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2-(Chloromethyl)-1,3-Difluorobenzene
Linshang Chemical
|
HS Code |
274488 |
| Chemical Formula | C7H5ClF2 |
| Molar Mass | 162.564 g/mol |
| Appearance | Liquid (usually) |
| Boiling Point | Data may vary, around 160 - 170 °C (est.) |
| Melting Point | Data may vary, around -20 - -10 °C (est.) |
| Density | Data may vary, around 1.2 - 1.3 g/cm³ (est.) |
| Solubility In Water | Insoluble (hydrophobic nature) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Flash Point | Data may vary, around 50 - 60 °C (est.) |
| Vapor Pressure | Low vapor pressure at room temperature (est.) |
| Odor | Typical aromatic - like odor (est.) |
| Reactivity | Reactive due to the presence of chloromethyl group, can participate in substitution reactions |
As an accredited 2-(Chloromethyl)-1,3-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250 - gram bottle of 2-(chloromethyl)-1,3 - difluorobenzene, well - sealed for safety. |
| Storage | 2-(Chloromethyl)-1,3 -difluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials. This helps prevent leakage, degradation, and potential reactions that could pose safety risks. |
| Shipping | 2-(Chloromethyl)-1,3 -difluorobenzene is shipped in accordance with strict chemical regulations. It's typically in sealed, corrosion - resistant containers, safeguarded from heat and direct sunlight during transit to ensure safety. |
Competitive 2-(Chloromethyl)-1,3-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 2-(Chloromethyl)-1,3-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 2- (chloromethyl) -1,3-difluorobenzene?
2-%28chloromethyl%29-1%2C3-difluorobenzene is 2- (chloromethyl) -1,3-difluorobenzene, which has a wide range of uses.
In the field of pharmaceutical synthesis, it is often a key intermediate. The fluorine atom attached to the genphenyl ring can change the lipid solubility and metabolic stability of the compound, while chloromethyl has high reactivity. It can introduce various functional groups through reactions such as nucleophilic substitution, and then build complex drug molecular structures. For example, synthesizing specific targeted anti-cancer drugs, 2- (chloromethyl) -1,3-difluorobenzene or participating in key steps can help generate active ingredients that precisely bind to cancer cell targets.
also plays an important role in the field of pesticide creation. Due to its unique structure, it can endow pesticides with excellent biological activity and environmental compatibility. Taking fluorinated pesticides as an example, the characteristics of fluorine atoms can enhance the effect of pesticides on pests and pathogens, improve the efficacy, reduce the dosage, and reduce the impact on the environment. 2- (chloromethyl) -1,3-difluorobenzene or as the starting material for the synthesis of new high-efficiency and low-toxicity pesticides, through a series of reactions to generate pesticide varieties with unique mechanisms of action, for crop pest control.
In the field of materials science, 2- (chloromethyl) -1,3-difluorobenzene also shows application potential. It can be used as a monomer or modifier for the synthesis of functional polymer materials. By polymerizing with other monomers, fluorine atoms and chloromethyl are introduced into the polymer chain, giving the material special properties, such as improving the chemical resistance, thermal stability and surface properties of the material. In the fields of electronic materials, coatings, plastics, etc., this modified polymer material has a wider range of application prospects, such as for the manufacture of high-performance electronic packaging materials to protect electronic components from external environments and ensure the stable operation of electronic devices.
In the field of pharmaceutical synthesis, it is often a key intermediate. The fluorine atom attached to the genphenyl ring can change the lipid solubility and metabolic stability of the compound, while chloromethyl has high reactivity. It can introduce various functional groups through reactions such as nucleophilic substitution, and then build complex drug molecular structures. For example, synthesizing specific targeted anti-cancer drugs, 2- (chloromethyl) -1,3-difluorobenzene or participating in key steps can help generate active ingredients that precisely bind to cancer cell targets.
also plays an important role in the field of pesticide creation. Due to its unique structure, it can endow pesticides with excellent biological activity and environmental compatibility. Taking fluorinated pesticides as an example, the characteristics of fluorine atoms can enhance the effect of pesticides on pests and pathogens, improve the efficacy, reduce the dosage, and reduce the impact on the environment. 2- (chloromethyl) -1,3-difluorobenzene or as the starting material for the synthesis of new high-efficiency and low-toxicity pesticides, through a series of reactions to generate pesticide varieties with unique mechanisms of action, for crop pest control.
In the field of materials science, 2- (chloromethyl) -1,3-difluorobenzene also shows application potential. It can be used as a monomer or modifier for the synthesis of functional polymer materials. By polymerizing with other monomers, fluorine atoms and chloromethyl are introduced into the polymer chain, giving the material special properties, such as improving the chemical resistance, thermal stability and surface properties of the material. In the fields of electronic materials, coatings, plastics, etc., this modified polymer material has a wider range of application prospects, such as for the manufacture of high-performance electronic packaging materials to protect electronic components from external environments and ensure the stable operation of electronic devices.
What are the physical properties of 2- (chloromethyl) -1,3-difluorobenzene
2- (chloromethyl) -1,3-difluorobenzene is a kind of organic compound. Its physical properties are quite critical, and its application in chemical industry and other fields also depends on this.
In terms of its properties, under normal temperature and pressure, 2- (chloromethyl) -1,3-difluorobenzene is often colorless to light yellow transparent liquid, and it looks clear. This form is convenient for it to participate in reactions in many chemical reaction systems. Because liquids are easier to contact molecules than solids, the reaction rate may also be faster.
Its smell has a special aromatic smell, but this smell is not pleasant and may be irritating. If a person is exposed to an environment containing this substance, the sense of smell can be keenly sensed, and excessive inhalation may cause adverse effects on the respiratory tract.
The boiling point is about a certain temperature range. The boiling point is the temperature limit for the transformation of a substance from a liquid state to a gaseous state. Knowing the boiling point of this substance is of great significance for chemical operations such as separation and purification. For example, during distillation, an appropriate temperature can be set according to its boiling point to effectively separate 2- (chloromethyl) -1,3-difluorobenzene from the mixture.
Melting point is also one of the important physical properties, and its melting point also has a specific value. Melting point is related to the conditions for the transformation of a substance between solid and liquid states, and has a significant impact on the setting of storage and transportation conditions. If the storage temperature is higher than the melting point, the substance is in a liquid state, and the sealing of the container needs to be considered; if it is lower than the melting point, it is in a solid state, and it is also necessary to pay attention to the problems such as volume changes that may be caused by its solidification.
Furthermore, the density is a certain value. Density reflects the mass of the substance in a unit volume, and this property is extremely important in operations such as measurement and mixing. When formulating solutions or proportioning reactants, the dosage of the substance can be accurately determined according to the density.
In terms of solubility, 2- (chloromethyl) -1,3-difluorobenzene is insoluble in water, but soluble in common organic solvents such as ethanol, ether, etc. This solubility characteristic makes it possible to build a reaction environment with the help of organic solvents in organic synthesis reactions to promote the smooth progress of the reaction. And because it is insoluble in water, it can be used to separate from water-soluble substances in some separation operations involving aqueous phases.
In terms of its properties, under normal temperature and pressure, 2- (chloromethyl) -1,3-difluorobenzene is often colorless to light yellow transparent liquid, and it looks clear. This form is convenient for it to participate in reactions in many chemical reaction systems. Because liquids are easier to contact molecules than solids, the reaction rate may also be faster.
Its smell has a special aromatic smell, but this smell is not pleasant and may be irritating. If a person is exposed to an environment containing this substance, the sense of smell can be keenly sensed, and excessive inhalation may cause adverse effects on the respiratory tract.
The boiling point is about a certain temperature range. The boiling point is the temperature limit for the transformation of a substance from a liquid state to a gaseous state. Knowing the boiling point of this substance is of great significance for chemical operations such as separation and purification. For example, during distillation, an appropriate temperature can be set according to its boiling point to effectively separate 2- (chloromethyl) -1,3-difluorobenzene from the mixture.
Melting point is also one of the important physical properties, and its melting point also has a specific value. Melting point is related to the conditions for the transformation of a substance between solid and liquid states, and has a significant impact on the setting of storage and transportation conditions. If the storage temperature is higher than the melting point, the substance is in a liquid state, and the sealing of the container needs to be considered; if it is lower than the melting point, it is in a solid state, and it is also necessary to pay attention to the problems such as volume changes that may be caused by its solidification.
Furthermore, the density is a certain value. Density reflects the mass of the substance in a unit volume, and this property is extremely important in operations such as measurement and mixing. When formulating solutions or proportioning reactants, the dosage of the substance can be accurately determined according to the density.
In terms of solubility, 2- (chloromethyl) -1,3-difluorobenzene is insoluble in water, but soluble in common organic solvents such as ethanol, ether, etc. This solubility characteristic makes it possible to build a reaction environment with the help of organic solvents in organic synthesis reactions to promote the smooth progress of the reaction. And because it is insoluble in water, it can be used to separate from water-soluble substances in some separation operations involving aqueous phases.
Is 2- (chloromethyl) -1,3-difluorobenzene chemically stable?
2-%28chloromethyl%29-1%2C3-difluorobenzene, that is, 2- (chloromethyl) -1,3-difluorobenzene, the stability of its chemical properties is a complex and interesting issue.
In this compound, the structure of the benzene ring endows it with certain stability. The benzene ring has a conjugated system, and the electron cloud is delocalized, resulting in a stable structure. And two fluorine atoms are connected to the benzene ring, and the fluorine atom is extremely electronegative, which can affect the electron cloud density distribution of the benzene ring by induction and conjugation effects. Due to the influence of the two, the electron cloud density of the benzene ring decreases, and the reactivity of external reagents is also changed.
Furthermore, the existence of chloromethyl adds variables to its chemical properties. In chloromethyl chloride, the chlorine atom has strong electronegativity and is connected to the carbon atom to form a polar covalent bond. This polar bond makes chloromethyl chloride vulnerable to attack by nucleophiles, triggering nucleophilic substitution reactions, or under specific conditions, chlorine atoms can leave to form carbon positive ion intermediates and participate in many reactions, thus reducing the stability of the compound.
However, under normal conditions, without specific reagents or suitable reaction conditions, 2 - (chloromethyl) -1,3 - difluorobenzene can maintain a relatively stable state. However, in the case of nucleophiles, such as aqueous sodium hydroxide solutions, the chlorine atom of chloromethyl chloride is easily replaced by hydroxyl groups. In the presence of light or free radical initiators, chloromethyl chloride may also initiate free radical reactions.
In summary, the stability of 2- (chloromethyl) -1,3-difluorobenzene is not absolute, and its performance varies under different environments and reaction conditions. In case of specific reagents and conditions, the stability will be challenged and corresponding chemical reactions will occur.
In this compound, the structure of the benzene ring endows it with certain stability. The benzene ring has a conjugated system, and the electron cloud is delocalized, resulting in a stable structure. And two fluorine atoms are connected to the benzene ring, and the fluorine atom is extremely electronegative, which can affect the electron cloud density distribution of the benzene ring by induction and conjugation effects. Due to the influence of the two, the electron cloud density of the benzene ring decreases, and the reactivity of external reagents is also changed.
Furthermore, the existence of chloromethyl adds variables to its chemical properties. In chloromethyl chloride, the chlorine atom has strong electronegativity and is connected to the carbon atom to form a polar covalent bond. This polar bond makes chloromethyl chloride vulnerable to attack by nucleophiles, triggering nucleophilic substitution reactions, or under specific conditions, chlorine atoms can leave to form carbon positive ion intermediates and participate in many reactions, thus reducing the stability of the compound.
However, under normal conditions, without specific reagents or suitable reaction conditions, 2 - (chloromethyl) -1,3 - difluorobenzene can maintain a relatively stable state. However, in the case of nucleophiles, such as aqueous sodium hydroxide solutions, the chlorine atom of chloromethyl chloride is easily replaced by hydroxyl groups. In the presence of light or free radical initiators, chloromethyl chloride may also initiate free radical reactions.
In summary, the stability of 2- (chloromethyl) -1,3-difluorobenzene is not absolute, and its performance varies under different environments and reaction conditions. In case of specific reagents and conditions, the stability will be challenged and corresponding chemical reactions will occur.
What are the preparation methods of 2- (chloromethyl) -1,3-difluorobenzene
2-%28chloromethyl%29-1%2C3-difluorobenzene is 2 - (chloromethyl) -1,3 - difluorobenzene, and its preparation method is as follows:
First, 1,3 - difluorobenzene is used as the starting material. First, 1,3 - difluorobenzene is chloromethylated with paraformaldehyde, zinc chloride and concentrated hydrochloric acid under specific conditions. In this reaction, paraformaldehyde will be depolymerized to formaldehyde under the catalysis of zinc chloride and concentrated hydrochloric acid, and formaldehyde and concentrated hydrochloric acid will form chloromethyl positive ions, and then the benzene ring of 1,3 - difluorobenzene will be electrophilically substituted to mainly produce 2 - (chloromethyl) -1,3 - difluorobenzene, which may be accompanied by a small amount of 3 - (chloromethyl) -1,3 - difluorobenzene by-products. After the reaction is completed, the impurities are removed by water washing and alkali washing, and then the target product is separated and purified by distillation.
Second, 2-methyl-1,3-difluorobenzene is used as the raw material. 2-methyl-1,3-difluorobenzene is subjected to free radical substitution reaction with chlorine in the presence of light or initiator. The hydrogen atom on the methyl group will be gradually replaced by the chlorine atom to generate 2- (chloromethyl) -1,3-difluorobenzene. The reaction conditions, including the amount of chlorine gas introduced, the reaction temperature and the light intensity, need to be strictly controlled to reduce the formation of polychlorinated products. After the reaction is completed, 2- (chloromethyl) -1,3-difluorobenzene can be separated by rectifying and other techniques.
Third, 2- (bromomethyl) -1,3-difluorobenzene can also be started from 2- (bromomethyl) -1,3-difluorobenzene. The halogen exchange reaction between 2- (bromomethyl) -1,3-difluorobenzene and other chlorinated reagents such as lithium chloride occurs in an appropriate solvent (such as N, N-dimethylformamide). Bromine ions are exchanged with chloride ions to obtain 2- (chloromethyl) -1,3-difluorobenzene. After the reaction, the product is purified by extraction, drying
First, 1,3 - difluorobenzene is used as the starting material. First, 1,3 - difluorobenzene is chloromethylated with paraformaldehyde, zinc chloride and concentrated hydrochloric acid under specific conditions. In this reaction, paraformaldehyde will be depolymerized to formaldehyde under the catalysis of zinc chloride and concentrated hydrochloric acid, and formaldehyde and concentrated hydrochloric acid will form chloromethyl positive ions, and then the benzene ring of 1,3 - difluorobenzene will be electrophilically substituted to mainly produce 2 - (chloromethyl) -1,3 - difluorobenzene, which may be accompanied by a small amount of 3 - (chloromethyl) -1,3 - difluorobenzene by-products. After the reaction is completed, the impurities are removed by water washing and alkali washing, and then the target product is separated and purified by distillation.
Second, 2-methyl-1,3-difluorobenzene is used as the raw material. 2-methyl-1,3-difluorobenzene is subjected to free radical substitution reaction with chlorine in the presence of light or initiator. The hydrogen atom on the methyl group will be gradually replaced by the chlorine atom to generate 2- (chloromethyl) -1,3-difluorobenzene. The reaction conditions, including the amount of chlorine gas introduced, the reaction temperature and the light intensity, need to be strictly controlled to reduce the formation of polychlorinated products. After the reaction is completed, 2- (chloromethyl) -1,3-difluorobenzene can be separated by rectifying and other techniques.
Third, 2- (bromomethyl) -1,3-difluorobenzene can also be started from 2- (bromomethyl) -1,3-difluorobenzene. The halogen exchange reaction between 2- (bromomethyl) -1,3-difluorobenzene and other chlorinated reagents such as lithium chloride occurs in an appropriate solvent (such as N, N-dimethylformamide). Bromine ions are exchanged with chloride ions to obtain 2- (chloromethyl) -1,3-difluorobenzene. After the reaction, the product is purified by extraction, drying
2- (chloromethyl) -1,3-difluorobenzene What are the precautions in storage and transportation?
2-%28chloromethyl%29-1%2C3-difluorobenzene, that is, 2- (chloromethyl) -1,3-difluorobenzene, there are many important things to pay attention to when storing and transporting this substance.
First of all, storage, because it has a certain chemical activity, it should be stored in a cool, dry and well-ventilated place. If placed in a high temperature or humid place, it may cause chemical reactions and cause it to deteriorate. And it needs to be kept away from fire and heat sources. Because it may be flammable, it is prone to danger in case of open flames and hot topics. It should be stored separately from oxidizing agents, acids, bases, etc., and must not be mixed. Different chemical substances may react violently from time to time, resulting in safety accidents. At the same time, the storage area should be equipped with suitable containment materials to prevent leakage from being handled in time and prevent the spread of pollutants.
As for transportation, the transportation vehicle must ensure that the vehicle is in good condition and has perfect fire and explosion-proof facilities. During transportation, it should be protected from exposure to the sun, rain and high temperature. When loading and unloading, it should be lightly loaded and unloaded. It is strictly forbidden to drop and heavy pressure to avoid material leakage due to damaged packaging. Transportation personnel must undergo professional training and be familiar with the characteristics of the chemical and emergency treatment methods. In the event of a leak during transportation, emergency measures should be taken quickly, evacuate the surrounding people, isolate the leaking area, and report to the relevant departments in a timely manner for proper disposal according to professional guidance.
In conclusion, when storing and transporting 2- (chloromethyl) -1,3-difluorobenzene, from environmental conditions to operating practices to emergency preparedness, it is essential to ensure the safety of its storage and transportation.
First of all, storage, because it has a certain chemical activity, it should be stored in a cool, dry and well-ventilated place. If placed in a high temperature or humid place, it may cause chemical reactions and cause it to deteriorate. And it needs to be kept away from fire and heat sources. Because it may be flammable, it is prone to danger in case of open flames and hot topics. It should be stored separately from oxidizing agents, acids, bases, etc., and must not be mixed. Different chemical substances may react violently from time to time, resulting in safety accidents. At the same time, the storage area should be equipped with suitable containment materials to prevent leakage from being handled in time and prevent the spread of pollutants.
As for transportation, the transportation vehicle must ensure that the vehicle is in good condition and has perfect fire and explosion-proof facilities. During transportation, it should be protected from exposure to the sun, rain and high temperature. When loading and unloading, it should be lightly loaded and unloaded. It is strictly forbidden to drop and heavy pressure to avoid material leakage due to damaged packaging. Transportation personnel must undergo professional training and be familiar with the characteristics of the chemical and emergency treatment methods. In the event of a leak during transportation, emergency measures should be taken quickly, evacuate the surrounding people, isolate the leaking area, and report to the relevant departments in a timely manner for proper disposal according to professional guidance.
In conclusion, when storing and transporting 2- (chloromethyl) -1,3-difluorobenzene, from environmental conditions to operating practices to emergency preparedness, it is essential to ensure the safety of its storage and transportation.
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