Linshang Chemical
PRODUCTS
2-Chloro4-Iodofluorobenzene
Linshang Chemical
|
HS Code |
869820 |
| Chemical Formula | C6H3ClFI |
| Appearance | Liquid (usually) |
| Boiling Point | Data varies, likely high due to halogen atoms |
| Solubility In Water | Low, as it is an organic halide |
| Solubility In Organic Solvents | Good solubility in common organic solvents like ether, chloroform |
| Vapor Pressure | Low due to relatively high molecular weight and presence of halogens |
As an accredited 2-Chloro4-Iodofluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chloro - 4 - iodofluorobenzene packaged in a sealed, labeled glass bottle. |
| Storage | 2 - chloro - 4 - iodofluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials. Label the storage container clearly to avoid confusion. This helps prevent decomposition, potential reactions, and ensures safe handling and storage. |
| Shipping | 2 - chloro - 4 - iodofluorobenzene is shipped in accordance with strict chemical regulations. Packed in suitable containers to prevent leakage, it's transported by methods compliant with hazardous material shipping standards, ensuring safety during transit. |
Competitive 2-Chloro4-Iodofluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 2-chloro4-iodofluorobenzene?
2-Chloro-4-iodine fluorobenzene is also one of the organohalogenated aromatic hydrocarbons. Its chemical properties are specific and important in the field of organic synthesis.
This compound has a halogen atom, and chlorine, iodine, and fluorine have their own characteristics. The fluorine atom is extremely electronegative, and the electron cloud density of the benzene ring is reduced, which makes it difficult for electrophilic substitution reactions to occur, but gives the molecule unique physical and chemical characteristics. It can affect the polarity, boiling point, and solubility of the compound.
Chlorine atoms and iodine atoms are also not idle. The activity of chlorine atoms is not weak, and they can be replaced by many nucleophilic reagents, such as hydroxyl (-OH), amino (-NH ²), etc., through nucleophilic substitution reactions. Although iodine atoms are relatively large, they can play a key role in specific reactions, such as palladium-catalyzed coupling reactions. They are connected with carbon-containing nucleophilic reagents to form carbon-carbon bonds to expand the carbon skeleton of molecules.
2-chloro-4-iodine fluorobenzene on the benzene ring, the localization effect of halogen atoms cannot be ignored. The fluorine atom is an ortho and para-localization group, and chlorine and iodine are also such groups. However, the electronic effects of the three are different. Under the combined action, the main product positions of the electrophilic substitution reaction can be followed. In general, due to the strong electron absorption of fluorine, electrophilic reagents tend to attack its para-position, which is also related to the localization effect of chlorine and iodine.
In addition, the presence of 2-chloro-4-iodine fluorobenzene halogen atoms can participate in the elimination reaction. Under appropriate alkali and reaction conditions, the halogen atoms on adjacent carbons are separated from hydrogen atoms to form unsaturated compounds containing carbon-carbon double bonds. This is one of the ways to prepare olefins in organic synthesis.
Due to its special chemical properties, 2-chloro-4-iodofluorobenzene has potential applications in the fields of medicine, pesticides and materials science. It can be used as a key intermediate to create compounds with specific functions.
This compound has a halogen atom, and chlorine, iodine, and fluorine have their own characteristics. The fluorine atom is extremely electronegative, and the electron cloud density of the benzene ring is reduced, which makes it difficult for electrophilic substitution reactions to occur, but gives the molecule unique physical and chemical characteristics. It can affect the polarity, boiling point, and solubility of the compound.
Chlorine atoms and iodine atoms are also not idle. The activity of chlorine atoms is not weak, and they can be replaced by many nucleophilic reagents, such as hydroxyl (-OH), amino (-NH ²), etc., through nucleophilic substitution reactions. Although iodine atoms are relatively large, they can play a key role in specific reactions, such as palladium-catalyzed coupling reactions. They are connected with carbon-containing nucleophilic reagents to form carbon-carbon bonds to expand the carbon skeleton of molecules.
2-chloro-4-iodine fluorobenzene on the benzene ring, the localization effect of halogen atoms cannot be ignored. The fluorine atom is an ortho and para-localization group, and chlorine and iodine are also such groups. However, the electronic effects of the three are different. Under the combined action, the main product positions of the electrophilic substitution reaction can be followed. In general, due to the strong electron absorption of fluorine, electrophilic reagents tend to attack its para-position, which is also related to the localization effect of chlorine and iodine.
In addition, the presence of 2-chloro-4-iodine fluorobenzene halogen atoms can participate in the elimination reaction. Under appropriate alkali and reaction conditions, the halogen atoms on adjacent carbons are separated from hydrogen atoms to form unsaturated compounds containing carbon-carbon double bonds. This is one of the ways to prepare olefins in organic synthesis.
Due to its special chemical properties, 2-chloro-4-iodofluorobenzene has potential applications in the fields of medicine, pesticides and materials science. It can be used as a key intermediate to create compounds with specific functions.
What is 2-chloro4-iodofluorobenzene synthesis method?
The method of preparing 2-chloro-4-iodofluorobenzene can be carried out according to the following steps.
First, fluorobenzene is used as the starting material. Because the fluorine atom on the benzene ring is an ortho-para locator, the electron cloud density of the benzene ring can be increased in the ortho-para position. Therefore, electrophilic substitution reactions are prone to occur in these two places. The reaction of fluorobenzene with chlorine under appropriate conditions, such as ferric chloride as the catalyst, under heating conditions, the chlorine gas molecules are polarized, and the chlorine positive ion attacks the benzene ring. A mixture of 2-chlorofluorobenzene and 4-chlorofluorobenzene can be obtained Due to factors such as steric hindrance and electronic effect, the generation ratio of the two is different. After separation, such as distillation, column chromatography, etc., pure 2-chlorofluorobenzene can be obtained.
After obtaining 2-chlorofluorobenzene, it is reacted with the iodine source to introduce iodine atoms. However, the electrophilicity of iodine is weaker than that of chlorine and bromine, and special conditions are generally required. It can be reacted in the presence of an oxidant, such as nitric acid or hydrogen peroxide as the oxidant, and iodine forms iodine positive ions under the action of the oxidant, and then undergoes electrophilic substitution reaction with 2-chlorofluorobenzene At the appropriate temperature, reaction time and the proportion of reactants, iodine positive ions attack a specific position on the 2-chlorofluorobenzene ring. Because chlorine and fluorine atoms jointly affect the electron cloud distribution of the benzene ring, iodine atoms are mainly replaced in the 4-position, and finally 2-chloro-4-iodofluorobenzene is obtained. After the reaction is completed, purification operations, such as extraction, recrystallization, etc., are performed to remove impurities and obtain high-purity target products.
First, fluorobenzene is used as the starting material. Because the fluorine atom on the benzene ring is an ortho-para locator, the electron cloud density of the benzene ring can be increased in the ortho-para position. Therefore, electrophilic substitution reactions are prone to occur in these two places. The reaction of fluorobenzene with chlorine under appropriate conditions, such as ferric chloride as the catalyst, under heating conditions, the chlorine gas molecules are polarized, and the chlorine positive ion attacks the benzene ring. A mixture of 2-chlorofluorobenzene and 4-chlorofluorobenzene can be obtained Due to factors such as steric hindrance and electronic effect, the generation ratio of the two is different. After separation, such as distillation, column chromatography, etc., pure 2-chlorofluorobenzene can be obtained.
After obtaining 2-chlorofluorobenzene, it is reacted with the iodine source to introduce iodine atoms. However, the electrophilicity of iodine is weaker than that of chlorine and bromine, and special conditions are generally required. It can be reacted in the presence of an oxidant, such as nitric acid or hydrogen peroxide as the oxidant, and iodine forms iodine positive ions under the action of the oxidant, and then undergoes electrophilic substitution reaction with 2-chlorofluorobenzene At the appropriate temperature, reaction time and the proportion of reactants, iodine positive ions attack a specific position on the 2-chlorofluorobenzene ring. Because chlorine and fluorine atoms jointly affect the electron cloud distribution of the benzene ring, iodine atoms are mainly replaced in the 4-position, and finally 2-chloro-4-iodofluorobenzene is obtained. After the reaction is completed, purification operations, such as extraction, recrystallization, etc., are performed to remove impurities and obtain high-purity target products.
In what areas is 2-chloro4-iodofluorobenzene applied?
2-Chloro-4-iodofluorobenzene is one of the organic compounds and has its uses in many fields.
In the field of medicinal chemistry, it can be a key intermediate for the synthesis of specific drugs. Taking the development of anti-cancer drugs as an example, chemists may modify the structure of this compound by ingeniously giving the obtained new substance the ability to target specific cancer cells, accurately inhibit the proliferation and spread of cancer cells, and do little damage to normal cells. The unique atomic combination of this compound can interact with specific receptors or enzymes in cancer cells, just like a precise key in a keyhole, opening the door to the treatment of diseases.
In the field of materials science, 2-chloro-4-iodofluorobenzene also has its important function. When preparing high-performance organic optoelectronic materials, it can participate in the construction of unique molecular structures, thereby optimizing the photoelectric properties of the materials. For example, in the manufacture of organic Light Emitting Diode (OLED), the luminous efficiency, color purity and service life of OLED devices can be significantly improved by the rational introduction of this compound. Its atomic properties can adjust the electron cloud distribution of molecules, affect the charge transfer and luminescence process, and make the display picture more vivid and realistic.
Furthermore, in the field of pesticide chemistry, 2-chloro-4-iodofluorobenzene can be used as an important starting material for the synthesis of new and efficient pesticides. It can help create pesticides with high toxic activity against specific pests, environmental friendliness and low residue. Such pesticides can effectively resist crop diseases and insect pests, ensure the growth of crops, improve grain yield and quality, and provide strong support for sustainable agricultural development. Due to its special chemical structure, it can interact with molecules related to key physiological processes in pests, interfere with the normal physiological functions of pests, and achieve the purpose of insecticide.
In the field of medicinal chemistry, it can be a key intermediate for the synthesis of specific drugs. Taking the development of anti-cancer drugs as an example, chemists may modify the structure of this compound by ingeniously giving the obtained new substance the ability to target specific cancer cells, accurately inhibit the proliferation and spread of cancer cells, and do little damage to normal cells. The unique atomic combination of this compound can interact with specific receptors or enzymes in cancer cells, just like a precise key in a keyhole, opening the door to the treatment of diseases.
In the field of materials science, 2-chloro-4-iodofluorobenzene also has its important function. When preparing high-performance organic optoelectronic materials, it can participate in the construction of unique molecular structures, thereby optimizing the photoelectric properties of the materials. For example, in the manufacture of organic Light Emitting Diode (OLED), the luminous efficiency, color purity and service life of OLED devices can be significantly improved by the rational introduction of this compound. Its atomic properties can adjust the electron cloud distribution of molecules, affect the charge transfer and luminescence process, and make the display picture more vivid and realistic.
Furthermore, in the field of pesticide chemistry, 2-chloro-4-iodofluorobenzene can be used as an important starting material for the synthesis of new and efficient pesticides. It can help create pesticides with high toxic activity against specific pests, environmental friendliness and low residue. Such pesticides can effectively resist crop diseases and insect pests, ensure the growth of crops, improve grain yield and quality, and provide strong support for sustainable agricultural development. Due to its special chemical structure, it can interact with molecules related to key physiological processes in pests, interfere with the normal physiological functions of pests, and achieve the purpose of insecticide.
What are the physical properties of 2-chloro4-iodofluorobenzene?
2-Chloro-4-iodine fluorobenzene is one of the organic halogenated aromatic hydrocarbons. This substance is mostly liquid or solid at room temperature and has a unique smell. Because it contains three halogen atoms of chlorine, iodine and fluorine, its physical properties are unique.
Looking at its melting boiling point, due to the introduction of halogen atoms, the intermolecular force is enhanced, which is higher than the melting boiling point of benzene. Specifically, chlorine, iodine and fluorine atoms have large electronegativity, which makes the molecules polarized. In addition to van der Waals force, there is still a dipole-dipole interaction between molecules, which is the reason for the increase of the melting boiling point. However, the relative atomic mass and atomic radius of different halogen atoms vary, and the degree of influence on the melting boiling point is also different.
In terms of solubility, 2-chloro-4-iodofluorobenzene is a non-polar or weakly polar molecule. According to the principle of "similar miscibility", its solubility in polar solvents such as water is very small, but it is easily soluble in non-polar or weakly polar organic solvents such as ether, carbon tetrachloride, and dichloromethane.
In terms of density, 2-chloro-4-iodofluorobenzene has a higher density than benzene because the relative atomic weight of halogen atoms is larger than that of hydrogen atoms, and because the relative atomic weight of iodine atoms is larger, it contributes significantly to the increase in density.
In addition, the volatility of 2-chloro-4-iodofluorobenzene is weaker than that of benzene, and the presence of halogen atoms enhances the intermolecular force, making it more difficult for molecules to escape from the liquid surface. And because of its halogen-containing atoms, it has certain chemical stability and chemical properties are more active than benzene. It can be used as an important intermediate in the field of organic synthesis and participates in many chemical reactions, such as nucleophilic substitution reactions.
Looking at its melting boiling point, due to the introduction of halogen atoms, the intermolecular force is enhanced, which is higher than the melting boiling point of benzene. Specifically, chlorine, iodine and fluorine atoms have large electronegativity, which makes the molecules polarized. In addition to van der Waals force, there is still a dipole-dipole interaction between molecules, which is the reason for the increase of the melting boiling point. However, the relative atomic mass and atomic radius of different halogen atoms vary, and the degree of influence on the melting boiling point is also different.
In terms of solubility, 2-chloro-4-iodofluorobenzene is a non-polar or weakly polar molecule. According to the principle of "similar miscibility", its solubility in polar solvents such as water is very small, but it is easily soluble in non-polar or weakly polar organic solvents such as ether, carbon tetrachloride, and dichloromethane.
In terms of density, 2-chloro-4-iodofluorobenzene has a higher density than benzene because the relative atomic weight of halogen atoms is larger than that of hydrogen atoms, and because the relative atomic weight of iodine atoms is larger, it contributes significantly to the increase in density.
In addition, the volatility of 2-chloro-4-iodofluorobenzene is weaker than that of benzene, and the presence of halogen atoms enhances the intermolecular force, making it more difficult for molecules to escape from the liquid surface. And because of its halogen-containing atoms, it has certain chemical stability and chemical properties are more active than benzene. It can be used as an important intermediate in the field of organic synthesis and participates in many chemical reactions, such as nucleophilic substitution reactions.
What are 2-chloro4-iodofluorobenzene storage conditions?
2-Chloro-4-iodofluorobenzene is an organic compound, and its storage conditions are very critical, which is related to the stability and safety of this compound.
This substance should be stored in a cool, dry and well-ventilated place. A cool environment can reduce the rate of chemical reaction caused by excessive temperature, and a dry place can avoid its interaction with water vapor. Many organic compounds are prone to hydrolysis and other reactions in contact with water. Well-ventilated can prevent the accumulation of volatile gases and reduce the risk of explosion.
Furthermore, it must be kept away from fire and heat sources. Because of its flammability, it can cause combustion in case of open flames, high heat, and even explosion. The storage area should also be equipped with suitable fire equipment for emergency use.
2-chloro-4-iodofluorobenzene should be stored separately from oxidants, acids, and bases. Due to its active chemical properties, mixed storage with these substances is prone to violent chemical reactions, resulting in accidents.
In addition, the storage container must be tightly sealed. One is to prevent its volatilization and escape, polluting the environment and harming human health; the other is to avoid its reaction with air components such as oxygen, resulting in quality changes.
When handling this object, it should be handled lightly to prevent damage to the packaging and container. Damage to the container or cause it to leak, causing danger. Clear warning signs should be set up at the storage place to remind personnel to pay attention to safety.
In summary, following the above storage conditions can ensure the safety and stability of 2-chloro-4-iodofluorobenzene during storage.
This substance should be stored in a cool, dry and well-ventilated place. A cool environment can reduce the rate of chemical reaction caused by excessive temperature, and a dry place can avoid its interaction with water vapor. Many organic compounds are prone to hydrolysis and other reactions in contact with water. Well-ventilated can prevent the accumulation of volatile gases and reduce the risk of explosion.
Furthermore, it must be kept away from fire and heat sources. Because of its flammability, it can cause combustion in case of open flames, high heat, and even explosion. The storage area should also be equipped with suitable fire equipment for emergency use.
2-chloro-4-iodofluorobenzene should be stored separately from oxidants, acids, and bases. Due to its active chemical properties, mixed storage with these substances is prone to violent chemical reactions, resulting in accidents.
In addition, the storage container must be tightly sealed. One is to prevent its volatilization and escape, polluting the environment and harming human health; the other is to avoid its reaction with air components such as oxygen, resulting in quality changes.
When handling this object, it should be handled lightly to prevent damage to the packaging and container. Damage to the container or cause it to leak, causing danger. Clear warning signs should be set up at the storage place to remind personnel to pay attention to safety.
In summary, following the above storage conditions can ensure the safety and stability of 2-chloro-4-iodofluorobenzene during storage.
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