Linshang Chemical
PRODUCTS
2-Chloro-Benzenemethanol
Linshang Chemical
|
HS Code |
421000 |
| Chemical Formula | C7H7ClO |
| Molar Mass | 142.58 g/mol |
| Appearance | Colorless to light - yellow liquid or solid |
| Boiling Point | 236 - 238 °C |
| Melting Point | 28 - 30 °C |
| Density | 1.254 g/cm³ |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 101 °C |
| Odor | Characteristic aromatic odor |
As an accredited 2-Chloro-Benzenemethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - benzenemethanol packaged in a sealed, corrosion - resistant plastic bottle. |
| Storage | 2 - chloro - benzenemethanol should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent moisture absorption and vapor leakage. Store it separately from oxidizing agents, acids, and bases to avoid chemical reactions. Label the storage clearly for easy identification and safety. |
| Shipping | 2 - chloro - benzenemethanol should be shipped in well - sealed, corrosion - resistant containers. Ensure compliance with chemical transportation regulations. Mark the containers clearly with relevant hazard warnings for safe and proper handling during transit. |
Competitive 2-Chloro-Benzenemethanol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What are the chemical properties of 2-chloro-benzenemethanol?
2-Chloro-benzyl alcohol is an organic compound with unique chemical properties. Its molecule contains a benzene ring, a chlorine atom and a methanol group, which gives it a variety of reactivity.
The presence of hydroxyl groups makes it possible to participate in many reactions. Due to its nucleophilicity, hydroxyl groups can be substituted with electrophilic reagents. Such as reacting with halogenated hydrocarbons to form ether compounds, this reaction is often used in organic synthesis to form carbon-oxygen bonds and is of great value in the preparation of complex organic molecules.
Furthermore, hydroxyl groups can participate in esterification reactions. When coexisted with carboxylic acids or their derivatives, under the action of suitable catalysts, corresponding esters can be formed. Ester compounds are widely used in the fields of fragrances, solvents and polymer materials. Esters formed by the esterification reaction of 2-chloro-benzyl alcohol, or due to the introduction of benzene ring and chlorine atoms, exhibit unique physical and chemical properties, expanding their application scope.
In addition, the chlorine atom of 2-chloro-benzyl alcohol also has important reactivity. Chlorine atoms can be replaced by nucleophiles to achieve functional group conversion. For example, when reacted with nucleophiles containing nitrogen, oxygen or sulfur, chlorine atoms can be replaced with other functional groups, enriching the diversity of molecular structures and providing an effective way for the synthesis of various organic compounds.
Moreover, due to the influence of benzene ring and chlorine atom, the benzene ring of this compound can undergo electrophilic substitution reaction. The benzene ring itself is rich in electrons and vulnerable to attack by electrophilic reagents. Although the chlorine atom is an electron-withdrawing group, its p-π conjugation effect affects the electron cloud distribution of the benzene ring to a certain extent, making the position selectivity of the electrophilic substitution reaction different. Common electrophilic substitution reactions such as nitrification, halogenation, sulfonation, etc., can introduce new functional groups at specific positions in the benzene ring, and further derive many organic compounds.
2-chloro-benzyl alcohol exhibits diverse chemical properties due to its unique molecular structure, and has broad application prospects in the field of organic synthesis. It can construct complex organic molecules through various reactions to meet the needs of different fields for special organic compounds.
The presence of hydroxyl groups makes it possible to participate in many reactions. Due to its nucleophilicity, hydroxyl groups can be substituted with electrophilic reagents. Such as reacting with halogenated hydrocarbons to form ether compounds, this reaction is often used in organic synthesis to form carbon-oxygen bonds and is of great value in the preparation of complex organic molecules.
Furthermore, hydroxyl groups can participate in esterification reactions. When coexisted with carboxylic acids or their derivatives, under the action of suitable catalysts, corresponding esters can be formed. Ester compounds are widely used in the fields of fragrances, solvents and polymer materials. Esters formed by the esterification reaction of 2-chloro-benzyl alcohol, or due to the introduction of benzene ring and chlorine atoms, exhibit unique physical and chemical properties, expanding their application scope.
In addition, the chlorine atom of 2-chloro-benzyl alcohol also has important reactivity. Chlorine atoms can be replaced by nucleophiles to achieve functional group conversion. For example, when reacted with nucleophiles containing nitrogen, oxygen or sulfur, chlorine atoms can be replaced with other functional groups, enriching the diversity of molecular structures and providing an effective way for the synthesis of various organic compounds.
Moreover, due to the influence of benzene ring and chlorine atom, the benzene ring of this compound can undergo electrophilic substitution reaction. The benzene ring itself is rich in electrons and vulnerable to attack by electrophilic reagents. Although the chlorine atom is an electron-withdrawing group, its p-π conjugation effect affects the electron cloud distribution of the benzene ring to a certain extent, making the position selectivity of the electrophilic substitution reaction different. Common electrophilic substitution reactions such as nitrification, halogenation, sulfonation, etc., can introduce new functional groups at specific positions in the benzene ring, and further derive many organic compounds.
2-chloro-benzyl alcohol exhibits diverse chemical properties due to its unique molecular structure, and has broad application prospects in the field of organic synthesis. It can construct complex organic molecules through various reactions to meet the needs of different fields for special organic compounds.
What are the physical properties of 2-chloro-benzenemethanol?
2-Chlorobenzyl alcohol is a kind of organic compound. It has unique physical properties, which are described in detail by you.
Under normal temperature and pressure, 2-chlorobenzyl alcohol is mostly colorless to light yellow liquid, or sometimes white crystalline solid, depending on environmental conditions. When its texture is pure, its appearance is clear, and there are no impurities mixed in.
As for the smell, 2-chlorobenzyl alcohol emits a weak and special aromatic smell. This smell is not pungent and unpleasant, but it is also different from the common fragrance. It is unique. In the category of organic compounds, this smell can be used as a preliminary identification feature.
The melting point of 2-chlorobenzyl alcohol is about 25-27 ° C. When the temperature reaches this range, the solid 2-chlorobenzyl alcohol will slowly melt into a liquid state. The boiling point is about 238-240 ° C. At this temperature, the liquid will vaporize violently and turn into a gaseous state. This boiling point characteristic is extremely critical in the process of organic synthesis and separation and purification. Chemists can use this to separate 2-chlorobenzyl alcohol from other substances by controlling the temperature, or perform related reactions under specific temperature conditions.
In terms of solubility, 2-chlorobenzyl alcohol is slightly soluble in water. Water is a common solvent, and the degree of solubility of 2-chlorobenzyl alcohol in water is limited due to the difference in molecular forces between the two. However, it is soluble in organic solvents such as ethanol, ether, acetone, etc. Organic solvents and 2-chlorobenzyl alcohol are more likely to interact with each other due to the similarity of molecular structure and polarity, so as to achieve dissolution. This solubility property is of great significance in the operation of medium selection and product extraction in organic reactions.
The density of 2-chlorobenzyl alcohol is slightly higher than that of water. When mixed with water, it will sink to the bottom of the water. This property can be used as one of the separation bases in experiments or industrial production involving liquid-liquid separation.
To sum up, the physical properties of 2-chlorobenzyl alcohol vary from properties, odor, melting point, solubility to density. These properties are interrelated and together determine its application and treatment in the field of organic chemistry. It plays an important role in many aspects such as organic synthesis and drug development.
Under normal temperature and pressure, 2-chlorobenzyl alcohol is mostly colorless to light yellow liquid, or sometimes white crystalline solid, depending on environmental conditions. When its texture is pure, its appearance is clear, and there are no impurities mixed in.
As for the smell, 2-chlorobenzyl alcohol emits a weak and special aromatic smell. This smell is not pungent and unpleasant, but it is also different from the common fragrance. It is unique. In the category of organic compounds, this smell can be used as a preliminary identification feature.
The melting point of 2-chlorobenzyl alcohol is about 25-27 ° C. When the temperature reaches this range, the solid 2-chlorobenzyl alcohol will slowly melt into a liquid state. The boiling point is about 238-240 ° C. At this temperature, the liquid will vaporize violently and turn into a gaseous state. This boiling point characteristic is extremely critical in the process of organic synthesis and separation and purification. Chemists can use this to separate 2-chlorobenzyl alcohol from other substances by controlling the temperature, or perform related reactions under specific temperature conditions.
In terms of solubility, 2-chlorobenzyl alcohol is slightly soluble in water. Water is a common solvent, and the degree of solubility of 2-chlorobenzyl alcohol in water is limited due to the difference in molecular forces between the two. However, it is soluble in organic solvents such as ethanol, ether, acetone, etc. Organic solvents and 2-chlorobenzyl alcohol are more likely to interact with each other due to the similarity of molecular structure and polarity, so as to achieve dissolution. This solubility property is of great significance in the operation of medium selection and product extraction in organic reactions.
The density of 2-chlorobenzyl alcohol is slightly higher than that of water. When mixed with water, it will sink to the bottom of the water. This property can be used as one of the separation bases in experiments or industrial production involving liquid-liquid separation.
To sum up, the physical properties of 2-chlorobenzyl alcohol vary from properties, odor, melting point, solubility to density. These properties are interrelated and together determine its application and treatment in the field of organic chemistry. It plays an important role in many aspects such as organic synthesis and drug development.
What are the main uses of 2-chloro-benzenemethanol?
2-Chlorobenzyl alcohol, an organic compound, has important uses in many fields.
In the field of organic synthesis, it is a key intermediate. It can react with many nucleophilic reagents by nucleophilic substitution reaction to generate various derivatives containing benzyl alcohol structures. Such as esterification reaction with carboxylic acids under suitable catalysts and conditions, the corresponding ester compounds are prepared. Such esters are widely used in industries such as fragrances, drugs and polymer materials. Like some fragrances, such esters can impart a unique aroma; in the modification of drug molecular structure, specific ester groups can improve drug solubility, stability and bioavailability.
In the field of medicinal chemistry, derivatives of 2-chlorobenzyl alcohol have potential biological activity. Some derivatives have been found to have inhibitory or regulatory effects on specific disease targets, and can be used as lead compounds to provide ideas and bases for the development of new drugs. Medicinal chemists can modify and optimize their structures to explore new drugs with more curative effect and lower toxic and side effects.
In the field of materials science, some polymer materials involved in the synthesis of 2-chlorobenzyl alcohol have special properties. For example, they can be used to prepare functional polymers to impart specific adsorption, separation or optical properties to the materials. In adsorption materials, such polymers can selectively adsorb specific substances to achieve the purpose of separation and enrichment; in the field of optical materials, they may endow materials with unique photoluminescence or photoresponse characteristics, which can be used in optoelectronic devices.
In summary, although 2-chlorobenzyl alcohol is a small organic molecule, it plays a key role in modern chemical industry and related scientific research due to its important uses in organic synthesis, medicinal chemistry and materials science.
In the field of organic synthesis, it is a key intermediate. It can react with many nucleophilic reagents by nucleophilic substitution reaction to generate various derivatives containing benzyl alcohol structures. Such as esterification reaction with carboxylic acids under suitable catalysts and conditions, the corresponding ester compounds are prepared. Such esters are widely used in industries such as fragrances, drugs and polymer materials. Like some fragrances, such esters can impart a unique aroma; in the modification of drug molecular structure, specific ester groups can improve drug solubility, stability and bioavailability.
In the field of medicinal chemistry, derivatives of 2-chlorobenzyl alcohol have potential biological activity. Some derivatives have been found to have inhibitory or regulatory effects on specific disease targets, and can be used as lead compounds to provide ideas and bases for the development of new drugs. Medicinal chemists can modify and optimize their structures to explore new drugs with more curative effect and lower toxic and side effects.
In the field of materials science, some polymer materials involved in the synthesis of 2-chlorobenzyl alcohol have special properties. For example, they can be used to prepare functional polymers to impart specific adsorption, separation or optical properties to the materials. In adsorption materials, such polymers can selectively adsorb specific substances to achieve the purpose of separation and enrichment; in the field of optical materials, they may endow materials with unique photoluminescence or photoresponse characteristics, which can be used in optoelectronic devices.
In summary, although 2-chlorobenzyl alcohol is a small organic molecule, it plays a key role in modern chemical industry and related scientific research due to its important uses in organic synthesis, medicinal chemistry and materials science.
What are 2-chloro-benzenemethanol synthesis methods?
To prepare 2-chlorobenzyl alcohol, there are three methods.
One is the hydrolysis of halogenated aromatics. Start with 2-chlorobenzyl halogen and heat it with alkali. In this reaction, the halogen atom is replaced by a hydroxyl group and goes through a nucleophilic substitution. Halogenated aromatics In an alkaline environment, hydroxyl ions attack the carbon connected to the halogen atom, and the halogen ions leave to obtain 2-chlorobenzyl alcohol. The reaction needs to be temperature controlled to maintain the purity of the product, and the post-treatment needs to be purified by extraction, distillation, etc.
The second is the Grignard reagent method. First, 2-chlorobenzene and magnesium are prepared in anhydrous ethyl ether. This is the Grignard reagent. After reacting with formaldehyde, the carbon-magnesium bond of Grignard's reagent has strong nucleophilicity, attacking the carbonyl carbon of formaldehyde to form a new carbon-carbon bond. After acidic hydrolysis, the oxygen-magnesium bond is converted into a hydroxyl group to obtain the target product. This method has strict requirements on the reaction environment and requires anhydrous and oxygen-free, otherwise Grignard's reagent is easy to decompose.
The third is the reduction method. Using 2-chlorobenzoic acid or its esters as raw materials, it is reduced with strong reducing agents such as lithium aluminum hydride. The negative hydrogen ions in lithium aluminum hydride have strong reducing properties and can reduce carboxyl groups or ester groups to hydroxyl groups. After the reaction is completed, after hydrolysis, excess reducing agents and by-products are removed, and purified by column chromatography to obtain pure 2-chlorobenzyl alcohol. However, lithium aluminum hydride is active, so be careful during operation to prevent water explosion.
One is the hydrolysis of halogenated aromatics. Start with 2-chlorobenzyl halogen and heat it with alkali. In this reaction, the halogen atom is replaced by a hydroxyl group and goes through a nucleophilic substitution. Halogenated aromatics In an alkaline environment, hydroxyl ions attack the carbon connected to the halogen atom, and the halogen ions leave to obtain 2-chlorobenzyl alcohol. The reaction needs to be temperature controlled to maintain the purity of the product, and the post-treatment needs to be purified by extraction, distillation, etc.
The second is the Grignard reagent method. First, 2-chlorobenzene and magnesium are prepared in anhydrous ethyl ether. This is the Grignard reagent. After reacting with formaldehyde, the carbon-magnesium bond of Grignard's reagent has strong nucleophilicity, attacking the carbonyl carbon of formaldehyde to form a new carbon-carbon bond. After acidic hydrolysis, the oxygen-magnesium bond is converted into a hydroxyl group to obtain the target product. This method has strict requirements on the reaction environment and requires anhydrous and oxygen-free, otherwise Grignard's reagent is easy to decompose.
The third is the reduction method. Using 2-chlorobenzoic acid or its esters as raw materials, it is reduced with strong reducing agents such as lithium aluminum hydride. The negative hydrogen ions in lithium aluminum hydride have strong reducing properties and can reduce carboxyl groups or ester groups to hydroxyl groups. After the reaction is completed, after hydrolysis, excess reducing agents and by-products are removed, and purified by column chromatography to obtain pure 2-chlorobenzyl alcohol. However, lithium aluminum hydride is active, so be careful during operation to prevent water explosion.
What do 2-chloro-benzenemethanol need to pay attention to when storing and transporting?
2-Chlorobenzyl alcohol is an organic compound, and many aspects must be paid attention to when storing and transporting.
When storing, the first environment selection. When placed in a cool and ventilated warehouse, due to high temperature or poor ventilation, or cause its volatilization to accelerate, or even cause dangerous chemical reactions. The temperature of the warehouse should be strictly controlled within a specific range, not too high, to prevent the properties of the substance from changing.
Furthermore, it is necessary to ensure that the packaging is complete. The packaging of this substance should be tightly sealed to avoid contact with the air. Because of its chemical properties or due to reactions with oxygen, water vapor and other components in the air, it will affect the quality and safety.
In addition, keep away from fire and heat sources. 2-Chlorobenzyl alcohol is a flammable substance. It is very easy to burn in case of open flames and hot topics. Therefore, fireworks are strictly prohibited in the storage area. All electrical equipment and lighting should have explosion-proof functions.
As for transportation, transportation vehicles must meet safety standards. Vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment for emergencies. The transportation process must be stable to avoid severe bumps and collisions to prevent material leakage due to damaged packaging.
Moreover, transportation personnel should also be professionally trained and familiar with the characteristics of 2-chlorobenzyl alcohol and emergency treatment methods. In the event of leakage and other conditions, they can be disposed of quickly and correctly to reduce hazards.
In summary, when storing and transporting 2-chlorobenzyl alcohol, all aspects, including the environment, packaging, fire protection, and personnel professionalism, need to be treated with caution to ensure its safety and quality.
When storing, the first environment selection. When placed in a cool and ventilated warehouse, due to high temperature or poor ventilation, or cause its volatilization to accelerate, or even cause dangerous chemical reactions. The temperature of the warehouse should be strictly controlled within a specific range, not too high, to prevent the properties of the substance from changing.
Furthermore, it is necessary to ensure that the packaging is complete. The packaging of this substance should be tightly sealed to avoid contact with the air. Because of its chemical properties or due to reactions with oxygen, water vapor and other components in the air, it will affect the quality and safety.
In addition, keep away from fire and heat sources. 2-Chlorobenzyl alcohol is a flammable substance. It is very easy to burn in case of open flames and hot topics. Therefore, fireworks are strictly prohibited in the storage area. All electrical equipment and lighting should have explosion-proof functions.
As for transportation, transportation vehicles must meet safety standards. Vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment for emergencies. The transportation process must be stable to avoid severe bumps and collisions to prevent material leakage due to damaged packaging.
Moreover, transportation personnel should also be professionally trained and familiar with the characteristics of 2-chlorobenzyl alcohol and emergency treatment methods. In the event of leakage and other conditions, they can be disposed of quickly and correctly to reduce hazards.
In summary, when storing and transporting 2-chlorobenzyl alcohol, all aspects, including the environment, packaging, fire protection, and personnel professionalism, need to be treated with caution to ensure its safety and quality.
What are the physical properties of 2-chloro-benzenemethanol?
2-Chlorobenzyl alcohol is a kind of organic compound. It has specific physical properties, which are described below.
Looking at its appearance, under room temperature and pressure, 2-chlorobenzyl alcohol is often colorless to light yellow liquid, or white to off-white crystalline powder. When pure, the appearance is pure and uniform.
When it comes to the melting point, the melting point of this compound is about 38-42 ° C. When the temperature reaches this range, the solid 2-chlorobenzyl alcohol gradually melts into a liquid state. This phase transition temperature is of great significance in terms of identification and purity determination.
The boiling point of 2-chlorobenzyl alcohol is about 244-246 ° C. At this high temperature, 2-chlorobenzyl alcohol in the liquid state can be turned into a gaseous state, which is very critical in chemical operations such as separation and purification.
Its density is about 1.245 g/cm ³, indicating the amount of substances contained in the unit volume. This value plays an important role in guiding material balance and reaction system configuration.
In terms of solubility, 2-chlorobenzyl alcohol is slightly soluble in water, but can be soluble in organic solvents such as ethanol, ether, and chloroform. This difference in solubility provides a clear basis for extraction, reaction solvent selection, etc.
In addition, 2-chlorobenzyl alcohol has a certain volatility and can evaporate slowly in the air. Although the volatilization rate is not extremely fast, it is also necessary to pay attention to this property when storing and using it to prevent its dissipation and impact on the environment. And because its molecular structure contains chlorine atoms and hydroxyl groups, it is chemically active and can participate in a variety of chemical reactions. Its physical properties affect the conditions and processes of these reactions, which is a key point that cannot be ignored in research and application.
Looking at its appearance, under room temperature and pressure, 2-chlorobenzyl alcohol is often colorless to light yellow liquid, or white to off-white crystalline powder. When pure, the appearance is pure and uniform.
When it comes to the melting point, the melting point of this compound is about 38-42 ° C. When the temperature reaches this range, the solid 2-chlorobenzyl alcohol gradually melts into a liquid state. This phase transition temperature is of great significance in terms of identification and purity determination.
The boiling point of 2-chlorobenzyl alcohol is about 244-246 ° C. At this high temperature, 2-chlorobenzyl alcohol in the liquid state can be turned into a gaseous state, which is very critical in chemical operations such as separation and purification.
Its density is about 1.245 g/cm ³, indicating the amount of substances contained in the unit volume. This value plays an important role in guiding material balance and reaction system configuration.
In terms of solubility, 2-chlorobenzyl alcohol is slightly soluble in water, but can be soluble in organic solvents such as ethanol, ether, and chloroform. This difference in solubility provides a clear basis for extraction, reaction solvent selection, etc.
In addition, 2-chlorobenzyl alcohol has a certain volatility and can evaporate slowly in the air. Although the volatilization rate is not extremely fast, it is also necessary to pay attention to this property when storing and using it to prevent its dissipation and impact on the environment. And because its molecular structure contains chlorine atoms and hydroxyl groups, it is chemically active and can participate in a variety of chemical reactions. Its physical properties affect the conditions and processes of these reactions, which is a key point that cannot be ignored in research and application.
What are the chemical properties of 2-chloro-benzenemethanol?
2-Chloro-benzyl alcohol, this is an organic compound with unique chemical properties. Its structure contains a benzene ring, and the chlorine atom and hydroxymethyl group are respectively connected to the benzene ring.
Let's talk about its physical properties first. At room temperature, it may be a solid or a liquid, depending on the specific environment. Because it contains a benzene ring, it may have a certain aromatic odor. It is slightly soluble in water, and the benzene ring is a hydrophobic group. Although hydroxymethyl can form hydrogen bonds with water, the overall hydrophobicity is still dominant, so it has better solubility in organic solvents such as ethanol and ether.
In terms of chemical properties, hydroxymethyl groups have typical properties of alcohols. Esterification reaction can occur, and under the catalysis of carboxylic acids, corresponding esters and water are formed. If it reacts with acetic acid, 2-chlorobenzyl acetate is obtained with water. It can also be oxidized, and can be converted into 2-chlorobenzaldehyde under the action of mild oxidants such as Dess-Martin oxidants; in case of strong oxidants, such as acidic potassium permanganate, or further oxidized to 2-chlorobenzoic acid.
Furthermore, chlorine atoms are attached to the benzene ring, which changes the electron cloud density of the benzene ring, causing the electrophilic substitution activity of the benzene ring to be different from that of benzene. Since the chlorine atom is an ortho-para-site, when the electrophilic reagent attacks the benzene ring, it is mostly substituted in the ortho-site or para-site of the chlorine atom. For example, under the catalysis of iron with bromine, the bromine atom or the ortho or para-hydrogen atom of the substituted chlorine atom can obtain the corresponding bromogenic product.
In addition, the chlorine atom in 2-chloro-benzyl alcohol can undergo nucleophilic substitution reaction. Under basic conditions or the action of nucleophilic reagents, the chlorine atom can be replaced by other nucleophilic groups. For example, when co-heated with an aqueous solution of sodium hydroxide, the chlorine atom is replaced by a hydroxyl group to obtain catechol.
In short, 2-chloro-benzyl alcohol has a wide range of uses in the field of organic synthesis due to its special structure and the properties of alcohols and halogenated aromatics. It can be used as an intermediate to synthesize many organic compounds.
Let's talk about its physical properties first. At room temperature, it may be a solid or a liquid, depending on the specific environment. Because it contains a benzene ring, it may have a certain aromatic odor. It is slightly soluble in water, and the benzene ring is a hydrophobic group. Although hydroxymethyl can form hydrogen bonds with water, the overall hydrophobicity is still dominant, so it has better solubility in organic solvents such as ethanol and ether.
In terms of chemical properties, hydroxymethyl groups have typical properties of alcohols. Esterification reaction can occur, and under the catalysis of carboxylic acids, corresponding esters and water are formed. If it reacts with acetic acid, 2-chlorobenzyl acetate is obtained with water. It can also be oxidized, and can be converted into 2-chlorobenzaldehyde under the action of mild oxidants such as Dess-Martin oxidants; in case of strong oxidants, such as acidic potassium permanganate, or further oxidized to 2-chlorobenzoic acid.
Furthermore, chlorine atoms are attached to the benzene ring, which changes the electron cloud density of the benzene ring, causing the electrophilic substitution activity of the benzene ring to be different from that of benzene. Since the chlorine atom is an ortho-para-site, when the electrophilic reagent attacks the benzene ring, it is mostly substituted in the ortho-site or para-site of the chlorine atom. For example, under the catalysis of iron with bromine, the bromine atom or the ortho or para-hydrogen atom of the substituted chlorine atom can obtain the corresponding bromogenic product.
In addition, the chlorine atom in 2-chloro-benzyl alcohol can undergo nucleophilic substitution reaction. Under basic conditions or the action of nucleophilic reagents, the chlorine atom can be replaced by other nucleophilic groups. For example, when co-heated with an aqueous solution of sodium hydroxide, the chlorine atom is replaced by a hydroxyl group to obtain catechol.
In short, 2-chloro-benzyl alcohol has a wide range of uses in the field of organic synthesis due to its special structure and the properties of alcohols and halogenated aromatics. It can be used as an intermediate to synthesize many organic compounds.
What are the common synthetic methods of 2-chloro-benzenemethanol?
2-Chlorobenzyl alcohol is an important intermediate in organic synthesis. There are three common synthesis methods, which are described as follows.
First, 2-chlorobenzaldehyde is used as a raw material and can be obtained by reduction reaction. This reduction method can be obtained by metal hydrides, such as sodium borohydride ($NaBH_4 $) or lithium aluminum hydride ($LiAlH_4 $). Taking sodium borohydride as an example, in an alcohol solvent, under mild reaction conditions, the aldehyde group of 2-chlorobenzaldehyde can be reduced to a hydroxyl group to obtain 2-chlorobenzyl alcohol. This reaction has good selectivity, simple operation, and few side reactions. It is a common method for laboratory and industrial production.
Second, using 2-chlorobenzyl halide as raw material, it is prepared by hydrolysis reaction. The 2-chlorobenzyl halide, such as 2-chlorobenzyl chloride, is heated with the aqueous solution of the base, and the halogen atom is replaced by a hydroxyl group to generate 2-chlorobenzyl alcohol. However, this reaction needs to pay attention to the control of the reaction conditions. If the concentration of the base is too high or the reaction temperature is too high, it is easy to initiate side reactions such as elimination reaction, which affects the purity and yield of the product.
Third, with 2-chlorobenzoic acid as the starting material, it is first converted into acid chloride, and then prepared by reduction. 2-Chlorobenzoic acid reacts with thionyl chloride ($SOCl_2 $) to form 2-chlorobenzoyl chloride, which is then reduced with a suitable reducing agent, such as lithium tri-tert-butoxy aluminum hydride ($LiAlH (OC (CH_3) _3) _3 $), to obtain 2-chlorobenzoyl alcohol. Although this approach is slightly complicated, it is also a feasible method for specific reaction systems and raw material sources.
All these synthesis methods have advantages and disadvantages. It is necessary to choose carefully according to specific needs, availability of raw materials and reaction conditions to achieve the best synthetic effect.
First, 2-chlorobenzaldehyde is used as a raw material and can be obtained by reduction reaction. This reduction method can be obtained by metal hydrides, such as sodium borohydride ($NaBH_4 $) or lithium aluminum hydride ($LiAlH_4 $). Taking sodium borohydride as an example, in an alcohol solvent, under mild reaction conditions, the aldehyde group of 2-chlorobenzaldehyde can be reduced to a hydroxyl group to obtain 2-chlorobenzyl alcohol. This reaction has good selectivity, simple operation, and few side reactions. It is a common method for laboratory and industrial production.
Second, using 2-chlorobenzyl halide as raw material, it is prepared by hydrolysis reaction. The 2-chlorobenzyl halide, such as 2-chlorobenzyl chloride, is heated with the aqueous solution of the base, and the halogen atom is replaced by a hydroxyl group to generate 2-chlorobenzyl alcohol. However, this reaction needs to pay attention to the control of the reaction conditions. If the concentration of the base is too high or the reaction temperature is too high, it is easy to initiate side reactions such as elimination reaction, which affects the purity and yield of the product.
Third, with 2-chlorobenzoic acid as the starting material, it is first converted into acid chloride, and then prepared by reduction. 2-Chlorobenzoic acid reacts with thionyl chloride ($SOCl_2 $) to form 2-chlorobenzoyl chloride, which is then reduced with a suitable reducing agent, such as lithium tri-tert-butoxy aluminum hydride ($LiAlH (OC (CH_3) _3) _3 $), to obtain 2-chlorobenzoyl alcohol. Although this approach is slightly complicated, it is also a feasible method for specific reaction systems and raw material sources.
All these synthesis methods have advantages and disadvantages. It is necessary to choose carefully according to specific needs, availability of raw materials and reaction conditions to achieve the best synthetic effect.
2-chloro-benzenemethanol in what areas?
2-Chloro-benzyl alcohol has a wide range of uses. In the field of medicine, it is often used as an intermediate in organic synthesis and participates in the preparation process of many drugs. Because its structure contains active groups, it can be linked to other compounds through specific reactions to synthesize drug molecules with specific pharmacological activities. For example, in the synthesis of some antibacterial drugs, it can be used as a key starting material to construct complex structures with antibacterial effects through a series of reactions.
In the field of materials science, 2-chloro-benzyl alcohol also has applications. It can be used to prepare polymer materials with special properties. In polymerization reactions, it can participate as a functional monomer, giving polymer materials special chemical or physical properties. For example, by copolymerizing with other monomers, the solubility, thermal stability or surface properties of the material can be changed to meet the special needs of different fields for material properties.
In the fragrance industry, 2-chloro-benzyl alcohol can add a special aroma to the fragrance due to its unique chemical structure. Some fragrance formulations will be added in moderation to create a unique and attractive fragrance, enrich the layering and uniqueness of the fragrance, and are widely used in the preparation of perfumes, air fresheners and various aromatic products.
In addition, in the field of organic synthetic chemistry research, 2-chloro-benzyl alcohol is a commonly used reagent. Scientists use their chemical properties to conduct research and exploration of various organic reactions, and through in-depth study of their reaction conditions and reaction paths, develop new organic synthesis methods and strategies to promote the development and progress of organic chemistry.
In the field of materials science, 2-chloro-benzyl alcohol also has applications. It can be used to prepare polymer materials with special properties. In polymerization reactions, it can participate as a functional monomer, giving polymer materials special chemical or physical properties. For example, by copolymerizing with other monomers, the solubility, thermal stability or surface properties of the material can be changed to meet the special needs of different fields for material properties.
In the fragrance industry, 2-chloro-benzyl alcohol can add a special aroma to the fragrance due to its unique chemical structure. Some fragrance formulations will be added in moderation to create a unique and attractive fragrance, enrich the layering and uniqueness of the fragrance, and are widely used in the preparation of perfumes, air fresheners and various aromatic products.
In addition, in the field of organic synthetic chemistry research, 2-chloro-benzyl alcohol is a commonly used reagent. Scientists use their chemical properties to conduct research and exploration of various organic reactions, and through in-depth study of their reaction conditions and reaction paths, develop new organic synthesis methods and strategies to promote the development and progress of organic chemistry.
What is the market outlook for 2-chloro-benzenemethanol?
2-Chloro-benzyl alcohol, an organic compound, is widely used in the chemical synthesis field, and also plays an important role in the pharmaceutical, pesticide and materials industries.
Looking at its market prospects, from the perspective of the pharmaceutical industry, with the growth of the global population, the aging and the improvement of health concerns, the pharmaceutical market continues to expand. 2-Chloro-benzyl alcohol, as a pharmaceutical intermediate, can be used to synthesize a variety of drugs, such as antibacterial drugs, anti-inflammatory drugs, etc. Therefore, the development of the pharmaceutical industry, the demand for 2-chloro-benzyl alcohol will also rise steadily.
In the field of pesticides, in order to ensure the yield and quality of crops, the demand for high-efficiency and low-toxicity pesticides continues to increase. 2-Chloro-benzyl alcohol can be used as a key raw material for pesticide synthesis. With the continuous innovation and upgrading of the pesticide industry, the demand for 2-chloro-benzyl alcohol is expected to maintain a stable growth.
For the material industry, with the progress of science and technology, the research and development and application of new materials are increasingly extensive. 2-chloro-benzyl alcohol can play an important role in the synthesis of some high-performance materials, such as special plastics, coatings, etc. With the rapid development of the material industry, its market demand will also expand.
However, the market development also faces challenges. Environmental protection requirements are increasingly stringent, and the production process of 2-chloro-benzyl alcohol may need to meet higher environmental protection standards, which puts forward higher requirements At the same time, the market competition is fierce, and many production enterprises coexist. Enterprises need to continuously improve product quality and production efficiency to enhance market competitiveness.
Overall, the market prospect of 2-chloro-benzyl alcohol is quite broad. Although it faces challenges such as environmental protection and competition, with the continuous development of various application industries, its market demand is expected to maintain a growth trend. For enterprises with technological and cost advantages, there are many development opportunities.
Looking at its market prospects, from the perspective of the pharmaceutical industry, with the growth of the global population, the aging and the improvement of health concerns, the pharmaceutical market continues to expand. 2-Chloro-benzyl alcohol, as a pharmaceutical intermediate, can be used to synthesize a variety of drugs, such as antibacterial drugs, anti-inflammatory drugs, etc. Therefore, the development of the pharmaceutical industry, the demand for 2-chloro-benzyl alcohol will also rise steadily.
In the field of pesticides, in order to ensure the yield and quality of crops, the demand for high-efficiency and low-toxicity pesticides continues to increase. 2-Chloro-benzyl alcohol can be used as a key raw material for pesticide synthesis. With the continuous innovation and upgrading of the pesticide industry, the demand for 2-chloro-benzyl alcohol is expected to maintain a stable growth.
For the material industry, with the progress of science and technology, the research and development and application of new materials are increasingly extensive. 2-chloro-benzyl alcohol can play an important role in the synthesis of some high-performance materials, such as special plastics, coatings, etc. With the rapid development of the material industry, its market demand will also expand.
However, the market development also faces challenges. Environmental protection requirements are increasingly stringent, and the production process of 2-chloro-benzyl alcohol may need to meet higher environmental protection standards, which puts forward higher requirements At the same time, the market competition is fierce, and many production enterprises coexist. Enterprises need to continuously improve product quality and production efficiency to enhance market competitiveness.
Overall, the market prospect of 2-chloro-benzyl alcohol is quite broad. Although it faces challenges such as environmental protection and competition, with the continuous development of various application industries, its market demand is expected to maintain a growth trend. For enterprises with technological and cost advantages, there are many development opportunities.
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