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2-(Chloromethyl)-1,4-Difluorobenzene
Linshang Chemical
|
HS Code |
286842 |
| Chemical Formula | C7H5ClF2 |
| Molecular Weight | 162.564 |
| Appearance | Liquid (likely, based on similar compounds) |
| Solubility In Water | Low (aromatic halides are generally hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, toluene (common for aromatic halides) |
| Vapor Pressure | Low (due to its relatively high molecular weight and non - volatile nature typical of aromatic halides) |
As an accredited 2-(Chloromethyl)-1,4-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2-(chloromethyl)-1,4 - difluorobenzene packaged in a sealed glass bottle. |
| Storage | 2-(Chloromethyl)-1,4 -difluorobenzene should be stored in a cool, dry, well - ventilated area, away from direct sunlight. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials like stainless steel or certain plastics. Store it separately from oxidizing agents, strong bases, and reactive chemicals to prevent unwanted reactions. |
| Shipping | 2-(Chloromethyl)-1,4 -difluorobenzene is shipped in well - sealed, corrosion - resistant containers. Strict safety protocols are followed, ensuring compliance with regulations for transporting hazardous chemicals to prevent spills and environmental risks. |
Competitive 2-(Chloromethyl)-1,4-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the main use of 2- (chloromethyl) -1,4-difluorobenzene?
2-%28chloromethyl%29-1%2C4-difluorobenzene is 2- (chloromethyl) -1,4-difluorobenzene, which is widely used in the chemical industry.
One of them is a key intermediate in organic synthesis. Organic synthesis is like building a delicate chemical building project, and 2- (chloromethyl) -1,4-difluorobenzene is an indispensable cornerstone raw material. With its unique chemical structure, the combination of chloromethyl and difluorobenzene ring allows chemists to use many chemical reactions, such as nucleophilic substitution, to introduce other specific functional groups, thereby constructing organic compounds with more complex structures and more unique functions. Such as the preparation of certain pharmaceutical intermediates with specific pharmacological activities, or the synthesis of material monomers with special properties, 2- (chloromethyl) -1,4-difluorobenzene plays an important role as a starting material, opening up a rich and diverse synthesis path.
Second, it also has important value in the field of materials science. With the rapid development of materials science, the demand for materials with special properties is increasing day by day. 2- (chloromethyl) -1,4-difluorobenzene can participate in the synthesis of new polymer materials. For example, when this substance is introduced in the synthesis of fluoropolymers, the properties of fluorine atoms give the polymers excellent chemical resistance, low surface energy and good thermal stability. Such fluoropolymers are widely used in high-end fields such as aerospace and electronics industries. For example, coating materials for aerospace vehicles require excellent weather resistance and chemical stability. Insulating materials used in the electronics industry to make high-performance circuit boards require materials to have good thermal stability and electrical properties. 2- (chloromethyl) -1,4-difluorobenzene lays the foundation for material performance improvement in this process.
Third, it has also emerged in the field of pharmaceutical research and development. Drug research and development aims to find compounds with specific biological activities that are safe and effective. 2- (chloromethyl) -1,4-difluorobenzene, as an intermediate, can be chemically modified and converted to synthesize compounds with potential pharmacological activities. Due to its fluorine-containing structure, it can affect the lipid solubility, metabolic stability, and interaction with biological targets of drug molecules, which can help improve drug efficacy, prolong action time, or reduce toxic and side effects. Researchers have cleverly designed a synthetic route with 2- (chloromethyl) -1,4-difluorobenzene as the starting point to screen for lead compounds with the potential to treat specific diseases, paving the way for the development of new drugs.
One of them is a key intermediate in organic synthesis. Organic synthesis is like building a delicate chemical building project, and 2- (chloromethyl) -1,4-difluorobenzene is an indispensable cornerstone raw material. With its unique chemical structure, the combination of chloromethyl and difluorobenzene ring allows chemists to use many chemical reactions, such as nucleophilic substitution, to introduce other specific functional groups, thereby constructing organic compounds with more complex structures and more unique functions. Such as the preparation of certain pharmaceutical intermediates with specific pharmacological activities, or the synthesis of material monomers with special properties, 2- (chloromethyl) -1,4-difluorobenzene plays an important role as a starting material, opening up a rich and diverse synthesis path.
Second, it also has important value in the field of materials science. With the rapid development of materials science, the demand for materials with special properties is increasing day by day. 2- (chloromethyl) -1,4-difluorobenzene can participate in the synthesis of new polymer materials. For example, when this substance is introduced in the synthesis of fluoropolymers, the properties of fluorine atoms give the polymers excellent chemical resistance, low surface energy and good thermal stability. Such fluoropolymers are widely used in high-end fields such as aerospace and electronics industries. For example, coating materials for aerospace vehicles require excellent weather resistance and chemical stability. Insulating materials used in the electronics industry to make high-performance circuit boards require materials to have good thermal stability and electrical properties. 2- (chloromethyl) -1,4-difluorobenzene lays the foundation for material performance improvement in this process.
Third, it has also emerged in the field of pharmaceutical research and development. Drug research and development aims to find compounds with specific biological activities that are safe and effective. 2- (chloromethyl) -1,4-difluorobenzene, as an intermediate, can be chemically modified and converted to synthesize compounds with potential pharmacological activities. Due to its fluorine-containing structure, it can affect the lipid solubility, metabolic stability, and interaction with biological targets of drug molecules, which can help improve drug efficacy, prolong action time, or reduce toxic and side effects. Researchers have cleverly designed a synthetic route with 2- (chloromethyl) -1,4-difluorobenzene as the starting point to screen for lead compounds with the potential to treat specific diseases, paving the way for the development of new drugs.
What are the physical properties of 2- (chloromethyl) -1,4-difluorobenzene
2-%28chloromethyl%29-1%2C4-difluorobenzene, namely 2- (chloromethyl) -1,4-difluorobenzene, its physical properties are as follows:
This substance is mostly liquid at room temperature, and it looks clear and transparent, or has a slight light color. It has a special smell, but the smell is not pleasant, or uncomfortable, and has a certain volatility. It can slowly diffuse in the air.
2- (chloromethyl) -1,4-difluorobenzene has a density different from that of water and is heavier than water. If it is mixed with water, it will sink to the bottom of the water. Its boiling point is in a specific temperature range. At this temperature, the liquid state will change to a gaseous state. The melting point is also a fixed value. When the temperature drops below the melting point, the substance will condense from a liquid state to a solid state.
This compound is insoluble in water and difficult to blend with water, but it is soluble in organic solvents such as ethanol and ether, and can be uniformly dispersed in such solvents. In addition, due to the structure of chloromethyl and difluorobenzene, it is chemically active. It can be used as a key intermediate in the field of organic synthesis, participating in various chemical reactions, and then preparing various organic compounds.
This substance is mostly liquid at room temperature, and it looks clear and transparent, or has a slight light color. It has a special smell, but the smell is not pleasant, or uncomfortable, and has a certain volatility. It can slowly diffuse in the air.
2- (chloromethyl) -1,4-difluorobenzene has a density different from that of water and is heavier than water. If it is mixed with water, it will sink to the bottom of the water. Its boiling point is in a specific temperature range. At this temperature, the liquid state will change to a gaseous state. The melting point is also a fixed value. When the temperature drops below the melting point, the substance will condense from a liquid state to a solid state.
This compound is insoluble in water and difficult to blend with water, but it is soluble in organic solvents such as ethanol and ether, and can be uniformly dispersed in such solvents. In addition, due to the structure of chloromethyl and difluorobenzene, it is chemically active. It can be used as a key intermediate in the field of organic synthesis, participating in various chemical reactions, and then preparing various organic compounds.
What are the chemical properties of 2- (chloromethyl) -1,4-difluorobenzene?
2-%28chloromethyl%29-1%2C4-difluorobenzene, Chinese name 2- (chloromethyl) -1,4-difluorobenzene, is an organic compound with specific chemical properties.
Among its chemical properties, chloromethyl has high activity. The chloromethyl group of halogenated hydrocarbons can undergo nucleophilic substitution reaction. When encountering nucleophilic reagents, such as sodium alcohols and amines, chlorine atoms can be replaced. Sodium alcohols react with it, and chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds; when reacting with amines, nitrogen-containing derivatives are formed. This reaction occurs because chlorine atoms are easy to leave, and nucleophilic reagents are easy to attack electron-deficient carbon.
Because the benzene ring has a conjugated system, its properties are stable, but it can also occur electrophilic sub Although the fluorine atoms in difluorobenzene have electron-sucking induction effect and electron-giving conjugation effect, the overall electron cloud density of the benzene ring is reduced, and the electrophilic substitution reaction activity is slightly lower than that of benzene. However, under suitable conditions, it can still react with electrophilic reagents, such as bromine, nitric acid, etc. Halogenation and nitrification. And the fluorine atom localization effect will affect the reaction check point, so that the electrophilic reagents mainly attack the specific position of the benzene ring.
2- (chloromethyl) -1,4-difluorobenzene has active chemical properties. The main reaction types are chloromethyl nucleophilic substitution and benzene ring electrophilic substitution. It has a wide range of
Among its chemical properties, chloromethyl has high activity. The chloromethyl group of halogenated hydrocarbons can undergo nucleophilic substitution reaction. When encountering nucleophilic reagents, such as sodium alcohols and amines, chlorine atoms can be replaced. Sodium alcohols react with it, and chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds; when reacting with amines, nitrogen-containing derivatives are formed. This reaction occurs because chlorine atoms are easy to leave, and nucleophilic reagents are easy to attack electron-deficient carbon.
Because the benzene ring has a conjugated system, its properties are stable, but it can also occur electrophilic sub Although the fluorine atoms in difluorobenzene have electron-sucking induction effect and electron-giving conjugation effect, the overall electron cloud density of the benzene ring is reduced, and the electrophilic substitution reaction activity is slightly lower than that of benzene. However, under suitable conditions, it can still react with electrophilic reagents, such as bromine, nitric acid, etc. Halogenation and nitrification. And the fluorine atom localization effect will affect the reaction check point, so that the electrophilic reagents mainly attack the specific position of the benzene ring.
2- (chloromethyl) -1,4-difluorobenzene has active chemical properties. The main reaction types are chloromethyl nucleophilic substitution and benzene ring electrophilic substitution. It has a wide range of
What are the synthesis methods of 2- (chloromethyl) -1,4-difluorobenzene
There are several common methods for synthesizing 2 - (chloromethyl) -1,4 - difluorobenzene.
One is the halogenated benzyl method. First, take 1,4 - difluorobenzene and make it react with paraformaldehyde and hydrogen chloride under the action of a specific catalyst. This reaction requires a suitable temperature and pressure. Usually, the temperature should be controlled at tens of degrees Celsius, and the pressure is slightly higher than normal pressure. After depolymerization of paraformaldehyde, formaldehyde and 1,4 - difluorobenzene with the help of a catalyst undergo an electrophilic substitution reaction to form an intermediate product, and then react with hydrogen chloride to obtain 2- (chloromethyl) -1,4 - difluorobenzene. The catalyst used, or Lewis acid or the like, such as anhydrous zinc chloride, can effectively promote the reaction process, improve the reaction rate and yield.
The second is the chloromethylation reagent method. Chloromethylation reagents such as chloromethyl ether can be selected to react with 1,4-difluorobenzene under appropriate conditions. In this process, the choice of reaction solvent is very critical, and inert organic solvents such as dichloromethane are often selected to ensure the smooth progress of the reaction. During the reaction, the chloromethyl part of chloromethyl methyl ether is attracted by the electron cloud of 1,4-difluorobenzene benzene ring, and electrophilic substitution occurs. However, this reagent is highly toxic, and special attention needs to be paid to protection during operation, and fine post-reaction treatment is also required to remove residual toxic reagents.
The third is the halogenated hydrocarbon substitution method. If there is a suitable halogenated difluorobenzene derivative, and there is a substitutable group adjacent to the carbon attached to the halogen atom, it can react with the chloromethylating reagent in the presence of a base. The base can promote the departure of halogenated hydrocarbons and the smooth substitution of chloromethyl. For example, a weak base such as potassium carbonate is appropriate, and the reaction conditions are controlled to make the reaction proceed in the direction of generating 2- (chloromethyl) -1,4-difluorobenzene. This method requires high raw materials and requires halogenated difluorobenzene derivatives with specific structures, but its selectivity or high selectivity. If the raw materials are easily available, it is also a feasible synthesis path.
One is the halogenated benzyl method. First, take 1,4 - difluorobenzene and make it react with paraformaldehyde and hydrogen chloride under the action of a specific catalyst. This reaction requires a suitable temperature and pressure. Usually, the temperature should be controlled at tens of degrees Celsius, and the pressure is slightly higher than normal pressure. After depolymerization of paraformaldehyde, formaldehyde and 1,4 - difluorobenzene with the help of a catalyst undergo an electrophilic substitution reaction to form an intermediate product, and then react with hydrogen chloride to obtain 2- (chloromethyl) -1,4 - difluorobenzene. The catalyst used, or Lewis acid or the like, such as anhydrous zinc chloride, can effectively promote the reaction process, improve the reaction rate and yield.
The second is the chloromethylation reagent method. Chloromethylation reagents such as chloromethyl ether can be selected to react with 1,4-difluorobenzene under appropriate conditions. In this process, the choice of reaction solvent is very critical, and inert organic solvents such as dichloromethane are often selected to ensure the smooth progress of the reaction. During the reaction, the chloromethyl part of chloromethyl methyl ether is attracted by the electron cloud of 1,4-difluorobenzene benzene ring, and electrophilic substitution occurs. However, this reagent is highly toxic, and special attention needs to be paid to protection during operation, and fine post-reaction treatment is also required to remove residual toxic reagents.
The third is the halogenated hydrocarbon substitution method. If there is a suitable halogenated difluorobenzene derivative, and there is a substitutable group adjacent to the carbon attached to the halogen atom, it can react with the chloromethylating reagent in the presence of a base. The base can promote the departure of halogenated hydrocarbons and the smooth substitution of chloromethyl. For example, a weak base such as potassium carbonate is appropriate, and the reaction conditions are controlled to make the reaction proceed in the direction of generating 2- (chloromethyl) -1,4-difluorobenzene. This method requires high raw materials and requires halogenated difluorobenzene derivatives with specific structures, but its selectivity or high selectivity. If the raw materials are easily available, it is also a feasible synthesis path.
2- (chloromethyl) -1,4-difluorobenzene What are the precautions in storage and transportation?
2-%28chloromethyl%29-1%2C4-difluorobenzene is 2- (chloromethyl) -1,4-difluorobenzene. When storing and transporting this substance, many matters need to be paid attention to.
First, it is related to storage. Because it has a certain chemical activity, it must be stored in a cool, dry and well-ventilated place. Avoid heat and fire to prevent fire or accelerate its chemical reaction. The substance should be stored in a sealed container to prevent contact with air and moisture. It may deteriorate due to reactions such as hydrolysis in contact with water or humid air, affecting its quality and performance. In addition, it needs to be stored separately from oxidants, strong bases and other substances, because it may react violently with these substances, endangering storage safety.
Second, about transportation. Before transportation, ensure that the packaging is intact. Packaging materials need to be able to resist vibration, collision and friction to prevent material leakage caused by damage to the container. During transportation, temperature should be strictly controlled to avoid high temperature environments. At the same time, transportation vehicles need to be equipped with corresponding fire protection equipment and leakage emergency treatment equipment for emergencies. Transportation personnel also need to be professionally trained to be familiar with the characteristics of the substance and emergency treatment methods. If a leak occurs during transportation, surrounding personnel should be evacuated quickly and access should be strictly restricted. Emergency response personnel need to wear protective equipment and properly handle leaks according to established procedures.
First, it is related to storage. Because it has a certain chemical activity, it must be stored in a cool, dry and well-ventilated place. Avoid heat and fire to prevent fire or accelerate its chemical reaction. The substance should be stored in a sealed container to prevent contact with air and moisture. It may deteriorate due to reactions such as hydrolysis in contact with water or humid air, affecting its quality and performance. In addition, it needs to be stored separately from oxidants, strong bases and other substances, because it may react violently with these substances, endangering storage safety.
Second, about transportation. Before transportation, ensure that the packaging is intact. Packaging materials need to be able to resist vibration, collision and friction to prevent material leakage caused by damage to the container. During transportation, temperature should be strictly controlled to avoid high temperature environments. At the same time, transportation vehicles need to be equipped with corresponding fire protection equipment and leakage emergency treatment equipment for emergencies. Transportation personnel also need to be professionally trained to be familiar with the characteristics of the substance and emergency treatment methods. If a leak occurs during transportation, surrounding personnel should be evacuated quickly and access should be strictly restricted. Emergency response personnel need to wear protective equipment and properly handle leaks according to established procedures.
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