Linshang Chemical
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2-Chloroisocyanatobenzene
Linshang Chemical
|
HS Code |
435032 |
| Chemical Formula | C7H4ClNO |
| Molar Mass | 153.57 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 218 - 220 °C |
| Melting Point | 12 - 14 °C |
| Density | 1.32 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 92 °C |
| Vapor Pressure | Low vapor pressure |
| Odor | Pungent odor |
As an accredited 2-Chloroisocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 2 - chloroisocyanatobenzene in 5 - kg sealed containers for secure packaging. |
| Storage | 2 - chloroisocyanatobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It should be kept in a tightly - sealed container to prevent leakage and exposure to moisture, which could lead to decomposition. Store it separately from incompatible substances like amines, alcohols, and strong acids to avoid dangerous reactions. |
| Shipping | 2 - chloroisocyanatobenzene is a chemical that requires careful shipping. It should be packed in appropriate, well - sealed containers to prevent leakage. Shipment must comply with hazardous chemical regulations, ensuring proper labeling and handling during transit. |
Competitive 2-Chloroisocyanatobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemistry of 2-chloroisocyanatobenzene?
2-Phenyl chloroisocyanate is an important chemical substance in organic synthesis. It has unique chemical characteristics and is very active.
In this substance, both the chlorine atom and the isocyanate group are active functional groups. Chlorine atoms have nucleophilic substitution activity and can react with many nucleophilic reagents. For example, when encountering hydroxyl compounds, such as alcohols, chlorine atoms are easily attacked by the nucleophilic attack of the oxygen atom of alcohols, and then form ether derivatives. This process is like a delicate chemical "dance", where atoms interact and rearrange.
The activity of isocyanate groups should not be underestimated, and they are extremely sensitive to water. Once it comes into contact with water, it reacts rapidly. The carbon and nitrogen double bonds in the isocyanate group open and add to the water, resulting in unstable carbamate, which is then decomposed to produce carbon dioxide and amine compounds. This reaction is rapid, and in the environment of water, 2-chloroisocyanate phenyl ester is difficult to survive.
In addition, isocyanate groups can also react with compounds containing active hydrogen, such as amines and carboxylic acids. When reacted with amines, urea compounds are formed, which are often used in the preparation of drugs, polymers, etc. When reacted with carboxylic acids, acid anhydrides and amines are formed, and this process also provides an important path for organic synthesis.
Due to its reactive chemical properties, phenyl 2-chloroisocyanate needs to be stored and used with extreme caution. It needs to be stored in a dry, non-reactive hydrogen compound environment to prevent unnecessary reactions and ensure its chemical stability, so that in the stage of organic synthesis, it can accurately play its role according to the wishes of chemists and construct various complex and useful organic compounds.
In this substance, both the chlorine atom and the isocyanate group are active functional groups. Chlorine atoms have nucleophilic substitution activity and can react with many nucleophilic reagents. For example, when encountering hydroxyl compounds, such as alcohols, chlorine atoms are easily attacked by the nucleophilic attack of the oxygen atom of alcohols, and then form ether derivatives. This process is like a delicate chemical "dance", where atoms interact and rearrange.
The activity of isocyanate groups should not be underestimated, and they are extremely sensitive to water. Once it comes into contact with water, it reacts rapidly. The carbon and nitrogen double bonds in the isocyanate group open and add to the water, resulting in unstable carbamate, which is then decomposed to produce carbon dioxide and amine compounds. This reaction is rapid, and in the environment of water, 2-chloroisocyanate phenyl ester is difficult to survive.
In addition, isocyanate groups can also react with compounds containing active hydrogen, such as amines and carboxylic acids. When reacted with amines, urea compounds are formed, which are often used in the preparation of drugs, polymers, etc. When reacted with carboxylic acids, acid anhydrides and amines are formed, and this process also provides an important path for organic synthesis.
Due to its reactive chemical properties, phenyl 2-chloroisocyanate needs to be stored and used with extreme caution. It needs to be stored in a dry, non-reactive hydrogen compound environment to prevent unnecessary reactions and ensure its chemical stability, so that in the stage of organic synthesis, it can accurately play its role according to the wishes of chemists and construct various complex and useful organic compounds.
What are the common uses of 2-chloroisocyanatobenzene?
2-Phenyl chloroisocyanate, which has high activity, its common use is related to the field of organic synthesis, and it is a key raw material in many chemical reactions.
It can be used as an important intermediate in the synthesis of drugs. The molecular structure of many drugs is complex and requires fine construction. 2-Phenyl chloroisocyanate can react with various compounds containing active hydrogen, such as alcohols and amines, due to its special chemical properties, to form urethane or urea structures. These structures are widely found in many active ingredients of drugs, providing a key basis for the development of new drugs.
Furthermore, it also plays an important role in the creation of pesticides. Pesticides need to be efficient and have specific biological activities. 2-Chloroisocyanate phenyl ester participates in the reaction, which can prepare compounds containing specific functional groups, giving pesticides excellent insecticidal, bactericidal or herbicidal activities.
In addition, in the synthesis of polymer materials, 2-chloroisocyanate phenyl ester also plays a role. React with polyols and other compounds to prepare polyurethane polymer materials. Polyurethane materials are widely used, such as foam plastics, elastomers, coatings and other fields, and are indispensable in industry and daily life.
To sum up, 2-chloroisocyanate phenyl ester is an indispensable raw material in many aspects of organic synthesis of drugs, pesticides and polymer materials, and has made great contributions to the development of various fields.
It can be used as an important intermediate in the synthesis of drugs. The molecular structure of many drugs is complex and requires fine construction. 2-Phenyl chloroisocyanate can react with various compounds containing active hydrogen, such as alcohols and amines, due to its special chemical properties, to form urethane or urea structures. These structures are widely found in many active ingredients of drugs, providing a key basis for the development of new drugs.
Furthermore, it also plays an important role in the creation of pesticides. Pesticides need to be efficient and have specific biological activities. 2-Chloroisocyanate phenyl ester participates in the reaction, which can prepare compounds containing specific functional groups, giving pesticides excellent insecticidal, bactericidal or herbicidal activities.
In addition, in the synthesis of polymer materials, 2-chloroisocyanate phenyl ester also plays a role. React with polyols and other compounds to prepare polyurethane polymer materials. Polyurethane materials are widely used, such as foam plastics, elastomers, coatings and other fields, and are indispensable in industry and daily life.
To sum up, 2-chloroisocyanate phenyl ester is an indispensable raw material in many aspects of organic synthesis of drugs, pesticides and polymer materials, and has made great contributions to the development of various fields.
What is 2-chloroisocyanatobenzene synthesis method?
The method of preparing phenyl 2-chloroisocyanate is quite complicated and requires caution. The common method is to use o-chloroaniline as the starting material.
First, the o-chloroaniline is reacted with phosgene. This reaction needs to be carried out under suitable temperature and pressure conditions. Usually, the o-chloroaniline is dissolved in a suitable organic solvent, such as toluene, xylene, etc., and then slowly introduced into the phosgene. During the reaction process, the phosgene will substitution react with the amino group of the o-chloroaniline to form the corresponding carbamoyl chloride intermediate. This intermediate is not stable and will further decompose, removing a molecule of hydrogen chloride, resulting in the formation of 2-chloroisocyanate phenyl ester.
However, phosgene is very toxic, and strict safety measures must be taken during operation. Operate in a well-ventilated environment, and precisely control the amount of phosgene and the reaction temperature. If the temperature is too high, side reactions may occur, reducing the purity and yield of the product; if the amount of phosgene is not properly introduced, it will also affect the reaction process and product quality.
Another relatively mild method can use solid phosgene (triphosgene) instead of phosgene. Triphosgene is easier to store and operate than phosgene. During the reaction, o-chloroaniline and triphosgene are also reacted in the presence of suitable organic solvents and catalysts. The catalyst can be selected from organic bases, such as pyridine, triethylamine, etc., which can promote the reaction. The reaction mechanism is similar to that of phosgene method, and phenyl 2-chloroisocyanate is finally formed through a series of reactions. However, this method also requires fine control of the reaction conditions to obtain the ideal product.
First, the o-chloroaniline is reacted with phosgene. This reaction needs to be carried out under suitable temperature and pressure conditions. Usually, the o-chloroaniline is dissolved in a suitable organic solvent, such as toluene, xylene, etc., and then slowly introduced into the phosgene. During the reaction process, the phosgene will substitution react with the amino group of the o-chloroaniline to form the corresponding carbamoyl chloride intermediate. This intermediate is not stable and will further decompose, removing a molecule of hydrogen chloride, resulting in the formation of 2-chloroisocyanate phenyl ester.
However, phosgene is very toxic, and strict safety measures must be taken during operation. Operate in a well-ventilated environment, and precisely control the amount of phosgene and the reaction temperature. If the temperature is too high, side reactions may occur, reducing the purity and yield of the product; if the amount of phosgene is not properly introduced, it will also affect the reaction process and product quality.
Another relatively mild method can use solid phosgene (triphosgene) instead of phosgene. Triphosgene is easier to store and operate than phosgene. During the reaction, o-chloroaniline and triphosgene are also reacted in the presence of suitable organic solvents and catalysts. The catalyst can be selected from organic bases, such as pyridine, triethylamine, etc., which can promote the reaction. The reaction mechanism is similar to that of phosgene method, and phenyl 2-chloroisocyanate is finally formed through a series of reactions. However, this method also requires fine control of the reaction conditions to obtain the ideal product.
What are the precautions in storage and transportation of 2-chloroisocyanatobenzene?
2-Phenyl chloroisocyanate, when storing and transporting, be sure to pay attention to many matters. This is a highly toxic chemical, highly irritating, and can cause serious harm to the human body and the environment.
First words storage. First, choose a cool, dry and well-ventilated place, away from fire and heat sources, and must not be exposed to sunlight. Because it is easily decomposed by heat, it can be dangerous. Second, it should be separated from oxidants, acids, alkalis and food chemicals, and must not be mixed. This is because of its active chemical properties, contact with the above substances can easily cause violent chemical reactions, and even cause explosion. Third, the storage place should be equipped with suitable materials to contain leaks, just in case of leaks, which can be dealt with in time to avoid greater harm.
As for transportation. Before transportation, make sure that the packaging is complete and the loading is safe. Packaging materials should be able to resist its corrosion and chemical reactions. During transportation, the speed should not be too fast, nor should it be braked abruptly to prevent package damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. And during transportation, it is strictly forbidden to stop in residential areas and densely populated areas. Escort personnel must always pay attention to the status of the goods, and if there is any abnormality, deal with it immediately.
All storage and transportation of phenyl 2-chloroisocyanate shall be carried out in strict accordance with regulations and with caution to ensure the safety of personnel and the environment from pollution.
First words storage. First, choose a cool, dry and well-ventilated place, away from fire and heat sources, and must not be exposed to sunlight. Because it is easily decomposed by heat, it can be dangerous. Second, it should be separated from oxidants, acids, alkalis and food chemicals, and must not be mixed. This is because of its active chemical properties, contact with the above substances can easily cause violent chemical reactions, and even cause explosion. Third, the storage place should be equipped with suitable materials to contain leaks, just in case of leaks, which can be dealt with in time to avoid greater harm.
As for transportation. Before transportation, make sure that the packaging is complete and the loading is safe. Packaging materials should be able to resist its corrosion and chemical reactions. During transportation, the speed should not be too fast, nor should it be braked abruptly to prevent package damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. And during transportation, it is strictly forbidden to stop in residential areas and densely populated areas. Escort personnel must always pay attention to the status of the goods, and if there is any abnormality, deal with it immediately.
All storage and transportation of phenyl 2-chloroisocyanate shall be carried out in strict accordance with regulations and with caution to ensure the safety of personnel and the environment from pollution.
2-chloroisocyanatobenzene impact on the environment and human health
2-Phenyl chloroisocyanate, which has a significant impact on both the environment and human health.
At the environmental level, it is highly toxic. If accidentally leaked into the soil, it will cause serious damage to the soil ecosystem. It can inhibit the activities of many microorganisms in the soil, and microorganisms play a key role in the process of soil nutrient cycling and organic matter decomposition. Once microbial activity is suppressed, soil fertility decreases, affecting plant growth. If it flows into water bodies, it is even more harmful to aquatic organisms. It can cause poisoning of aquatic organisms such as fish and shellfish, destroy the balance of aquatic ecology, and cause a sharp decrease in biodiversity. And because of its relatively stable chemical properties, it is difficult to degrade rapidly in the environment, and will remain for a long time, which will continue to have adverse effects on the surrounding environment.
As for personal health, its harm should not be underestimated. Inhalation through the respiratory tract can strongly irritate the mucosa of the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term exposure or massive inhalation may even damage lung function and induce lung diseases. If it comes into contact with the skin, it can cause skin allergies, burns, redness, pain, blisters and other symptoms. If it accidentally enters the eyes, the damage to the eyes is extremely serious, which may cause congestion, pain, and even affect vision, causing vision loss and even blindness. In addition, from a toxicological point of view, studies have shown that it may have potential carcinogenicity. Long-term exposure to this substance will increase the risk of cancer and seriously threaten human life and health. Therefore, when manufacturing and using products containing phenyl 2-chloroisocyanate, strict protective measures must be taken to prevent irreversible damage to the environment and human health.
At the environmental level, it is highly toxic. If accidentally leaked into the soil, it will cause serious damage to the soil ecosystem. It can inhibit the activities of many microorganisms in the soil, and microorganisms play a key role in the process of soil nutrient cycling and organic matter decomposition. Once microbial activity is suppressed, soil fertility decreases, affecting plant growth. If it flows into water bodies, it is even more harmful to aquatic organisms. It can cause poisoning of aquatic organisms such as fish and shellfish, destroy the balance of aquatic ecology, and cause a sharp decrease in biodiversity. And because of its relatively stable chemical properties, it is difficult to degrade rapidly in the environment, and will remain for a long time, which will continue to have adverse effects on the surrounding environment.
As for personal health, its harm should not be underestimated. Inhalation through the respiratory tract can strongly irritate the mucosa of the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term exposure or massive inhalation may even damage lung function and induce lung diseases. If it comes into contact with the skin, it can cause skin allergies, burns, redness, pain, blisters and other symptoms. If it accidentally enters the eyes, the damage to the eyes is extremely serious, which may cause congestion, pain, and even affect vision, causing vision loss and even blindness. In addition, from a toxicological point of view, studies have shown that it may have potential carcinogenicity. Long-term exposure to this substance will increase the risk of cancer and seriously threaten human life and health. Therefore, when manufacturing and using products containing phenyl 2-chloroisocyanate, strict protective measures must be taken to prevent irreversible damage to the environment and human health.
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