Linshang Chemical
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2-Chloro-N-Methyl-Benzenemethanamin
Linshang Chemical
|
HS Code |
520535 |
| Chemical Formula | C8H10ClN |
| Molar Mass | 155.625 g/mol |
| Appearance | Typically a liquid |
| Solubility In Water | Limited solubility, as it is an organic compound with non - polar benzene rings |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone, and dichloromethane |
| Odor | May have a characteristic organic amine - like odor |
| Flash Point | Unknown, needs experimental measurement or prediction based on structure - activity relationships |
As an accredited 2-Chloro-N-Methyl-Benzenemethanamin factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottle packaging for 2 - chloro - N - methyl - benzenemethanamine chemical. |
| Storage | 2 - chloro - N - methyl - benzenemethanamin should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent moisture and air exposure, which could lead to degradation. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. |
| Shipping | 2 - chloro - N - methyl - benzenemethanamin, a chemical, should be shipped in accordance with hazardous material regulations. Use proper packaging to prevent leaks, and label containers clearly. Ship via approved carriers following safety protocols. |
Competitive 2-Chloro-N-Methyl-Benzenemethanamin prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemistry of 2-chloro-n-methyl-benzenemethanamin?
2-Chloro-N-methyl-aniline, this is an organic compound. It has many unique chemical properties.
Looking at its structure, it contains chlorine atoms, methyl groups and benzamine groups. The presence of chlorine atoms makes the compound have certain electrophilic properties. Because of its high electronegativity, it can reduce the electron cloud density of ortho and para-sites, making the benzene ring more prone to electrophilic substitution. In many chemical reactions, chlorine atoms can act as leaving groups and undergo substitution reactions with nucleophiles, such as with nucleophiles such as alcohols and amines, to form new organic compounds.
The N-methyl part imparts certain alkalinity to the molecule. The solitary pair electrons on the nitrogen atom can bind protons and easily form ammonium salts in acidic media. And the electron induction effect of methyl will enhance the electron cloud density of the nitrogen atom, thereby improving its alkalinity.
The benzene ring structure of the compound endows it with aromaticity. The conjugate system of the benzene ring is stable, which makes the molecule relatively stable and less prone to addition reactions, but more prone to electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The position and properties of the substituents on the benzene ring can significantly affect the activity and selectivity of the reaction.
In terms of physical properties, 2-chloro-N-methyl-benzamine is usually a liquid or a solid, with certain volatility. Because it contains polar groups, it has a certain solubility in organic solvents, while the solubility in water is relatively small, which depends on the relative ratio of polar and non-polar parts in the molecule.
In the field of organic synthesis, 2-chloro-N-methyl-aniline is often used as an important intermediate. Through the transformation and modification of its functional groups, a variety of organic compounds such as biologically active drugs, pesticides and functional materials can be synthesized, which play an important role in medicinal chemistry and materials science.
Looking at its structure, it contains chlorine atoms, methyl groups and benzamine groups. The presence of chlorine atoms makes the compound have certain electrophilic properties. Because of its high electronegativity, it can reduce the electron cloud density of ortho and para-sites, making the benzene ring more prone to electrophilic substitution. In many chemical reactions, chlorine atoms can act as leaving groups and undergo substitution reactions with nucleophiles, such as with nucleophiles such as alcohols and amines, to form new organic compounds.
The N-methyl part imparts certain alkalinity to the molecule. The solitary pair electrons on the nitrogen atom can bind protons and easily form ammonium salts in acidic media. And the electron induction effect of methyl will enhance the electron cloud density of the nitrogen atom, thereby improving its alkalinity.
The benzene ring structure of the compound endows it with aromaticity. The conjugate system of the benzene ring is stable, which makes the molecule relatively stable and less prone to addition reactions, but more prone to electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The position and properties of the substituents on the benzene ring can significantly affect the activity and selectivity of the reaction.
In terms of physical properties, 2-chloro-N-methyl-benzamine is usually a liquid or a solid, with certain volatility. Because it contains polar groups, it has a certain solubility in organic solvents, while the solubility in water is relatively small, which depends on the relative ratio of polar and non-polar parts in the molecule.
In the field of organic synthesis, 2-chloro-N-methyl-aniline is often used as an important intermediate. Through the transformation and modification of its functional groups, a variety of organic compounds such as biologically active drugs, pesticides and functional materials can be synthesized, which play an important role in medicinal chemistry and materials science.
What are the common uses of 2-chloro-n-methyl-benzenemethanamin?
2-Chloro-N-methyl-aniline is also an organic compound. Its common use involves the field of organic synthesis.
It is often an important intermediate in the synthesis of medicine. Due to its unique structure, it can react with many reagents to build complex drug molecular structures. It can introduce various functional groups through nucleophilic substitution, coupling and other reactions, so as to prepare compounds with specific pharmacological activities, such as the synthesis of certain nervous system drugs and cardiovascular system drugs, which may be useful.
It is also used in the field of materials science. Or participate in the preparation of polymer materials, with its reactivity, introduce specific functional groups into the polymer chain to improve the properties of the material, such as improving the solubility and thermal stability of the material or endowing it with special optical and electrical properties, in the development of optoelectronic materials, special polymer materials, or can play a role.
Furthermore, in the field of pesticide chemistry, it is also a useful raw material. After a series of reactions, pesticides, fungicides and other pesticide products can be prepared. By modifying its structure, the biological activity and selectivity of the compound can be adjusted to achieve the purpose of creating high-efficiency, low-toxicity and targeted pesticides, providing assistance for agricultural pest control.
Overall, 2-chloro-N-methyl-aniline has important uses in many fields such as organic synthesis, medicine, materials, and pesticides, and is one of the key compounds to promote the development of various fields.
It is often an important intermediate in the synthesis of medicine. Due to its unique structure, it can react with many reagents to build complex drug molecular structures. It can introduce various functional groups through nucleophilic substitution, coupling and other reactions, so as to prepare compounds with specific pharmacological activities, such as the synthesis of certain nervous system drugs and cardiovascular system drugs, which may be useful.
It is also used in the field of materials science. Or participate in the preparation of polymer materials, with its reactivity, introduce specific functional groups into the polymer chain to improve the properties of the material, such as improving the solubility and thermal stability of the material or endowing it with special optical and electrical properties, in the development of optoelectronic materials, special polymer materials, or can play a role.
Furthermore, in the field of pesticide chemistry, it is also a useful raw material. After a series of reactions, pesticides, fungicides and other pesticide products can be prepared. By modifying its structure, the biological activity and selectivity of the compound can be adjusted to achieve the purpose of creating high-efficiency, low-toxicity and targeted pesticides, providing assistance for agricultural pest control.
Overall, 2-chloro-N-methyl-aniline has important uses in many fields such as organic synthesis, medicine, materials, and pesticides, and is one of the key compounds to promote the development of various fields.
What is 2-chloro-n-methyl-benzenemethanamin synthesis method?
To prepare 2-chloro-N-methyl-aniline, the following ancient method can be used.
First take toluene as the starting material, and use chlorine as the halogenating agent. Under the condition of light or heating, the side chain halogenation reaction of toluene occurs. Because light or heating can lead to the formation of chlorine radicals, which are easy to interact with hydrogen atoms on the methyl group of the side chain of toluene to obtain benzyl chloride. In this step, the reaction needs to pay attention to the reaction temperature and the rate of chlorine gas introduction. If the temperature is too high or the chlorine gas is too high, the by-product of polyhalogenation may be generated.
Benzyl chloride is obtained, and methylamine is reacted with it. The nitrogen atom of methylamine has a lone pair of electrons and is nucleophilic, while in the carbon-chlorine bond of benzyl chloride, the chlorine atom has electron-absorbing properties, resulting in a partial positive charge of the benzyl carbon, so it is easy to be attacked by the nucleophilic of methylamine. This reaction should be carried out in suitable solvents, such as ethanol, dichloromethane, etc., and the reaction temperature and time need to be controlled. If the temperature is too low, the reaction will be slow, and if it is too high, side reactions may occur, such as the hydrolysis of benzyl chloride.
After the reaction is completed, the product often contains impurities such as unreacted raw materials and by-products. It can be purified by distillation, column chromatography, etc. During distillation, the target product is Column chromatography achieves separation by the difference of distribution coefficients between stationary and mobile phases of different substances. After these steps, a relatively pure 2-chloro-N-methyl-aniline can be obtained.
First take toluene as the starting material, and use chlorine as the halogenating agent. Under the condition of light or heating, the side chain halogenation reaction of toluene occurs. Because light or heating can lead to the formation of chlorine radicals, which are easy to interact with hydrogen atoms on the methyl group of the side chain of toluene to obtain benzyl chloride. In this step, the reaction needs to pay attention to the reaction temperature and the rate of chlorine gas introduction. If the temperature is too high or the chlorine gas is too high, the by-product of polyhalogenation may be generated.
Benzyl chloride is obtained, and methylamine is reacted with it. The nitrogen atom of methylamine has a lone pair of electrons and is nucleophilic, while in the carbon-chlorine bond of benzyl chloride, the chlorine atom has electron-absorbing properties, resulting in a partial positive charge of the benzyl carbon, so it is easy to be attacked by the nucleophilic of methylamine. This reaction should be carried out in suitable solvents, such as ethanol, dichloromethane, etc., and the reaction temperature and time need to be controlled. If the temperature is too low, the reaction will be slow, and if it is too high, side reactions may occur, such as the hydrolysis of benzyl chloride.
After the reaction is completed, the product often contains impurities such as unreacted raw materials and by-products. It can be purified by distillation, column chromatography, etc. During distillation, the target product is Column chromatography achieves separation by the difference of distribution coefficients between stationary and mobile phases of different substances. After these steps, a relatively pure 2-chloro-N-methyl-aniline can be obtained.
What are the physical properties of 2-chloro-n-methyl-benzenemethanamin?
2-Chloro-N-methyl-aniline, this is an organic compound. Looking at its structure, it contains a benzene ring, a chlorine atom, a methyl group and a methylamine group. Its physical properties are unique, let me tell them one by one.
Let's talk about the properties first. At room temperature, most of them are liquid. This is because of the moderate intermolecular forces, which cannot be closely arranged into a solid state, but it is attractive enough to maintain a certain volume and does not become a gaseous state.
Besides the boiling point, due to the presence of hydrogen bonds and van der Waals forces between molecules, the boiling point is relatively high. The conjugated system of the benzene ring works together with polar groups to enhance the intermolecular forces. To make it boil, more energy is required to overcome these forces.
In terms of solubility, due to the presence of polar methylamino groups, it has a certain solubility in polar solvents (such as water and alcohols). However, the benzene ring has a non-polar structure, which limits its solubility in water. In general, the solubility is better in organic solvents (such as ether and dichloromethane).
As for the density, compared with water, it is usually different. Its molecular composition and structure determine the density, which is generally slightly larger than that of common organic solvents and less than that of water.
In addition, its volatility is moderate. Although it contains polar groups, under the influence of the benzene ring, the intermolecular force will not make the volatility extremely low, and because it is not a simple small molecule, the volatility is not very high.
This is the approximate physical property of 2-chloro-N-methyl-aniline, which is a substance worthy of further investigation in organic chemistry.
Let's talk about the properties first. At room temperature, most of them are liquid. This is because of the moderate intermolecular forces, which cannot be closely arranged into a solid state, but it is attractive enough to maintain a certain volume and does not become a gaseous state.
Besides the boiling point, due to the presence of hydrogen bonds and van der Waals forces between molecules, the boiling point is relatively high. The conjugated system of the benzene ring works together with polar groups to enhance the intermolecular forces. To make it boil, more energy is required to overcome these forces.
In terms of solubility, due to the presence of polar methylamino groups, it has a certain solubility in polar solvents (such as water and alcohols). However, the benzene ring has a non-polar structure, which limits its solubility in water. In general, the solubility is better in organic solvents (such as ether and dichloromethane).
As for the density, compared with water, it is usually different. Its molecular composition and structure determine the density, which is generally slightly larger than that of common organic solvents and less than that of water.
In addition, its volatility is moderate. Although it contains polar groups, under the influence of the benzene ring, the intermolecular force will not make the volatility extremely low, and because it is not a simple small molecule, the volatility is not very high.
This is the approximate physical property of 2-chloro-N-methyl-aniline, which is a substance worthy of further investigation in organic chemistry.
2-chloro-n-methyl-benzenemethanamin what are the precautions during use
2-Chloro-N-methyl-aniline, when using, many things should be paid attention to.
First safety protection. This substance may be toxic, irritating, and can be harmful when it touches the skin, enters the eyes, or is ingested through respiration. Therefore, when using it, be sure to wear protective clothing, such as laboratory clothes, protective gloves, and the material must be resistant to this chemical erosion; also wear protective glasses to prevent liquid from splashing into the eyes; if working in poorly ventilated areas, be equipped with suitable respiratory protective equipment, such as gas masks, to avoid inhaling its volatile aerosols.
Next time, store properly. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent its volatilization from intensifying due to high temperature, or to cause dangerous chemical reactions. At the same time, it must be stored separately from oxidants, acids, alkalis, etc., because of mixing with them, or reacting violently, causing disasters. The storage container should also be well sealed to prevent leakage.
Furthermore, the operation process also needs to be rigorous. Operating in a fume hood can allow the volatile gas to be discharged in time and reduce its concentration in the air. Just take an appropriate amount to avoid waste, and the operation should be slow to prevent it from splashing out. If you accidentally leak, don't panic. When evacuating the surrounding people immediately, isolate the leakage area, and strictly prohibit fire from approaching. When a small amount of leakage occurs, it can be absorbed by inert materials such as sand and vermiculite and collected in a closed container. If a large amount of leakage occurs, it needs to be built into a dike or dug for containment, and transferred to a tank car or a special collector for recycling or transportation to a waste treatment site for disposal.
In addition, relevant personnel need to be professionally trained to be familiar with its nature, hazards and emergency treatment methods. In the event of an accident, such as skin contact, immediately remove contaminated clothing and rinse with a large amount of flowing water. If it enters the eye, quickly rinse with a large amount of water and seek medical treatment. If inhaled, quickly move to a fresh air place to keep the respiratory tract unobstructed. If necessary, perform artificial respiration and seek medical attention.
First safety protection. This substance may be toxic, irritating, and can be harmful when it touches the skin, enters the eyes, or is ingested through respiration. Therefore, when using it, be sure to wear protective clothing, such as laboratory clothes, protective gloves, and the material must be resistant to this chemical erosion; also wear protective glasses to prevent liquid from splashing into the eyes; if working in poorly ventilated areas, be equipped with suitable respiratory protective equipment, such as gas masks, to avoid inhaling its volatile aerosols.
Next time, store properly. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent its volatilization from intensifying due to high temperature, or to cause dangerous chemical reactions. At the same time, it must be stored separately from oxidants, acids, alkalis, etc., because of mixing with them, or reacting violently, causing disasters. The storage container should also be well sealed to prevent leakage.
Furthermore, the operation process also needs to be rigorous. Operating in a fume hood can allow the volatile gas to be discharged in time and reduce its concentration in the air. Just take an appropriate amount to avoid waste, and the operation should be slow to prevent it from splashing out. If you accidentally leak, don't panic. When evacuating the surrounding people immediately, isolate the leakage area, and strictly prohibit fire from approaching. When a small amount of leakage occurs, it can be absorbed by inert materials such as sand and vermiculite and collected in a closed container. If a large amount of leakage occurs, it needs to be built into a dike or dug for containment, and transferred to a tank car or a special collector for recycling or transportation to a waste treatment site for disposal.
In addition, relevant personnel need to be professionally trained to be familiar with its nature, hazards and emergency treatment methods. In the event of an accident, such as skin contact, immediately remove contaminated clothing and rinse with a large amount of flowing water. If it enters the eye, quickly rinse with a large amount of water and seek medical treatment. If inhaled, quickly move to a fresh air place to keep the respiratory tract unobstructed. If necessary, perform artificial respiration and seek medical attention.
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