in chemical operations such as distillation and separation. Appropriate temperature conditions can be set accordingly to separate 2-chloro-6-fluoronitrobenzene from the mixture.
Density is also one of the important physical properties, about 1.497g/cm ³. This value reflects the mass of the substance per unit volume. When it comes to mixing, proportioning, etc., the density can be used to calculate the volume of the desired substance to accurately meet the requirements of the reaction or product.
In terms of solubility, 2-chloro-6-fluoronitrobenzene is insoluble in water. This property makes it relatively independent in the aqueous phase system and can be distinguished from water-soluble substances by means of aqueous phase separation. However, it is soluble in organic solvents such as ethanol, ether, and acetone. This solubility provides convenience for its use in organic synthesis reactions. Many organic reactions are often carried out in organic solvents. Because it can dissolve the substance, the reaction can occur smoothly.
Looking at its properties, at room temperature, 2-chloro-6-fluoronitrobenzene is in a white to light yellow crystalline powder form. This form is very critical in actual operation and storage. Because it is powdery, it is easy to disperse and can provide a larger reaction area in some reactions. However, attention should also be paid to prevent dust flying, so as not to cause safety problems.
As for the melting point, it is about 35-39 ° C. The characteristics of the melting point can be used to identify the purity of the substance. If the substance contains impurities, the melting point will often change, or decrease, or the melting range will become wider. Therefore, in production and research, measuring the melting point is a common means to detect its purity.
In terms of boiling point, it is about 237-238 ° C. The boiling point determines the temperature at which the substance changes from liquid to gaseous. Knowing the boiling point is of great significance in chemical operations such as distillation and separation. Appropriate temperature conditions can be set accordingly to separate 2-chloro-6-fluoronitrobenzene from the mixture.
Density is also one of the important physical properties, about 1.497g/cm ³. This value reflects the mass of the substance per unit volume. When it comes to mixing, proportioning, etc., the density can be used to calculate the volume of the desired substance to accurately meet the requirements of the reaction or product.
In terms of solubility, 2-chloro-6-fluoronitrobenzene is insoluble in water. This property makes it relatively independent in the aqueous phase system and can be distinguished from water-soluble substances by means of aqueous phase separation. However, it is soluble in organic solvents such as ethanol, ether, and acetone. This solubility provides convenience for its use in organic synthesis reactions. Many organic reactions are often carried out in organic solvents. Because it can dissolve the substance, the reaction can occur smoothly.
What are 2-chloro-6-fluoronitrobenzene synthesis methods?
The synthesis method of 2-chloro-6-fluoronitrobenzene, as mentioned in the ancient books, probably has various paths.
First, the compound can be obtained by using 2-chloro-6-fluoroaniline as the starting material, through the diazotization reaction, and then substituting the diazo group with the nitro group. First take an appropriate amount of 2-chloro-6-fluoroaniline and dissolve it in the acid solution, usually hydrochloric acid. At low temperature, slowly add the sodium nitrite solution and carry out the diazotization reaction to form a diazo salt. Then, under specific conditions, a suitable nitrobenzene, such as a mixture of sodium nitrite and copper salt, is added to replace the diazo group with a nitro group to obtain 2-chloro-6-fluoronitrobenzene. This process requires fine control of the reaction temperature, reagent dosage and reaction time to obtain a higher yield.
Second, the nucleophilic substitution reaction of halogenated aromatics can also be used. Select a suitable halogenated benzene derivative, such as 2-chloro-6-fluorobromobenzene, and react with the nitrogenation reagent in a suitable solvent under the catalysis of a base. Commonly used bases include potassium carbonate, sodium carbonate, etc. Using dimethylformamide (DMF) as a solvent, halobenzene derivatives, nitrogenation reagents and bases are mixed, heated and stirred, and after a nucleophilic substitution process, halogen atoms are replaced by nitro groups to achieve 2-chloro-6-fluoronitrobenzene. In this way, the choice of solvent, the type and dosage of bases, and the reaction temperature all have a great impact on the reaction effect.
Third, it can also be achieved step by step by nitrification and halogenation of aromatic hydrocarbons. First nitrate the benzene ring, introduce nitro groups, and then halogenate at a specific location, introduce chlorine atoms and fluorine atoms. However, this method requires precise regulation of the reaction conditions. Due to the positioning effect of nitrification and halogenation, it needs to be properly considered. Otherwise, side reactions will easily occur, resulting in complex products and increased difficulty in separation and purification. The methods for synthesizing 2-chloro-6-fluoronitrobenzene have their own advantages and disadvantages. In practical application, the choice should be based on many factors such as raw material availability, cost, yield and product purity.
First, the compound can be obtained by using 2-chloro-6-fluoroaniline as the starting material, through the diazotization reaction, and then substituting the diazo group with the nitro group. First take an appropriate amount of 2-chloro-6-fluoroaniline and dissolve it in the acid solution, usually hydrochloric acid. At low temperature, slowly add the sodium nitrite solution and carry out the diazotization reaction to form a diazo salt. Then, under specific conditions, a suitable nitrobenzene, such as a mixture of sodium nitrite and copper salt, is added to replace the diazo group with a nitro group to obtain 2-chloro-6-fluoronitrobenzene. This process requires fine control of the reaction temperature, reagent dosage and reaction time to obtain a higher yield.
Second, the nucleophilic substitution reaction of halogenated aromatics can also be used. Select a suitable halogenated benzene derivative, such as 2-chloro-6-fluorobromobenzene, and react with the nitrogenation reagent in a suitable solvent under the catalysis of a base. Commonly used bases include potassium carbonate, sodium carbonate, etc. Using dimethylformamide (DMF) as a solvent, halobenzene derivatives, nitrogenation reagents and bases are mixed, heated and stirred, and after a nucleophilic substitution process, halogen atoms are replaced by nitro groups to achieve 2-chloro-6-fluoronitrobenzene. In this way, the choice of solvent, the type and dosage of bases, and the reaction temperature all have a great impact on the reaction effect.
Third, it can also be achieved step by step by nitrification and halogenation of aromatic hydrocarbons. First nitrate the benzene ring, introduce nitro groups, and then halogenate at a specific location, introduce chlorine atoms and fluorine atoms. However, this method requires precise regulation of the reaction conditions. Due to the positioning effect of nitrification and halogenation, it needs to be properly considered. Otherwise, side reactions will easily occur, resulting in complex products and increased difficulty in separation and purification. The methods for synthesizing 2-chloro-6-fluoronitrobenzene have their own advantages and disadvantages. In practical application, the choice should be based on many factors such as raw material availability, cost, yield and product purity.
2-chloro-6-fluoronitrobenzene What are the precautions during storage and transportation?
2-Chloro-6-fluoronitrobenzene is also an organic compound. During storage and transportation, many matters need to be carefully paid attention to.
When storing, the first choice of environment. It must be placed in a cool and ventilated warehouse, away from fires and heat sources. The cover can easily cause danger due to the heat of the compound, such as decomposition, combustion, etc. And the temperature of the warehouse should not be too high to prevent its chemical properties from changing.
Second, it should be stored separately from oxidants, reducing agents, alkalis, etc., and must not be mixed. Due to its active chemical properties, contact with the above substances may cause severe chemical reactions, resulting in accidents.
Furthermore, the storage area should be equipped with suitable materials to contain leaks. In case of leakage, it can be properly handled in time to prevent the harm from expanding.
As for transportation, there are also many points. Before transportation, it is necessary to ensure that the packaging is complete and the loading is secure. The packaging must be able to withstand a certain amount of external force, so as not to be damaged during transportation, resulting in leakage of items.
During transportation, the driving speed should not be too fast to avoid sudden braking and violent vibration. This is to prevent the packaging from being damaged due to vibration, and to reduce the risk of accidents caused by emergencies due to excessive speed.
Transportation vehicles also need to be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. In the event of an accident on the way, rescue and treatment can be carried out in time.
When transporting, you should follow the specified route and do not stop in densely populated areas, residential areas, etc. In this way, the harm to the public in the event of an accident can be minimized.
When storing, the first choice of environment. It must be placed in a cool and ventilated warehouse, away from fires and heat sources. The cover can easily cause danger due to the heat of the compound, such as decomposition, combustion, etc. And the temperature of the warehouse should not be too high to prevent its chemical properties from changing.
Second, it should be stored separately from oxidants, reducing agents, alkalis, etc., and must not be mixed. Due to its active chemical properties, contact with the above substances may cause severe chemical reactions, resulting in accidents.
Furthermore, the storage area should be equipped with suitable materials to contain leaks. In case of leakage, it can be properly handled in time to prevent the harm from expanding.
As for transportation, there are also many points. Before transportation, it is necessary to ensure that the packaging is complete and the loading is secure. The packaging must be able to withstand a certain amount of external force, so as not to be damaged during transportation, resulting in leakage of items.
During transportation, the driving speed should not be too fast to avoid sudden braking and violent vibration. This is to prevent the packaging from being damaged due to vibration, and to reduce the risk of accidents caused by emergencies due to excessive speed.
Transportation vehicles also need to be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. In the event of an accident on the way, rescue and treatment can be carried out in time.
When transporting, you should follow the specified route and do not stop in densely populated areas, residential areas, etc. In this way, the harm to the public in the event of an accident can be minimized.
2-chloro-6-fluoronitrobenzene impact on the environment and human health
2-Chloro-6-fluoronitrobenzene has an impact on the environment and human health.
In the environment, it is toxic, stable and difficult to degrade. If released in nature, it can exist in water, soil and atmosphere. In water, it will cause sewage sources, harm aquatic organisms, and damage their survival and reproduction. Such as entering rivers, lakes and seas, or causing biological poisoning such as fish, shrimp and shellfish, destroying the ecological balance of water. In soil, it will inhibit plant growth, change soil microbial communities, and then affect the entire soil ecosystem. Because of its volatility, in the atmosphere, or participating in photochemical reactions, it generates harmful secondary pollutants, such as ozone, which damage air quality.
For human health, it can enter the body through respiratory tract, skin contact and ingestion. It has a stimulating effect. If it comes into contact with the skin, it may cause redness, swelling, itching, and burns. Entering the eyes, it also hurts the eye tissue, causing pain, tears, and vision loss. Inhalation of its vapor irritates the respiratory tract, causing cough, asthma, and breathing difficulties. Long-term exposure, toxicity accumulates in the body, damaging organs such as the liver and kidneys. And it may be a carcinogen, long-term exposure increases the risk of cancer, such as lung cancer, bladder cancer, etc. Therefore, the production, use and disposal of 2-chloro-6-fluoronitrobenzene should be handled with caution and strict prevention and control measures should be taken to reduce its harm to the environment and human health.
In the environment, it is toxic, stable and difficult to degrade. If released in nature, it can exist in water, soil and atmosphere. In water, it will cause sewage sources, harm aquatic organisms, and damage their survival and reproduction. Such as entering rivers, lakes and seas, or causing biological poisoning such as fish, shrimp and shellfish, destroying the ecological balance of water. In soil, it will inhibit plant growth, change soil microbial communities, and then affect the entire soil ecosystem. Because of its volatility, in the atmosphere, or participating in photochemical reactions, it generates harmful secondary pollutants, such as ozone, which damage air quality.
For human health, it can enter the body through respiratory tract, skin contact and ingestion. It has a stimulating effect. If it comes into contact with the skin, it may cause redness, swelling, itching, and burns. Entering the eyes, it also hurts the eye tissue, causing pain, tears, and vision loss. Inhalation of its vapor irritates the respiratory tract, causing cough, asthma, and breathing difficulties. Long-term exposure, toxicity accumulates in the body, damaging organs such as the liver and kidneys. And it may be a carcinogen, long-term exposure increases the risk of cancer, such as lung cancer, bladder cancer, etc. Therefore, the production, use and disposal of 2-chloro-6-fluoronitrobenzene should be handled with caution and strict prevention and control measures should be taken to reduce its harm to the environment and human health.
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