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2-(Chloromethyl)-5-Methoxy-1,3-Dimethylbenzene
Linshang Chemical
|
HS Code |
477481 |
| Chemical Formula | C10H13ClO |
| Molar Mass | 184.66 g/mol |
| Physical State | Solid (usually) |
| Appearance | Colorless to light - yellow solid |
| Melting Point | Data needed |
| Boiling Point | Data needed |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone |
| Density | Data needed |
| Flash Point | Data needed |
| Vapor Pressure | Data needed |
| Logp | Data needed |
| Refractive Index | Data needed |
As an accredited 2-(Chloromethyl)-5-Methoxy-1,3-Dimethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2-(chloromethyl)-5-methoxy-1,3 -dimethylbenzene in a sealed chemical - grade bottle. |
| Storage | 2-(Chloromethyl)-5-methoxy-1,3 -dimethylbenzene should be stored in a cool, dry, well - ventilated area away from sources of ignition. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents, acids, and bases to avoid potential chemical reactions. |
| Shipping | 2-(Chloromethyl)-5-methoxy-1,3 -dimethylbenzene is shipped in accordance with strict chemical regulations. Packed in suitable, sealed containers to prevent leakage, transported via approved carriers following safety protocols for hazardous chemicals. |
Competitive 2-(Chloromethyl)-5-Methoxy-1,3-Dimethylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 2-(Chloromethyl)-5-Methoxy-1,3-Dimethylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2- (chloromethyl) -5-methoxy-1,3-dimethylbenzene
2-%28chloromethyl%29-5-methoxy-1%2C3-dimethylbenzene, Chinese name 2 - (chloromethyl) - 5 - methoxy - 1,3 - dimethylbenzene. The chemical properties of this substance are unique and have the following characteristics:
First, the characteristics of halogenated hydrocarbons. It contains chlorine methyl groups and has high activity of chlorine atoms. In nucleophilic substitution reactions, chlorine atoms are easily replaced by nucleophilic reagents. For example, when co-heated with sodium hydroxide aqueous solution, chlorine in chloromethyl groups can be replaced by hydroxyl groups to form compounds containing hydroxyl groups. This reaction is a common nucleophilic substitution path. If it reacts with sodium alcohol, chlorine atoms may be replaced by alkoxy groups to form corresponding ethers.
Second, the properties of benzene rings. The molecule contains a benzene ring structure and has aromatic properties. A typical electrophilic substitution reaction of benzene rings can occur. If the bromination reaction occurs with bromine under the action of an appropriate catalyst, the bromine atom will replace the hydrogen atom on the benzene ring, mainly in the position where the electron cloud density is higher on the benzene ring. Because both methoxy and methyl are electron-giving groups, the electron cloud density of the ortho and para-site of the benzene ring can be increased, so the bromination reaction may mainly occur in the ortho and para-site.
Third, the influence of methoxy groups. The methoxy group in the molecule is an electron-giving group, which can enhance the electron cloud density of the benzene ring, thereby affecting the activity and selectivity of the electrophilic substitution reaction on the benzene ring. At the same time, the oxygen atom of the methoxy group has an unshared electron pair, which can participate in some chemical reactions. For example, under certain conditions, it binds with protons, making the molecule positively charged
Fourth, the role of methyl. The presence of 1,3-dimethyl also affects the distribution of benzene ring electron cloud. Methyl is a donor electron group, which can increase the density of benzene ring electron cloud, and the steric hindrance effect cannot be ignored. In the electrophilic substitution reaction, the steric hindrance of methyl affects the position of the substituent entering the benzene ring, and interacts with the methoxy group to determine the selectivity of the reaction.
2- (chloromethyl) -5-methoxy-1,3-dimethylphenyl interacts with the benzene ring, showing a variety of chemical properties and is widely used in the field of organic synthesis.
First, the characteristics of halogenated hydrocarbons. It contains chlorine methyl groups and has high activity of chlorine atoms. In nucleophilic substitution reactions, chlorine atoms are easily replaced by nucleophilic reagents. For example, when co-heated with sodium hydroxide aqueous solution, chlorine in chloromethyl groups can be replaced by hydroxyl groups to form compounds containing hydroxyl groups. This reaction is a common nucleophilic substitution path. If it reacts with sodium alcohol, chlorine atoms may be replaced by alkoxy groups to form corresponding ethers.
Second, the properties of benzene rings. The molecule contains a benzene ring structure and has aromatic properties. A typical electrophilic substitution reaction of benzene rings can occur. If the bromination reaction occurs with bromine under the action of an appropriate catalyst, the bromine atom will replace the hydrogen atom on the benzene ring, mainly in the position where the electron cloud density is higher on the benzene ring. Because both methoxy and methyl are electron-giving groups, the electron cloud density of the ortho and para-site of the benzene ring can be increased, so the bromination reaction may mainly occur in the ortho and para-site.
Third, the influence of methoxy groups. The methoxy group in the molecule is an electron-giving group, which can enhance the electron cloud density of the benzene ring, thereby affecting the activity and selectivity of the electrophilic substitution reaction on the benzene ring. At the same time, the oxygen atom of the methoxy group has an unshared electron pair, which can participate in some chemical reactions. For example, under certain conditions, it binds with protons, making the molecule positively charged
Fourth, the role of methyl. The presence of 1,3-dimethyl also affects the distribution of benzene ring electron cloud. Methyl is a donor electron group, which can increase the density of benzene ring electron cloud, and the steric hindrance effect cannot be ignored. In the electrophilic substitution reaction, the steric hindrance of methyl affects the position of the substituent entering the benzene ring, and interacts with the methoxy group to determine the selectivity of the reaction.
2- (chloromethyl) -5-methoxy-1,3-dimethylphenyl interacts with the benzene ring, showing a variety of chemical properties and is widely used in the field of organic synthesis.
What is the main use of 2- (chloromethyl) -5-methoxy-1,3-dimethylbenzene?
2-%28chloromethyl%29-5-methoxy-1%2C3-dimethylbenzene is 2 - (chloromethyl) -5 -methoxy-1,3 -dimethylbenzene, which has a wide range of uses.
In the field of organic synthesis, it is often used as a key intermediate. Due to its structure containing chloromethyl, methoxy and dimethylphenyl ring, chloromethyl has high activity and can be converted into nucleophilic substitution through many reactions, such as nucleophilic substitution. It can react with nucleophilic reagents such as alcohols, phenols, amines, etc., to derive a variety of compounds. Taking alcohols as an example, chloromethyl can be replaced by alkoxy groups under alkaline conditions to form new ether compounds, which are of great significance in the synthesis of medicines and fragrances.
In the research and development of medicine, this compound may become a potential lead compound By modifying and optimizing the structure, explore its biological activity and pharmacological effects, or develop new drugs. In the fragrance industry, the special odor and chemical stability imparted by its methoxy group and dimethyl group can be used to prepare unique aroma fragrance components through reaction, enhancing the complexity and layering of the fragrance.
In the field of materials science, polymer materials can be introduced through polymerization or modification reactions. Its benzene ring structure can enhance the rigidity and stability of materials, chloromethyl group, methoxy group or endow materials with special functions, such as improving material solubility and compatibility, and expand their applications in coatings, plastics, fibers and other fields. In conclusion, 2 - (chloromethyl) -5 -methoxy-1,3 -dimethylbenzene has important uses in organic synthesis, medicine, fragrances, materials and other fields due to its unique structure, providing a foundation for the development and production of many chemicals and materials.
In the field of organic synthesis, it is often used as a key intermediate. Due to its structure containing chloromethyl, methoxy and dimethylphenyl ring, chloromethyl has high activity and can be converted into nucleophilic substitution through many reactions, such as nucleophilic substitution. It can react with nucleophilic reagents such as alcohols, phenols, amines, etc., to derive a variety of compounds. Taking alcohols as an example, chloromethyl can be replaced by alkoxy groups under alkaline conditions to form new ether compounds, which are of great significance in the synthesis of medicines and fragrances.
In the research and development of medicine, this compound may become a potential lead compound By modifying and optimizing the structure, explore its biological activity and pharmacological effects, or develop new drugs. In the fragrance industry, the special odor and chemical stability imparted by its methoxy group and dimethyl group can be used to prepare unique aroma fragrance components through reaction, enhancing the complexity and layering of the fragrance.
In the field of materials science, polymer materials can be introduced through polymerization or modification reactions. Its benzene ring structure can enhance the rigidity and stability of materials, chloromethyl group, methoxy group or endow materials with special functions, such as improving material solubility and compatibility, and expand their applications in coatings, plastics, fibers and other fields. In conclusion, 2 - (chloromethyl) -5 -methoxy-1,3 -dimethylbenzene has important uses in organic synthesis, medicine, fragrances, materials and other fields due to its unique structure, providing a foundation for the development and production of many chemicals and materials.
What are the synthesis methods of 2- (chloromethyl) -5-methoxy-1,3-dimethylbenzene
To prepare 2 - (chloromethyl) -5 -methoxy-1,3 -dimethylbenzene, the following synthesis methods can be used.
First, 5-methoxy-1,3 -dimethylbenzoic acid is used as the starting material. First, the acid is co-heated with dichlorosulfoxide to convert the carboxyl group into an acid chloride. This step requires attention to temperature control to avoid side reactions. The obtained acid chloride is then reacted with lithium aluminum hydride at low temperature to reduce the acid chloride to an alcohol. Thereafter, the alcohol is reacted with reagents such as dichlorosulfoxide or phosphorus trichloride to replace the hydroxyl group with chloromethyl, thereby obtaining the target product. The steps of this path are slightly complicated, but the reaction conditions of each step are relatively clear, and the yield can be controlled.
Second, 1,3-dimethyl-5-methoxybenzene is used as the raw material. First, N-chlorosuccinimide (NCS) and the benzene are chloromethylated under light or heat in the presence of an initiator such as benzoyl peroxide. This reaction requires precise control of the reaction time, temperature and NCS dosage. Due to excessive chlorination, polychlorinated by-products are prone to occur. If the reaction conditions are suitable, 2 - (chloromethyl) -5 -methoxy-1,3 -dimethylbenzene can be efficiently obtained. This method is simple and requires strict reaction conditions.
Third, take 2-methyl-5-methoxy-1,3-dimethylbenzene as the starting material. First, it is chloromethylated with formaldehyde and hydrogen chloride in the presence of specific catalysts such as zinc chloride. This process requires attention to the pH and temperature of the reaction system to ensure that the reaction progresses smoothly and the final product is obtained. The raw materials of this method are relatively easy to obtain, but the selectivity of the reaction needs to be carefully controlled.
All synthesis methods have advantages and disadvantages. In actual operation, the appropriate method should be carefully selected according to the availability of raw materials, cost, reaction conditions and product purity requirements.
First, 5-methoxy-1,3 -dimethylbenzoic acid is used as the starting material. First, the acid is co-heated with dichlorosulfoxide to convert the carboxyl group into an acid chloride. This step requires attention to temperature control to avoid side reactions. The obtained acid chloride is then reacted with lithium aluminum hydride at low temperature to reduce the acid chloride to an alcohol. Thereafter, the alcohol is reacted with reagents such as dichlorosulfoxide or phosphorus trichloride to replace the hydroxyl group with chloromethyl, thereby obtaining the target product. The steps of this path are slightly complicated, but the reaction conditions of each step are relatively clear, and the yield can be controlled.
Second, 1,3-dimethyl-5-methoxybenzene is used as the raw material. First, N-chlorosuccinimide (NCS) and the benzene are chloromethylated under light or heat in the presence of an initiator such as benzoyl peroxide. This reaction requires precise control of the reaction time, temperature and NCS dosage. Due to excessive chlorination, polychlorinated by-products are prone to occur. If the reaction conditions are suitable, 2 - (chloromethyl) -5 -methoxy-1,3 -dimethylbenzene can be efficiently obtained. This method is simple and requires strict reaction conditions.
Third, take 2-methyl-5-methoxy-1,3-dimethylbenzene as the starting material. First, it is chloromethylated with formaldehyde and hydrogen chloride in the presence of specific catalysts such as zinc chloride. This process requires attention to the pH and temperature of the reaction system to ensure that the reaction progresses smoothly and the final product is obtained. The raw materials of this method are relatively easy to obtain, but the selectivity of the reaction needs to be carefully controlled.
All synthesis methods have advantages and disadvantages. In actual operation, the appropriate method should be carefully selected according to the availability of raw materials, cost, reaction conditions and product purity requirements.
What is the market price of 2- (chloromethyl) -5-methoxy-1,3-dimethylbenzene?
Today, the world is changing, and it is difficult to determine the market price of 2 - (chloromethyl) - 5 - methoxy - 1,3 - dimethylbenzene based on past examples.
The price of chemical products often depends on many reasons. The first one to bear the brunt is the abundance of raw materials. If the raw materials of this compound, such as chloromethane, methoxy compounds, and dimethylbenzene, change in the production of the origin, or due to unfavorable weather, exhaustion of mineral sources, and human control, the price of raw materials can be moved, and then the price of finished products will be affected.
Furthermore, the clumsy process is also the key. New methods may save labor and time, and reduce its cost; if the old technology is difficult to improve, the cost will remain high, and the price will be different.
Market supply and demand are even more important. If the demand for this compound in the pharmaceutical, materials and other industries increases sharply, but the supply is limited, the price will rise; conversely, if the demand is low and the supply is excessive, the price will be depressed.
In addition, the different laws and taxes in various places also affect the price. Where taxes are high, the cost will accumulate, and the price will be high; where laws are loose, the cost may be reduced, and the price may fall.
Therefore, in order to know the confirmed price of 2 - (chloromethyl) - 5 - methoxy - 1,3 - dimethylbenzene, it is necessary to carefully observe the current raw material market, process progress, supply and demand conditions, and changes in local laws and taxes, in order to obtain a more accurate price. It is difficult to generalize from past examples.
The price of chemical products often depends on many reasons. The first one to bear the brunt is the abundance of raw materials. If the raw materials of this compound, such as chloromethane, methoxy compounds, and dimethylbenzene, change in the production of the origin, or due to unfavorable weather, exhaustion of mineral sources, and human control, the price of raw materials can be moved, and then the price of finished products will be affected.
Furthermore, the clumsy process is also the key. New methods may save labor and time, and reduce its cost; if the old technology is difficult to improve, the cost will remain high, and the price will be different.
Market supply and demand are even more important. If the demand for this compound in the pharmaceutical, materials and other industries increases sharply, but the supply is limited, the price will rise; conversely, if the demand is low and the supply is excessive, the price will be depressed.
In addition, the different laws and taxes in various places also affect the price. Where taxes are high, the cost will accumulate, and the price will be high; where laws are loose, the cost may be reduced, and the price may fall.
Therefore, in order to know the confirmed price of 2 - (chloromethyl) - 5 - methoxy - 1,3 - dimethylbenzene, it is necessary to carefully observe the current raw material market, process progress, supply and demand conditions, and changes in local laws and taxes, in order to obtain a more accurate price. It is difficult to generalize from past examples.
What are the precautions for 2- (chloromethyl) -5-methoxy-1,3-dimethylbenzene during storage and transportation?
2-%28chloromethyl%29-5-methoxy-1%2C3-dimethylbenzene is 2- (chloromethyl) -5-methoxy-1,3-dimethylbenzene, which is an organic compound. When storing and transporting, pay attention to many matters to ensure safety.
First, when storing, choose a cool, dry and well-ventilated place. Because of its flammability, if the ambient temperature is too high or the ventilation is not smooth, once it encounters an open flame or hot topic, it is easy to cause a combustion accident, endangering the safety of personnel and facilities. And it may deteriorate in humid air, affecting the quality and performance, so a dry environment is indispensable.
Second, it must be stored separately from oxidants, acids, bases, etc., and must not be mixed. This compound is chemically active, and in contact with the above substances, it may cause severe chemical reactions, or cause serious consequences such as fire and explosion.
Third, the storage area should be equipped with suitable containment materials, so that in case of leakage, it can be collected and processed in time to prevent the spread of pollution.
Fourth, during transportation, ensure that the container is well sealed to avoid its leakage and volatilization. Transportation vehicles should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. Driving routes should also be carefully selected to avoid densely populated areas and traffic-congested road sections.
Fifth, operators must undergo special training and strictly abide by the operating procedures. When handling, it should be handled lightly to prevent damage to packaging and containers and reduce the risk of leakage.
In conclusion, the storage and transportation of 2- (chloromethyl) -5-methoxy-1,3-dimethylbenzene requires careful treatment of every step and strict compliance with relevant regulations and requirements to ensure the safety and stability of the entire process.
First, when storing, choose a cool, dry and well-ventilated place. Because of its flammability, if the ambient temperature is too high or the ventilation is not smooth, once it encounters an open flame or hot topic, it is easy to cause a combustion accident, endangering the safety of personnel and facilities. And it may deteriorate in humid air, affecting the quality and performance, so a dry environment is indispensable.
Second, it must be stored separately from oxidants, acids, bases, etc., and must not be mixed. This compound is chemically active, and in contact with the above substances, it may cause severe chemical reactions, or cause serious consequences such as fire and explosion.
Third, the storage area should be equipped with suitable containment materials, so that in case of leakage, it can be collected and processed in time to prevent the spread of pollution.
Fourth, during transportation, ensure that the container is well sealed to avoid its leakage and volatilization. Transportation vehicles should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. Driving routes should also be carefully selected to avoid densely populated areas and traffic-congested road sections.
Fifth, operators must undergo special training and strictly abide by the operating procedures. When handling, it should be handled lightly to prevent damage to packaging and containers and reduce the risk of leakage.
In conclusion, the storage and transportation of 2- (chloromethyl) -5-methoxy-1,3-dimethylbenzene requires careful treatment of every step and strict compliance with relevant regulations and requirements to ensure the safety and stability of the entire process.
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