Linshang Chemical
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2-(Chloromethyl)-1-Fluoro-4-Methoxybenzene
Linshang Chemical
|
HS Code |
395546 |
| Chemical Formula | C8H8ClFO |
| Molar Mass | 174.599 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approx. 210 - 212 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, ethyl acetate |
| Vapor Pressure | Low vapor pressure at room temperature |
| Odor | Characteristic organic odor |
As an accredited 2-(Chloromethyl)-1-Fluoro-4-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2-(chloromethyl)-1-fluoro-4-methoxybenzene packaged in a sealed, labeled bottle. |
| Storage | 2-(Chloromethyl)-1-fluoro-4-methoxybenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent vapor leakage. As it is a potentially hazardous chemical, ensure storage is in a location accessible only to authorized personnel, in compliance with safety regulations. |
| Shipping | 2-(Chloromethyl)-1 -fluoro-4-methoxybenzene, a chemical, is shipped in properly sealed and labeled containers. Compliance with hazardous material shipping regulations ensures safe transport to prevent leakage and potential risks. |
Competitive 2-(Chloromethyl)-1-Fluoro-4-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-(Chloromethyl)-1-Fluoro-4-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2- (chloromethyl) -1-fluoro-4-methoxybenzene?
2-%28chloromethyl%29-1-fluoro-4-methoxybenzene is 2 - (chloromethyl) -1 -fluoro-4 -methoxybenzene, which has a wide range of uses.
In the field of organic synthesis, it can be used as a key intermediate. Because the molecule contains active groups such as chloromethyl, fluorine atom and methoxy group, many organic compounds with different structures can be derived through a series of chemical reactions, such as nucleophilic substitution and coupling reactions. For example, nucleophiles can be substituted with chloromethyl to form new carbon-heteroatomic bonds, thereby preparing pharmaceutical intermediates or fine chemicals with specific functions.
In the field of medicinal chemistry, this is used as a starting material to synthesize biologically active compounds through multi-step reactions. Due to the unique electronic effects of fluorine atoms and the emission characteristics of bioelectronics, the introduction of fluorine-containing groups can often improve the fat solubility, metabolic stability and binding ability of drug molecules to targets. In the development of some anticancer and antimicrobial drugs, 2- (chloromethyl) -1 -fluoro-4 -methoxybenzene may be involved as an important intermediate to help design and synthesize innovative drugs with better efficacy and fewer side effects.
It is also useful in materials science. It can be introduced into the main chain or side chain of polymer materials through polymerization or modification reactions to endow materials with novel properties. For example, improving the surface properties, optical properties or electrical properties of materials provides new paths and options for the preparation of new functional materials.
In summary, 2- (chloromethyl) -1 -fluoro-4 -methoxybenzene has shown important uses in organic synthesis, drug development, materials science and other fields due to its unique chemical structure, providing a key material basis and possibility for innovation and development in various fields.
In the field of organic synthesis, it can be used as a key intermediate. Because the molecule contains active groups such as chloromethyl, fluorine atom and methoxy group, many organic compounds with different structures can be derived through a series of chemical reactions, such as nucleophilic substitution and coupling reactions. For example, nucleophiles can be substituted with chloromethyl to form new carbon-heteroatomic bonds, thereby preparing pharmaceutical intermediates or fine chemicals with specific functions.
In the field of medicinal chemistry, this is used as a starting material to synthesize biologically active compounds through multi-step reactions. Due to the unique electronic effects of fluorine atoms and the emission characteristics of bioelectronics, the introduction of fluorine-containing groups can often improve the fat solubility, metabolic stability and binding ability of drug molecules to targets. In the development of some anticancer and antimicrobial drugs, 2- (chloromethyl) -1 -fluoro-4 -methoxybenzene may be involved as an important intermediate to help design and synthesize innovative drugs with better efficacy and fewer side effects.
It is also useful in materials science. It can be introduced into the main chain or side chain of polymer materials through polymerization or modification reactions to endow materials with novel properties. For example, improving the surface properties, optical properties or electrical properties of materials provides new paths and options for the preparation of new functional materials.
In summary, 2- (chloromethyl) -1 -fluoro-4 -methoxybenzene has shown important uses in organic synthesis, drug development, materials science and other fields due to its unique chemical structure, providing a key material basis and possibility for innovation and development in various fields.
What are the physical properties of 2- (chloromethyl) -1-fluoro-4-methoxybenzene
2 - (chloromethyl) -1 -fluoro-4 -methoxybenzene, is a kind of organic compound. Its physical properties are well-researched.
In terms of its appearance, under room temperature and pressure, it often appears colorless to pale yellow liquid. The view is clear, like ancient dew, or shimmering in sunlight. Its smell may have a special aroma, but this fragrance is not pleasant and fragrant, but has a pungent smell of chemicals, which makes people feel strong.
As for the boiling point, it is about a specific temperature range, which depends on the strength of the intermolecular force. Just like ancient man-made utensils, the grasp of the temperature is related to the formation of the utensils, and the exact value of the boiling point is of great significance for its separation, purification and other operations. After experimental investigation, the number of its boiling point can be used as a guide for chemical operations.
Melting point is also an important physical property. The state of the melting point of this object, such as the freezing of water in winter, the molecular arrangement tends to be orderly from disorder. The value of the melting point can help identify its purity. If the purity is high, the melting point is close to the theoretical value, like the edge of a good sword, pure and sharp.
In terms of solubility, it may have better solubility in organic solvents, such as ethanol and ether. This is due to the principle of "similarity and dissolution". Its molecular structure fits with the molecules of organic solvents, just like tenon and mortise. In water, due to the difference between molecular polarity and water, the dissolution is not good, such as oil floating in water, and the two are difficult to blend.
Density is also an irreversible property. Its density value can be compared with water or other common liquids. If the density is greater than water, it sinks in water, just like a stone sinking to the bottom of the abyss; if it is less than water, it floats on water, like a wood drifting in the flow. This property can be an important basis in experimental operations such as separation and extraction.
In summary, the physical properties of 2 - (chloromethyl) -1 -fluoro-4 -methoxybenzene are of great value in the fields of chemical industry and scientific research, and can be the cornerstone for exploring its chemical behavior and application.
In terms of its appearance, under room temperature and pressure, it often appears colorless to pale yellow liquid. The view is clear, like ancient dew, or shimmering in sunlight. Its smell may have a special aroma, but this fragrance is not pleasant and fragrant, but has a pungent smell of chemicals, which makes people feel strong.
As for the boiling point, it is about a specific temperature range, which depends on the strength of the intermolecular force. Just like ancient man-made utensils, the grasp of the temperature is related to the formation of the utensils, and the exact value of the boiling point is of great significance for its separation, purification and other operations. After experimental investigation, the number of its boiling point can be used as a guide for chemical operations.
Melting point is also an important physical property. The state of the melting point of this object, such as the freezing of water in winter, the molecular arrangement tends to be orderly from disorder. The value of the melting point can help identify its purity. If the purity is high, the melting point is close to the theoretical value, like the edge of a good sword, pure and sharp.
In terms of solubility, it may have better solubility in organic solvents, such as ethanol and ether. This is due to the principle of "similarity and dissolution". Its molecular structure fits with the molecules of organic solvents, just like tenon and mortise. In water, due to the difference between molecular polarity and water, the dissolution is not good, such as oil floating in water, and the two are difficult to blend.
Density is also an irreversible property. Its density value can be compared with water or other common liquids. If the density is greater than water, it sinks in water, just like a stone sinking to the bottom of the abyss; if it is less than water, it floats on water, like a wood drifting in the flow. This property can be an important basis in experimental operations such as separation and extraction.
In summary, the physical properties of 2 - (chloromethyl) -1 -fluoro-4 -methoxybenzene are of great value in the fields of chemical industry and scientific research, and can be the cornerstone for exploring its chemical behavior and application.
What are the synthesis methods of 2- (chloromethyl) -1-fluoro-4-methoxybenzene
To prepare 2 - (chloromethyl) -1 - fluoro - 4 - methoxybenzene, the following methods can be used.
First, 4 - methoxy - 2 - fluorotoluene is used as the starting material. First, N - chlorosuccinimide (NCS) is used as a chlorination reagent, and in the presence of an initiator such as benzoyl peroxide (BPO) or azobisisobutyronitrile (AIBN), heating or light initiates a free radical reaction. In this process, NCS provides chlorine radicals, captures hydrogen atoms on 4-methoxy-2-fluorotoluene methyl, generates benzyl radicals, and then combines with chlorine radicals to obtain the target product 2- (chloromethyl) -1 -fluoro-4-methoxybenzene. The reaction needs to be carried out in an inert solvent such as carbon tetrachloride to ensure a smooth reaction, and can better control the reaction process and selectivity.
Second, start from 4-methoxy-2-fluorobenzoic acid. First reduce it to 4-methoxy-2-fluorobenzyl alcohol, and reducing agents such as lithium aluminum hydride (LiAlH) or sodium borohydride (NaBH) can be selected. Taking LiAlHas an example, add LiAlHslowly at low temperature in an anhydrous ether or tetrahydrofuran solvent, and carefully hydrolyze after the reaction to obtain 4-methoxy-2-fluorobenzyl alcohol. Subsequently, 4-methoxy-2-fluorobenzyl alcohol is reacted with chlorinated reagents such as sulfoxide chloride (SOCl ²) or phosphorus trichloride (PCl ²). Taking thionyl chloride as an example, under the catalysis of an organic base such as pyridine, the alcohol hydroxyl group is replaced by a chlorine atom at an appropriate temperature to generate 2- (chloromethyl) -1 -fluoro-4 -methoxybenzene.
Third, 4-methoxy-2-fluorobromobenzene is reacted with formaldehyde and zinc chloride-hydrochloric acid system. This is a chloromethylation reaction. 4-Methoxy-2-fluorobromobenzene reacts with formaldehyde in hydrochloric acid solution catalyzed by zinc chloride, formaldehyde and hydrogen chloride form chloromethyl positive ions, attack the benzene ring, and introduce chloromethyl at a specific position in the benzene ring through electrophilic substitution reaction to obtain 2- (chloromethyl) -1-fluoro-4-methoxybenzene. The reaction temperature, the proportion of reactants and other conditions need to be controlled to improve the yield and selectivity.
First, 4 - methoxy - 2 - fluorotoluene is used as the starting material. First, N - chlorosuccinimide (NCS) is used as a chlorination reagent, and in the presence of an initiator such as benzoyl peroxide (BPO) or azobisisobutyronitrile (AIBN), heating or light initiates a free radical reaction. In this process, NCS provides chlorine radicals, captures hydrogen atoms on 4-methoxy-2-fluorotoluene methyl, generates benzyl radicals, and then combines with chlorine radicals to obtain the target product 2- (chloromethyl) -1 -fluoro-4-methoxybenzene. The reaction needs to be carried out in an inert solvent such as carbon tetrachloride to ensure a smooth reaction, and can better control the reaction process and selectivity.
Second, start from 4-methoxy-2-fluorobenzoic acid. First reduce it to 4-methoxy-2-fluorobenzyl alcohol, and reducing agents such as lithium aluminum hydride (LiAlH) or sodium borohydride (NaBH) can be selected. Taking LiAlHas an example, add LiAlHslowly at low temperature in an anhydrous ether or tetrahydrofuran solvent, and carefully hydrolyze after the reaction to obtain 4-methoxy-2-fluorobenzyl alcohol. Subsequently, 4-methoxy-2-fluorobenzyl alcohol is reacted with chlorinated reagents such as sulfoxide chloride (SOCl ²) or phosphorus trichloride (PCl ²). Taking thionyl chloride as an example, under the catalysis of an organic base such as pyridine, the alcohol hydroxyl group is replaced by a chlorine atom at an appropriate temperature to generate 2- (chloromethyl) -1 -fluoro-4 -methoxybenzene.
Third, 4-methoxy-2-fluorobromobenzene is reacted with formaldehyde and zinc chloride-hydrochloric acid system. This is a chloromethylation reaction. 4-Methoxy-2-fluorobromobenzene reacts with formaldehyde in hydrochloric acid solution catalyzed by zinc chloride, formaldehyde and hydrogen chloride form chloromethyl positive ions, attack the benzene ring, and introduce chloromethyl at a specific position in the benzene ring through electrophilic substitution reaction to obtain 2- (chloromethyl) -1-fluoro-4-methoxybenzene. The reaction temperature, the proportion of reactants and other conditions need to be controlled to improve the yield and selectivity.
2- (chloromethyl) -1-fluoro-4-methoxybenzene What are the precautions in storage and transportation
2-%28chloromethyl%29-1-fluoro-4-methoxybenzene is 2- (chloromethyl) -1 -fluoro-4 -methoxybenzene, which is an organic compound. During storage and transportation, many matters should be paid attention to to to avoid danger and endanger personnel and the environment.
First, when storing, be sure to place it in a cool and ventilated warehouse. Due to its nature or instability, high temperature and unventilated environment are prone to chemical reactions or cause danger. And the warehouse temperature should not be too high, should be strictly controlled to prevent the compound from deteriorating or volatilizing.
Second, keep away from fire and heat sources. This compound may be flammable. In case of open flame, hot topic or cause combustion and explosion, fireworks are strictly prohibited in storage and transportation places. All electrical equipment and tools should have explosion-proof functions.
Third, it should be stored separately from oxidizing agents, acids, alkalis, etc., and should not be mixed. Due to its active chemical properties, contact with these substances or violent chemical reactions can produce toxic gases, heat, and even explosions.
Fourth, the container in which the substance is stored must be tightly sealed to prevent leakage. If leakage occurs, it will not only cause environmental pollution, but also pose a threat to human health. When transporting, it is necessary to ensure that the container does not leak, collapse, fall, or damage.
Fifth, during transportation, drive strictly according to the specified route, and do not stop in densely populated areas and residential areas. In the event of an accident, the harm will be greater in densely populated areas. At the same time, transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment in order to respond to emergencies in a timely manner.
Sixth, those who operate and come into contact with this compound need to receive professional training and strictly abide by the operating procedures. When operating, appropriate protective equipment should be worn, such as gloves, goggles, protective clothing, etc., to avoid direct contact and prevent harm to the body.
First, when storing, be sure to place it in a cool and ventilated warehouse. Due to its nature or instability, high temperature and unventilated environment are prone to chemical reactions or cause danger. And the warehouse temperature should not be too high, should be strictly controlled to prevent the compound from deteriorating or volatilizing.
Second, keep away from fire and heat sources. This compound may be flammable. In case of open flame, hot topic or cause combustion and explosion, fireworks are strictly prohibited in storage and transportation places. All electrical equipment and tools should have explosion-proof functions.
Third, it should be stored separately from oxidizing agents, acids, alkalis, etc., and should not be mixed. Due to its active chemical properties, contact with these substances or violent chemical reactions can produce toxic gases, heat, and even explosions.
Fourth, the container in which the substance is stored must be tightly sealed to prevent leakage. If leakage occurs, it will not only cause environmental pollution, but also pose a threat to human health. When transporting, it is necessary to ensure that the container does not leak, collapse, fall, or damage.
Fifth, during transportation, drive strictly according to the specified route, and do not stop in densely populated areas and residential areas. In the event of an accident, the harm will be greater in densely populated areas. At the same time, transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment in order to respond to emergencies in a timely manner.
Sixth, those who operate and come into contact with this compound need to receive professional training and strictly abide by the operating procedures. When operating, appropriate protective equipment should be worn, such as gloves, goggles, protective clothing, etc., to avoid direct contact and prevent harm to the body.
What are the effects of 2- (chloromethyl) -1-fluoro-4-methoxybenzene on the environment and human health?
2-%28chloromethyl%29-1-fluoro-4-methoxybenzene is 2- (chloromethyl) -1 -fluoro-4 -methoxybenzene, which is an organic compound. Its impact on the environment and human health cannot be ignored.
In terms of the environment, after entering the natural environment, it may be difficult to be rapidly degraded by microorganisms, and then retained for a long time. If released in water bodies, it can cause water pollution and affect the survival of aquatic organisms. Because it has certain toxicity, it may interfere with the physiological functions of aquatic organisms, such as hindering their growth and development, affecting reproduction, and even causing death. Flowing into the soil can change the physical and chemical properties of the soil, affect the structure and function of soil microbial communities, and then affect plant growth. And because of its volatilization, after entering the atmosphere, or participating in photochemical reactions, it causes adverse effects on air quality.
As for human health, it enters the human body through respiratory inhalation, skin contact or accidental ingestion. When inhaled, it may irritate the respiratory mucosa, causing symptoms such as cough and asthma, and long-term contact or damage lung function. Skin contact can cause skin allergies, redness, swelling, itching, etc. If ingested by mistake, it will irritate the gastrointestinal tract, causing nausea, vomiting, abdominal pain and other digestive system symptoms. What's more, the compound may have potential carcinogenicity, teratogenicity and mutagenicity. Long-term exposure or increase the risk of cancer, affect the normal development of the fetus, and cause gene mutations. Therefore, in the production, use and disposal of substances containing 2- (chloromethyl) -1 -fluoro-4 -methoxybenzene, strict protective measures must be taken to reduce the harm to the environment and human health.
In terms of the environment, after entering the natural environment, it may be difficult to be rapidly degraded by microorganisms, and then retained for a long time. If released in water bodies, it can cause water pollution and affect the survival of aquatic organisms. Because it has certain toxicity, it may interfere with the physiological functions of aquatic organisms, such as hindering their growth and development, affecting reproduction, and even causing death. Flowing into the soil can change the physical and chemical properties of the soil, affect the structure and function of soil microbial communities, and then affect plant growth. And because of its volatilization, after entering the atmosphere, or participating in photochemical reactions, it causes adverse effects on air quality.
As for human health, it enters the human body through respiratory inhalation, skin contact or accidental ingestion. When inhaled, it may irritate the respiratory mucosa, causing symptoms such as cough and asthma, and long-term contact or damage lung function. Skin contact can cause skin allergies, redness, swelling, itching, etc. If ingested by mistake, it will irritate the gastrointestinal tract, causing nausea, vomiting, abdominal pain and other digestive system symptoms. What's more, the compound may have potential carcinogenicity, teratogenicity and mutagenicity. Long-term exposure or increase the risk of cancer, affect the normal development of the fetus, and cause gene mutations. Therefore, in the production, use and disposal of substances containing 2- (chloromethyl) -1 -fluoro-4 -methoxybenzene, strict protective measures must be taken to reduce the harm to the environment and human health.
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