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2-Chlorobenzenesulfonl Isocyanate
Linshang Chemical
|
HS Code |
553602 |
| Chemical Formula | C7H4ClNO3S |
| Molar Mass | 217.63 g/mol |
| Appearance | likely a solid (but depends on conditions) |
| Physical State At Stp | solid |
| Odor | pungent (expected for isocyanate - containing compound) |
| Solubility In Water | low (isocyanates generally react with water rather than dissolve well) |
| Solubility In Organic Solvents | soluble in many organic solvents like dichloromethane, toluene |
| Reactivity | reactive towards nucleophiles like amines, alcohols, and water |
| Hazard Class | corrosive and toxic (due to isocyanate group) |
As an accredited 2-Chlorobenzenesulfonl Isocyanate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 2 - Chlorobenzenesulfonyl Isocyanate: Packed in 5 - kg drums for secure storage and transport. |
| Storage | 2 - Chlorobenzenesulfonyl Isocyanate should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and incompatible substances such as amines, alcohols, and water. Store in a tightly - sealed container to prevent moisture ingress, which can lead to decomposition. It should be segregated from reactive chemicals to avoid potential hazardous reactions. |
| Shipping | 2 - Chlorobenzenesulfonyl Isocyanate is a hazardous chemical. Shipping must follow strict regulations. It should be properly packaged in approved containers, labeled clearly, and transported by carriers licensed for such hazardous substances. |
Competitive 2-Chlorobenzenesulfonl Isocyanate prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 2-chlorobenzenesulfonl Isocyanate?
2-Chlorobenzenesulfonyl isocyanate, its use is quite important. In the field of organic synthesis, this compound is often used to prepare a variety of nitrogen-containing heterocyclic compounds. Because of its unique properties, it has both sulfonyl and isocyanate groups in its structure, and plays a significant role in the construction of complex organic molecular structures.
Taking the construction of sulfonamide compounds as an example, 2-chlorobenzenesulfonyl isocyanate can react with various amines. The nitrogen atom of the amine nucleophilic attacks the carbon atom of the isocyanate group, and then a series of reactions such as rearrangement can efficiently generate sulfonamide products. Such sulfonamide compounds are widely used in the field of medicinal chemistry. Many biologically active drug molecules contain this structural unit. For example, in the synthesis of some antibacterial and anti-inflammatory drugs, 2-chlorobenzenesulfonyl isocyanate is the key raw material.
Furthermore, in the synthesis of polymer materials, 2-chlorobenzenesulfonyl isocyanate also has its uses. It can be used as a functional monomer to participate in the polymerization reaction. By carefully designing the reaction conditions, it can be introduced into the main chain or side chain of the polymer, giving the polymer materials special properties, such as improving the solubility, thermal stability and compatibility with other substances of the material.
In addition, in dye chemistry, 2-chlorobenzenesulfonyl isocyanate can be used to synthesize dye intermediates with specific structures. By reacting with aromatic compounds containing active hydrogen, dye molecular structures with specific colors and photostability can be constructed to meet the requirements of dye properties in different fields.
From this perspective, 2-chlorobenzenesulfonyl isocyanate plays an indispensable role in many fields such as organic synthesis, medicine, polymer materials and dyes, and has made great contributions to the development of related fields.
Taking the construction of sulfonamide compounds as an example, 2-chlorobenzenesulfonyl isocyanate can react with various amines. The nitrogen atom of the amine nucleophilic attacks the carbon atom of the isocyanate group, and then a series of reactions such as rearrangement can efficiently generate sulfonamide products. Such sulfonamide compounds are widely used in the field of medicinal chemistry. Many biologically active drug molecules contain this structural unit. For example, in the synthesis of some antibacterial and anti-inflammatory drugs, 2-chlorobenzenesulfonyl isocyanate is the key raw material.
Furthermore, in the synthesis of polymer materials, 2-chlorobenzenesulfonyl isocyanate also has its uses. It can be used as a functional monomer to participate in the polymerization reaction. By carefully designing the reaction conditions, it can be introduced into the main chain or side chain of the polymer, giving the polymer materials special properties, such as improving the solubility, thermal stability and compatibility with other substances of the material.
In addition, in dye chemistry, 2-chlorobenzenesulfonyl isocyanate can be used to synthesize dye intermediates with specific structures. By reacting with aromatic compounds containing active hydrogen, dye molecular structures with specific colors and photostability can be constructed to meet the requirements of dye properties in different fields.
From this perspective, 2-chlorobenzenesulfonyl isocyanate plays an indispensable role in many fields such as organic synthesis, medicine, polymer materials and dyes, and has made great contributions to the development of related fields.
What are the physical properties of 2-chlorobenzenesulfonl Isocyanate?
2-Chlorobenzenesulfonyl isocyanate, this is an organic compound with unique physical properties. It is mostly liquid at room temperature, and its appearance may be a colorless to slightly yellow transparent liquid with a clear texture, which can be observed under specific light conditions.
Looking at its odor, it often has a pungent smell and is uncomfortable to smell. This smell comes from the isocyanate group and benzene ring structure it contains. Its volatility is strong, and in an open environment, the molecule easily escapes from the liquid state to the air, causing its odor to diffuse.
When it comes to solubility, 2-chlorobenzenesulfonyl isocyanate is soluble in common organic solvents such as dichloromethane, chloroform, and tetrahydrofuran. This is because it can form specific forces with these organic solvent molecules, such as van der Waals forces, which promote its uniform dispersion in the solvent. However, it is insoluble in water because its structure lacks groups that form strong interactions with water molecules, such as hydroxyl groups, carboxyl groups, and other groups that can form hydrogen bonds with water.
In addition to its density, it is relatively dense compared to water. When mixed with water, it will sink to the bottom of the water. This property is due to the fact that there are heavier atoms and groups such as chlorine atoms and benzene rings in its molecular structure, resulting in an increase in mass per unit volume. The melting point and boiling point of
2-chlorobenzenesulfonyl isocyanate are also determined by its intermolecular forces and structure. Due to the interaction of certain van der Waals forces and polarities between molecules, its melting point is in a specific temperature range, and its boiling point makes it change from liquid to gaseous state when it reaches a certain high temperature. However, the specific value needs to be determined by precise experiments. These physical properties are of great significance in the field of organic synthesis. Organic chemists can reasonably select reaction solvents and optimize reaction conditions to achieve efficient synthesis of target products based on their solubility, volatility and other properties.
Looking at its odor, it often has a pungent smell and is uncomfortable to smell. This smell comes from the isocyanate group and benzene ring structure it contains. Its volatility is strong, and in an open environment, the molecule easily escapes from the liquid state to the air, causing its odor to diffuse.
When it comes to solubility, 2-chlorobenzenesulfonyl isocyanate is soluble in common organic solvents such as dichloromethane, chloroform, and tetrahydrofuran. This is because it can form specific forces with these organic solvent molecules, such as van der Waals forces, which promote its uniform dispersion in the solvent. However, it is insoluble in water because its structure lacks groups that form strong interactions with water molecules, such as hydroxyl groups, carboxyl groups, and other groups that can form hydrogen bonds with water.
In addition to its density, it is relatively dense compared to water. When mixed with water, it will sink to the bottom of the water. This property is due to the fact that there are heavier atoms and groups such as chlorine atoms and benzene rings in its molecular structure, resulting in an increase in mass per unit volume. The melting point and boiling point of
2-chlorobenzenesulfonyl isocyanate are also determined by its intermolecular forces and structure. Due to the interaction of certain van der Waals forces and polarities between molecules, its melting point is in a specific temperature range, and its boiling point makes it change from liquid to gaseous state when it reaches a certain high temperature. However, the specific value needs to be determined by precise experiments. These physical properties are of great significance in the field of organic synthesis. Organic chemists can reasonably select reaction solvents and optimize reaction conditions to achieve efficient synthesis of target products based on their solubility, volatility and other properties.
2-chlorobenzenesulfonl chemical properties of Isocyanate
2-Chlorobenzenesulfonyl isocyanate, an organic compound with unique and complex chemical properties and multiple characteristics, let me explain in detail.
First of all, it contains an isocyanate group (-N = C = O), which is highly active. The carbon atom of the isocyanate group is highly electron-deficient and vulnerable to attack by nucleophiles, triggering nucleophilic addition reactions. For example, in the case of alcohols, the oxygen atom in the hydroxyl group (-OH) of the alcohol is rich in lone pair electrons, which is nucleophilic and can attack the carbon atom of the isocyanate group to form urethane. This reaction is of great significance in the field of organic synthesis and is often used to prepare polyurethane materials.
Furthermore, the presence of 2-chlorobenzenesulfonyl groups also has a significant impact on its chemical properties. Chlorine atoms have an electron-absorbing effect, which can reduce the electron cloud density of benzene rings and weaken the electrophilic substitution activity of benzene rings. However, this electron-absorbing effect can enhance the electron-deficient degree of isocyanate-based carbon atoms and further enhance their nucleophilic reactivity.
At the same time, 2-chlorobenzenesulfonyl isocyanate is extremely sensitive to water. Water can be used as a nucleophilic reagent to react with isocyanate groups to form unstable carbamate, which can then decompose into amines and carbon dioxide. This characteristic determines that it needs to be strictly avoided from water during storage and use, otherwise it is easy to deteriorate and fail.
In addition, the compound can also react with amine substances. The nitrogen atom of the amine group (-NH ²) contains lone pairs of electrons, which has strong nucleophilicity and can react with the isocyanate group to form urea compounds. This reaction is widely used in the preparation of drugs, pesticides and polymer materials.
2 -chlorobenzenesulfonyl isocyanate plays a key role in organic synthesis and materials science due to its unique structure and active chemical properties. However, due to its high activity and water sensitivity, special attention should be paid to relevant conditions when using and storing.
First of all, it contains an isocyanate group (-N = C = O), which is highly active. The carbon atom of the isocyanate group is highly electron-deficient and vulnerable to attack by nucleophiles, triggering nucleophilic addition reactions. For example, in the case of alcohols, the oxygen atom in the hydroxyl group (-OH) of the alcohol is rich in lone pair electrons, which is nucleophilic and can attack the carbon atom of the isocyanate group to form urethane. This reaction is of great significance in the field of organic synthesis and is often used to prepare polyurethane materials.
Furthermore, the presence of 2-chlorobenzenesulfonyl groups also has a significant impact on its chemical properties. Chlorine atoms have an electron-absorbing effect, which can reduce the electron cloud density of benzene rings and weaken the electrophilic substitution activity of benzene rings. However, this electron-absorbing effect can enhance the electron-deficient degree of isocyanate-based carbon atoms and further enhance their nucleophilic reactivity.
At the same time, 2-chlorobenzenesulfonyl isocyanate is extremely sensitive to water. Water can be used as a nucleophilic reagent to react with isocyanate groups to form unstable carbamate, which can then decompose into amines and carbon dioxide. This characteristic determines that it needs to be strictly avoided from water during storage and use, otherwise it is easy to deteriorate and fail.
In addition, the compound can also react with amine substances. The nitrogen atom of the amine group (-NH ²) contains lone pairs of electrons, which has strong nucleophilicity and can react with the isocyanate group to form urea compounds. This reaction is widely used in the preparation of drugs, pesticides and polymer materials.
2 -chlorobenzenesulfonyl isocyanate plays a key role in organic synthesis and materials science due to its unique structure and active chemical properties. However, due to its high activity and water sensitivity, special attention should be paid to relevant conditions when using and storing.
What is the production method of 2-chlorobenzenesulfonl Isocyanate?
The preparation method of 2-chlorobenzenesulfonyl isocyanate is a crucial skill in the field of fine chemicals. In the past, Fang family explored this technique and tried to use various paths. Today, I will describe it in detail.
One method is to use 2-chlorobenzenesulfonamide as the starting material. First, make 2-chlorobenzenesulfonamide interact with phosgene in a suitable reaction environment. Phosgene is also a compound with active properties. When reacting, pay attention to the reaction temperature, pressure and the ratio of reactants. Generally speaking, the reaction temperature is controlled within a certain range, such as starting at low temperature and gradually heating up, so that the two can fully react. In this process, the introduction rate of phosgene is also quite important. Either too fast or too slow can affect the reaction process and the purity of the product. Phosgene and 2-chlorobenzenesulfonamide can be substituted to obtain 2-chlorobenzenesulfonyl isocyanate. However, phosgene is highly toxic, and safety procedures must be strictly followed during operation to prevent accidents.
The second method also uses 2-chlorobenzenesulfonic acid derivatives as starting materials. First convert 2-chlorobenzenesulfonic acid derivatives into corresponding acid chlorides, and this step can use reagents such as thionyl chloride. The reaction of thionyl chloride with 2-chlorobenzenesulfonic acid derivatives can efficiently generate acid chloride. The resulting acid chloride reacts with sodium cyanate or other cyanic acids in a specific solvent. This reaction is crucial to the choice of solvent, and different solvents may affect the reaction rate and product selectivity. Commonly used solvents include polar aprotic solvents. During the reaction process, it is necessary to properly control the reaction conditions, such as temperature, reaction time, etc., so that the acid chloride can fully react with the cyanic acid source to eventually generate 2-chlorobenzenesulfonyl isocyanate.
The methods for preparing 2-chlorobenzenesulfonyl isocyanate have their own advantages and disadvantages. In practice, when the appropriate method is carefully selected according to the specific situation, such as the availability of raw materials, cost, equipment conditions, etc., and it is necessary to strictly abide by safety and environmental protection regulations, the purpose of preparation can be achieved.
One method is to use 2-chlorobenzenesulfonamide as the starting material. First, make 2-chlorobenzenesulfonamide interact with phosgene in a suitable reaction environment. Phosgene is also a compound with active properties. When reacting, pay attention to the reaction temperature, pressure and the ratio of reactants. Generally speaking, the reaction temperature is controlled within a certain range, such as starting at low temperature and gradually heating up, so that the two can fully react. In this process, the introduction rate of phosgene is also quite important. Either too fast or too slow can affect the reaction process and the purity of the product. Phosgene and 2-chlorobenzenesulfonamide can be substituted to obtain 2-chlorobenzenesulfonyl isocyanate. However, phosgene is highly toxic, and safety procedures must be strictly followed during operation to prevent accidents.
The second method also uses 2-chlorobenzenesulfonic acid derivatives as starting materials. First convert 2-chlorobenzenesulfonic acid derivatives into corresponding acid chlorides, and this step can use reagents such as thionyl chloride. The reaction of thionyl chloride with 2-chlorobenzenesulfonic acid derivatives can efficiently generate acid chloride. The resulting acid chloride reacts with sodium cyanate or other cyanic acids in a specific solvent. This reaction is crucial to the choice of solvent, and different solvents may affect the reaction rate and product selectivity. Commonly used solvents include polar aprotic solvents. During the reaction process, it is necessary to properly control the reaction conditions, such as temperature, reaction time, etc., so that the acid chloride can fully react with the cyanic acid source to eventually generate 2-chlorobenzenesulfonyl isocyanate.
The methods for preparing 2-chlorobenzenesulfonyl isocyanate have their own advantages and disadvantages. In practice, when the appropriate method is carefully selected according to the specific situation, such as the availability of raw materials, cost, equipment conditions, etc., and it is necessary to strictly abide by safety and environmental protection regulations, the purpose of preparation can be achieved.
What are the precautions for using 2-chlorobenzenesulfonl Isocyanate?
2 - Chlorobenzenesulfonyl isocyanate in the chemical industry, there are many points to pay attention to.
First, it is related to its physical properties. This substance has specific chemical properties and physical properties, such as appearance, melting point, solubility, etc., which need to be carefully known. Because of its appearance or specific form, the characteristics of melting point depend on its state at different temperatures, while solubility affects its dispersion and reaction in various solvents. Those who handle this substance must know its details before they can be handy.
Second, safety is of great importance and should not be ignored. 2 - Chlorobenzenesulfonyl isocyanate may be toxic and irritating. When in use, protective gear is indispensable, such as protective clothing, gloves, goggles and gas masks, to prevent it from touching the skin, eyes, or inhaling into the body, causing harm to the body. And its storage should also be cautious, should be placed in a cool, dry, well-ventilated place, away from fire, heat and incompatible substances, so as not to cause danger.
Third, the rules of reaction must be understood. This substance often plays a key role in chemical reactions and participates in a variety of organic synthesis reactions. However, its reactivity is quite high, and it encounters with different reagents or produces very different reaction paths and products. Therefore, before use, it is necessary to know the reaction mechanism and conditions (such as temperature, pressure, and catalyst requirements) in order to control the reaction process and obtain the expected product.
Fourth, the order of operation must be rigorous. The steps of weighing, transfer, and mixing all need to follow precise procedures. When weighing, use precise instruments to ensure that the quantity is correct; during the transfer process, beware of leakage; when mixing, pay attention to the order and speed of addition to avoid sudden abnormalities.
In short, the use of 2-chlorobenzenesulfonyl isocyanate should be done with caution in terms of physical properties, safety, reaction, and operation to ensure the smooth and safe operation of the chemical industry.
First, it is related to its physical properties. This substance has specific chemical properties and physical properties, such as appearance, melting point, solubility, etc., which need to be carefully known. Because of its appearance or specific form, the characteristics of melting point depend on its state at different temperatures, while solubility affects its dispersion and reaction in various solvents. Those who handle this substance must know its details before they can be handy.
Second, safety is of great importance and should not be ignored. 2 - Chlorobenzenesulfonyl isocyanate may be toxic and irritating. When in use, protective gear is indispensable, such as protective clothing, gloves, goggles and gas masks, to prevent it from touching the skin, eyes, or inhaling into the body, causing harm to the body. And its storage should also be cautious, should be placed in a cool, dry, well-ventilated place, away from fire, heat and incompatible substances, so as not to cause danger.
Third, the rules of reaction must be understood. This substance often plays a key role in chemical reactions and participates in a variety of organic synthesis reactions. However, its reactivity is quite high, and it encounters with different reagents or produces very different reaction paths and products. Therefore, before use, it is necessary to know the reaction mechanism and conditions (such as temperature, pressure, and catalyst requirements) in order to control the reaction process and obtain the expected product.
Fourth, the order of operation must be rigorous. The steps of weighing, transfer, and mixing all need to follow precise procedures. When weighing, use precise instruments to ensure that the quantity is correct; during the transfer process, beware of leakage; when mixing, pay attention to the order and speed of addition to avoid sudden abnormalities.
In short, the use of 2-chlorobenzenesulfonyl isocyanate should be done with caution in terms of physical properties, safety, reaction, and operation to ensure the smooth and safe operation of the chemical industry.
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