Linshang Chemical
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2-(Β'-Chloroethoxy)Benzene Sulfonamide
Linshang Chemical
|
HS Code |
929806 |
| Chemical Formula | C8H10ClNO4S |
| Molar Mass | 251.69 g/mol |
| Appearance | Solid (usually white or off - white) |
| Melting Point | Specific value would require research |
| Boiling Point | Specific value would require research |
| Solubility In Water | Limited solubility, as it is an organic sulfonamide with a hydrophobic benzene ring |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, etc. |
| Pka Value | Related to the acidic nature of the sulfonamide group, specific value needs research |
| Density | Specific value would require research |
| Vapor Pressure | Low vapor pressure due to its solid state and relatively high molecular weight |
As an accredited 2-(Β'-Chloroethoxy)Benzene Sulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 2-(β'-chloroethoxy)benzene Sulfonamide in sealed chemical - grade packaging. |
| Storage | Store 2-(β'-chloroethoxy)benzene Sulfonamide in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent moisture absorption and contact with air, which could potentially lead to decomposition. Store separately from incompatible substances like oxidizing agents and bases to ensure safety. |
| Shipping | 2-(β'-chloroethoxy)benzene Sulfonamide should be shipped in properly sealed, corrosion - resistant containers. It must comply with chemical shipping regulations, ensuring safe handling during transit to prevent leakage and risks. |
Competitive 2-(Β'-Chloroethoxy)Benzene Sulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 2- (β '-chloroethoxy) benzene Sulfonamide?
The chemical structure of 2-% (β-chloroethoxy) benzene sulfonamide is also worth exploring. Looking at this name, it can be seen that it is based on a benzene ring. Above the benzene ring, a specific group is connected at the second position. In this group, there is an ethoxy group, and the beta position of the ethoxy group is connected by a chlorine atom. Furthermore, there is a benzene sulfonamide group.
The benzene ring is a six-membered carbon ring with a conjugated system and is stable in nature. Its six-position carbon atoms are numbered in sequence, and the substituents at the two positions affect the spatial structure and chemical activity of the molecule. β-chloroethoxy group, in ethoxy group, the oxygen atom is covalently bonded to the benzene ring dicarbon, and the chlorine atom at the β position has a certain polarity due to its electronegativity, which can affect the solubility and reactivity of the molecule. The presence of chlorine atoms may make the molecule exhibit unique properties in reactions such as nucleophilic substitution.
Benzenesulfonamide group, benzenesulfonyl group, and then linked to the amino group. In the sulfonyl group, the sulfur atom is connected to the double bond of the oxygen atom, which has strong electron absorption. Amino groups have lone pairs of electrons and can participate in various reactions, such as salt formation with acids. This benzene sulfonamide group coexists with benzene ring and β-chloroethoxy group, and the interaction between the three makes the chemical structure of 2-% (β-chloroethoxy) benzene Sulfonamide complex and unique. Its physicochemical properties and biological activities are determined by the interaction of these groups. In summary, the chemical structure of 2-% (β-chloroethoxy) benzene Sulfonamide is composed of benzene ring, β-chloroethoxy group and benzene sulfonamide group. Each group interacts to shape its unique chemical properties.
The benzene ring is a six-membered carbon ring with a conjugated system and is stable in nature. Its six-position carbon atoms are numbered in sequence, and the substituents at the two positions affect the spatial structure and chemical activity of the molecule. β-chloroethoxy group, in ethoxy group, the oxygen atom is covalently bonded to the benzene ring dicarbon, and the chlorine atom at the β position has a certain polarity due to its electronegativity, which can affect the solubility and reactivity of the molecule. The presence of chlorine atoms may make the molecule exhibit unique properties in reactions such as nucleophilic substitution.
Benzenesulfonamide group, benzenesulfonyl group, and then linked to the amino group. In the sulfonyl group, the sulfur atom is connected to the double bond of the oxygen atom, which has strong electron absorption. Amino groups have lone pairs of electrons and can participate in various reactions, such as salt formation with acids. This benzene sulfonamide group coexists with benzene ring and β-chloroethoxy group, and the interaction between the three makes the chemical structure of 2-% (β-chloroethoxy) benzene Sulfonamide complex and unique. Its physicochemical properties and biological activities are determined by the interaction of these groups. In summary, the chemical structure of 2-% (β-chloroethoxy) benzene Sulfonamide is composed of benzene ring, β-chloroethoxy group and benzene sulfonamide group. Each group interacts to shape its unique chemical properties.
What are the physical properties of 2- (β '-chloroethoxy) benzene Sulfonamide
2-% (β-chloroethoxy) benzene sulfonamide, this is an organic compound with unique physical properties.
Its appearance is often white to white crystalline powder, and it looks fine, like snow, or shimmers slightly under light. Its texture is uniform, and it may feel dry and delicate to the touch.
In terms of melting point, it is about a specific temperature range. This temperature characteristic is of great significance for material identification and purity determination. When heated to the melting point, the compound gradually melts from the solid state to the liquid state, just like ice and snow melting in the warm sun. This process requires accurate temperature control to measure the melting point in detail.
In terms of solubility, it has a certain solubility in some organic solvents such as ethanol and acetone, which is like a fish gradually melting into water. However, the solubility in water is relatively limited, just like oil floating in water, and it is difficult to blend. This difference in solubility has far-reaching effects on the separation, purification and preparation of compounds.
The density of this compound is also a specific value, which reflects its unit volume mass. Compared with other substances, it can help to distinguish its characteristics. Its density is like the "body weight" index of a substance, which is crucial for studying its behavior in different environments.
In addition, 2% (β-chloroethoxy) benzene Sulfonamide may have a certain odor, but the odor may not be strong and pungent, but is milder and requires a fine smell to detect. This odor property may be related to the molecular structure and composition, which is another manifestation of its physical properties.
Its appearance is often white to white crystalline powder, and it looks fine, like snow, or shimmers slightly under light. Its texture is uniform, and it may feel dry and delicate to the touch.
In terms of melting point, it is about a specific temperature range. This temperature characteristic is of great significance for material identification and purity determination. When heated to the melting point, the compound gradually melts from the solid state to the liquid state, just like ice and snow melting in the warm sun. This process requires accurate temperature control to measure the melting point in detail.
In terms of solubility, it has a certain solubility in some organic solvents such as ethanol and acetone, which is like a fish gradually melting into water. However, the solubility in water is relatively limited, just like oil floating in water, and it is difficult to blend. This difference in solubility has far-reaching effects on the separation, purification and preparation of compounds.
The density of this compound is also a specific value, which reflects its unit volume mass. Compared with other substances, it can help to distinguish its characteristics. Its density is like the "body weight" index of a substance, which is crucial for studying its behavior in different environments.
In addition, 2% (β-chloroethoxy) benzene Sulfonamide may have a certain odor, but the odor may not be strong and pungent, but is milder and requires a fine smell to detect. This odor property may be related to the molecular structure and composition, which is another manifestation of its physical properties.
What is the main use of 2- (β '-chloroethoxy) benzene Sulfonamide?
2-% (β-chloroethoxy) benzene Sulfonamide is one of the organic compounds. Its main use can be found in the field of medicinal chemistry.
In drug development, such compounds are often key intermediates. Because of its structure with specific active groups, it can interact with targets in vivo. If you want to make a drug with specific pharmacological activity, it is often used as a starting material, and through a series of chemical transformations, specific functional groups are added or modified to obtain the expected therapeutic effect of drug molecules.
For example, in the development of antibacterial drugs, the structure of 2-% (β-chloroethoxy) benzene Sulfonamide can be modified to inhibit or kill specific bacteria. The benzene ring, sulfonamide group and chloroethoxy group in its structure can all affect its ability to bind to the target of pathogens. The benzene ring can provide a certain hydrophobicity to help it cross the bacterial cell membrane; the sulfonamide group can interact with the activity check point of key enzymes in bacteria, interfering with the normal metabolism and growth of bacteria.
In addition, in the field of pesticide chemistry, it may also have its uses. It can be appropriately modified to develop pesticides with insecticidal, bactericidal or herbicidal activities. By adjusting its chemical structure, it can optimize the activity of specific pests or weeds, and reduce the impact on non-target organisms, achieving the purpose of precise prevention and control. Overall, 2% (β-chloroethoxy) benzene sulfonamide has potential and important uses in chemical-related industries such as pharmaceutical and pesticide research and development, providing a key foundation for the creation of new active compounds.
In drug development, such compounds are often key intermediates. Because of its structure with specific active groups, it can interact with targets in vivo. If you want to make a drug with specific pharmacological activity, it is often used as a starting material, and through a series of chemical transformations, specific functional groups are added or modified to obtain the expected therapeutic effect of drug molecules.
For example, in the development of antibacterial drugs, the structure of 2-% (β-chloroethoxy) benzene Sulfonamide can be modified to inhibit or kill specific bacteria. The benzene ring, sulfonamide group and chloroethoxy group in its structure can all affect its ability to bind to the target of pathogens. The benzene ring can provide a certain hydrophobicity to help it cross the bacterial cell membrane; the sulfonamide group can interact with the activity check point of key enzymes in bacteria, interfering with the normal metabolism and growth of bacteria.
In addition, in the field of pesticide chemistry, it may also have its uses. It can be appropriately modified to develop pesticides with insecticidal, bactericidal or herbicidal activities. By adjusting its chemical structure, it can optimize the activity of specific pests or weeds, and reduce the impact on non-target organisms, achieving the purpose of precise prevention and control. Overall, 2% (β-chloroethoxy) benzene sulfonamide has potential and important uses in chemical-related industries such as pharmaceutical and pesticide research and development, providing a key foundation for the creation of new active compounds.
What are the synthesis methods of 2- (β '-chloroethoxy) benzene Sulfonamide
To prepare 2 -（β - chloroethoxy) benzenesulfonamide, there are many methods, which are described in this article.
First, benzenesulfonamide is used as the beginning, and it is reacted with the base to deprotonate the nitrogen atom to obtain benzenesulfonamide negative ion. This negative ion has nucleophilicity and can undergo nucleophilic substitution reaction with the haloalkane of β-chloroethanol. During the reaction, the solvent selection is very important, such as the use of polar aprotic solvents, such as N, N-dimethylformamide (DMF) or dimethyl sulfoxide (DMSO), which can promote the activity of nucleophilic reagents and increase the reaction rate. Temperature and the ratio of reactants also have an impact. Temperature control is moderate, usually between room temperature and 50 ° C. Adjusting the ratio of the two, the molar ratio of benzenesulfonamide to β-chloroethanol is about 1:1.2 - 1:1.5, which can make the yield better.
Second, benzene is used as the starting material. First, through a sulfonation reaction, concentrated sulfuric acid or fuming sulfuric acid is co-heated with benzene, and a sulfonic acid group is introduced into the benzene ring to obtain benzenesulfonic acid. After converting it into benzenesulfonyl chloride, benzenesulfonic acid is often treated with sulfoxide chloride or phosphorus pentachloride. This reaction should be carried out in an anhydrous environment, such as dry carbon tet After the benzenesulfonyl chloride is obtained, it reacts with ammonia to form benzenesulfonamide. Then follow the above nucleophilic substitution method to react benzenesulfonamide with β-chloroethanol to obtain the target product.
Third, phenol is used as the starting material. First react with ethylene oxide, introduce β-hydroxyethoxy at the ortho position of the phenolic hydroxyl group to obtain 2 - （β - hydroxyethoxy) phenol. After that, the phenolic hydroxyl group is converted into a suitable leaving group, such as a sulfonate, and then nucleophilic substitution occurs with sodium sulfinate, and a sulfonyl group is introduced. After subsequent steps such as ammonolysis, 2 - （β - chloroethoxy) benzenesulfon Although the steps of this path are slightly complicated, the raw materials are easily available, and the reaction conditions of each step are relatively mild, which has certain advantages.
The method of preparing 2 - （β - chloroethoxy) benzenesulfonamide has its own advantages and disadvantages, and it needs to be selected according to the availability of raw materials, cost, yield and difficulty of operation.
First, benzenesulfonamide is used as the beginning, and it is reacted with the base to deprotonate the nitrogen atom to obtain benzenesulfonamide negative ion. This negative ion has nucleophilicity and can undergo nucleophilic substitution reaction with the haloalkane of β-chloroethanol. During the reaction, the solvent selection is very important, such as the use of polar aprotic solvents, such as N, N-dimethylformamide (DMF) or dimethyl sulfoxide (DMSO), which can promote the activity of nucleophilic reagents and increase the reaction rate. Temperature and the ratio of reactants also have an impact. Temperature control is moderate, usually between room temperature and 50 ° C. Adjusting the ratio of the two, the molar ratio of benzenesulfonamide to β-chloroethanol is about 1:1.2 - 1:1.5, which can make the yield better.
Second, benzene is used as the starting material. First, through a sulfonation reaction, concentrated sulfuric acid or fuming sulfuric acid is co-heated with benzene, and a sulfonic acid group is introduced into the benzene ring to obtain benzenesulfonic acid. After converting it into benzenesulfonyl chloride, benzenesulfonic acid is often treated with sulfoxide chloride or phosphorus pentachloride. This reaction should be carried out in an anhydrous environment, such as dry carbon tet After the benzenesulfonyl chloride is obtained, it reacts with ammonia to form benzenesulfonamide. Then follow the above nucleophilic substitution method to react benzenesulfonamide with β-chloroethanol to obtain the target product.
Third, phenol is used as the starting material. First react with ethylene oxide, introduce β-hydroxyethoxy at the ortho position of the phenolic hydroxyl group to obtain 2 - （β - hydroxyethoxy) phenol. After that, the phenolic hydroxyl group is converted into a suitable leaving group, such as a sulfonate, and then nucleophilic substitution occurs with sodium sulfinate, and a sulfonyl group is introduced. After subsequent steps such as ammonolysis, 2 - （β - chloroethoxy) benzenesulfon Although the steps of this path are slightly complicated, the raw materials are easily available, and the reaction conditions of each step are relatively mild, which has certain advantages.
The method of preparing 2 - （β - chloroethoxy) benzenesulfonamide has its own advantages and disadvantages, and it needs to be selected according to the availability of raw materials, cost, yield and difficulty of operation.
2- (β '-chloroethoxy) benzene Sulfonamide during use
2 -（β - chloroethoxy) benzenesulfonamide This substance, when using, many matters need to be paid attention to.
First safety protection. Because of its chemical properties, or harmful to the human body. When exposed, it is necessary to fit protective equipment, such as gloves, goggles, protective clothing, etc., to prevent it from touching the skin and eyes, causing burns, allergies and other diseases. If inadvertently exposed, rinse with plenty of water immediately, and seek medical treatment in time according to the specific situation.
Furthermore, use in a well-ventilated place. This substance or volatile harmful gases, good ventilation can reduce the concentration of harmful substances in the air and reduce the risk of human inhalation. And the operating environment should be far away from fire and heat sources, because it may be flammable or react violently with open flames and hot topics, creating the risk of fire and explosion.
During use, it is crucial to accurately control the dosage and reaction conditions. According to specific uses and reaction requirements, operate strictly according to regulations to achieve the desired effect, and prevent waste and environmental pollution caused by excessive use. Weighing, mixing and other operations must be fine to ensure the accuracy and stability of experiments or production.
Storage should not be ignored. It should be stored in a cool, dry and ventilated place, protected from direct sunlight and humid environment to prevent deterioration or degradation. And must be stored separately from oxidizing agents, acids, alkalis, etc., because of its chemical activity, it can mix with other substances or react dangerously.
In addition, properly dispose of waste after use. It should not be discarded at will. It should be collected and processed in accordance with relevant regulations and environmental protection requirements to prevent environmental pollution and ensure environmental safety.
All of these are for the use of 2 -（β - chloroethoxy) benzenesulfonamide. Care must be taken to ensure personnel safety, environmental harmlessness and the effectiveness of use.
First safety protection. Because of its chemical properties, or harmful to the human body. When exposed, it is necessary to fit protective equipment, such as gloves, goggles, protective clothing, etc., to prevent it from touching the skin and eyes, causing burns, allergies and other diseases. If inadvertently exposed, rinse with plenty of water immediately, and seek medical treatment in time according to the specific situation.
Furthermore, use in a well-ventilated place. This substance or volatile harmful gases, good ventilation can reduce the concentration of harmful substances in the air and reduce the risk of human inhalation. And the operating environment should be far away from fire and heat sources, because it may be flammable or react violently with open flames and hot topics, creating the risk of fire and explosion.
During use, it is crucial to accurately control the dosage and reaction conditions. According to specific uses and reaction requirements, operate strictly according to regulations to achieve the desired effect, and prevent waste and environmental pollution caused by excessive use. Weighing, mixing and other operations must be fine to ensure the accuracy and stability of experiments or production.
Storage should not be ignored. It should be stored in a cool, dry and ventilated place, protected from direct sunlight and humid environment to prevent deterioration or degradation. And must be stored separately from oxidizing agents, acids, alkalis, etc., because of its chemical activity, it can mix with other substances or react dangerously.
In addition, properly dispose of waste after use. It should not be discarded at will. It should be collected and processed in accordance with relevant regulations and environmental protection requirements to prevent environmental pollution and ensure environmental safety.
All of these are for the use of 2 -（β - chloroethoxy) benzenesulfonamide. Care must be taken to ensure personnel safety, environmental harmlessness and the effectiveness of use.
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