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2-(Chloromethyl)-1-Fluoro-4-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
162248 |
| Chemical Formula | C8H5ClF4 |
| Molecular Weight | 212.57 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 170 - 175 °C |
| Density | Around 1.35 - 1.45 g/cm³ |
| Solubility | Insoluble in water, soluble in organic solvents like ethanol, ether |
| Vapor Pressure | Low at room temperature |
| Flash Point | Around 60 - 70 °C |
| Refractive Index | Typically around 1.42 - 1.44 |
As an accredited 2-(Chloromethyl)-1-Fluoro-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2-(chloromethyl)-1-fluoro-4-(trifluoromethyl)benzene in a sealed, corrosion - resistant container. |
| Storage | Store 2-(chloromethyl)-1-fluoro-4-(trifluoromethyl)benzene in a cool, dry, well - ventilated area away from sources of heat, ignition, and oxidizing agents. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Avoid storing near incompatible substances to prevent potential reactions. |
| Shipping | 2-(Chloromethyl)-1-fluoro-4-(trifluoromethyl)benzene is shipped in accordance with strict chemical regulations. It's typically in sealed, specialized containers to prevent leakage and ensure safe transport during handling and transit. |
Competitive 2-(Chloromethyl)-1-Fluoro-4-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 2-(Chloromethyl)-1-Fluoro-4-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2- (chloromethyl) -1-fluoro-4- (trifluoromethyl) benzene?
2-%28chloromethyl%29-1-fluoro-4-%28trifluoromethyl%29benzene, Chinese name 2 - (chloromethyl) -1 -fluoro-4- (trifluoromethyl) benzene, this compound has a wide range of uses.
One of them is a key intermediate in the field of medicinal chemistry. Taking the synthesis of specific antifungal drugs as an example, the chloromethyl, fluorine and trifluoromethyl can precisely bind to specific targets in fungi. Chloromethyl has high activity and can form stable covalent bonds with some groups of the target through chemical reaction; fluorine atoms and trifluoromethyl can change the electron cloud distribution and lipid solubility of drug molecules, optimize the transmembrane transport of drugs and their affinity with targets, thereby enhancing the antifungal effect.
Second, in the field of materials science, it is an important raw material for the preparation of high-performance fluoropolymers. Through polymerization, the compound structural unit is introduced into the polymer backbone, giving the material unique properties. Due to the high electronegativity of fluorine atoms, the formed C-F bond energy is high, which can improve the chemical stability and thermal stability of the polymer; the presence of trifluoromethyl increases the distance between molecular chains and reduces the intermolecular force, so that the polymer has low surface energy and low friction coefficient, which can be used to make self-cleaning materials, low friction coatings, etc.
Third, in the field of pesticide research and development, it can be used to create new insecticides. Its special structure interferes with the nervous system of insects or other physiological processes. For example, by simulating some neurotransmitter or hormone structures in insects, binding to corresponding receptors, blocking nerve signal transmission or interfering with insect growth and development regulation, to achieve insecticidal purposes. And its fluoride-containing structure helps to improve the stability and biological activity of pesticides in the environment, reducing the dosage and frequency of application.
One of them is a key intermediate in the field of medicinal chemistry. Taking the synthesis of specific antifungal drugs as an example, the chloromethyl, fluorine and trifluoromethyl can precisely bind to specific targets in fungi. Chloromethyl has high activity and can form stable covalent bonds with some groups of the target through chemical reaction; fluorine atoms and trifluoromethyl can change the electron cloud distribution and lipid solubility of drug molecules, optimize the transmembrane transport of drugs and their affinity with targets, thereby enhancing the antifungal effect.
Second, in the field of materials science, it is an important raw material for the preparation of high-performance fluoropolymers. Through polymerization, the compound structural unit is introduced into the polymer backbone, giving the material unique properties. Due to the high electronegativity of fluorine atoms, the formed C-F bond energy is high, which can improve the chemical stability and thermal stability of the polymer; the presence of trifluoromethyl increases the distance between molecular chains and reduces the intermolecular force, so that the polymer has low surface energy and low friction coefficient, which can be used to make self-cleaning materials, low friction coatings, etc.
Third, in the field of pesticide research and development, it can be used to create new insecticides. Its special structure interferes with the nervous system of insects or other physiological processes. For example, by simulating some neurotransmitter or hormone structures in insects, binding to corresponding receptors, blocking nerve signal transmission or interfering with insect growth and development regulation, to achieve insecticidal purposes. And its fluoride-containing structure helps to improve the stability and biological activity of pesticides in the environment, reducing the dosage and frequency of application.
What are the physical properties of 2- (chloromethyl) -1-fluoro-4- (trifluoromethyl) benzene
2-%28chloromethyl%29-1-fluoro-4-%28trifluoromethyl%29benzene, organic compounds are also. Its physical properties are quite important, and will be described in detail today.
Looking at its properties, under room temperature and pressure, this compound is mostly colorless to slightly yellow liquid. Its color is pure and moist, like the clarity of a clear spring. This liquid flows freely, just like smart water, showing its good fluidity.
When it comes to smell, this substance often emits a special aromatic smell. However, this aroma is not as rich and sweet as ordinary flowers, but has a special charm of an organic compound. Although it is not pungent, it can also be noticed.
As for the boiling point, it is about a specific temperature range. The value of this boiling point is closely related to the force between molecules. The strength of the interaction between molecules determines the energy required to convert from liquid to gaseous state. When the external temperature rises to the boiling point, the molecules are energized enough to break free from each other and form gaseous state.
In terms of melting point, there is also a specific value. At the melting point, the solid state and the liquid state reach equilibrium. Below the melting point, the molecules are arranged in an orderly manner, showing a regular solid state; above the melting point, the molecular activity intensifies and turns into a liquid state.
Solubility is also an important property. In organic solvents, such as common ethanol, ether, etc., 2-%28chloromethyl%29-1-fluoro-4-%28trifluoromethyl%29benzene have good solubility. Due to the principle of "similarity and miscibility", its molecular structure is compatible with the molecular structure of organic solvents, so it can blend with each other and mix into one. In water, its solubility is poor, because the polarity of water and the polarity of the compound are quite different, and the two are difficult to dissolve each other.
The value of density is relatively stable. Compared with water, its density is either light or heavy, which is of great significance in many practical applications. For example, in the process of liquid-liquid separation, the difference in density can help to realize the separation operation.
The physical properties of 2-%28chloromethyl%29-1-fluoro-4-%28trifluoromethyl%29benzene are of great value in chemical research, industrial production and other fields, providing a key basis for the development of related work.
Looking at its properties, under room temperature and pressure, this compound is mostly colorless to slightly yellow liquid. Its color is pure and moist, like the clarity of a clear spring. This liquid flows freely, just like smart water, showing its good fluidity.
When it comes to smell, this substance often emits a special aromatic smell. However, this aroma is not as rich and sweet as ordinary flowers, but has a special charm of an organic compound. Although it is not pungent, it can also be noticed.
As for the boiling point, it is about a specific temperature range. The value of this boiling point is closely related to the force between molecules. The strength of the interaction between molecules determines the energy required to convert from liquid to gaseous state. When the external temperature rises to the boiling point, the molecules are energized enough to break free from each other and form gaseous state.
In terms of melting point, there is also a specific value. At the melting point, the solid state and the liquid state reach equilibrium. Below the melting point, the molecules are arranged in an orderly manner, showing a regular solid state; above the melting point, the molecular activity intensifies and turns into a liquid state.
Solubility is also an important property. In organic solvents, such as common ethanol, ether, etc., 2-%28chloromethyl%29-1-fluoro-4-%28trifluoromethyl%29benzene have good solubility. Due to the principle of "similarity and miscibility", its molecular structure is compatible with the molecular structure of organic solvents, so it can blend with each other and mix into one. In water, its solubility is poor, because the polarity of water and the polarity of the compound are quite different, and the two are difficult to dissolve each other.
The value of density is relatively stable. Compared with water, its density is either light or heavy, which is of great significance in many practical applications. For example, in the process of liquid-liquid separation, the difference in density can help to realize the separation operation.
The physical properties of 2-%28chloromethyl%29-1-fluoro-4-%28trifluoromethyl%29benzene are of great value in chemical research, industrial production and other fields, providing a key basis for the development of related work.
Is 2- (chloromethyl) -1-fluoro-4- (trifluoromethyl) benzene chemically stable?
2- (chloromethyl) -1-fluoro-4- (trifluoromethyl) benzene is also an organic compound. The stability of its chemical properties needs to be investigated in many ways.
First, its structure. In this compound, the benzene ring is a stable conjugated system, but the substituents attached to the benzene ring have a great influence on its stability. In chloromethyl, the chlorine atom has an electron-sucking induction effect, which can reduce the electron cloud density of the benzene ring, and there is a p-π conjugation effect between the chlorine atom and the benzene ring. This conjugation effect is relatively weak. Overall, the presence of chloromethyl groups changes the activity of the benzene ring to a certain extent, which has a subtle impact on its stability. The fluorine atom also has a strong electron-absorbing effect, which further reduces the electron cloud density of the benzene ring, and the radius of the fluorine atom is small. After connecting with the benzene ring, the molecular space structure is compact, which affects the intermolecular force to a certain extent. Trifluoromethyl, due to the strong electron-absorbing action of three fluorine atoms, is a strong electron-absorbing group, which greatly reduces the electron cloud density of the benzene ring and has a significant impact on the stability of the benzene ring.
Re-view chemical reactivity. Due to the decrease in the electron cloud density of the benzene ring in its structure, the electrophilic substitution reaction activity is relatively low compared with that of benzene. For example, when halogenation, nitrification and other electrophilic substitution reactions occur, the reaction conditions are more severe than those of benzene. However, Chloromethyl, fluorine atom and trifluoromethyl are all ortho-para-sites. Although the electron cloud density of the benzene ring is reduced, in the electrophilic substitution reaction, the newly introduced groups tend to enter their ortho-sites.
As far as stability is concerned, this compound has certain stability under normal conditions without the action of special reagents due to the existence of the benzene ring conjugate system. In the presence of strong oxidizing agents, high temperatures or specific catalysts, the benzene ring or substituent can undergo chemical reactions, resulting in structural changes and loss of stability. In the case of strong oxidizing agents, the benzene ring may be oxidized to open the ring; at high temperatures, the substituent may undergo reactions such as elimination and rearrangement.
In summary, 2- (chloromethyl) -1-fluoro-4- (trifluoromethyl) benzene has certain stability under conventional conditions, but in a specific chemical environment, due to the influence of substituents, its chemical properties are active and its stability will be affected. Its stability is not absolute and varies with external conditions.
First, its structure. In this compound, the benzene ring is a stable conjugated system, but the substituents attached to the benzene ring have a great influence on its stability. In chloromethyl, the chlorine atom has an electron-sucking induction effect, which can reduce the electron cloud density of the benzene ring, and there is a p-π conjugation effect between the chlorine atom and the benzene ring. This conjugation effect is relatively weak. Overall, the presence of chloromethyl groups changes the activity of the benzene ring to a certain extent, which has a subtle impact on its stability. The fluorine atom also has a strong electron-absorbing effect, which further reduces the electron cloud density of the benzene ring, and the radius of the fluorine atom is small. After connecting with the benzene ring, the molecular space structure is compact, which affects the intermolecular force to a certain extent. Trifluoromethyl, due to the strong electron-absorbing action of three fluorine atoms, is a strong electron-absorbing group, which greatly reduces the electron cloud density of the benzene ring and has a significant impact on the stability of the benzene ring.
Re-view chemical reactivity. Due to the decrease in the electron cloud density of the benzene ring in its structure, the electrophilic substitution reaction activity is relatively low compared with that of benzene. For example, when halogenation, nitrification and other electrophilic substitution reactions occur, the reaction conditions are more severe than those of benzene. However, Chloromethyl, fluorine atom and trifluoromethyl are all ortho-para-sites. Although the electron cloud density of the benzene ring is reduced, in the electrophilic substitution reaction, the newly introduced groups tend to enter their ortho-sites.
As far as stability is concerned, this compound has certain stability under normal conditions without the action of special reagents due to the existence of the benzene ring conjugate system. In the presence of strong oxidizing agents, high temperatures or specific catalysts, the benzene ring or substituent can undergo chemical reactions, resulting in structural changes and loss of stability. In the case of strong oxidizing agents, the benzene ring may be oxidized to open the ring; at high temperatures, the substituent may undergo reactions such as elimination and rearrangement.
In summary, 2- (chloromethyl) -1-fluoro-4- (trifluoromethyl) benzene has certain stability under conventional conditions, but in a specific chemical environment, due to the influence of substituents, its chemical properties are active and its stability will be affected. Its stability is not absolute and varies with external conditions.
What are the preparation methods of 2- (chloromethyl) -1-fluoro-4- (trifluoromethyl) benzene
There are several methods for preparing 2 - (chloromethyl) -1 -fluoro-4- (trifluoromethyl) benzene.
First, an aromatic hydrocarbon containing the corresponding substituent is used as the starting material. 4-fluorotrifluorotoluene can be reacted with polyformaldehyde and hydrogen chloride in a suitable solvent, such as dichloroethane, under the catalysis of Lewis acid such as anhydrous zinc chloride, at an appropriate temperature, about 50-80 ℃. This reaction process is the electrophilic substitution of aromatic hydrocarbons. The interaction of polyformaldehyde and hydrogen chloride produces chloromethyl positive ions, which attack the benzene ring of 4-fluorotrifluorotoluene, and generate the target product through a series of electron transfer and rearrangement. The advantage is that the starting material is relatively easy to obtain, the reaction conditions are relatively mild, but there may be many side reactions, and the reaction conditions and post-treatment steps need to be carefully controlled to improve the yield and purity.
Second, aromatics containing halogenated methyl can be prepared by halogen exchange reaction. For example, first synthesize 2 - (bromomethyl) -1 - fluoro-4 - (trifluoromethyl) benzene, and then react with chlorinated reagents such as lithium chloride in polar aprotic solvents such as N, N - dimethylformamide, heated to 100 - 120 ° C. This halogen exchange reaction is carried out according to the difference in the activity of halogen ions, and the activity of bromine ions is higher than that of chloride ions, so bromine and chlorine exchange can be achieved. The advantage of this method is that the reaction selectivity is good, the product purity is high, but the appropriate bromogen needs to be prepared in advance, which increases the reaction steps and cost.
Third, through the Grignard reagent method. With 4-fluorotrifluorotoluene as the starting material, the corresponding Grignard reagent is first prepared, which is added with formaldehyde and then chlorinated. That is, 4-fluorotrifluorotoluene and magnesium are made into Grignard reagent in anhydrous ether or tetrahydrofuran, and then reacted with polyformaldehyde to generate alcohol, and then chlorinated with chlorinated reagents such as thionyl chloride. This process involves the preparation of Grignard reagents and subsequent reactions. Although there are many steps, different substituents can be introduced flexibly, which is of great significance for the construction of complex structures. The reaction conditions require anhydrous and oxygen-free, and the operation needs to be fine, otherwise it is easy to cause side reactions, affecting the yield and product quality.
First, an aromatic hydrocarbon containing the corresponding substituent is used as the starting material. 4-fluorotrifluorotoluene can be reacted with polyformaldehyde and hydrogen chloride in a suitable solvent, such as dichloroethane, under the catalysis of Lewis acid such as anhydrous zinc chloride, at an appropriate temperature, about 50-80 ℃. This reaction process is the electrophilic substitution of aromatic hydrocarbons. The interaction of polyformaldehyde and hydrogen chloride produces chloromethyl positive ions, which attack the benzene ring of 4-fluorotrifluorotoluene, and generate the target product through a series of electron transfer and rearrangement. The advantage is that the starting material is relatively easy to obtain, the reaction conditions are relatively mild, but there may be many side reactions, and the reaction conditions and post-treatment steps need to be carefully controlled to improve the yield and purity.
Second, aromatics containing halogenated methyl can be prepared by halogen exchange reaction. For example, first synthesize 2 - (bromomethyl) -1 - fluoro-4 - (trifluoromethyl) benzene, and then react with chlorinated reagents such as lithium chloride in polar aprotic solvents such as N, N - dimethylformamide, heated to 100 - 120 ° C. This halogen exchange reaction is carried out according to the difference in the activity of halogen ions, and the activity of bromine ions is higher than that of chloride ions, so bromine and chlorine exchange can be achieved. The advantage of this method is that the reaction selectivity is good, the product purity is high, but the appropriate bromogen needs to be prepared in advance, which increases the reaction steps and cost.
Third, through the Grignard reagent method. With 4-fluorotrifluorotoluene as the starting material, the corresponding Grignard reagent is first prepared, which is added with formaldehyde and then chlorinated. That is, 4-fluorotrifluorotoluene and magnesium are made into Grignard reagent in anhydrous ether or tetrahydrofuran, and then reacted with polyformaldehyde to generate alcohol, and then chlorinated with chlorinated reagents such as thionyl chloride. This process involves the preparation of Grignard reagents and subsequent reactions. Although there are many steps, different substituents can be introduced flexibly, which is of great significance for the construction of complex structures. The reaction conditions require anhydrous and oxygen-free, and the operation needs to be fine, otherwise it is easy to cause side reactions, affecting the yield and product quality.
2- (chloromethyl) -1-fluoro-4- (trifluoromethyl) benzene during storage and transportation
2-%28chloromethyl%29-1-fluoro-4-%28trifluoromethyl%29benzene, the things that are transformed are also. In the process of hiding, pay attention to things like this, and cannot be ignored.
The first place to hide is in a place where things are dry, dry, and good. This is because of the tide, encounter, or biological transformation of things, which will cause their nature to be different. If it is in a tidal environment, it is feared that it will be reversed, and its speed will be reduced.
In a high place, it may increase its speed, and there is a risk of explosion.
In addition, the storage device must be sealed. This prevents it from being connected to the outside air, moisture, etc. The container used must be able to withstand the corrosion of the material, such as glass, specific plastics, etc., to ensure that the material is not damaged. Biochemical reaction, so as not to stain this thing.
In the case of waste, there are also many things to be done. People will be affected by damage, well aware of the hazards of this thing, and it is urgent to be familiar with it.
The first place to hide is in a place where things are dry, dry, and good. This is because of the tide, encounter, or biological transformation of things, which will cause their nature to be different. If it is in a tidal environment, it is feared that it will be reversed, and its speed will be reduced.
In a high place, it may increase its speed, and there is a risk of explosion.
In addition, the storage device must be sealed. This prevents it from being connected to the outside air, moisture, etc. The container used must be able to withstand the corrosion of the material, such as glass, specific plastics, etc., to ensure that the material is not damaged. Biochemical reaction, so as not to stain this thing.
In the case of waste, there are also many things to be done. People will be affected by damage, well aware of the hazards of this thing, and it is urgent to be familiar with it.
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