Linshang Chemical
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2-(Chlorosulfonyl)-Benzenetrifluoride
Linshang Chemical
|
HS Code |
434061 |
| Chemical Formula | C7H4ClF3O2S |
| Molecular Weight | 246.62 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 165 - 167 °C |
| Density | Typically around 1.5 - 1.6 g/cm³ |
| Vapor Pressure | Low vapor pressure at room temperature |
| Solubility | Soluble in many organic solvents, insoluble in water |
| Reactivity | Reactive with nucleophiles, can undergo substitution reactions |
| Stability | Stable under normal storage conditions, but reacts with moisture |
As an accredited 2-(Chlorosulfonyl)-Benzenetrifluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250 mL glass bottle with screw - cap for 2-(chlorosulfonyl) - benzenetrifluoride. |
| Storage | 2-(Chlorosulfonyl) - benzenetrifluoride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and incompatible substances like strong bases and reducing agents. Store in a tightly - sealed container made of corrosion - resistant materials, such as stainless steel or certain plastics, to prevent leakage and degradation. |
| Shipping | 2-(Chlorosulfonyl) - benzenetrifluoride is a chemical that must be shipped in accordance with strict regulations. It should be in well - sealed, corrosion - resistant containers, transported by carriers licensed for hazardous chemicals to ensure safety during transit. |
Competitive 2-(Chlorosulfonyl)-Benzenetrifluoride prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 2-(Chlorosulfonyl)-Benzenetrifluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2- (chlorosulfonyl) -benzenetrifluoride?
The main use of 2 - (chlorosulfonyl) -trifluorotoluene is particularly important. This substance is widely used in the chemical industry.
The first application in pharmaceutical synthesis. In many drug creation processes, 2 - (chlorosulfonyl) -trifluorotoluene can be a key intermediate. Through specific chemical reactions, it can be introduced into the molecular structure of the drug to change the physicochemical properties and biological activities of the drug. For example, in the synthesis of some antidepressants and cardiovascular disease treatment drugs, its participation in the reaction plays an indispensable role in the construction of a drug molecular structure with precise efficacy.
Furthermore, it also has significant uses in pesticide manufacturing. With it as raw material, a variety of high-efficiency pesticides can be synthesized. Such pesticides have a unique killing mechanism against pests, or can interfere with the nervous system of pests, or can inhibit their physiological metabolic processes, thus effectively protecting crops from insect infestation. At the same time, due to its chemical structure characteristics, the prepared pesticides have good degradation performance in the environment, which can reduce the negative impact on the ecological environment, and meet the needs of the current green agriculture development.
In addition, in the field of materials science, 2- (chlorosulfonyl) -trifluorotoluene also plays an important role. In the preparation of high-performance polymer materials, it can participate in the reaction as a modifier. The modified polymer materials can be significantly improved in terms of heat resistance, chemical resistance and mechanical properties. These high-performance polymer materials are widely used in high-end fields such as aerospace, electronics, and electrical appliances, providing key support for technological progress in related industries.
In summary, 2 - (chlorosulfonyl) -trifluorotoluene has shown important value in many fields such as medicine, pesticides, and materials science, promoting technological innovation and development in various fields.
The first application in pharmaceutical synthesis. In many drug creation processes, 2 - (chlorosulfonyl) -trifluorotoluene can be a key intermediate. Through specific chemical reactions, it can be introduced into the molecular structure of the drug to change the physicochemical properties and biological activities of the drug. For example, in the synthesis of some antidepressants and cardiovascular disease treatment drugs, its participation in the reaction plays an indispensable role in the construction of a drug molecular structure with precise efficacy.
Furthermore, it also has significant uses in pesticide manufacturing. With it as raw material, a variety of high-efficiency pesticides can be synthesized. Such pesticides have a unique killing mechanism against pests, or can interfere with the nervous system of pests, or can inhibit their physiological metabolic processes, thus effectively protecting crops from insect infestation. At the same time, due to its chemical structure characteristics, the prepared pesticides have good degradation performance in the environment, which can reduce the negative impact on the ecological environment, and meet the needs of the current green agriculture development.
In addition, in the field of materials science, 2- (chlorosulfonyl) -trifluorotoluene also plays an important role. In the preparation of high-performance polymer materials, it can participate in the reaction as a modifier. The modified polymer materials can be significantly improved in terms of heat resistance, chemical resistance and mechanical properties. These high-performance polymer materials are widely used in high-end fields such as aerospace, electronics, and electrical appliances, providing key support for technological progress in related industries.
In summary, 2 - (chlorosulfonyl) -trifluorotoluene has shown important value in many fields such as medicine, pesticides, and materials science, promoting technological innovation and development in various fields.
What are the physical properties of 2- (chlorosulfonyl) -benzenetrifluoride
2 - (chlorosulfonyl) -trifluorotoluene is an important compound in the field of organic chemistry. Its physical properties are unique and it has a wide range of uses in many aspects of chemical industry.
When it comes to its properties, this compound is mostly colorless to light yellow liquid under normal conditions, and it looks clear and translucent. Its odor is special, with a certain degree of irritation, and the smell is pungent. When operating, be careful to prevent damage to the sense of smell.
The boiling point is a key physical constant. Under specific pressure, its boiling point is relatively clear, and this characteristic plays a significant role in the separation and purification process. By controlling the temperature, according to the difference in boiling point, the substance can be accurately separated from the mixture for the purpose of purification.
The melting point cannot be ignored. Defining the melting point is of great significance to the setting of storage and transportation conditions. If the temperature is not properly controlled, or the state of the substance is changed, its quality and performance will be affected.
In terms of solubility, 2 - (chlorosulfonyl) -trifluorotoluene has good solubility in some organic solvents, such as common toluene and dichloromethane. However, its solubility in water is poor, which determines its application range in different reaction systems. In organic synthesis reactions, according to its solubility, a suitable solvent can be selected to build an ideal reaction environment and promote the smooth progress of the reaction.
Density is another important physical property. Its density value is specific, and when mixed with other substances, due to density differences or stratification, this provides an important basis for separation and analysis processes.
In addition, the vapor pressure of 2- (chlorosulfonyl) -trifluorotoluene also has characteristics. At different temperatures, the vapor pressure change law can be followed, which is related to its volatilization degree in a closed space, which has a profound impact on safe production and storage.
It can be seen from the above that the physical properties of 2- (chlorosulfonyl) -trifluorotoluene are diverse, and each property is interrelated, which together determine its application direction and operation points in the chemical industry. Only by deeply understanding and accurately grasping these properties can the compound be used efficiently and safely to maximize its value.
When it comes to its properties, this compound is mostly colorless to light yellow liquid under normal conditions, and it looks clear and translucent. Its odor is special, with a certain degree of irritation, and the smell is pungent. When operating, be careful to prevent damage to the sense of smell.
The boiling point is a key physical constant. Under specific pressure, its boiling point is relatively clear, and this characteristic plays a significant role in the separation and purification process. By controlling the temperature, according to the difference in boiling point, the substance can be accurately separated from the mixture for the purpose of purification.
The melting point cannot be ignored. Defining the melting point is of great significance to the setting of storage and transportation conditions. If the temperature is not properly controlled, or the state of the substance is changed, its quality and performance will be affected.
In terms of solubility, 2 - (chlorosulfonyl) -trifluorotoluene has good solubility in some organic solvents, such as common toluene and dichloromethane. However, its solubility in water is poor, which determines its application range in different reaction systems. In organic synthesis reactions, according to its solubility, a suitable solvent can be selected to build an ideal reaction environment and promote the smooth progress of the reaction.
Density is another important physical property. Its density value is specific, and when mixed with other substances, due to density differences or stratification, this provides an important basis for separation and analysis processes.
In addition, the vapor pressure of 2- (chlorosulfonyl) -trifluorotoluene also has characteristics. At different temperatures, the vapor pressure change law can be followed, which is related to its volatilization degree in a closed space, which has a profound impact on safe production and storage.
It can be seen from the above that the physical properties of 2- (chlorosulfonyl) -trifluorotoluene are diverse, and each property is interrelated, which together determine its application direction and operation points in the chemical industry. Only by deeply understanding and accurately grasping these properties can the compound be used efficiently and safely to maximize its value.
What are the chemical properties of 2- (chlorosulfonyl) -benzenetrifluoride
2-%28chlorosulfonyl%29-benzenetrifluoride, that is, 2- (chlorosulfonyl) -trifluorotoluene, which is an organic compound. Its chemical properties are unique and have the following characteristics:
- ** Electrophilic Substitution Activity **: The benzene ring is an electron-rich system, while the chlorosulfonyl group of 2- (chlorosulfonyl) -trifluorotoluene is a strong electron-absorbing group. Through induction and conjugation effects, the electron cloud density of the benzene ring is reduced. However, due to the high stability of the benzene ring, electrophilic substitution reactions can still occur, but the reactivity is lower than that of benzene. For example, under certain conditions, it can nitrify and sulfonate with electrophilic reagents such as nitric acid and sulfuric acid, and the substituents mainly enter the benzene ring interposition. Due to the electron-absorbing action of the chlorosulfonyl group, the density of the adjacent and para-position electron clouds decreases more significantly, and the interposition is relatively high, and the electrophilic reagent is more likely to attack the interposition.
- * Chlorosulfonyl reactivity **: This group has high activity and good exodus of chlorine atoms. When exposed to water, it is very prone to hydrolysis, and the chlorine atoms are replaced by hydroxyl groups to generate 2- (sulfonyl) -trifluorobenzoic acid, and release hydrogen chloride gas. When reacting with alcohols, chlorine atoms can be substituted by alkoxy groups to form sulfonate esters. This reaction is often used in organic synthesis to prepare sulfonates, which are widely used in nucleophilic substitution reactions and other fields.
- ** Effect of trifluoromethyl **: Trifluoromethyl is a strong electron-absorbing group, and its presence further reduces the electron cloud density of the benzene ring, strengthens molecular polarity, and improves the stability and fat solubility of the compound. Because of its strong electron-absorbing property, it also affects the reactivity of other substituents on the benzene ring, so that the electron cloud density of the ortho and para-position decreases more than that of the meta-position, which affects the selectivity of the check point of the electrophilic At the same time, the presence of trifluoromethyl improves the physical properties of compounds, such as enhancing the volatility and solubility of compounds, which is of great significance in the fields of materials science and medicinal chemistry.
- ** Redox stability **: 2 - (chlorosulfonyl) -trifluorotoluene is relatively stable to common oxidants and reducing agents under normal conditions. Because there are no functional groups in the molecule that are easily oxidized or reduced, such as carbon-carbon double bonds, aldehyde groups, etc. However, under strong oxidation or strong reduction conditions, benzene rings or chlorosulfonyl groups will react. For example, under the action of strong oxidants, benzene rings may be oxidized to open rings; under the action of strong reducing agents such as lithium aluminum hydride, chlorine atoms of chlorosulfonyl groups may be reduced to hydrogen atoms.
- ** Electrophilic Substitution Activity **: The benzene ring is an electron-rich system, while the chlorosulfonyl group of 2- (chlorosulfonyl) -trifluorotoluene is a strong electron-absorbing group. Through induction and conjugation effects, the electron cloud density of the benzene ring is reduced. However, due to the high stability of the benzene ring, electrophilic substitution reactions can still occur, but the reactivity is lower than that of benzene. For example, under certain conditions, it can nitrify and sulfonate with electrophilic reagents such as nitric acid and sulfuric acid, and the substituents mainly enter the benzene ring interposition. Due to the electron-absorbing action of the chlorosulfonyl group, the density of the adjacent and para-position electron clouds decreases more significantly, and the interposition is relatively high, and the electrophilic reagent is more likely to attack the interposition.
- * Chlorosulfonyl reactivity **: This group has high activity and good exodus of chlorine atoms. When exposed to water, it is very prone to hydrolysis, and the chlorine atoms are replaced by hydroxyl groups to generate 2- (sulfonyl) -trifluorobenzoic acid, and release hydrogen chloride gas. When reacting with alcohols, chlorine atoms can be substituted by alkoxy groups to form sulfonate esters. This reaction is often used in organic synthesis to prepare sulfonates, which are widely used in nucleophilic substitution reactions and other fields.
- ** Effect of trifluoromethyl **: Trifluoromethyl is a strong electron-absorbing group, and its presence further reduces the electron cloud density of the benzene ring, strengthens molecular polarity, and improves the stability and fat solubility of the compound. Because of its strong electron-absorbing property, it also affects the reactivity of other substituents on the benzene ring, so that the electron cloud density of the ortho and para-position decreases more than that of the meta-position, which affects the selectivity of the check point of the electrophilic At the same time, the presence of trifluoromethyl improves the physical properties of compounds, such as enhancing the volatility and solubility of compounds, which is of great significance in the fields of materials science and medicinal chemistry.
- ** Redox stability **: 2 - (chlorosulfonyl) -trifluorotoluene is relatively stable to common oxidants and reducing agents under normal conditions. Because there are no functional groups in the molecule that are easily oxidized or reduced, such as carbon-carbon double bonds, aldehyde groups, etc. However, under strong oxidation or strong reduction conditions, benzene rings or chlorosulfonyl groups will react. For example, under the action of strong oxidants, benzene rings may be oxidized to open rings; under the action of strong reducing agents such as lithium aluminum hydride, chlorine atoms of chlorosulfonyl groups may be reduced to hydrogen atoms.
What are the synthesis methods of 2- (chlorosulfonyl) -benzenetrifluoride
2-%28chlorosulfonyl%29-benzenetrifluoride is 2 - (chlorosulfonyl) -trifluorotoluene, and its synthesis method is as follows:
First, use o-trifluoromethylbenzoic acid as the starting material. First, mix o-trifluoromethylbenzoic acid with thionyl chloride, add an appropriate amount of N, N - dimethylformamide as a catalyst, and heat the reflux reaction. The carboxyl group in o-trifluoromethylbenzoic acid is acylated with chlorinated sulfoxide, and the carboxyl group is converted into an acyl chloride to form o-trifluoromethylbenzoyl chloride. Subsequently, the obtained o-trifluoromethylbenzoyl chloride is slowly added dropwise to the mixture of fuming sulfuric acid and chlorosulfonic acid at low temperature to maintain the low temperature reaction for a In this process, under strong acidic conditions, the acyl chloride group is introduced into the chlorosulfonyl group at a specific position in the benzene ring through complex reactions such as electrophilic substitution, thereby obtaining 2- (chlorosulfonyl) -trifluorotoluene.
Second, take o-trifluoromethylchlorobenzene as the starting material. In the presence of Lewis acid catalysts such as anhydrous aluminum trichloride, the o-trifluoromethylchlorobenzene is reacted with chlorosulfonic acid. Chlorosulfonic acid is used as a sulfonation reagent to attack the benzene ring, and chlorosulfonyl is introduced into the benzene ring through electrophilic substitution reaction to generate 2- (chlorosulfonyl) -trifluorotoluene. The reaction process requires strict control of the reaction temperature and the
Third, trifluorotoluene is used as raw material. First, under the action of light or initiator, trifluorotoluene and chlorine gas undergo free radical substitution reaction, and chlorine atoms are introduced into the benzene ring to generate the corresponding chlorotrifluorotoluene. After that, chlorosulfonic acid is used to sulfonate chlorotrifluorotoluene, and chlorosulfonyl is introduced at a specific position to obtain 2- (chlorosulfonyl) -trifluorotoluene. This method requires attention to the selective control of free radical substitution reaction and the optimization of subsequent sulfonation reaction conditions.
First, use o-trifluoromethylbenzoic acid as the starting material. First, mix o-trifluoromethylbenzoic acid with thionyl chloride, add an appropriate amount of N, N - dimethylformamide as a catalyst, and heat the reflux reaction. The carboxyl group in o-trifluoromethylbenzoic acid is acylated with chlorinated sulfoxide, and the carboxyl group is converted into an acyl chloride to form o-trifluoromethylbenzoyl chloride. Subsequently, the obtained o-trifluoromethylbenzoyl chloride is slowly added dropwise to the mixture of fuming sulfuric acid and chlorosulfonic acid at low temperature to maintain the low temperature reaction for a In this process, under strong acidic conditions, the acyl chloride group is introduced into the chlorosulfonyl group at a specific position in the benzene ring through complex reactions such as electrophilic substitution, thereby obtaining 2- (chlorosulfonyl) -trifluorotoluene.
Second, take o-trifluoromethylchlorobenzene as the starting material. In the presence of Lewis acid catalysts such as anhydrous aluminum trichloride, the o-trifluoromethylchlorobenzene is reacted with chlorosulfonic acid. Chlorosulfonic acid is used as a sulfonation reagent to attack the benzene ring, and chlorosulfonyl is introduced into the benzene ring through electrophilic substitution reaction to generate 2- (chlorosulfonyl) -trifluorotoluene. The reaction process requires strict control of the reaction temperature and the
Third, trifluorotoluene is used as raw material. First, under the action of light or initiator, trifluorotoluene and chlorine gas undergo free radical substitution reaction, and chlorine atoms are introduced into the benzene ring to generate the corresponding chlorotrifluorotoluene. After that, chlorosulfonic acid is used to sulfonate chlorotrifluorotoluene, and chlorosulfonyl is introduced at a specific position to obtain 2- (chlorosulfonyl) -trifluorotoluene. This method requires attention to the selective control of free radical substitution reaction and the optimization of subsequent sulfonation reaction conditions.
2- (chlorosulfonyl) -benzenetrifluoride in the use of what are the precautions
2-%28chlorosulfonyl%29-benzenetrifluoride is 2- (chlorosulfonyl) -trifluorotoluene, which is used in chemical industry, many matters need to be paid attention to.
The first is about its toxicity and harm. This substance is irritating, or harmful to the eyes, skin and respiratory tract. When operating, be sure to wear protective clothing, such as protective gloves, goggles and gas masks, to prevent contact and inhalation, to avoid damage to the body. If inadvertently contacted, rinse with plenty of water immediately and seek medical treatment in time.
The second is its chemical properties. 2- (chlorosulfonyl) -trifluorotoluene is chemically active and easily reacts in contact with water to form corrosive substances such as hydrogen chloride and sulfuric acid. Therefore, during storage and use, it should be kept dry and away from water sources. And it may also react with other chemical substances. Before use, its compatibility with the substances it comes into contact with must be clarified to prevent dangerous chemical reactions.
The other is the storage condition. It should be stored in a cool and well-ventilated place, away from fire and heat sources. Because of its volatility, the storage container should be tightly sealed to prevent leakage. At the same time, it should be stored separately from oxidants and alkalis, and mixed storage should not be avoided.
The other is the operating specification. The operation process needs to be carried out in a fume hood to ensure good ventilation and reduce the concentration of harmful gases. Use accurate measuring equipment and use it according to the specified amount to avoid waste and excessive danger. After the operation is completed, clean the equipment, properly dispose of the remaining substances and waste, and follow environmental protection and safety regulations.
In short, the use of 2 - (chlorosulfonyl) -trifluorotoluene requires a good understanding of its properties, hazards and operating specifications, careful operation, and strict adherence to safety guidelines to ensure personal safety and smooth production.
The first is about its toxicity and harm. This substance is irritating, or harmful to the eyes, skin and respiratory tract. When operating, be sure to wear protective clothing, such as protective gloves, goggles and gas masks, to prevent contact and inhalation, to avoid damage to the body. If inadvertently contacted, rinse with plenty of water immediately and seek medical treatment in time.
The second is its chemical properties. 2- (chlorosulfonyl) -trifluorotoluene is chemically active and easily reacts in contact with water to form corrosive substances such as hydrogen chloride and sulfuric acid. Therefore, during storage and use, it should be kept dry and away from water sources. And it may also react with other chemical substances. Before use, its compatibility with the substances it comes into contact with must be clarified to prevent dangerous chemical reactions.
The other is the storage condition. It should be stored in a cool and well-ventilated place, away from fire and heat sources. Because of its volatility, the storage container should be tightly sealed to prevent leakage. At the same time, it should be stored separately from oxidants and alkalis, and mixed storage should not be avoided.
The other is the operating specification. The operation process needs to be carried out in a fume hood to ensure good ventilation and reduce the concentration of harmful gases. Use accurate measuring equipment and use it according to the specified amount to avoid waste and excessive danger. After the operation is completed, clean the equipment, properly dispose of the remaining substances and waste, and follow environmental protection and safety regulations.
In short, the use of 2 - (chlorosulfonyl) -trifluorotoluene requires a good understanding of its properties, hazards and operating specifications, careful operation, and strict adherence to safety guidelines to ensure personal safety and smooth production.
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