Linshang Chemical
PRODUCTS
2-Chlorobenzeneboronic Acid
Linshang Chemical
|
HS Code |
448927 |
| Chemical Formula | C6H6BClO2 |
| Molar Mass | 156.38 g/mol |
| Appearance | White to off - white solid |
| Melting Point | 148 - 152 °C |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, dichloromethane |
| Pka Value | Around 8 - 9 |
| Stability | Stable under normal conditions, but sensitive to moisture and air over time |
| Odor | Odorless or very faint odor |
As an accredited 2-Chlorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - chlorobenzeneboronic Acid packaged in a sealed, chemical - resistant bottle. |
| Storage | 2 - Chlorobenzeneboronic acid should be stored in a cool, dry place, away from direct sunlight. Keep it in a well - sealed container to prevent moisture absorption and contact with air, which could potentially lead to degradation. Store it separately from incompatible substances, like strong oxidizing agents. Ideal storage temperature is around 2 - 8 °C if possible, especially for long - term storage to maintain its stability. |
| Shipping | 2 - Chlorobenzeneboronic acid is shipped in well - sealed containers. Packaging adheres to chemical transportation regulations. It's often sent via ground or air freight, ensuring proper handling to prevent breakage and exposure. |
Competitive 2-Chlorobenzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Chlorobenzeneboronic Acid in China?
As a trusted 2-Chlorobenzeneboronic Acid manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Chlorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-chlorobenzeneboronic Acid?
2-Chlorophenylboronic acid, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique electronic properties, Gein boron atoms can participate in a variety of chemical reactions, especially the Suzuki coupling reaction, which is an important means of building carbon-carbon bonds. In this reaction, 2-chlorophenylboronic acid and halogenated aromatics or alkenyl halides can efficiently form biaryl or alkenyl aromatics under the action of palladium catalysts and bases. Such compounds are of great significance in medicinal chemistry. In the structure of many drug molecules, biaryl structural units are common. The Suzuki coupling reaction involving 2-chlorophenylboronic acid can accurately construct such structures and help the research and development of new drugs.
Furthermore, in the field of materials science, 2-chlorophenylboronic acid also has wonderful uses. It can participate in the preparation of organic materials with specific functions, such as optoelectronic materials. Due to its structural properties, it may endow materials with unique optical and electrical properties, such as for the synthesis of organic Light Emitting Diode (OLED) materials, or to improve the luminous efficiency and stability of devices.
In addition, in the field of chemical biology, 2-chlorophenylboronic acid can be used for the identification and detection of biomolecules such as glycoproteins and glyconucleic acids. Boric acid groups can specifically bind to cis-diol structures, and many sugar molecules in organisms have such structures. With this property, selective recognition of biomolecules can be realized, and then applied to biological analysis and disease diagnosis. In short, 2-chlorophenylboronic acid has important uses in organic synthesis, materials science, chemical biology and other fields, promoting research and development in various fields.
Furthermore, in the field of materials science, 2-chlorophenylboronic acid also has wonderful uses. It can participate in the preparation of organic materials with specific functions, such as optoelectronic materials. Due to its structural properties, it may endow materials with unique optical and electrical properties, such as for the synthesis of organic Light Emitting Diode (OLED) materials, or to improve the luminous efficiency and stability of devices.
In addition, in the field of chemical biology, 2-chlorophenylboronic acid can be used for the identification and detection of biomolecules such as glycoproteins and glyconucleic acids. Boric acid groups can specifically bind to cis-diol structures, and many sugar molecules in organisms have such structures. With this property, selective recognition of biomolecules can be realized, and then applied to biological analysis and disease diagnosis. In short, 2-chlorophenylboronic acid has important uses in organic synthesis, materials science, chemical biology and other fields, promoting research and development in various fields.
What are the physical properties of 2-chlorobenzeneboronic Acid?
2-Chlorophenylboronic acid is a commonly used reagent in organic synthesis. Its physical properties are quite characteristic.
Looking at its appearance, it often takes the form of a white to off-white solid powder, which is easy to store and use. In many reaction systems, the powder can increase the contact area with other reactants, which is conducive to the efficient reaction.
When it comes to the melting point, it is about 245-250 ° C. As one of the characteristics of the substance, the melting point is of great significance for its identification and purity judgment. A higher melting point indicates that the substance has strong intermolecular forces and relatively stable structure. When heated, this specific temperature range is required to transform it from solid to liquid.
In terms of solubility, it is slightly soluble in water. This property is related to the molecular structure. The hydrophobicity of the benzene ring and the hydrophilicity of the boric acid group work together, resulting in limited solubility in water. However, it is soluble in some organic solvents, such as dichloromethane, tetrahydrofuran, etc. This provides a basis for the selection of solvents in organic synthesis reactions. According to specific reaction requirements, suitable organic solvents can be selected to dissolve 2-chlorophenylboronic acid, creating a good reaction environment and promoting the smooth development of the reaction.
Its density is also an important physical property. Although the specific value varies slightly due to the measurement conditions, it is roughly within a certain range. Density reflects the mass of a substance per unit volume. When it comes to solution preparation, reaction material measurement, etc., density data is indispensable, which helps to accurately control the amount of reaction material and ensure that the reaction progresses according to the expected process.
In summary, the physical properties of 2-chlorophenylboronic acid are of great significance to its application in the field of organic synthesis. Synthesizers need to be familiar with these properties in order to use the reagent more effectively to achieve synthesis goals.
Looking at its appearance, it often takes the form of a white to off-white solid powder, which is easy to store and use. In many reaction systems, the powder can increase the contact area with other reactants, which is conducive to the efficient reaction.
When it comes to the melting point, it is about 245-250 ° C. As one of the characteristics of the substance, the melting point is of great significance for its identification and purity judgment. A higher melting point indicates that the substance has strong intermolecular forces and relatively stable structure. When heated, this specific temperature range is required to transform it from solid to liquid.
In terms of solubility, it is slightly soluble in water. This property is related to the molecular structure. The hydrophobicity of the benzene ring and the hydrophilicity of the boric acid group work together, resulting in limited solubility in water. However, it is soluble in some organic solvents, such as dichloromethane, tetrahydrofuran, etc. This provides a basis for the selection of solvents in organic synthesis reactions. According to specific reaction requirements, suitable organic solvents can be selected to dissolve 2-chlorophenylboronic acid, creating a good reaction environment and promoting the smooth development of the reaction.
Its density is also an important physical property. Although the specific value varies slightly due to the measurement conditions, it is roughly within a certain range. Density reflects the mass of a substance per unit volume. When it comes to solution preparation, reaction material measurement, etc., density data is indispensable, which helps to accurately control the amount of reaction material and ensure that the reaction progresses according to the expected process.
In summary, the physical properties of 2-chlorophenylboronic acid are of great significance to its application in the field of organic synthesis. Synthesizers need to be familiar with these properties in order to use the reagent more effectively to achieve synthesis goals.
What are the synthetic methods of 2-chlorobenzeneboronic Acid?
There are several common methods for synthesizing 2-chlorophenylboronic acid.
One is the Grignard reagent method. Using 2-chlorobromobenzene as the starting material, the corresponding Grignard reagent is first reacted with magnesium chips in an organic solvent such as anhydrous ether or tetrahydrofuran at a low temperature and in a nitrogen-protected atmosphere. This process requires careful operation, because the Grignard reagent has high activity and is very easy to react with water and oxygen. Then the resulting Grignard reagent is reacted with borate esters, such as trimethyl borate or triethyl borate, at an appropriate temperature. After the reaction is completed, after hydrolysis, 2-chlorophenylboronic acid can be obtained. The advantage of this method is that the reaction route is relatively clear and the yield is acceptable; however, there are also disadvantages. The preparation conditions of Grignard reagent are harsh, and the requirements for the reaction environment are very strict, and the magnesium chips need to be pretreated, which is complicated to operate.
The second is the lithium reagent method. 2-chlorobromobenzene reacts with lithium reagents such as butyl lithium at low temperature (such as -78 ° C) and under anhydrous and anaerobic conditions to form a lithiated intermediate. This lithiated intermediate is extremely active, and then reacts with borate esters to obtain the target product after hydrolysis. The reaction conditions of this method are more severe, and butyl lithium needs to be stored and taken at low temperature, which is difficult to operate. However, its reaction selectivity is good, which
Furthermore, the palladium catalytic coupling method. Using 2-chlorobenzene halide (such as 2-chlorobrombenzene or 2-chloroiodobenzene) and borate as raw materials, in the presence of palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.) and ligands (such as tri-tert-butylphosphine, etc.), in appropriate organic solvents (such as dioxane, toluene, etc.), the coupling reaction occurs under the action of bases (such as potassium carbonate, sodium carbonate, etc.). This method has relatively mild reaction conditions, simple operation, and compatibility with various functional groups. In recent years, it has become more and more widely used. However, palladium catalysts are expensive and increase production costs to a certain extent.
One is the Grignard reagent method. Using 2-chlorobromobenzene as the starting material, the corresponding Grignard reagent is first reacted with magnesium chips in an organic solvent such as anhydrous ether or tetrahydrofuran at a low temperature and in a nitrogen-protected atmosphere. This process requires careful operation, because the Grignard reagent has high activity and is very easy to react with water and oxygen. Then the resulting Grignard reagent is reacted with borate esters, such as trimethyl borate or triethyl borate, at an appropriate temperature. After the reaction is completed, after hydrolysis, 2-chlorophenylboronic acid can be obtained. The advantage of this method is that the reaction route is relatively clear and the yield is acceptable; however, there are also disadvantages. The preparation conditions of Grignard reagent are harsh, and the requirements for the reaction environment are very strict, and the magnesium chips need to be pretreated, which is complicated to operate.
The second is the lithium reagent method. 2-chlorobromobenzene reacts with lithium reagents such as butyl lithium at low temperature (such as -78 ° C) and under anhydrous and anaerobic conditions to form a lithiated intermediate. This lithiated intermediate is extremely active, and then reacts with borate esters to obtain the target product after hydrolysis. The reaction conditions of this method are more severe, and butyl lithium needs to be stored and taken at low temperature, which is difficult to operate. However, its reaction selectivity is good, which
Furthermore, the palladium catalytic coupling method. Using 2-chlorobenzene halide (such as 2-chlorobrombenzene or 2-chloroiodobenzene) and borate as raw materials, in the presence of palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.) and ligands (such as tri-tert-butylphosphine, etc.), in appropriate organic solvents (such as dioxane, toluene, etc.), the coupling reaction occurs under the action of bases (such as potassium carbonate, sodium carbonate, etc.). This method has relatively mild reaction conditions, simple operation, and compatibility with various functional groups. In recent years, it has become more and more widely used. However, palladium catalysts are expensive and increase production costs to a certain extent.
2-chlorobenzeneboronic Acid in storage and transportation
For 2-chlorophenylboronic acid, many precautions must be made clear during storage and transportation.
Its properties are more active, and when stored, the first environment is dry. If the environment is humid, water vapor is easy to interact with, or cause deterioration, affecting its chemical properties and use efficiency. Therefore, it should be placed in a dry, well-ventilated place, away from water sources and moisture intrusion.
Temperature is also critical. This substance is more sensitive to temperature. Excessive temperature may cause chemical reactions such as decomposition, which will damage its quality. Usually should be stored in a cool place, generally 2-8 ° C, according to the instructions of the product manual.
In addition, when storing, it must be isolated from oxidants, alkalis and other substances. Because of its certain chemical activity, contact with the above substances is easy to cause violent chemical reactions, or cause fires, explosions and other dangerous situations.
As for transportation, the packaging must be solid and reliable. Choose suitable packaging materials, such as sealed glass bottles or plastic bottles, plus buffer materials to prevent package damage and material leakage during transportation.
Pay attention to temperature and humidity control during transportation. The car body of the vehicle should be kept dry and stable at temperature, and avoid direct sunlight to prevent the temperature from rising suddenly. At the same time, the transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods, so that in case of leakage and other accidents, they can respond quickly and properly. In this way, Fangbao 2-chlorophenylboronic acid is safe and secure during storage and transportation, and the quality is intact.
Its properties are more active, and when stored, the first environment is dry. If the environment is humid, water vapor is easy to interact with, or cause deterioration, affecting its chemical properties and use efficiency. Therefore, it should be placed in a dry, well-ventilated place, away from water sources and moisture intrusion.
Temperature is also critical. This substance is more sensitive to temperature. Excessive temperature may cause chemical reactions such as decomposition, which will damage its quality. Usually should be stored in a cool place, generally 2-8 ° C, according to the instructions of the product manual.
In addition, when storing, it must be isolated from oxidants, alkalis and other substances. Because of its certain chemical activity, contact with the above substances is easy to cause violent chemical reactions, or cause fires, explosions and other dangerous situations.
As for transportation, the packaging must be solid and reliable. Choose suitable packaging materials, such as sealed glass bottles or plastic bottles, plus buffer materials to prevent package damage and material leakage during transportation.
Pay attention to temperature and humidity control during transportation. The car body of the vehicle should be kept dry and stable at temperature, and avoid direct sunlight to prevent the temperature from rising suddenly. At the same time, the transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods, so that in case of leakage and other accidents, they can respond quickly and properly. In this way, Fangbao 2-chlorophenylboronic acid is safe and secure during storage and transportation, and the quality is intact.
What is the price range of 2-chlorobenzeneboronic Acid in the market?
The price range of 2-chlorophenylboronic acid in the market varies for many reasons. Looking at the market conditions in the past, its price was often influenced by factors such as raw material cost, production process, and market supply and demand.
If the raw materials are easily available and the supply is stable, coupled with the mature and efficient production process, the cost may be controllable, and the price may be relatively low. However, if the raw materials are scarce, difficult to obtain, and the cost is high, the price will also rise.
According to past trading conditions, the price of 2-chlorophenylboronic acid varies greatly under different purity and packaging specifications. Generally speaking, the price per gram of low purity may be in the tens of yuan. If it is of high purity, such as used in high-end fields such as fine chemicals and pharmaceutical research and development, its price can reach 100 yuan per gram or even higher.
As for packaging, the unit price of small packaging may be high due to additional packaging costs; while bulk packaging, due to economies of scale, the unit price may be slightly lower. And the market supply and demand situation is also key. If demand is strong and supply is limited, the price will rise; on the contrary, if supply exceeds demand, the price will easily fall.
According to past data and market conditions, the price of 2-chlorophenylboronic acid per gram may range from tens of yuan to more than 100 yuan. The actual price needs to be determined according to the actual situation of the current market.
If the raw materials are easily available and the supply is stable, coupled with the mature and efficient production process, the cost may be controllable, and the price may be relatively low. However, if the raw materials are scarce, difficult to obtain, and the cost is high, the price will also rise.
According to past trading conditions, the price of 2-chlorophenylboronic acid varies greatly under different purity and packaging specifications. Generally speaking, the price per gram of low purity may be in the tens of yuan. If it is of high purity, such as used in high-end fields such as fine chemicals and pharmaceutical research and development, its price can reach 100 yuan per gram or even higher.
As for packaging, the unit price of small packaging may be high due to additional packaging costs; while bulk packaging, due to economies of scale, the unit price may be slightly lower. And the market supply and demand situation is also key. If demand is strong and supply is limited, the price will rise; on the contrary, if supply exceeds demand, the price will easily fall.
According to past data and market conditions, the price of 2-chlorophenylboronic acid per gram may range from tens of yuan to more than 100 yuan. The actual price needs to be determined according to the actual situation of the current market.
Scan to WhatsApp
