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2-Chlorobenzenethiolate
Linshang Chemical
|
HS Code |
289263 |
| Chemical Formula | C6H4ClS- |
| Molar Mass | 144.61 g/mol (approximate for the anion) |
| Appearance | Typically exists as a salt, appearance depends on the cation; colorless to pale - colored solids possible |
| Solubility | Soluble in polar solvents, solubility may vary with the counter - cation |
| Pka Of Conjugate Acid 2 Chlorobenzenethiol | Approximately 8.5 (estimated, can vary with conditions) |
| Stability | Stable under normal conditions when stored properly, may react with strong oxidizing agents |
| Reactivity | Can react as a nucleophile, participates in substitution reactions |
As an accredited 2-Chlorobenzenethiolate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 2 - Chlorobenzenethiolate packaged in 1 - kg containers for secure storage and transport. |
| Storage | 2 - Chlorobenzenethiolate should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. It should be kept in a tightly sealed container to prevent exposure to air and moisture, which could potentially lead to decomposition or reactivity. Store it separately from oxidizing agents and incompatible substances to avoid hazardous reactions. |
| Shipping | 2 - Chlorobenzenethiolate, a chemical, should be shipped in accordance with regulations for hazardous substances. It must be in properly sealed, corrosion - resistant containers, labeled clearly, and transported by carriers approved for such chemicals. |
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What is the chemistry of 2-chlorobenzenethiolate?
2-Chlorothiophenol salt is a class of organic compounds. This compound has unique chemical properties and is widely used in organic synthesis and chemical industry.
Looking at its chemical activity, the sulfur atom in 2-chlorothiophenol salt is electron-rich and nucleophilic. This nucleophilic property makes this compound often used as a nucleophilic reagent in nucleophilic substitution reactions. For example, it can meet halogenated hydrocarbons. The sulfur atom attacks the carbon atom of the halogenated hydrocarbon, and the halogen atom leaves to form a new sulfur-containing organic compound. This reaction is crucial in the formation of carbon-sulfur bonds and has many uses in drug synthesis, materials science and other fields.
And because of its chlorine atoms, 2-chlorothiophenol is also particularly reactive. Chlorine atoms can participate in the reaction under specific conditions, or be replaced by other groups, or play a role in the elimination reaction. For example, in a basic environment and with appropriate catalysts, chlorine atoms can be detached to form double-bonded thiophenol derivatives, which can participate in subsequent addition reactions, etc., providing a way for the synthesis of complex organic molecules.
2-chlorothiophenol also has special performance in acid-base environments. Its anion form is relatively stable, and when exposed to strong acids, it can protonate to form 2-chlorothiophenol. The balance of protonation and deprotonation varies according to the pH of the environment, which has a great influence on its reactivity and existence form in different systems.
In addition, the physical properties of 2-chlorothiophenol salts, such as solubility, melting point, boiling point, etc., are also related to their chemical properties. Its solubility varies depending on the polarity of the solvent. When selecting a suitable solvent in organic synthesis, it is necessary to consider carefully to make the reaction proceed smoothly.
Looking at its chemical activity, the sulfur atom in 2-chlorothiophenol salt is electron-rich and nucleophilic. This nucleophilic property makes this compound often used as a nucleophilic reagent in nucleophilic substitution reactions. For example, it can meet halogenated hydrocarbons. The sulfur atom attacks the carbon atom of the halogenated hydrocarbon, and the halogen atom leaves to form a new sulfur-containing organic compound. This reaction is crucial in the formation of carbon-sulfur bonds and has many uses in drug synthesis, materials science and other fields.
And because of its chlorine atoms, 2-chlorothiophenol is also particularly reactive. Chlorine atoms can participate in the reaction under specific conditions, or be replaced by other groups, or play a role in the elimination reaction. For example, in a basic environment and with appropriate catalysts, chlorine atoms can be detached to form double-bonded thiophenol derivatives, which can participate in subsequent addition reactions, etc., providing a way for the synthesis of complex organic molecules.
2-chlorothiophenol also has special performance in acid-base environments. Its anion form is relatively stable, and when exposed to strong acids, it can protonate to form 2-chlorothiophenol. The balance of protonation and deprotonation varies according to the pH of the environment, which has a great influence on its reactivity and existence form in different systems.
In addition, the physical properties of 2-chlorothiophenol salts, such as solubility, melting point, boiling point, etc., are also related to their chemical properties. Its solubility varies depending on the polarity of the solvent. When selecting a suitable solvent in organic synthesis, it is necessary to consider carefully to make the reaction proceed smoothly.
2-chlorobenzenethiolate are used in which reactions
2-Chlorothiophenol, which is useful in many reactions. It can be used for nucleophilic substitution reactions. Due to the nucleophilic properties of thiophenol anions, it can attack electrophilic reagents such as halogenated hydrocarbons, such as reacting with halogenated alkanes to form thioether compounds. This reaction is often used in organic synthesis to form carbon-sulfur bonds, and can prepare a variety of sulfur-containing organic compounds. It is of great significance in the fields of medicine, pesticides and materials.
In metal-catalyzed coupling reactions, 2-chlorothiophenol can also play a role. Such as palladium-catalyzed coupling reactions, which can be coupled with halogenated aromatics or alkenyl halides to generate sulfur-containing aromatic compounds with specific structures. Such reactions can effectively construct complex organic molecular structures, which is of great significance for the synthesis of functional materials and bioactive molecules.
In addition, in some reactions involving the introduction of sulfur atoms, 2-chlorothiophenol salts can be used as sulfur sources. For example, in reactions that participate in the formation of sulfur-containing heterocyclic compounds, by cyclization with suitable substrates, sulfur-containing cyclic structures can be constructed. Such sulfur-containing heterocyclic compounds are often used in the fields of medicinal chemistry and total synthesis of natural products.
At the same time, in some organic synthesis strategies, 2-chlorothiophenol can also be used to protect or activate specific functional groups. By reacting with specific functional groups to form thioether bonds, the functional groups are protected, and then the deprotection operation is carried out at an appropriate time to achieve precise control of the functional groups in the organic synthesis route.
In metal-catalyzed coupling reactions, 2-chlorothiophenol can also play a role. Such as palladium-catalyzed coupling reactions, which can be coupled with halogenated aromatics or alkenyl halides to generate sulfur-containing aromatic compounds with specific structures. Such reactions can effectively construct complex organic molecular structures, which is of great significance for the synthesis of functional materials and bioactive molecules.
In addition, in some reactions involving the introduction of sulfur atoms, 2-chlorothiophenol salts can be used as sulfur sources. For example, in reactions that participate in the formation of sulfur-containing heterocyclic compounds, by cyclization with suitable substrates, sulfur-containing cyclic structures can be constructed. Such sulfur-containing heterocyclic compounds are often used in the fields of medicinal chemistry and total synthesis of natural products.
At the same time, in some organic synthesis strategies, 2-chlorothiophenol can also be used to protect or activate specific functional groups. By reacting with specific functional groups to form thioether bonds, the functional groups are protected, and then the deprotection operation is carried out at an appropriate time to achieve precise control of the functional groups in the organic synthesis route.
What are the preparation methods of 2-chlorobenzenethiolate?
There are various ways to prepare 2-chlorothiophenol, and each has its own method. Let me explain them one by one.
First, it can be prepared by the reaction of 2-chlorothiophenol with alkali metal hydroxide or alkali metal carbonate. This is a common method, just like a suitable base, and 2-chlorothiophenol phase. Take an appropriate amount of 2-chlorothiophenol first, place it in a clean container, and then slowly add the solution of alkali metal hydroxide or alkali metal carbonate. In this process, it needs to be stirred continuously to promote its full reaction. If sodium hydroxide solution is mixed with 2-chlorothiophenol, the neutralization reaction between the two occurs, resulting in 2-chlorothiophenol salt and water. The reaction formula is roughly as follows: 2-chlorothiophenol + sodium hydroxide → 2-chlorothiophenol sodium + water. In this operation, pay attention to the temperature and time of the reaction. If the temperature is too high or too low, and the time is too long or too short, it may affect the purity and yield of the product.
Second, halogenated benzene can also be prepared by reacting with thiolates under suitable conditions. When selecting halogenated benzene, 2-chlorobenzene is the top choice, and thiolates should also be carefully selected. The two are placed in a suitable reaction system, an appropriate amount of catalyst is added, and the temperature, pressure and other conditions are controlled. The halogen atom of halogenated benzene is combined with the sulfur atom of mercaptan to form 2-chlorobenzene thiophenate. Among them, the amount of catalyst, the temperature and pressure of the reaction are all key factors. If the temperature is too low, the reaction may be difficult to start; if the temperature is too high, there may be side reactions, resulting in impure products.
Third, other paths of organic synthesis can be used, such as the structure of 2-chlorobenzene thiophenate can be constructed by multi-step reaction from basic organic raw materials with a specific organic reaction mechanism. However, this path is often cumbersome and requires a deep understanding of the principles and skills of organic synthesis. First, a specific intermediate is prepared through several steps of reaction, and then the intermediate is modified to obtain 2-chlorothiophenol salt. Each step of the reaction must be carefully controlled, and there are extremely high requirements for the reaction conditions and the purity of the reagent. Otherwise, if you are not careful, you will lose everything and affect the quality of the final product.
First, it can be prepared by the reaction of 2-chlorothiophenol with alkali metal hydroxide or alkali metal carbonate. This is a common method, just like a suitable base, and 2-chlorothiophenol phase. Take an appropriate amount of 2-chlorothiophenol first, place it in a clean container, and then slowly add the solution of alkali metal hydroxide or alkali metal carbonate. In this process, it needs to be stirred continuously to promote its full reaction. If sodium hydroxide solution is mixed with 2-chlorothiophenol, the neutralization reaction between the two occurs, resulting in 2-chlorothiophenol salt and water. The reaction formula is roughly as follows: 2-chlorothiophenol + sodium hydroxide → 2-chlorothiophenol sodium + water. In this operation, pay attention to the temperature and time of the reaction. If the temperature is too high or too low, and the time is too long or too short, it may affect the purity and yield of the product.
Second, halogenated benzene can also be prepared by reacting with thiolates under suitable conditions. When selecting halogenated benzene, 2-chlorobenzene is the top choice, and thiolates should also be carefully selected. The two are placed in a suitable reaction system, an appropriate amount of catalyst is added, and the temperature, pressure and other conditions are controlled. The halogen atom of halogenated benzene is combined with the sulfur atom of mercaptan to form 2-chlorobenzene thiophenate. Among them, the amount of catalyst, the temperature and pressure of the reaction are all key factors. If the temperature is too low, the reaction may be difficult to start; if the temperature is too high, there may be side reactions, resulting in impure products.
Third, other paths of organic synthesis can be used, such as the structure of 2-chlorobenzene thiophenate can be constructed by multi-step reaction from basic organic raw materials with a specific organic reaction mechanism. However, this path is often cumbersome and requires a deep understanding of the principles and skills of organic synthesis. First, a specific intermediate is prepared through several steps of reaction, and then the intermediate is modified to obtain 2-chlorothiophenol salt. Each step of the reaction must be carefully controlled, and there are extremely high requirements for the reaction conditions and the purity of the reagent. Otherwise, if you are not careful, you will lose everything and affect the quality of the final product.
What are the physical properties of 2-chlorobenzenethiolate?
2-Chlorothiophenate, organic compounds and the like. Its physical properties are particularly important, related to the use and properties of this compound.
Looking at its morphology, at room temperature, 2-chlorothiophenate is often in the form of a solid, white or nearly white, and the state of fine powder is common. This morphology is easy to use and store. In many reactions, powdered substances are easily mixed with other substances to promote the reaction.
When it comes to melting point, the melting point of 2-chlorothiophenate is fixed. This value is the inherent nature of the compound and is crucial for identification and purification. By measuring the melting point, the purity can be determined. The melting point of the pure is usually sharp and close to the value stated in the literature; if it contains impurities, the melting point drops and the melting range increases.
Solubility is also an important physical property. 2-Chlorothiophenol salt has a certain solubility in organic solvents, such as ethanol, ether, etc. This property makes it suitable for organic synthesis. Solvents can be used to help it participate in various reactions, or for separation and purification processes. In water, its solubility is limited. Due to the molecular structure, parts such as benzene ring and sulfur atom are lipophilic, and the affinity with water is weak.
As for density, although it is not very specific, it is also one of its physical properties. Knowing its density is meaningful in the process of preparation, storage and use, related to the accuracy of dosage, container selection, etc. And the value of density is related to other physical properties, which affects the behavior of compounds in different environments.
The physical properties, morphology, melting point, solubility, density, etc. of 2-chlorothiophenol salts are all useful in the research, synthesis and related industrial applications of organic chemistry. It is an indispensable consideration to understand its properties in order to make good use of this compound and achieve the desired purpose.
Looking at its morphology, at room temperature, 2-chlorothiophenate is often in the form of a solid, white or nearly white, and the state of fine powder is common. This morphology is easy to use and store. In many reactions, powdered substances are easily mixed with other substances to promote the reaction.
When it comes to melting point, the melting point of 2-chlorothiophenate is fixed. This value is the inherent nature of the compound and is crucial for identification and purification. By measuring the melting point, the purity can be determined. The melting point of the pure is usually sharp and close to the value stated in the literature; if it contains impurities, the melting point drops and the melting range increases.
Solubility is also an important physical property. 2-Chlorothiophenol salt has a certain solubility in organic solvents, such as ethanol, ether, etc. This property makes it suitable for organic synthesis. Solvents can be used to help it participate in various reactions, or for separation and purification processes. In water, its solubility is limited. Due to the molecular structure, parts such as benzene ring and sulfur atom are lipophilic, and the affinity with water is weak.
As for density, although it is not very specific, it is also one of its physical properties. Knowing its density is meaningful in the process of preparation, storage and use, related to the accuracy of dosage, container selection, etc. And the value of density is related to other physical properties, which affects the behavior of compounds in different environments.
The physical properties, morphology, melting point, solubility, density, etc. of 2-chlorothiophenol salts are all useful in the research, synthesis and related industrial applications of organic chemistry. It is an indispensable consideration to understand its properties in order to make good use of this compound and achieve the desired purpose.
What are 2-chlorobenzenethiolate application fields?
2-Chlorothiophenol salt has a wide range of uses and is useful in many affairs.
In the corner of chemical manufacturing, it can be used as a raw material for organic synthesis. In the chemical industry, to make organic compounds with special structures, 2-chlorothiophenol salt is often a key starting material. Through specific chemical reactions, it can be skillfully transformed and combined with other chemical substances to build a complex molecular structure, forming various fine chemical products, such as specific drug intermediates, paving the way for the pharmaceutical industry.
In the field of materials science, it also plays a role. Or it can be used to prepare special materials, with its unique chemical properties, giving materials different properties. For example, in the synthesis process of some polymer materials, the addition of 2-chlorothiophenol salts may change the chemical reaction process, so that the resulting polymer materials have better stability, flexibility or other unique physical and chemical properties to meet the special needs of materials in different fields.
Furthermore, in the case of metal surface treatment, 2-chlorothiophenol salts can also play a role. It can react with the metal surface to form a protective film. This film can effectively resist the erosion of the external environment on the metal, such as anti-oxidation, anti-corrosion, etc., and prolong the service life of metal products. It is of great significance in many industries that rely on metal materials such as construction and machinery manufacturing.
In addition, in the field of catalysis, it may be used as a catalyst or catalytic aid for some chemical reactions. By promoting chemical reactions, reducing the activation energy of the reaction, making the reaction more likely to occur, improving the reaction rate and efficiency, and having a positive impact on energy conservation and emission reduction in chemical production, and improving production efficiency.
In summary, 2-chlorothiophenol salts have shown unique uses in many fields such as chemicals, materials, metal protection, catalysis, etc., contributing to the development of many industries.
In the corner of chemical manufacturing, it can be used as a raw material for organic synthesis. In the chemical industry, to make organic compounds with special structures, 2-chlorothiophenol salt is often a key starting material. Through specific chemical reactions, it can be skillfully transformed and combined with other chemical substances to build a complex molecular structure, forming various fine chemical products, such as specific drug intermediates, paving the way for the pharmaceutical industry.
In the field of materials science, it also plays a role. Or it can be used to prepare special materials, with its unique chemical properties, giving materials different properties. For example, in the synthesis process of some polymer materials, the addition of 2-chlorothiophenol salts may change the chemical reaction process, so that the resulting polymer materials have better stability, flexibility or other unique physical and chemical properties to meet the special needs of materials in different fields.
Furthermore, in the case of metal surface treatment, 2-chlorothiophenol salts can also play a role. It can react with the metal surface to form a protective film. This film can effectively resist the erosion of the external environment on the metal, such as anti-oxidation, anti-corrosion, etc., and prolong the service life of metal products. It is of great significance in many industries that rely on metal materials such as construction and machinery manufacturing.
In addition, in the field of catalysis, it may be used as a catalyst or catalytic aid for some chemical reactions. By promoting chemical reactions, reducing the activation energy of the reaction, making the reaction more likely to occur, improving the reaction rate and efficiency, and having a positive impact on energy conservation and emission reduction in chemical production, and improving production efficiency.
In summary, 2-chlorothiophenol salts have shown unique uses in many fields such as chemicals, materials, metal protection, catalysis, etc., contributing to the development of many industries.
What are the main uses of 2-chlorobenzenethiolate?
2-Chlorothiophenate is an important raw material for organic synthesis and has a wide range of uses in the chemical industry.
First, it can be used in drug synthesis. In the pharmaceutical process, through specific chemical reactions, 2-chlorothiophenate can be used as a key intermediate, ingeniously combined with other compounds, and then construct drug molecular structures with specific pharmacological activities. For example, when developing some antibacterial and anti-inflammatory drugs, it can participate in key steps to help the drug achieve the desired therapeutic effect.
Second, it is also indispensable in dye synthesis. With its unique chemical properties, it can be used as an important starting material for the synthesis of a variety of dyes. Through a series of reactions, it is converted into dye components with specific color and stability, which are used in textile, printing and dyeing industries to give fabrics brilliant colors.
Third, it has emerged in the field of materials science. It can participate in the preparation of organic materials with certain special properties, such as materials with good electrical conductivity, optical properties or thermal stability. Through chemical modification and polymerization, functional materials that meet different needs can be obtained, providing assistance for the development of electronic devices, optical instruments, etc.
Furthermore, it plays an important role in the field of pesticide synthesis. It can be used as a key fragment in the synthesis of specific pesticide molecules to enhance the poisoning effect of pesticides on pests, improve its stability and durability, and help agricultural pest control, ensuring crop yield and quality. With its diverse and critical uses, 2-chlorothiophenol salts play an important role in many fields of modern chemical industry, promoting the sustainable development and innovation of drugs, dyes, materials, pesticides and other industries.
First, it can be used in drug synthesis. In the pharmaceutical process, through specific chemical reactions, 2-chlorothiophenate can be used as a key intermediate, ingeniously combined with other compounds, and then construct drug molecular structures with specific pharmacological activities. For example, when developing some antibacterial and anti-inflammatory drugs, it can participate in key steps to help the drug achieve the desired therapeutic effect.
Second, it is also indispensable in dye synthesis. With its unique chemical properties, it can be used as an important starting material for the synthesis of a variety of dyes. Through a series of reactions, it is converted into dye components with specific color and stability, which are used in textile, printing and dyeing industries to give fabrics brilliant colors.
Third, it has emerged in the field of materials science. It can participate in the preparation of organic materials with certain special properties, such as materials with good electrical conductivity, optical properties or thermal stability. Through chemical modification and polymerization, functional materials that meet different needs can be obtained, providing assistance for the development of electronic devices, optical instruments, etc.
Furthermore, it plays an important role in the field of pesticide synthesis. It can be used as a key fragment in the synthesis of specific pesticide molecules to enhance the poisoning effect of pesticides on pests, improve its stability and durability, and help agricultural pest control, ensuring crop yield and quality. With its diverse and critical uses, 2-chlorothiophenol salts play an important role in many fields of modern chemical industry, promoting the sustainable development and innovation of drugs, dyes, materials, pesticides and other industries.
What are the physical properties of 2-chlorobenzenethiolate?
2-Chlorothiophenol salt has many physical properties. At room temperature, it is mostly in the shape of a solid state, but it is indeterminate, or its state changes slightly due to the presence of impurities. Looking at its color, it is often white to light yellow powder granular, delicate and touchable, and slightly shiny when viewed under light.
On its melting point, it is within a specific range. Due to the influence of impurities and test conditions on accurate measurement, it hovers roughly within a certain range. This temperature is the critical point for its conversion from solid to liquid, which is related to many application scenarios. Its solubility is also an important property. In organic solvents, such as ethanol, ether, etc., it has a certain solubility. However, in water, it dissolves very little. Due to the characteristics of benzene ring and sulfur atoms in the molecular structure, the interaction between it and water molecules is weak, and the hydrophilicity is poor.
Its density is also one of the characteristics. Compared with common organic salts, it has its unique value. Although it varies slightly with temperature and pressure, it can be regarded as a relatively stable value under conventional conditions. And 2-chlorothiophenol salt has low volatility, and it is difficult to escape into the air at room temperature and pressure. This characteristic makes it relatively safe for storage and use, and it is not easy to be lost due to volatilization or cause safety hazards. Its crystal structure is maintained by intermolecular interactions, and the atoms are arranged in an orderly manner. This microstructure also affects its macroscopic physical properties, such as hardness, brittleness, etc. Overall, the texture is more brittle, and it is easy to break into smaller particles under external force.
On its melting point, it is within a specific range. Due to the influence of impurities and test conditions on accurate measurement, it hovers roughly within a certain range. This temperature is the critical point for its conversion from solid to liquid, which is related to many application scenarios. Its solubility is also an important property. In organic solvents, such as ethanol, ether, etc., it has a certain solubility. However, in water, it dissolves very little. Due to the characteristics of benzene ring and sulfur atoms in the molecular structure, the interaction between it and water molecules is weak, and the hydrophilicity is poor.
Its density is also one of the characteristics. Compared with common organic salts, it has its unique value. Although it varies slightly with temperature and pressure, it can be regarded as a relatively stable value under conventional conditions. And 2-chlorothiophenol salt has low volatility, and it is difficult to escape into the air at room temperature and pressure. This characteristic makes it relatively safe for storage and use, and it is not easy to be lost due to volatilization or cause safety hazards. Its crystal structure is maintained by intermolecular interactions, and the atoms are arranged in an orderly manner. This microstructure also affects its macroscopic physical properties, such as hardness, brittleness, etc. Overall, the texture is more brittle, and it is easy to break into smaller particles under external force.
What is the chemistry of 2-chlorobenzenethiolate?
2-Chlorophenylthiophenol salt, this is a kind of organic compound. Its chemical properties are very interesting, let me tell you in detail.
Let me talk about its reactivity first. Due to the chlorine atom and thiophenol structure in the molecule, its activity is quite high. Chlorine atoms have certain electronegativity, which can change the electron cloud density of the benzene ring, making the benzene ring more prone to nucleophilic substitution. When encountering nucleophilic reagents, chlorine atoms are easily replaced to form new organic compounds. For example, if it encounters sodium alcohol, chlorine atoms may be replaced by alkoxy groups to produce corresponding ether compounds.
Let's talk about its stability. The sulfur atom in the thiophenate part has lone pairs of electrons, which can form coordination bonds with metal ions, but its stability is not very high. In air, it is easy to be oxidized, and the sulfur atom may be oxidized to a higher valence state, resulting in the change of the structure and properties of the compound. If it is not well preserved, its quality may be affected.
In terms of acidity and alkalinity, 2-chlorobenzene thiophenol salt has a certain alkalinity due to thiophenol ions. In solution, it can react with acid to generate corresponding thiophenol. This reaction is reversible, and the compounds exist in different forms depending on the pH of the solution.
In terms of solubility, its solubility in organic solvents is acceptable, such as common organic solvents such as ethanol and ether, which can make it have a certain solubility. However, the solubility in water is relatively small, because it is an organic salt, and the molecular polarity is limited.
In summary, 2-chlorothiophenol salts have chemical properties such as active reactivity, specific stability, acidity and alkalinity and solubility due to their unique structure. In organic synthesis and other fields, their properties may be a key factor affecting many reaction processes and product formation.
Let me talk about its reactivity first. Due to the chlorine atom and thiophenol structure in the molecule, its activity is quite high. Chlorine atoms have certain electronegativity, which can change the electron cloud density of the benzene ring, making the benzene ring more prone to nucleophilic substitution. When encountering nucleophilic reagents, chlorine atoms are easily replaced to form new organic compounds. For example, if it encounters sodium alcohol, chlorine atoms may be replaced by alkoxy groups to produce corresponding ether compounds.
Let's talk about its stability. The sulfur atom in the thiophenate part has lone pairs of electrons, which can form coordination bonds with metal ions, but its stability is not very high. In air, it is easy to be oxidized, and the sulfur atom may be oxidized to a higher valence state, resulting in the change of the structure and properties of the compound. If it is not well preserved, its quality may be affected.
In terms of acidity and alkalinity, 2-chlorobenzene thiophenol salt has a certain alkalinity due to thiophenol ions. In solution, it can react with acid to generate corresponding thiophenol. This reaction is reversible, and the compounds exist in different forms depending on the pH of the solution.
In terms of solubility, its solubility in organic solvents is acceptable, such as common organic solvents such as ethanol and ether, which can make it have a certain solubility. However, the solubility in water is relatively small, because it is an organic salt, and the molecular polarity is limited.
In summary, 2-chlorothiophenol salts have chemical properties such as active reactivity, specific stability, acidity and alkalinity and solubility due to their unique structure. In organic synthesis and other fields, their properties may be a key factor affecting many reaction processes and product formation.
What are the applications of 2-chlorobenzenethiolate in synthesis?
2-Chlorophenylthiophenol is widely used in the field of organic synthesis.
First, it can be used as a nucleophilic reagent. The sulfur atom of the cover has a lone pair of electrons, and the nucleophilic property is quite strong. For example, in the nucleophilic substitution reaction, it can meet with halogenated hydrocarbons, and the halogen atom leaves, and the sulfur atom of 2-chlorophenylthiophenol replaces it to form a new sulfur-containing compound. This reaction condition is relatively mild and has good selectivity. It can produce a variety of sulfur-containing organic molecules, which are commonly used in the creation of medicines and pesticides.
Second, it can be used to construct heterocyclic compounds. Co-reaction with compounds containing suitable functional groups, through the cyclization process, can form sulfur If it reacts with dihalides and is replaced by nucleophiles in molecules, a sulfur-containing heterocyclic skeleton can be constructed. Such heterocyclic compounds often have unique properties and biological activities in the fields of materials science and medicinal chemistry.
Third, in the field of metal-organic chemistry, 2-chlorothiophenol salt can be used as a ligand. Its sulfur atoms can coordinate with metal centers to form metal complexes. These complexes may have catalytic activity and can be used as catalysts or catalyst precursors in catalytic organic reactions, such as coupling reactions, to accelerate the reaction process and improve the reaction efficiency.
Fourth, it is also used in surface modification of materials. 2-Chlorothiophenate can be fixed on the surface of the material by chemical reaction, giving the material new properties. If modified on the metal surface, it may improve its corrosion resistance; if modified on the semiconductor surface, it may have the effect of regulating its optical and electrical properties.
In summary, 2-chlorothiophenate has important applications in organic synthesis, materials science, metal-organic chemistry and other fields due to its unique chemical properties, and is an important tool for creating new compounds and developing new materials.
First, it can be used as a nucleophilic reagent. The sulfur atom of the cover has a lone pair of electrons, and the nucleophilic property is quite strong. For example, in the nucleophilic substitution reaction, it can meet with halogenated hydrocarbons, and the halogen atom leaves, and the sulfur atom of 2-chlorophenylthiophenol replaces it to form a new sulfur-containing compound. This reaction condition is relatively mild and has good selectivity. It can produce a variety of sulfur-containing organic molecules, which are commonly used in the creation of medicines and pesticides.
Second, it can be used to construct heterocyclic compounds. Co-reaction with compounds containing suitable functional groups, through the cyclization process, can form sulfur If it reacts with dihalides and is replaced by nucleophiles in molecules, a sulfur-containing heterocyclic skeleton can be constructed. Such heterocyclic compounds often have unique properties and biological activities in the fields of materials science and medicinal chemistry.
Third, in the field of metal-organic chemistry, 2-chlorothiophenol salt can be used as a ligand. Its sulfur atoms can coordinate with metal centers to form metal complexes. These complexes may have catalytic activity and can be used as catalysts or catalyst precursors in catalytic organic reactions, such as coupling reactions, to accelerate the reaction process and improve the reaction efficiency.
Fourth, it is also used in surface modification of materials. 2-Chlorothiophenate can be fixed on the surface of the material by chemical reaction, giving the material new properties. If modified on the metal surface, it may improve its corrosion resistance; if modified on the semiconductor surface, it may have the effect of regulating its optical and electrical properties.
In summary, 2-chlorothiophenate has important applications in organic synthesis, materials science, metal-organic chemistry and other fields due to its unique chemical properties, and is an important tool for creating new compounds and developing new materials.
What is the preparation method of 2-chlorobenzenethiolate?
The method for preparing 2-chlorothiophenol is described below.
Take 2-chlorothiophenol as the starting material. This compound has a special thiophenol functional group and is highly active. It can often be obtained by the conversion of the corresponding halogenated aromatic hydrocarbons through specific reactions. For example, 2-chlorothiophenol can be prepared by nucleophilic substitution of 2-chlorobromobenzene with sulfur-containing reagents under appropriate reaction conditions.
To obtain 2-chlorothiophenol, 2-chlorothiophenol needs to be reacted with a base. The choice of base is very critical, and common bases such as sodium hydroxide and potassium hydroxide can be used. Place 2-chlorothiophenol in a suitable reaction vessel and add an appropriate amount of alkaline aqueous solution or alcohol solution. The amount of alkali, according to the stoichiometric ratio, usually needs to be slightly excessive to ensure that 2-chlorothiophenol is fully reacted.
When reacting, proceed under appropriate temperature and stirring conditions. Generally speaking, conditions at room temperature or slightly heated can promote the progress of the reaction. Stirring can fully contact the reactants and speed up the reaction rate. The hydrogen on the hydroxyl group of thiophenol of 2-chlorothiophenol has a certain acidity, which can neutralize with acid and base, and then generate 2-chlorothiophenol salt and water.
After the reaction is completed, a suitable separation and purification method can be selected according to the characteristics of the product and the reaction system. If the product has high solubility in water, it can be considered to extract with an organic solvent to remove impurities, and then obtain pure 2-chlorothiophenol salt by evaporation of solvent, crystallization and other operations. If the product is insoluble in water, the product can be separated directly through filtration, washing and other steps, and then dried to obtain pure 2-chlorothiophenol salt.
In this way, 2-chlorothiophenol salt can be prepared according to the above method.
Take 2-chlorothiophenol as the starting material. This compound has a special thiophenol functional group and is highly active. It can often be obtained by the conversion of the corresponding halogenated aromatic hydrocarbons through specific reactions. For example, 2-chlorothiophenol can be prepared by nucleophilic substitution of 2-chlorobromobenzene with sulfur-containing reagents under appropriate reaction conditions.
To obtain 2-chlorothiophenol, 2-chlorothiophenol needs to be reacted with a base. The choice of base is very critical, and common bases such as sodium hydroxide and potassium hydroxide can be used. Place 2-chlorothiophenol in a suitable reaction vessel and add an appropriate amount of alkaline aqueous solution or alcohol solution. The amount of alkali, according to the stoichiometric ratio, usually needs to be slightly excessive to ensure that 2-chlorothiophenol is fully reacted.
When reacting, proceed under appropriate temperature and stirring conditions. Generally speaking, conditions at room temperature or slightly heated can promote the progress of the reaction. Stirring can fully contact the reactants and speed up the reaction rate. The hydrogen on the hydroxyl group of thiophenol of 2-chlorothiophenol has a certain acidity, which can neutralize with acid and base, and then generate 2-chlorothiophenol salt and water.
After the reaction is completed, a suitable separation and purification method can be selected according to the characteristics of the product and the reaction system. If the product has high solubility in water, it can be considered to extract with an organic solvent to remove impurities, and then obtain pure 2-chlorothiophenol salt by evaporation of solvent, crystallization and other operations. If the product is insoluble in water, the product can be separated directly through filtration, washing and other steps, and then dried to obtain pure 2-chlorothiophenol salt.
In this way, 2-chlorothiophenol salt can be prepared according to the above method.
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