2-Chlorobenzenesulfamide

Linshang Chemical

Specifications

HS Code

686074

Chemical Formula C6H6ClNO2S
Molecular Weight 191.64
Appearance Solid
Color White to off - white
Odor Odorless
Melting Point 158 - 162 °C
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in some organic solvents like ethanol

As an accredited 2-Chlorobenzenesulfamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 250g of 2 - chlorobenzenesulfamide packaged in a sealed plastic - lined cardboard box.
Storage 2 - Chlorobenzenesulfamide should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture absorption and potential reaction with air components. Separate from incompatible substances to avoid chemical reactions that could pose risks like release of harmful fumes or decomposition.
Shipping 2 - Chlorobenzenesulfamide is shipped in well - sealed containers, following strict chemical transportation regulations. It's typically dispatched via specialized freight services to ensure safe transit and prevent any potential leakage or hazards.
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2-Chlorobenzenesulfamide 2-Chlorobenzenesulfamide
General Information
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Frequently Asked Questions

As a leading 2-Chlorobenzenesulfamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 2-chlorobenzenesulfamide?
2-Chlorobenzenesulfonamide, an organic compound, has unique chemical properties and is of great significance to the development of organic synthetic chemistry.
It is weakly acidic. Under specific conditions, the hydrogen atom of the sulfonamide group in the molecule can dissociate and release protons. It is acidic and can neutralize with bases to form corresponding salts. This property can be used in organic synthesis to adjust the pH of the reaction system and promote specific reactions.
2-Chlorobenzenesulfonamide contains chlorine atoms and sulfonamide groups, both of which are reactive. Chlorine atoms can participate in nucleophilic substitution reactions. Many nucleophilic reagents, such as alcohols and amines, can attack the carbon atoms attached to the chlorine atoms, causing the chlorine atoms to be replaced, thereby forming new carbon-heteroatom bonds and synthesizing organic compounds with diverse structures.
Sulfonamide groups can also participate in various reactions, such as reacting with alcaldes and ketones to form new structures such as nitrogen-containing heterocycles. Moreover, the sulfonamide groups of this substance can coordinate with metal ions to form complexes, which may have potential applications in the fields of materials science and catalysis.
In addition, 2-chlorobenzenesulfonamide contains chlorine atoms and sulfonamide groups, which may inhibit the growth of some microorganisms. It can be used as a lead compound in the field of medicine and pesticides. After structural modification and optimization, new antibacterial and insecticidal drugs have been developed. The diversity of its chemical properties provides many possibilities for organic synthesis, drug development and other fields, and is a class of organic compounds worthy of further study.
What are the physical properties of 2-chlorobenzenesulfamide?
2-Chlorobenzenesulfonamide is one of the organic compounds. Its physical properties are worth exploring.
Looking at its morphology, at room temperature, 2-chlorobenzenesulfonamide is mostly in the shape of white crystalline powder, with fine texture, as far as the eye can see, pure and uniform. This morphology is easy to store and use, and also shows unique advantages in many chemical reactions.
The melting point is about 150-154 ° C. When the temperature gradually rises, the substance begins to melt from a solid state to a liquid state. This melting point range is an important physical marker and is of great significance in identification and purity detection.
Solubility is also a key physical property. In water, its solubility is limited. Although there are polar groups in the molecular structure, the non-polar influence of the benzene ring is quite large, making it difficult to dissolve in water with strong polarity. However, in organic solvents, such as ethanol and acetone, the solubility is relatively high. The polarity of ethanol is in line with the partial group of 2-chlorobenzenesulfonamide, and the good solubility of acetone can also make 2-chlorobenzenesulfonamide molecules uniformly disperse. This property is crucial in organic synthesis, separation and purification.
Furthermore, its density is also fixed. Although the exact value varies slightly according to specific conditions, it is roughly within a specific range. Density reflects the mass per unit volume of a substance and is an indispensable parameter in chemical production and material ratio.
In terms of odor, 2-chlorobenzenesulfonamide usually has a weak special odor, which is not pungent and unpleasant. However, when it is concentrated in a confined space or in large quantities, the odor is slightly obvious. This odor characteristic also helps to identify the substance initially.
What are the main uses of 2-chlorobenzenesulfamide?
2-Chlorobenzenesulfonamide has a wide range of uses. In the field of medicine, it is an important raw material for the creation of a variety of drugs. Because of its specific chemical structure and properties, it can be chemically modified and modified to obtain compounds with different pharmacological activities. For example, it can be used to prepare drugs with antibacterial, anti-inflammatory and other effects, by acting on pathogens or inflammation-related targets in the body, in order to achieve the purpose of treating diseases.
In the field of agriculture, it is also useful. Or it can be used as an intermediate for pesticide synthesis. After further synthesis, pesticide products with functions such as insecticidal, bactericidal, and weeding can be prepared. By precisely acting on specific physiological processes of pests, the goal of protecting crops, improving yield and quality is achieved.
In the field of materials science, 2-chlorobenzenesulfonamide also shows unique value. It can participate in the synthesis of special materials, such as some polymer materials. It can be used as a functional monomer, introduced into the polymer structure, endowing the material with excellent properties such as special solubility, thermal stability, mechanical properties, etc., so as to expand the application of materials in different fields, such as aerospace, electronics and other industries that require strict material properties.
Furthermore, in scientific research, 2-chlorobenzenesulfonamide is also a common chemical reagent. Researchers use it to carry out various organic synthesis reaction research, explore new reaction paths and methods, and enrich the knowledge system of organic synthesis chemistry, laying the foundation for the synthesis and application of more novel compounds. All of this highlights the important uses of 2-chlorobenzenesulfonamide in many fields.
What are 2-chlorobenzenesulfamide synthesis methods?
The synthesis method of 2-chlorobenzenesulfonamide, although the ancient book "Tiangong Kaiwu" does not directly describe the synthesis of this specific compound, ideas can be found from the chemical process wisdom of the ancients.
In the past, synthetic chemicals often relied on natural raw materials and simple operation. To obtain 2-chlorobenzenesulfonamide, you can first find natural substances containing benzene rings, such as some plant extracts or coal tar components. First chlorination reaction is carried out on the benzene ring-containing raw materials. Ancient chlorine sources or chlorine-containing substances such as sea salt are specially treated, and chlorine atoms replace hydrogen atoms at specific positions in the benzene ring in a suitable way to obtain 2-chlorobenzene.
Then, 2-chlorobenzene is converted into benzenesulfonic acid The ancients used sulfonating agents such as fuming sulfuric acid (although the understanding at that time was different from today), and the sulfonic acid group was introduced into 2-chlorobenzene through ingenious processes to obtain 2-chlorobenzenesulfonic acid.
Finally, 2-chlorobenzenesulfonic acid is converted into 2-chlorobenzenesulfenamide. Ammonia sources can be found, such as natural ammonium salts or nitrogen-containing organisms, and the hydroxyl groups in the sulfonic acid group are replaced by amino groups through reaction, and finally 2-chlorobenzenesulfenamide is obtained. Although the ancient method is simple, it is wise to control the transformation of substances and reaction conditions,
2-chlorobenzenesulfamide what are the precautions during use
2-Chlorobenzenesulfonamide is an important chemical substance, and many precautions should be kept in mind during use.
First of all, safety protection must be comprehensive. Because of its toxicity and irritation, it is necessary to be fully armed when touching. Wearing protective clothing can effectively resist its damage to the body; wearing protective gloves can avoid direct contact with the skin of the hands; goggles can protect the eyes to prevent accidental splashing. The operation should be carried out in a well-ventilated place, preferably in a fume hood, to ensure that harmful gases are discharged in time and will not endanger the human body.
Secondly, the storage process should not be ignored. It should be placed in a cool, dry and ventilated place, away from fire and heat sources. Due to its active chemical properties, under high temperature environments, chemical reactions may be triggered, resulting in deterioration or danger. At the same time, it should be stored separately from oxidants, acids, bases, etc., to avoid adverse reactions caused by mixed storage.
Furthermore, strictly follow the operating procedures when using. Accurate weighing and measurement, according to experimental or production requirements, to ensure accurate dosage. The reaction conditions need to be precisely controlled, and parameters such as temperature, pressure, and reaction time have a significant impact on the reaction results. If the temperature is too high or too low, it may cause abnormal reaction rates and affect the purity of the product.
In addition, waste treatment is also standardized. After use, the remaining 2-chlorobenzenesulfonamide and related waste cannot be discarded at will. It should be treated harmlessly in accordance with relevant environmental regulations to prevent pollution to the environment.
In short, when using 2-chlorobenzenesulfonamide, care must be taken in terms of safety, storage, operation and waste disposal to ensure safe and efficient use and avoid accidents and pollution.
What are the main uses of 2-chlorobenzenesulfamide?
2-Chlorobenzenesulfonamide has a wide range of uses. In the field of medicine, it is often a key raw material for the synthesis of a variety of drugs. Because of its specific chemical structure and properties, it can participate in the construction of many drug molecules, which has a great impact on drug activity and efficacy. For example, in the synthesis of some antibacterial drugs, it can provide key structural fragments to enhance the inhibition and killing ability of drugs to specific bacteria.
In the chemical industry, 2-chlorobenzenesulfonamide can be used as an intermediate in organic synthesis. With its chemical activity, many organic compounds with different properties and uses can be derived through various chemical reactions. For example, polymer materials used for the synthesis of special properties can improve some physical and chemical properties of materials, such as enhancing the stability and corrosion resistance of materials.
Furthermore, in the field of agriculture, 2-chlorobenzenesulfonamide is also used in the preparation of some pesticides. It helps to develop new pesticides, improve the control effect of pesticides on pests and diseases, and plays an important role in ensuring crop yield and quality. In short, 2-chlorobenzenesulfonamide has important uses in medicine, chemical industry, agriculture and other fields, and is of great significance to promote the development of various industries.
What are the physical properties of 2-chlorobenzenesulfamide?
2-Chlorobenzenesulfonamide is one of the organic compounds. Its physical properties are quite important, and it is related to its use and related characteristics.
Looking at its appearance, under room temperature and pressure, it is mostly white to light yellow crystalline powder. This form is easy to identify and provides a convenient processing basis in many operation and application scenarios.
As for the melting point, it is about 132-136 ° C. The melting point is an inherent property of the substance. This value indicates that 2-chlorobenzenesulfonamide will undergo a solid-to-liquid transformation in this temperature range. This property is of great significance in many fields such as material processing and purification. If it needs to be integrated into a specific system, knowing the melting point can precisely control the temperature to ensure that it participates in the reaction or mixing in an appropriate state.
Solubility is also a key physical property. 2-Chlorobenzenesulfonamide is slightly soluble in water, but soluble in common organic solvents such as ethanol and acetone. The slightly soluble nature of water limits its application in water-based systems; while soluble in organic solvents broadens its use in organic synthesis, coatings, inks and other industrial fields using organic solvents as media. In organic synthesis, organic solvents are used as reaction media to promote the full contact of 2-chlorobenzenesulfonamide with other reactants and promote the reaction process.
In addition, although its density is not widely circulated with extremely accurate constants, it is inferred that the relative density is within a certain reasonable range based on similar compounds and structural characteristics. The value of density is of reference value in operations involving mass and volume conversion, such as storage, container selection during transportation, and reaction system ratio.
In summary, the physical properties of 2-chlorobenzenesulfonamide, such as appearance, melting point, solubility, and approximate density range, together form the basis of its material properties, and are indispensable factors for industrial production, scientific research, and many other aspects.
Is 2-chlorobenzenesulfamide chemically stable?
The chemical stability of 2-chlorobenzenesulfonamide depends on many aspects. This compound has a specific molecular structure, and the benzene ring is connected to the sulfonamide group and the chlorine atom.
From the perspective of chemical activity, the benzene ring has a certain stability, but it can also participate in the aromatic electrophilic substitution reaction. In the sulfonamide group, the nitrogen atom has a lone pair electron, which can be used as a nucleophilic reagent to participate in the reaction, and it is conjugated with the benzene ring, which affects the electron cloud distribution of the molecule. Although the chlorine atom is connected to the benzene ring, due to the electronegativity of the chlorine, the electron cloud density of the benzene ring can be reduced, making it difficult for the electrophil
Under normal conditions, 2-chlorobenzenesulfonamide can maintain certain stability without specific reagents and conditions. However, in case of strong oxidants, strong acids, strong bases, etc., it is easy to react. For example, in case of strong bases, the sulfonamide group may hydrolyze and the nitrogen-sulfur bond will break. In case of strong oxidants, or the substituents or sulfonamide groups on the benzene ring may be oxidized.
In summary, the chemical properties of 2-chlorobenzenesulfonamide are relatively stable under conventional environments, but under special chemical environments and conditions, it is prone to chemical changes and is not absolutely stable.
2-chlorobenzenesulfamide What are the precautions during the synthesis process?
When synthesizing 2-chlorobenzenesulfonamide, many precautions need to be engraved in your mind. Bearing the brunt, the selection of raw materials is crucial. The quality of chlorobenzene and sulfonating reagents is directly related to the purity and yield of the product. Be sure to choose high-purity raw materials, and check their shelf life and storage conditions in detail to prevent reaction deviations caused by raw material deterioration.
The reaction conditions should not be underestimated. Factors such as temperature, pressure, and reaction time have a profound impact on the reaction process. If the temperature is too high, it may cause frequent side reactions and damage the purity of the product; if the temperature is too low, the reaction rate will be slow and take a long time. The pressure also needs to be precisely adjusted according to the reaction characteristics to ensure the smooth progress of the reaction. The reaction time needs to be flexibly adjusted according to experimental monitoring to The use of
catalysts is also crucial. Appropriate catalysts can significantly improve the reaction rate and selectivity. However, the amount of the catalyst needs to be carefully considered, and too much or too little will affect the reaction effect. Before use, it is also necessary to deeply explore the activity and selectivity of the catalyst, and choose the one that meets the needs of the reaction.
The construction and operation of the reaction device should also not be ignored. The device must have good air tightness to prevent safety accidents and abnormal reactions caused by gas leakage. The operation process must follow the standard process, carefully add reagents, and avoid dangers such as flushing and explosion caused by improper operation.
The separation and purification of the product also needs to be carefully treated. After the reaction, the appropriate separation technology, such as filtration, extraction, distillation, etc., is used to separate the product from the reaction system. Subsequently, recrystallization, column chromatography and other methods are further purified to obtain high-purity products.
In terms of safety protection, the reagents used in the synthesis of 2-chlorobenzenesulfonamide may be toxic, corrosive and flammable. Experimenters must wear protective clothing, protective gloves and goggles, operate in a well-ventilated environment, and properly dispose of waste reagents and products to avoid environmental pollution and personal injury.
Only by paying careful attention to the above precautions and operating strictly can we hope to successfully synthesize 2-chlorobenzenesulfonamide and obtain an ideal product.
2-chlorobenzenesulfamide impact on the environment
2-Chlorobenzenesulfonamide, the impact on the environment is particularly important, and it should be carefully reviewed. The properties of this compound may cause multiple effects.
First of all, discuss its state in the water environment. If 2-chlorobenzenesulfonamide enters the water body, it may dissolve and disperse. Its molecules may come into contact with various substances in the water, or combine with floating particles and dissolved substances. This combination may cause its migration to change, or gather in the bottom mud. For aquatic organisms, 2-chlorobenzenesulfonamide may be harmful. It may enter the body of fish, shellfish, algae, etc., causing physiological disorders. Or disturb its ability to breathe, feed, reproduce, or even cause death.
The second observation is the condition of the soil. If it falls in the soil, it may be acted upon by microorganisms in the soil. or decomposed, or changed its shape. However, if the decomposition is slow, it may accumulate in the soil. This accumulation may affect the organisms in the soil, such as earthworms, disturbing their survival and activities. And it may hinder the uptake of nutrients and moisture by plant roots, causing plant growth to be trapped, plant body to be weakened, and yield to be reduced.
Also in the atmosphere. Although it may be rare in the atmosphere, it may escape from the process or evaporate into the air. Or it may drift with the air and fall in different places. In the atmospheric chemical process, or participate in the reaction, affecting the composition and quality of the atmosphere.
Overall, the impact of 2-chlorobenzenesulfonamide on the environment is complex, related to the three realms of water, soil and air, and has potential threats to the survival of organisms and ecological balance. It is necessary to observe it carefully to ensure the stability of the environment and ecology.