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2-Chlorobenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
438217 |
| Chemical Formula | C6H4Cl2O2S |
| Molar Mass | 211.06 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 145 - 146 °C (15 mmHg) |
| Melting Point | 18 - 20 °C |
| Density | 1.485 g/cm³ |
| Solubility | Insoluble in water, soluble in organic solvents like benzene, toluene |
| Flash Point | 132 °C |
| Odor | Pungent odor |
| Hazard Class | Corrosive |
As an accredited 2-Chlorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 2 - chlorobenzenesulfonyl chloride packaged in a sealed glass bottle. |
| Storage | 2 - Chlorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and direct sunlight. It must be stored in a tightly - sealed container to prevent contact with moisture, as it can react with water. Keep it separated from incompatible substances like bases, amines, and reducing agents to avoid hazardous reactions. |
| Shipping | 2 - Chlorobenzenesulfonyl chloride is a hazardous chemical. Shipping requires proper packaging in accordance with regulations, like in corrosion - resistant containers. It must be labeled clearly for safe handling during transport to avoid spills and ensure safety. |
Competitive 2-Chlorobenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What are the main uses of 2-chlorobenzenesulfonyl Chloride?
2-Chlorobenzenesulfonyl chloride has a wide range of uses. In the field of organic synthesis, it is a key intermediate. Chlorine atoms and sulfonyl chloride groups on the phenyl ring have high reactivity and can participate in many types of chemical reactions.
First, it is often used to prepare 2-chlorobenzenesulfonamide compounds. When reacted with ammonia or amines, sulfonyl chloride groups can be smoothly converted into sulfonamide groups. Such sulfonamide compounds are of great significance in the field of medicinal chemistry. The structure of many drug molecules contains sulfonamide fragments, which may have various biological activities such as antibacterial, anti-inflammatory, and diuretic. For example, in the synthesis of some sulfonamides, 2-chlorobenzenesulfonyl chloride is an important starting material. Specific substituents are introduced through a series of reactions to construct molecular structures with antibacterial activity.
Second, it also plays an important role in the synthesis of sulfur-containing heterocyclic compounds. By reacting with compounds containing active hydrogen, such as some compounds containing sulfhydryl groups, intermediate products such as thioether bonds are formed first, and then cyclized, sulfur-containing heterocyclic compounds with different structures can be prepared. These heterocyclic compounds have unique uses in materials science, pesticide chemistry, etc. In the field of pesticides, some sulfur-containing heterocyclic pesticides have efficient killing or inhibitory effects on pests.
Third, it can be used to modify the surface of organic materials. By reacting with the active group on the surface of the material, the structure of 2-chlorobenzenesulfonyl chloride is introduced into the surface of the material to change the physical and chemical properties of the material surface, such as hydrophobicity, surface charge, etc. In coatings, polymer materials and other industries, this modification can improve the properties of materials, such as improving the adhesion between coatings and substrates, and improving the stain resistance of polymer materials.
First, it is often used to prepare 2-chlorobenzenesulfonamide compounds. When reacted with ammonia or amines, sulfonyl chloride groups can be smoothly converted into sulfonamide groups. Such sulfonamide compounds are of great significance in the field of medicinal chemistry. The structure of many drug molecules contains sulfonamide fragments, which may have various biological activities such as antibacterial, anti-inflammatory, and diuretic. For example, in the synthesis of some sulfonamides, 2-chlorobenzenesulfonyl chloride is an important starting material. Specific substituents are introduced through a series of reactions to construct molecular structures with antibacterial activity.
Second, it also plays an important role in the synthesis of sulfur-containing heterocyclic compounds. By reacting with compounds containing active hydrogen, such as some compounds containing sulfhydryl groups, intermediate products such as thioether bonds are formed first, and then cyclized, sulfur-containing heterocyclic compounds with different structures can be prepared. These heterocyclic compounds have unique uses in materials science, pesticide chemistry, etc. In the field of pesticides, some sulfur-containing heterocyclic pesticides have efficient killing or inhibitory effects on pests.
Third, it can be used to modify the surface of organic materials. By reacting with the active group on the surface of the material, the structure of 2-chlorobenzenesulfonyl chloride is introduced into the surface of the material to change the physical and chemical properties of the material surface, such as hydrophobicity, surface charge, etc. In coatings, polymer materials and other industries, this modification can improve the properties of materials, such as improving the adhesion between coatings and substrates, and improving the stain resistance of polymer materials.
What are the physical properties of 2-chlorobenzenesulfonyl Chloride?
2-Chlorobenzenesulfonyl chloride is an important raw material in organic synthesis. Its physical properties are rich and diverse.
Looking at its properties, under room temperature and pressure, 2-chlorobenzenesulfonyl chloride is colorless to light yellow liquid, and it is easy to darken in color under sunlight or when heated. This state can be regarded as its external representation, providing a basis for identifying this substance at an intuitive level.
When it comes to odor, it emits a strong irritating odor, which is close to being smelled. The smell is pungent and can cause respiratory discomfort. This odor characteristic is also one of its important physical properties, which can be preliminarily judged when actually exposed.
When it comes to the melting boiling point, the melting point is about -15 ° C, and the boiling point is 153-155 ° C (2.67kPa). The melting point is low, resulting in a liquid state at room temperature; the boiling point at a specific pressure is of great significance for its separation, purification and other operations. Knowing this melting boiling point data can accurately control the temperature conditions in industrial production and laboratory operations.
2-chlorobenzenesulfonyl chloride has a density of about 1.49 g/cm ³, which is higher than that of water. If mixed with water, it will sink to the bottom. This density property needs to be taken into account when dealing with operations such as liquid-liquid separation.
In terms of solubility, it is insoluble in water, but soluble in most organic solvents, such as ether, benzene, chloroform, etc. This solubility characteristic is widely used in organic synthesis reactions. With the help of organic solvents, 2-chlorobenzenesulfonyl chloride can be fully contacted and reacted with other organic reagents, thereby promoting the synthesis process.
In addition, 2-chlorobenzenesulfonyl chloride is highly volatile and easily volatilizes irritating gases in the air. This volatile characteristic needs to be properly handled during storage and use, such as sealing and storing in a cool and ventilated place to prevent its volatilization from causing losses and environmental hazards.
In summary, 2-chlorobenzenesulfonyl chloride has unique physical properties, such as properties, odor, melting point, density, solubility and volatility, which are of key significance for its storage, transportation, use and related chemical reaction operations.
Looking at its properties, under room temperature and pressure, 2-chlorobenzenesulfonyl chloride is colorless to light yellow liquid, and it is easy to darken in color under sunlight or when heated. This state can be regarded as its external representation, providing a basis for identifying this substance at an intuitive level.
When it comes to odor, it emits a strong irritating odor, which is close to being smelled. The smell is pungent and can cause respiratory discomfort. This odor characteristic is also one of its important physical properties, which can be preliminarily judged when actually exposed.
When it comes to the melting boiling point, the melting point is about -15 ° C, and the boiling point is 153-155 ° C (2.67kPa). The melting point is low, resulting in a liquid state at room temperature; the boiling point at a specific pressure is of great significance for its separation, purification and other operations. Knowing this melting boiling point data can accurately control the temperature conditions in industrial production and laboratory operations.
2-chlorobenzenesulfonyl chloride has a density of about 1.49 g/cm ³, which is higher than that of water. If mixed with water, it will sink to the bottom. This density property needs to be taken into account when dealing with operations such as liquid-liquid separation.
In terms of solubility, it is insoluble in water, but soluble in most organic solvents, such as ether, benzene, chloroform, etc. This solubility characteristic is widely used in organic synthesis reactions. With the help of organic solvents, 2-chlorobenzenesulfonyl chloride can be fully contacted and reacted with other organic reagents, thereby promoting the synthesis process.
In addition, 2-chlorobenzenesulfonyl chloride is highly volatile and easily volatilizes irritating gases in the air. This volatile characteristic needs to be properly handled during storage and use, such as sealing and storing in a cool and ventilated place to prevent its volatilization from causing losses and environmental hazards.
In summary, 2-chlorobenzenesulfonyl chloride has unique physical properties, such as properties, odor, melting point, density, solubility and volatility, which are of key significance for its storage, transportation, use and related chemical reaction operations.
What are the chemical properties of 2-chlorobenzenesulfonyl Chloride?
2-Chlorobenzenesulfonyl chloride is one of the organic compounds with unique chemical properties. Its activity is quite strong, and it often shows its skills in the field of organic synthesis.
First talk about its hydrolysis. 2-Chlorobenzenesulfonyl chloride is prone to hydrolysis in contact with water. In this hydrolysis process, the sulfonyl chloride group (-SO2O Cl) interacts with water, and the chlorine atom is replaced by the hydroxyl group to produce 2-chlorobenzenesulfonate and hydrogen chloride. The mechanism of the reaction is that the oxygen atom in the water molecule is rich in electrons, launching a nucleophilic attack on the carbon atom of the sulfonyl chloride group, and then a series of atomic rearrangements and bonds are broken and formed, and finally the hydrolysis product is obtained.
The characteristics of alcoholysis. When it meets alcohols, 2-chlorobenzenesulfonyl chloride can also undergo alcoholysis. In this reaction, the hydroxyl oxygen atom of the alcohol nucleophilically attacks the carbon atom of the sulfonyl chloride, and the chlorine atom leaves to form 2-chlorobenzenesulfonate and hydrogen chloride. This reaction provides an important path for the preparation of sulfonate compounds in organic synthesis.
Re-discussion of its aminolysis. When 2-chlorobenzenesulfonyl chloride interacts with ammonia (or amine), an aminolysis reaction occurs. The lone pair electron of the nitrogen atom in ammonia (or amine) nucleophilically attacks the carbon atom of the sulfonyl chloride, and the chlorine atom leaves to form 2-chlorobenzenesulfonam This reaction is very commonly used in the preparation of sulfonamide drugs or other compounds containing sulfonamide structures.
And because its molecule contains a benzene ring structure, 2-chlorobenzene sulfonyl chloride also has some properties of aromatic compounds. The electron cloud density distribution of the benzene ring enables the compound to participate in the electrophilic substitution reaction. Although the sulfonyl chloride group is an electron-withdrawing group, the electron cloud density of the benzene ring will be reduced, and the electrophilic substitution reaction activity is slightly lower than that of benzene. However, under appropriate conditions, such as in the presence of a catalyst and at a suitable temperature, electrophilic substitution reactions such as halogenation, nitrification, and sulfonation can still occur. Other functional groups are introduced at specific positions in the benzene ring, which greatly enriches the strategies and product types of organic synthesis. The chemical properties of 2-chlorobenzenesulfonyl chloride are active and diverse, and it is widely used in the field of organic synthetic chemistry. It can construct a variety of organic compounds with special structures and functions through various reactions.
First talk about its hydrolysis. 2-Chlorobenzenesulfonyl chloride is prone to hydrolysis in contact with water. In this hydrolysis process, the sulfonyl chloride group (-SO2O Cl) interacts with water, and the chlorine atom is replaced by the hydroxyl group to produce 2-chlorobenzenesulfonate and hydrogen chloride. The mechanism of the reaction is that the oxygen atom in the water molecule is rich in electrons, launching a nucleophilic attack on the carbon atom of the sulfonyl chloride group, and then a series of atomic rearrangements and bonds are broken and formed, and finally the hydrolysis product is obtained.
The characteristics of alcoholysis. When it meets alcohols, 2-chlorobenzenesulfonyl chloride can also undergo alcoholysis. In this reaction, the hydroxyl oxygen atom of the alcohol nucleophilically attacks the carbon atom of the sulfonyl chloride, and the chlorine atom leaves to form 2-chlorobenzenesulfonate and hydrogen chloride. This reaction provides an important path for the preparation of sulfonate compounds in organic synthesis.
Re-discussion of its aminolysis. When 2-chlorobenzenesulfonyl chloride interacts with ammonia (or amine), an aminolysis reaction occurs. The lone pair electron of the nitrogen atom in ammonia (or amine) nucleophilically attacks the carbon atom of the sulfonyl chloride, and the chlorine atom leaves to form 2-chlorobenzenesulfonam This reaction is very commonly used in the preparation of sulfonamide drugs or other compounds containing sulfonamide structures.
And because its molecule contains a benzene ring structure, 2-chlorobenzene sulfonyl chloride also has some properties of aromatic compounds. The electron cloud density distribution of the benzene ring enables the compound to participate in the electrophilic substitution reaction. Although the sulfonyl chloride group is an electron-withdrawing group, the electron cloud density of the benzene ring will be reduced, and the electrophilic substitution reaction activity is slightly lower than that of benzene. However, under appropriate conditions, such as in the presence of a catalyst and at a suitable temperature, electrophilic substitution reactions such as halogenation, nitrification, and sulfonation can still occur. Other functional groups are introduced at specific positions in the benzene ring, which greatly enriches the strategies and product types of organic synthesis. The chemical properties of 2-chlorobenzenesulfonyl chloride are active and diverse, and it is widely used in the field of organic synthetic chemistry. It can construct a variety of organic compounds with special structures and functions through various reactions.
What is the preparation method of 2-chlorobenzenesulfonyl Chloride?
The preparation of 2-chlorobenzenesulfonyl chloride is an important issue in organic synthesis. In the past, this compound was prepared by following a specific chemical path.
One method is to use 2-chlorobenzenesulfonic acid as the starting material. Mix 2-chlorobenzenesulfonic acid with an appropriate amount of chlorination reagents, such as phosphorus pentachloride (PCl) or sulfinyl chloride (SOCl ²). Both are commonly used chlorination agents. Taking phosphorus pentachloride as an example, the reaction of phosphorus pentachloride with 2-chlorobenzenesulfonic acid is a substitution process. The chlorine atom in phosphorus pentachloride replaces the hydroxyl group (-OH) in the sulfonic acid group (-SO 🥰 H) to form 2 When reacting, it is necessary to pay attention to the control of the reaction temperature and time. Usually, this reaction is carried out under moderate heating conditions, between about 50 ° C and 80 ° C, for several hours to ensure that the reaction is sufficient.
If thionyl chloride is used, this reaction is also a substitution type. Sulfuryl chloride reacts with 2-chlorobenzenesulfonic acid to form 2-chlorobenzenesulfonic chloride, and by-products of sulfur dioxide (SO 2O) and hydrogen chloride (HCl) gas. The advantage of this reaction is that the by-products are all gases, which can easily escape from the reaction system, making it easier to separate and purify the products. During the reaction, an appropriate amount of catalyst, such as N, N-dimethylformamide (DMF), can be added to promote the reaction rate. Temperature control is also crucial, and the reaction is usually carried out at the reflux temperature for 2 to 4 hours.
Another method is to use 2-chloroaniline as the starting material. 2-chloroaniline is first converted into diazonium salt by diazotization reaction, and then reacted with sodium bisulfite to produce 2-chlorobenzenesulfonate sodium, and then treated with chlorination reagents such as phosphorus pentachloride or sulfinyl chloride above, and finally 2-chlorobenzenesulfonyl chloride is obtained. Although this route is a little more complicated, the raw material 2-chloroaniline has a wide range of sources and may be cost The separation and purification of the product between each step requires conventional organic chemical methods, such as extraction, distillation, recrystallization, etc., to obtain high-purity 2-chlorobenzenesulfonyl chloride products.
One method is to use 2-chlorobenzenesulfonic acid as the starting material. Mix 2-chlorobenzenesulfonic acid with an appropriate amount of chlorination reagents, such as phosphorus pentachloride (PCl) or sulfinyl chloride (SOCl ²). Both are commonly used chlorination agents. Taking phosphorus pentachloride as an example, the reaction of phosphorus pentachloride with 2-chlorobenzenesulfonic acid is a substitution process. The chlorine atom in phosphorus pentachloride replaces the hydroxyl group (-OH) in the sulfonic acid group (-SO 🥰 H) to form 2 When reacting, it is necessary to pay attention to the control of the reaction temperature and time. Usually, this reaction is carried out under moderate heating conditions, between about 50 ° C and 80 ° C, for several hours to ensure that the reaction is sufficient.
If thionyl chloride is used, this reaction is also a substitution type. Sulfuryl chloride reacts with 2-chlorobenzenesulfonic acid to form 2-chlorobenzenesulfonic chloride, and by-products of sulfur dioxide (SO 2O) and hydrogen chloride (HCl) gas. The advantage of this reaction is that the by-products are all gases, which can easily escape from the reaction system, making it easier to separate and purify the products. During the reaction, an appropriate amount of catalyst, such as N, N-dimethylformamide (DMF), can be added to promote the reaction rate. Temperature control is also crucial, and the reaction is usually carried out at the reflux temperature for 2 to 4 hours.
Another method is to use 2-chloroaniline as the starting material. 2-chloroaniline is first converted into diazonium salt by diazotization reaction, and then reacted with sodium bisulfite to produce 2-chlorobenzenesulfonate sodium, and then treated with chlorination reagents such as phosphorus pentachloride or sulfinyl chloride above, and finally 2-chlorobenzenesulfonyl chloride is obtained. Although this route is a little more complicated, the raw material 2-chloroaniline has a wide range of sources and may be cost The separation and purification of the product between each step requires conventional organic chemical methods, such as extraction, distillation, recrystallization, etc., to obtain high-purity 2-chlorobenzenesulfonyl chloride products.
What are the precautions for 2-chlorobenzenesulfonyl Chloride in storage and transportation?
2-Chlorobenzenesulfonyl chloride is a chemical substance. When storing and transporting, many matters need to be paid attention to.
First word storage. This substance is more active in nature and should be placed in a cool, dry and well-ventilated place. Because it is more sensitive to heat, high temperature is easy to decompose or cause other adverse reactions, so it is necessary to avoid high temperature environment and keep away from fire and heat sources. Furthermore, it needs to be sealed and stored to prevent contact with moisture, oxygen and other substances in the air. The cover is prone to hydrolysis reaction when exposed to water or humid air, generating corresponding acids, which not only causes the substance to deteriorate, but also causes the generated acid to be corrosive, or causes damage to the storage container and surrounding environment. Storage containers should also be carefully selected, and corrosion-resistant materials, such as glass, certain plastics or metal alloys, should be used to resist their corrosiveness.
As for transportation. During transportation, ensure that the packaging is intact and sealed. The packaging materials selected should be able to effectively prevent leakage, and have certain compression and shock resistance to prevent package damage due to collisions and vibrations during transportation. Transportation vehicles should also be clean and dry, and there should be no residual substances that react with 2-chlorobenzenesulfonyl chloride. Transportation personnel should be familiar with the characteristics of this substance and emergency treatment methods. In case of leakage and other emergencies, they can be disposed of quickly and properly. During transportation, temperature control should also be strict to avoid excessive temperature fluctuations. At the same time, transportation-related documents need to be accurate and detailed, indicating key information such as material characteristics and emergency measures, so that all parties can know how to respond.
First word storage. This substance is more active in nature and should be placed in a cool, dry and well-ventilated place. Because it is more sensitive to heat, high temperature is easy to decompose or cause other adverse reactions, so it is necessary to avoid high temperature environment and keep away from fire and heat sources. Furthermore, it needs to be sealed and stored to prevent contact with moisture, oxygen and other substances in the air. The cover is prone to hydrolysis reaction when exposed to water or humid air, generating corresponding acids, which not only causes the substance to deteriorate, but also causes the generated acid to be corrosive, or causes damage to the storage container and surrounding environment. Storage containers should also be carefully selected, and corrosion-resistant materials, such as glass, certain plastics or metal alloys, should be used to resist their corrosiveness.
As for transportation. During transportation, ensure that the packaging is intact and sealed. The packaging materials selected should be able to effectively prevent leakage, and have certain compression and shock resistance to prevent package damage due to collisions and vibrations during transportation. Transportation vehicles should also be clean and dry, and there should be no residual substances that react with 2-chlorobenzenesulfonyl chloride. Transportation personnel should be familiar with the characteristics of this substance and emergency treatment methods. In case of leakage and other emergencies, they can be disposed of quickly and properly. During transportation, temperature control should also be strict to avoid excessive temperature fluctuations. At the same time, transportation-related documents need to be accurate and detailed, indicating key information such as material characteristics and emergency measures, so that all parties can know how to respond.
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