2-Chloro-Alpha-[[2-(2-Thienyl)Ethyl]Amino]Benzeneacetic Acid Methyl Ester
Linshang Chemical
HS Code |
289936 |
Chemical Formula | C16H16ClNO2S |
Molecular Weight | 321.82 |
Appearance | Solid (Typical) |
Melting Point | Data may vary depending on purity |
Boiling Point | Data may vary depending on purity |
Solubility In Water | Low solubility (organic compound nature) |
Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone |
Pka | Data may vary depending on experimental conditions |
Logp | Positive value indicating lipophilic nature |
Density | Data may vary depending on purity |
As an accredited 2-Chloro-Alpha-[[2-(2-Thienyl)Ethyl]Amino]Benzeneacetic Acid Methyl Ester factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 100 - gram pack of 2 - chloro - alpha - [[2 - (2 - thienyl)ethyl]amino]benzeneacetic acid methyl ester. |
Storage | Store 2 - chloro - α - [[2 - (2 - thienyl)ethyl]amino]benzeneacetic acid methyl ester in a cool, dry place. Keep it away from heat sources and direct sunlight. Store in a tightly - sealed container to prevent moisture absorption and exposure to air, which could potentially lead to degradation of this chemical compound. |
Shipping | The chemical "2 - chloro - alpha - [[2 - (2 - thienyl)ethyl]amino]benzeneacetic Acid Methyl Ester" will be shipped in sealed, corrosion - resistant containers. Shipment follows strict hazardous chemical transport regulations to ensure safety during transit. |
Competitive 2-Chloro-Alpha-[[2-(2-Thienyl)Ethyl]Amino]Benzeneacetic Acid Methyl Ester prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 2-Chloro-Alpha-[[2-(2-Thienyl)Ethyl]Amino]Benzeneacetic Acid Methyl Ester supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
Its core structure is a benzene ring, in the ortho-position of the benzene ring, that is, the 2 - position, connected with a chlorine atom, the presence of this chlorine atom endows the molecule with specific electronic effects and steric hindrance.
And the methyl phenylacetate part, the benzene ring is connected to the methyl acetate group to form an ester structure. In ester-COOCH, carbonyl carbons are electrophilic, while methoxy groups have a certain electronic effect, which affects the chemical activity of the whole molecule.
The key is the [2 - (2 - thiophenyl) ethyl] amino] group linked to the α-position. Thiophenyl is a sulfur-containing five-membered heterocycle with aromatic properties. Its electron cloud distribution is slightly different from that of the benzene ring, and it interacts with the benzene ring to affect the conjugation system and electron delocalization of the molecule. The thiophenyl group is connected to the amino group through the ethyl group. The amino group has the ability to give electrons and can interact with surrounding groups such as hydrogen bonds, which has a great impact on the physical and chemical properties of the molecule. Overall, this complex structure determines the unique chemical and physical properties of the compound, which may have important potential applications in fields such as organic synthesis and medicinal chemistry.
In terms of solubility, it may exhibit different properties in organic solvents. In polar organic solvents such as ethanol and acetone, it may exhibit a certain solubility. Due to the presence of polar groups in the molecular structure, interactions with polar solvent molecules can occur, such as hydrogen bonds, dipole-dipole interactions, etc., which in turn promote the dissolution process. In water, due to the large proportion of the hydrophobic part of its molecules, the solubility may be relatively low.
Its density is also an important physical property. Although the exact value needs to be accurately measured experimentally, it can be roughly inferred from its molecular structure and relative molecular mass. Due to the molecular structure containing benzene rings, thiophene rings, etc., the structure is relatively compact and the atomic weight is large, so the density may be greater than that of common organic solvents.
In addition, the compound may have a specific refractive index, which reflects the ability of the substance to refract light and depends on the molecular structure and composition, which is of great significance for identification and purity analysis. The above physical properties are indispensable factors in the synthesis, separation, purification and application of the compound.
In the process of drug development, it is often used as a key intermediate. Through specific chemical reactions, it can be cleverly spliced with other compounds to construct complex active pharmaceutical ingredients. For example, in the process of creating some new antihistamines, it can be used as a starting material. After multiple carefully designed reactions, it can shape a molecular structure that fits a specific pharmacological target to achieve anti-allergic efficacy.
In the field of organic synthesis, it is also a popular and important building block. With its unique chemical structure, it provides assistance for the synthesis of organic materials with specific functions and structures. For example, when designing and synthesizing materials with special optical or electrical properties, it can be integrated into them as a structural unit, giving novel properties to the material and contributing to the development of materials science.
In addition, in the field of pesticide chemistry, it may also have its own uses. Pesticide products with high insecticidal and bactericidal activities can be developed through reasonable chemical modification, contributing to the control of agricultural pests and diseases, protecting the growth of crops and ensuring agricultural harvests.
First, methyl 2-chlorophenylacetate is used as the starting material. Schilling 2 - chlorophenylacetic acid and methanol are esterified under the action of sulfuric acid and other catalysts to obtain methyl 2 - chlorophenylacetate. This step requires attention to the reaction temperature and time. If the temperature is too high or the time is too long, it is easy to cause side reactions and affect the purity and yield of the product. Then, methyl 2-chlorophenylacetate is reacted with 2 - (2-thiophenyl) ethylamine in an appropriate solvent, such as toluene and xylene, under the catalysis of alkali. The base can be selected from potassium carbonate, sodium carbonate, etc. The temperature should be controlled and stirred during the reaction to facilitate the full progress of the reaction. In this process, the amount of base, reaction temperature and time are all key factors, which have a great impact on the yield of the product.
Second, 2-chlorobenzoic acid is used as the starting material. First, 2-chlorobenzoic acid is esterified with methanol to obtain methyl 2-chlorobenzoate, and then through the Fu-gram alkylation reaction, in the presence of catalysts such as aluminum trichloride, it is reacted with 2- (2-chloroethyl) thiophene to introduce thiophenethyl. However, the Fu-gram reaction conditions are harsh, and the requirements for anhydrous environment are extremely high, and the catalyst dosage needs to be precisely controlled, otherwise it is easy to cause side reactions such as polyalkylation. Later, it is converted into the target product through reduction, amination and other steps. There are many steps in this route, and each step requires fine operation to ensure the quality and yield of the final product.
Third, it can be started from methyl 2- - α - bromophenylacetate. Methyl 2-chlorophenylacetate is brominated under appropriate conditions to obtain methyl 2- - α - bromophenylacetate, and then nucleophilic substitution with 2 - (2-thiophenyl) ethylamine. In this reaction, the activity of 2 - (2-thiophenyl) ethylamine and the polarity of the reaction solvent will affect the reaction rate and product purity. When synthesizing this compound, no matter what method is used, attention should be paid to the precise control of reaction conditions, the separation and purification of intermediate products, in order to improve the yield and purity of the target product, and meet the needs of industrial production or experiments.
First, protective measures are the key. Because it may be irritating, contact with the skin, eyes, or inhalation through the respiratory tract, accidental ingestion, can cause adverse effects. When operating, wear laboratory clothes and protective gloves. Appropriate glove materials, such as nitrile gloves, can be effectively protected. At the same time, be sure to wear protective glasses to prevent liquid from splashing into the eyes. If you need to be in the relevant environment for a long time, you should also wear a gas mask, and choose a suitable filter box according to the specific situation to ensure the safety of breathing.
Second, the operation specifications should not be ignored. It should be operated in a well-ventilated place, preferably in a fume hood, so that volatile gases can be discharged in time and the concentration of harmful substances in the air can be reduced. When taking the compound, the tools used should be clean and dry to prevent impurities from mixing into the reaction abnormality. And the operation should be slow and cautious, avoid violent vibration and impact, and prevent accidents.
Third, storage conditions should also be paid attention to. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Because it may be sensitive to light, it needs to be stored away from light and can be placed in a brown bottle. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed to prevent dangerous chemical reactions.
Fourth, emergency treatment must be clear. If you accidentally come into contact with the skin, you should immediately rinse with a large amount of flowing water for at least 15 minutes, and then seek medical treatment. If it splashes into the eyes, you should immediately lift the eyelids, rinse thoroughly with a large amount of water or normal saline, and seek medical attention as soon as possible. If inhaled, you should quickly move to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties, you should give oxygen. If breathing stops, you should immediately perform artificial respiration and seek medical attention. If taken by mistake, do not induce vomiting, you should seek medical attention immediately, and carry the relevant information of the compound to help doctors diagnose and treat.
In short, when using 2 - chloro - α - [ [ 2 - (2 - thiophenyl) ethyl] amino] phenylacetate methyl ester, it is necessary to fully understand its safety precautions and strictly follow the standard operation, so as to ensure the safety of personnel and the smooth progress of experiments and production.

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