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2-(Chloromethyl)-1-Methyl-4-(Trifluoromethyl)Benzene
|
HS Code |
339062 |
| Chemical Formula | C9H8ClF3 |
| Molar Mass | 208.61 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 195 - 200 °C |
| Density | Approx. 1.25 - 1.35 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Low vapor pressure at room temperature |
As an accredited 2-(Chloromethyl)-1-Methyl-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2-(chloromethyl)-1-methyl-4-(trifluoromethyl)benzene in a sealed chemical - grade bottle. |
| Storage | 2-(Chloromethyl)-1 -methyl-4-(trifluoromethyl)benzene should be stored in a cool, well - ventilated area away from heat, ignition sources, and oxidizing agents. It should be kept in a tightly sealed container made of materials resistant to its corrosive nature, such as stainless steel or certain plastics. This storage approach helps prevent potential reactions and ensures safety. |
| Shipping | 2-(Chloromethyl)-1 -methyl-4-(trifluoromethyl)benzene is shipped in specialized, leak - proof containers compliant with chemical transportation regulations. It's carefully packaged to prevent spills and ensure safe transit. |
Competitive 2-(Chloromethyl)-1-Methyl-4-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to sales01@alchemist-chem.com.
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What are the main uses of 2- (chloromethyl) -1-methyl-4- (trifluoromethyl) benzene?
2-%28chloromethyl%29-1-methyl-4-%28trifluoromethyl%29benzene is 2- (chloromethyl) -1-methyl-4- (trifluoromethyl) benzene, which has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
One of them can be used to create various functional materials with special properties. For example, in the preparation of new polymer materials, by ingenious chemical reactions, it is introduced into the main chain or side chain of the polymer. With the unique properties of chloromethyl, methyl and trifluoromethyl, it can significantly improve the chemical stability, thermal stability and weather resistance of the polymer material. Because of its strong electron absorption, trifluoromethyl can improve the oxidation resistance and chemical inertness of the material, so that the material can still maintain good performance in harsh environments.
Second, in the field of medicinal chemistry, it also plays an important role. It can be used as a starting material or key intermediate for the synthesis of drug molecules with specific structures. Due to its unique chemical structure, it can introduce special spatial structures and electronic effects to drug molecules, thereby changing the interaction between drug molecules and targets, and improving the activity, selectivity and bioavailability of drugs. For example, in the development process of some new drugs targeting specific disease targets, the structural characteristics of the compound will be used to construct a pharmacophore with higher compatibility with the target, enhancing the binding ability of the drug and the target, and improving the therapeutic effect.
Third, in the preparation of fine chemicals, 2- (chloromethyl) -1-methyl-4- (trifluoromethyl) benzene also has many applications. For example, the preparation of high-performance coatings, pigments and special additives. In coatings, it can improve the film-forming performance, adhesion and corrosion resistance of coatings; in the preparation of pigments, it can adjust the crystal form and color of pigments to improve the stability and coloring power of pigments; as a special additive, it can give products special functions such as antistatic and anti-fog.
One of them can be used to create various functional materials with special properties. For example, in the preparation of new polymer materials, by ingenious chemical reactions, it is introduced into the main chain or side chain of the polymer. With the unique properties of chloromethyl, methyl and trifluoromethyl, it can significantly improve the chemical stability, thermal stability and weather resistance of the polymer material. Because of its strong electron absorption, trifluoromethyl can improve the oxidation resistance and chemical inertness of the material, so that the material can still maintain good performance in harsh environments.
Second, in the field of medicinal chemistry, it also plays an important role. It can be used as a starting material or key intermediate for the synthesis of drug molecules with specific structures. Due to its unique chemical structure, it can introduce special spatial structures and electronic effects to drug molecules, thereby changing the interaction between drug molecules and targets, and improving the activity, selectivity and bioavailability of drugs. For example, in the development process of some new drugs targeting specific disease targets, the structural characteristics of the compound will be used to construct a pharmacophore with higher compatibility with the target, enhancing the binding ability of the drug and the target, and improving the therapeutic effect.
Third, in the preparation of fine chemicals, 2- (chloromethyl) -1-methyl-4- (trifluoromethyl) benzene also has many applications. For example, the preparation of high-performance coatings, pigments and special additives. In coatings, it can improve the film-forming performance, adhesion and corrosion resistance of coatings; in the preparation of pigments, it can adjust the crystal form and color of pigments to improve the stability and coloring power of pigments; as a special additive, it can give products special functions such as antistatic and anti-fog.
What are the physical properties of 2- (chloromethyl) -1-methyl-4- (trifluoromethyl) benzene
2-%28chloromethyl%29-1-methyl-4-%28trifluoromethyl%29benzene, organic compounds are also. Its physical properties are of great value for investigation.
Looking at its shape, under normal temperature and pressure, it is usually a colorless to light yellow liquid with a special smell. Although this smell is not highly toxic, it is not a pleasant fragrance. The smell can make the nasal nostrils feel it.
On its boiling point, it is about a specific numerical range. If the boiling point is covered, the critical temperature at which the substance changes from liquid to gaseous state is also. The boiling point of this compound makes it possible to realize the transformation of phase state under a certain temperature condition. When it is heated to the boiling point, the molecule is energized to break free from the shackles of the liquid phase and rise into a gaseous state.
As for the melting point, it also has its specific value. Melting point, the temperature limit at which a substance changes from a solid state to a liquid state. Below the melting point, the compound is in the shape of a solid state, and the molecules are arranged in a regular and orderly manner; when it reaches the melting point, the molecules are energized, and the order of the solid state begins to be disordered and gradually turns into a liquid state.
In terms of density, there is also a corresponding value. Density, the mass of the substance per unit volume is also. The density of this compound makes it exhibit a specific floating phenomenon when mixed with other substances. If mixed with liquids of different densities, depending on their density, either float above or sink below.
Solubility is also one of its important physical properties. In organic solvents, such as common ethanol, ether, etc., this compound exhibits good solubility. However, in water, its solubility is quite limited. This is due to the hydrogen bonding between water molecules, which is different from the interaction of the compound molecules, making it difficult to dissolve in water.
In addition, the vapor pressure of this compound also has characteristics. Vapor pressure is the pressure when the gas phase and its condensed phase reach equilibrium at a specific temperature. The size of the vapor pressure is related to the difficulty of volatilization. Higher vapor pressure indicates that the compound is more volatile into the gas phase at a certain temperature.
The physical properties of this 2-%28chloromethyl%29-1-methyl-4-%28trifluoromethyl%29benzene are of great significance in the research of organic chemistry, the application of industrial production and many other aspects. Its morphology, boiling point, melting point, density, solubility and vapor pressure are related to each other, collectively depicting the unique physical picture of the compound.
Looking at its shape, under normal temperature and pressure, it is usually a colorless to light yellow liquid with a special smell. Although this smell is not highly toxic, it is not a pleasant fragrance. The smell can make the nasal nostrils feel it.
On its boiling point, it is about a specific numerical range. If the boiling point is covered, the critical temperature at which the substance changes from liquid to gaseous state is also. The boiling point of this compound makes it possible to realize the transformation of phase state under a certain temperature condition. When it is heated to the boiling point, the molecule is energized to break free from the shackles of the liquid phase and rise into a gaseous state.
As for the melting point, it also has its specific value. Melting point, the temperature limit at which a substance changes from a solid state to a liquid state. Below the melting point, the compound is in the shape of a solid state, and the molecules are arranged in a regular and orderly manner; when it reaches the melting point, the molecules are energized, and the order of the solid state begins to be disordered and gradually turns into a liquid state.
In terms of density, there is also a corresponding value. Density, the mass of the substance per unit volume is also. The density of this compound makes it exhibit a specific floating phenomenon when mixed with other substances. If mixed with liquids of different densities, depending on their density, either float above or sink below.
Solubility is also one of its important physical properties. In organic solvents, such as common ethanol, ether, etc., this compound exhibits good solubility. However, in water, its solubility is quite limited. This is due to the hydrogen bonding between water molecules, which is different from the interaction of the compound molecules, making it difficult to dissolve in water.
In addition, the vapor pressure of this compound also has characteristics. Vapor pressure is the pressure when the gas phase and its condensed phase reach equilibrium at a specific temperature. The size of the vapor pressure is related to the difficulty of volatilization. Higher vapor pressure indicates that the compound is more volatile into the gas phase at a certain temperature.
The physical properties of this 2-%28chloromethyl%29-1-methyl-4-%28trifluoromethyl%29benzene are of great significance in the research of organic chemistry, the application of industrial production and many other aspects. Its morphology, boiling point, melting point, density, solubility and vapor pressure are related to each other, collectively depicting the unique physical picture of the compound.
What are the synthesis methods of 2- (chloromethyl) -1-methyl-4- (trifluoromethyl) benzene
2-%28chloromethyl%29-1-methyl-4-%28trifluoromethyl%29benzene that is, 2 - (chloromethyl) -1 -methyl-4- (trifluoromethyl) benzene. There are many methods for synthesizing this compound, which are described in detail below.
First, with 1-methyl-4- (trifluoromethyl) benzene as the starting material, chloromethylation can be used to introduce chloromethyl. This reaction requires the presence of a suitable catalyst. Common Lewis acids such as anhydrous zinc chloride and aluminum chloride are co-reacted with paraformaldehyde and hydrogen chloride gas. The reaction mechanism is that Lewis acid catalyzes the decomposition of paraformaldehyde to formaldehyde, formaldehyde interacts with hydrogen chloride to form chloromethanol, and then undergoes electrophilic substitution reaction with 1-methyl-4- (trifluoromethyl) benzene, and chloromethyl is introduced at a specific position in the benzene ring to obtain the target product 2 - (chloromethyl) -1 -methyl-4- (trifluoromethyl) benzene.
Second, benzoic acid derivatives containing appropriate substituents can also be used as starting materials. First, the benzoic acid derivative is converted into the corresponding benzyl alcohol derivative through appropriate steps, such as reduction with a reducing agent such as sodium borohydride. Subsequently, the benzyl alcohol is chlorinated with chlorination reagents such as thionyl chloride and phosphorus trichloride. When thionyl chloride reacts with benzyl alcohol, an intermediate product chlorosulfite is formed. This intermediate product is unstable and will further decompose. Chloride ions replace the hydroxyl group to form chloromethyl, resulting in 2 - (chloromethyl) -1 -methyl-4- (trifluoromethyl) benzene.
Third, the nucleophilic substitution reaction strategy of halogenated aromatics is used. Halogenated aromatics containing suitable leaving groups (such as bromine, iodine, etc.) are selected and reacted with nucleophiles containing methyl and trifluoromethyl to construct methyl and trifluoromethyl substituents on the benzene ring. After that, chloromethyl is introduced at the designated position of the benzene ring by a specific method. For example, first prepare phenyl lithium reagent or Grignard reagent containing methyl and trifluoromethyl, react with suitable halogenated aromatics to construct the basic skeleton of the benzene ring, and then introduce chloromethyl through chloromethylation steps.
The above methods have their own advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider the availability of starting materials, the difficulty of reaction conditions, the purity and yield of the product, and carefully select the appropriate synthesis route to efficiently obtain 2- (chloromethyl) -1 -methyl-4- (trifluoromethyl) benzene.
First, with 1-methyl-4- (trifluoromethyl) benzene as the starting material, chloromethylation can be used to introduce chloromethyl. This reaction requires the presence of a suitable catalyst. Common Lewis acids such as anhydrous zinc chloride and aluminum chloride are co-reacted with paraformaldehyde and hydrogen chloride gas. The reaction mechanism is that Lewis acid catalyzes the decomposition of paraformaldehyde to formaldehyde, formaldehyde interacts with hydrogen chloride to form chloromethanol, and then undergoes electrophilic substitution reaction with 1-methyl-4- (trifluoromethyl) benzene, and chloromethyl is introduced at a specific position in the benzene ring to obtain the target product 2 - (chloromethyl) -1 -methyl-4- (trifluoromethyl) benzene.
Second, benzoic acid derivatives containing appropriate substituents can also be used as starting materials. First, the benzoic acid derivative is converted into the corresponding benzyl alcohol derivative through appropriate steps, such as reduction with a reducing agent such as sodium borohydride. Subsequently, the benzyl alcohol is chlorinated with chlorination reagents such as thionyl chloride and phosphorus trichloride. When thionyl chloride reacts with benzyl alcohol, an intermediate product chlorosulfite is formed. This intermediate product is unstable and will further decompose. Chloride ions replace the hydroxyl group to form chloromethyl, resulting in 2 - (chloromethyl) -1 -methyl-4- (trifluoromethyl) benzene.
Third, the nucleophilic substitution reaction strategy of halogenated aromatics is used. Halogenated aromatics containing suitable leaving groups (such as bromine, iodine, etc.) are selected and reacted with nucleophiles containing methyl and trifluoromethyl to construct methyl and trifluoromethyl substituents on the benzene ring. After that, chloromethyl is introduced at the designated position of the benzene ring by a specific method. For example, first prepare phenyl lithium reagent or Grignard reagent containing methyl and trifluoromethyl, react with suitable halogenated aromatics to construct the basic skeleton of the benzene ring, and then introduce chloromethyl through chloromethylation steps.
The above methods have their own advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider the availability of starting materials, the difficulty of reaction conditions, the purity and yield of the product, and carefully select the appropriate synthesis route to efficiently obtain 2- (chloromethyl) -1 -methyl-4- (trifluoromethyl) benzene.
2- (chloromethyl) -1-methyl-4- (trifluoromethyl) benzene in storage and transportation
2-%28chloromethyl%29-1-methyl-4-%28trifluoromethyl%29benzene, the Chinese name is 2 - (chloromethyl) -1 -methyl-4- (trifluoromethyl) benzene. This substance should pay attention to the following things when it is stored.
The first priority is safety. Because it has a certain chemical activity, it should be placed in a dry, dry and good environment. Avoid direct sunlight to prevent the reaction caused by light, causing it to change its properties, or even cause damage. This phenomenon means that the temperature should be kept in a specific environment, and the temperature should not be high. The dry environment can prevent it from being damaged and rotten due to the tide, and avoid contact with water, which can generate reactions from this substance or water, and generate harmful substances.
Furthermore, in the process of transportation, the packaging material must be used. It is necessary to use the packaging material to ensure that it is well sealed to prevent leakage. If it is accidentally leaked, it will not pollute the environment, and it may endanger the safety of people and the surrounding people. The packaging container is also corrosion-resistant and can withstand a certain amount of force. It will not break due to bumps and collisions.
In addition, this material is oxidized and stored separately. Due to its chemical properties, it is easy to cause severe reactions, ignition, explosion and other serious accidents. In the storage or storage, it is necessary to divide the area and store different materials.
In the same way, people who have not stored in the world must be trained in the field, familiar with the characteristics of this material and the methods of emergency treatment. In the event of an accident such as leakage or fire, measures can be taken quickly and positively to reduce the harm.
Therefore, 2- (chloromethyl) -1 -methyl-4- (trifluoromethyl) benzene should be stored in the environment, environmental control, protection, and physical isolation to human cultivation. In order to ensure safety, all aspects should not be ignored.
The first priority is safety. Because it has a certain chemical activity, it should be placed in a dry, dry and good environment. Avoid direct sunlight to prevent the reaction caused by light, causing it to change its properties, or even cause damage. This phenomenon means that the temperature should be kept in a specific environment, and the temperature should not be high. The dry environment can prevent it from being damaged and rotten due to the tide, and avoid contact with water, which can generate reactions from this substance or water, and generate harmful substances.
Furthermore, in the process of transportation, the packaging material must be used. It is necessary to use the packaging material to ensure that it is well sealed to prevent leakage. If it is accidentally leaked, it will not pollute the environment, and it may endanger the safety of people and the surrounding people. The packaging container is also corrosion-resistant and can withstand a certain amount of force. It will not break due to bumps and collisions.
In addition, this material is oxidized and stored separately. Due to its chemical properties, it is easy to cause severe reactions, ignition, explosion and other serious accidents. In the storage or storage, it is necessary to divide the area and store different materials.
In the same way, people who have not stored in the world must be trained in the field, familiar with the characteristics of this material and the methods of emergency treatment. In the event of an accident such as leakage or fire, measures can be taken quickly and positively to reduce the harm.
Therefore, 2- (chloromethyl) -1 -methyl-4- (trifluoromethyl) benzene should be stored in the environment, environmental control, protection, and physical isolation to human cultivation. In order to ensure safety, all aspects should not be ignored.
What are the effects of 2- (chloromethyl) -1-methyl-4- (trifluoromethyl) benzene on the environment and human health?
2-%28chloromethyl%29-1-methyl-4-%28trifluoromethyl%29benzene, that is, 2 - (chloromethyl) -1 - methyl - 4 - (trifluoromethyl) benzene, this substance has an impact on the environment and human health.
In terms of the environment, this compound is easy to accumulate in the environment because of its stable chemical structure, difficult to degrade naturally. Once released into nature, or diffused by water, soil, and atmosphere, it will expand the scope of pollution. If it flows into water bodies, or affects aquatic organisms, disrupts the ecological balance of water; accumulates in soil, or affects soil microbial activities and plant growth. Its volatility can cause it to exist in the atmosphere, or participate in photochemical reactions, affect air quality, and even have indirect effects on global climate change.
As for human health, it is potentially toxic. Enter the human body through breathing, skin contact or ingestion, or damage multiple organ systems. Animal experiments or studies have shown that this substance may irritate the skin and eyes, causing redness, swelling and pain. Long-term exposure or inhalation, or affect the respiratory system, causing cough, asthma, breathing difficulties, etc. More serious cases, or damage the liver, kidney and other important organs function, interfering with the normal metabolism of the human body. And because of its halogen atoms and special structures, or with certain carcinogenicity, teratogenicity, mutagenicity, long-term exposure to this substance environment, the risk of cancer in the human body may increase, and it may also have adverse effects on fetal development. Therefore, the use and release of 2 - (chloromethyl) -1 - methyl - 4 - (trifluoromethyl) benzene should be carefully controlled to prevent serious harm to the environment and human health.
In terms of the environment, this compound is easy to accumulate in the environment because of its stable chemical structure, difficult to degrade naturally. Once released into nature, or diffused by water, soil, and atmosphere, it will expand the scope of pollution. If it flows into water bodies, or affects aquatic organisms, disrupts the ecological balance of water; accumulates in soil, or affects soil microbial activities and plant growth. Its volatility can cause it to exist in the atmosphere, or participate in photochemical reactions, affect air quality, and even have indirect effects on global climate change.
As for human health, it is potentially toxic. Enter the human body through breathing, skin contact or ingestion, or damage multiple organ systems. Animal experiments or studies have shown that this substance may irritate the skin and eyes, causing redness, swelling and pain. Long-term exposure or inhalation, or affect the respiratory system, causing cough, asthma, breathing difficulties, etc. More serious cases, or damage the liver, kidney and other important organs function, interfering with the normal metabolism of the human body. And because of its halogen atoms and special structures, or with certain carcinogenicity, teratogenicity, mutagenicity, long-term exposure to this substance environment, the risk of cancer in the human body may increase, and it may also have adverse effects on fetal development. Therefore, the use and release of 2 - (chloromethyl) -1 - methyl - 4 - (trifluoromethyl) benzene should be carefully controlled to prevent serious harm to the environment and human health.
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